23 relations: Active metabolite, Antiestrogen, Bioavailability, Boronic acid, Cmax (pharmacology), Estrogen receptor, Estrogen receptor alpha, First pass effect, Fulvestrant, Hydroxy group, IC50, In vivo, Intramuscular injection, Metastatic breast cancer, Moiety (chemistry), Oral administration, Organic compound, Pharmacodynamics, Receptor antagonist, Selective estrogen receptor degrader, Steroid, Structural analog, Subcutaneous injection.
Active metabolite
An active metabolite is an active form of a drug after it has been processed by the body.
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Antiestrogen
Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Boronic acid
A boronic acid is a compound related to boric acid in which one of the three hydroxyl groups is replaced by an alkyl or aryl group.
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Cmax (pharmacology)
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and before the administration of a second dose.
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Estrogen receptor
Estrogen receptors (ERs) are a group of proteins found inside cells.
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Estrogen receptor alpha
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.
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First pass effect
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.
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Fulvestrant
Fulvestrant, sold under the brand name Faslodex among others, is a medication used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression as well as HR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrine therapy.
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Hydroxy group
A hydroxy or hydroxyl group is the entity with the formula OH.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Intramuscular injection
Intramuscular (also IM or im) injection is the injection of a substance directly into muscle.
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Metastatic breast cancer
Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumours, secondaries or stage 4 breast cancer, is a stage of breast cancer where the disease has spread to distant sites beyond the axillary lymph nodes.
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Moiety (chemistry)
In organic chemistry, a moiety is a part of a molecule.
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Oral administration
| name.
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Organic compound
In chemistry, an organic compound is generally any chemical compound that contains carbon.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Selective estrogen receptor degrader
A selective estrogen receptor degrader or downregulator (SERD) is a type of drug which binds to the estrogen receptor (ER) and, in the process of doing so, causes the ER to be degraded and thus downregulated.
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Steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
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Structural analog
A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.
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Subcutaneous injection
A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis.
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Redirects here:
Fulvestrant 3 boronic acid, Fulvestrant 3 boronoate, Fulvestrant 3-boronic acid, Fulvestrant 3-boronoate, Fulvestrant-3 boronic acid, Fulvestrant-3 boronoate, Fulvestrant-3-boronic acid, Fulvestrant-3-boronoate, ZB 716, ZB-716.
References
[1] https://en.wikipedia.org/wiki/ZB716