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Van Leusen reaction

Index Van Leusen reaction

The Van Leusen reaction is the reaction of a ketone with TosMIC leading to the formation of a nitrile. [1]

21 relations: Aldehyde, Aldimine, American Chemical Society, Amine, Baldwin's rules, Carbonyl group, Condensation, Elimination reaction, Imidazole, Isocyanide, Journal of Organic Chemistry, Ketone, Leaving group, Nitrile, Organic Letters, Oxazole, Reaction mechanism, Sulfone, Tautomer, TosMIC, Tosyl.

Aldehyde

An aldehyde or alkanal is an organic compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen and to an R group, which is any generic alkyl or side chain.

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Aldimine

In organic chemistry, an aldimine is an imine that is an analog of an aldehyde.

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American Chemical Society

The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry.

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Amine

In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.

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Baldwin's rules

Baldwin's rules in organic chemistry are a series of guidelines outlining the relative favorabilities of ring closure reactions in alicyclic compounds.

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Carbonyl group

In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C.

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Condensation

Condensation is the change of the physical state of matter from gas phase into liquid phase, and is the reverse of vapourisation.

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Elimination reaction

An elimination reaction is a type of organic reaction in which two substituents are removed from a molecule in either a one or two-step mechanism.

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Imidazole

Imidazole is an organic compound with the formula C3N2H4.

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Isocyanide

An isocyanide (also called isonitrile or carbylamine) is an organic compound with the functional group -N≡C.

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Journal of Organic Chemistry

The Journal of Organic Chemistry, colloquially known as JOC or J Org, is a peer-reviewed scientific journal for original contributions of fundamental research in all branches of theory and practice in organic and bioorganic chemistry.

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Ketone

In chemistry, a ketone (alkanone) is an organic compound with the structure RC(.

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Leaving group

In chemistry, a leaving group is a molecular fragment that departs with a pair of electrons in heterolytic bond cleavage.

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Nitrile

A nitrile is any organic compound that has a −C≡N functional group.

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Organic Letters

Organic Letters (usually abbreviated as Org. Lett.), is a peer-reviewed biweekly scientific journal, published since 1999 by the American Chemical Society.

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Oxazole

Oxazole is the parent compound for a vast class of heterocyclic aromatic organic compounds.

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Reaction mechanism

In chemistry, a reaction mechanism is the step by step sequence of elementary reactions by which overall chemical change occurs.

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Sulfone

A sulfone is a chemical compound containing a sulfonyl functional group attached to two carbon atoms.

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Tautomer

Tautomers are constitutional isomers of organic compounds that readily interconvert.

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TosMIC

Toluenesulfonylmethyl isocyanide or TOSMIC is an organic compound with the formula CH3C6H4SO2CH2NC.

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Tosyl

A toluenesulfonyl (shortened tosyl, abbreviated Ts or Tos) group is CH3C6H4SO2.

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References

[1] https://en.wikipedia.org/wiki/Van_Leusen_reaction

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