Logo
Unionpedia
Communication
Get it on Google Play
New! Download Unionpedia on your Android™ device!
Download
Faster access than browser!
 

Zinc finger

+ Save concept

A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. [1]

65 relations: Aaron Klug, African clawed frog, B-box zinc finger, Beta hairpin, Beta sheet, Biomolecular structure, Caenorhabditis elegans, Cell adhesion, Chromatin, Conformational change, Coordination complex, Cysteine, Cytoskeleton, DNA, DNA-binding protein, Drosophila melanogaster, EGR1, Epithelium, Eukaryote, Evolution, Extended X-ray absorption fine structure, FokI, Gal4 transcription factor, GC box, Gene, GTF3A, Histidine, Histone acetyltransferase, HIV/AIDS, Ion, Krüppel associated box, Ligand, Lipid, Maize, Molecular binding, Myelin, Nuclear receptor, Phage display, PROSITE, Protein, Protein domain, Protein engineering, Protein folding, Protein primary structure, Protein superfamily, Rat, RING finger domain, RNA, Salt bridge (protein and supramolecular), Sequence motif, ..., Steroid hormone receptor, Structural motif, Substrate (chemistry), Supersecondary structure, TAL effector, Tobacco, Transcription (biology), Transcription activator-like effector nuclease, Transcription factor, Xenopus, Zebrafish, Zinc, Zinc finger inhibitor, Zinc finger nuclease, Zinc finger transcription factor. Expand index (15 more) »

Aaron Klug

Sir Aaron Klug (born 11 August 1926) is a Lithuanian-born, South African-educated, British chemist and biophysicist, and winner of the 1982 Nobel Prize in Chemistry for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes.

New!!: Zinc finger and Aaron Klug · See more »

African clawed frog

The African clawed frog (Xenopus laevis, also known as the xenopus, African clawed toad, African claw-toed frog or the platanna) is a species of African aquatic frog of the family Pipidae.

New!!: Zinc finger and African clawed frog · See more »

B-box zinc finger

In molecular biology the B-box-type zinc finger domain is a short protein domain of around 40 amino acid residues in length.

New!!: Zinc finger and B-box zinc finger · See more »

Beta hairpin

The beta hairpin (sometimes also called beta-ribbon or beta-beta unit) is a simple protein structural motif involving two beta strands that look like a hairpin.

New!!: Zinc finger and Beta hairpin · See more »

Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

New!!: Zinc finger and Beta sheet · See more »

Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.

New!!: Zinc finger and Biomolecular structure · See more »

Caenorhabditis elegans

Caenorhabditis elegans is a free-living (not parasitic), transparent nematode (roundworm), about 1 mm in length, that lives in temperate soil environments.

New!!: Zinc finger and Caenorhabditis elegans · See more »

Cell adhesion

Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface.

New!!: Zinc finger and Cell adhesion · See more »

Christmas

Christmas is an annual festival commemorating the birth of Jesus Christ,Martindale, Cyril Charles.

New!!: Zinc finger and Christmas · See more »

Christmas and holiday season

The Christmas season, also called the festive season, or the holiday season (mainly in the U.S. and Canada; often simply called the holidays),, is an annually recurring period recognized in many Western and Western-influenced countries that is generally considered to run from late November to early January.

New!!: Zinc finger and Christmas and holiday season · See more »

Christmas Eve

Christmas Eve is the evening or entire day before Christmas Day, the festival commemorating the birth of Jesus.

New!!: Zinc finger and Christmas Eve · See more »

Christmas traditions

Christmas traditions vary from country to country.

New!!: Zinc finger and Christmas traditions · See more »

Chromatin

Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.

New!!: Zinc finger and Chromatin · See more »

Conformational change

In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.

New!!: Zinc finger and Conformational change · See more »

Coordination complex

In chemistry, a coordination complex consists of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents.

New!!: Zinc finger and Coordination complex · See more »

Cysteine

Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

New!!: Zinc finger and Cysteine · See more »

Cytoskeleton

A cytoskeleton is present in all cells of all domains of life (archaea, bacteria, eukaryotes).

New!!: Zinc finger and Cytoskeleton · See more »

DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

New!!: Zinc finger and DNA · See more »

DNA-binding protein

DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA.

New!!: Zinc finger and DNA-binding protein · See more »

Drosophila melanogaster

Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.

New!!: Zinc finger and Drosophila melanogaster · See more »

EGR1

EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

New!!: Zinc finger and EGR1 · See more »

Epithelium

Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.

New!!: Zinc finger and Epithelium · See more »

Eukaryote

Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).

New!!: Zinc finger and Eukaryote · See more »

Evolution

Evolution is change in the heritable characteristics of biological populations over successive generations.

New!!: Zinc finger and Evolution · See more »

Extended X-ray absorption fine structure

X-ray Absorption Spectroscopy (XAS) includes both Extended X-Ray Absorption Fine Structure (EXAFS) and X-ray Absorption Near Edge Structure (XANES).

New!!: Zinc finger and Extended X-ray absorption fine structure · See more »

FokI

The enzyme FokI, naturally found in Flavobacterium okeanokoites, is a bacterial type IIS restriction endonuclease consisting of an N-terminal DNA-binding domain and a non-specific DNA cleavage domain at the C-terminal.

New!!: Zinc finger and FokI · See more »

Gal4 transcription factor

The Gal4 transcription factor is a positive regulator of gene expression of galactose-induced genes.

New!!: Zinc finger and Gal4 transcription factor · See more »

GC box

In molecular biology, a GC box, also known as a GSG box, is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes.

New!!: Zinc finger and GC box · See more »

Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

New!!: Zinc finger and Gene · See more »

GTF3A

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.

New!!: Zinc finger and GTF3A · See more »

Histidine

Histidine (symbol His or H) is an α-amino acid that is used in the biosynthesis of proteins.

New!!: Zinc finger and Histidine · See more »

Histone acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine.

New!!: Zinc finger and Histone acetyltransferase · See more »

HIV/AIDS

Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).

New!!: Zinc finger and HIV/AIDS · See more »

Ion

An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).

New!!: Zinc finger and Ion · See more »

Krüppel associated box

The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 400 human zinc finger protein-based transcription factors (KRAB zinc finger proteins).

New!!: Zinc finger and Krüppel associated box · See more »

Ligand

In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.

New!!: Zinc finger and Ligand · See more »

Lipid

In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.

New!!: Zinc finger and Lipid · See more »

Maize

Maize (Zea mays subsp. mays, from maíz after Taíno mahiz), also known as corn, is a cereal grain first domesticated by indigenous peoples in southern Mexico about 10,000 years ago.

New!!: Zinc finger and Maize · See more »

Molecular binding

Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other.

New!!: Zinc finger and Molecular binding · See more »

Myelin

Myelin is a lipid-rich substance that surrounds the axon of some nerve cells, forming an electrically insulating layer.

New!!: Zinc finger and Myelin · See more »

New Year

New Year is the time or day at which a new calendar year begins and the calendar's year count increments by one.

New!!: Zinc finger and New Year · See more »

New Year's Day

New Year's Day, also called simply New Year's or New Year, is observed on January 1, the first day of the year on the modern Gregorian calendar as well as the Julian calendar.

New!!: Zinc finger and New Year's Day · See more »

New Year's Eve

In the Gregorian calendar, New Year's Eve (also known as Old Year's Day or Saint Sylvester's Day in many countries), the last day of the year, is on 31 December which is the seventh day of Christmastide.

New!!: Zinc finger and New Year's Eve · See more »

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.

New!!: Zinc finger and Nuclear receptor · See more »

Phage display

Phage display is a laboratory technique for the study of protein–protein, protein–peptide, and protein–DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them.

New!!: Zinc finger and Phage display · See more »

PROSITE

PROSITE is a protein database.

New!!: Zinc finger and PROSITE · See more »

Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

New!!: Zinc finger and Protein · See more »

Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

New!!: Zinc finger and Protein domain · See more »

Protein engineering

Protein engineering is the process of developing useful or valuable proteins.

New!!: Zinc finger and Protein engineering · See more »

Protein folding

Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner.

New!!: Zinc finger and Protein folding · See more »

Protein primary structure

Protein primary structure is the linear sequence of amino acids in a peptide or protein.

New!!: Zinc finger and Protein primary structure · See more »

Protein superfamily

A protein superfamily is the largest grouping (clade) of proteins for which common ancestry can be inferred (see homology).

New!!: Zinc finger and Protein superfamily · See more »

Rat

Rats are various medium-sized, long-tailed rodents in the superfamily Muroidea.

New!!: Zinc finger and Rat · See more »

RING finger domain

In molecular biology, a RING (Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively).

New!!: Zinc finger and RING finger domain · See more »

RNA

Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.

New!!: Zinc finger and RNA · See more »

Salt bridge (protein and supramolecular)

In chemistry, a salt bridge is a combination of two non-covalent interactions: hydrogen bonding and ionic bonding (Figure 1).

New!!: Zinc finger and Salt bridge (protein and supramolecular) · See more »

Sequence motif

In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance.

New!!: Zinc finger and Sequence motif · See more »

Steroid hormone receptor

Steroid hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells.

New!!: Zinc finger and Steroid hormone receptor · See more »

Structural motif

In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which also appears in a variety of other molecules.

New!!: Zinc finger and Structural motif · See more »

Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

New!!: Zinc finger and Substrate (chemistry) · See more »

Supersecondary structure

A supersecondary structure is a compact three-dimensional protein structure of several adjacent elements of a secondary structure that is smaller than a protein domain or a subunit.

New!!: Zinc finger and Supersecondary structure · See more »

TAL effector

TAL (transcription activator-like) effectors (often referred to as TALEs, but not to be confused with the three amino acid loop extension homeobox class of proteins) are proteins secreted by Xanthomonas bacteria via their type III secretion system when they infect various plant species.

New!!: Zinc finger and TAL effector · See more »

Tobacco

Tobacco is a product prepared from the leaves of the tobacco plant by curing them.

New!!: Zinc finger and Tobacco · See more »

Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

New!!: Zinc finger and Transcription (biology) · See more »

Transcription activator-like effector nuclease

Transcription activator-like effector nucleases (TALEN) are restriction enzymes that can be engineered to cut specific sequences of DNA.

New!!: Zinc finger and Transcription activator-like effector nuclease · See more »

Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

New!!: Zinc finger and Transcription factor · See more »

Xenopus

Xenopus (Gk., ξενος, xenos.

New!!: Zinc finger and Xenopus · See more »

Zebrafish

The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.

New!!: Zinc finger and Zebrafish · See more »

Zinc

Zinc is a chemical element with symbol Zn and atomic number 30.

New!!: Zinc finger and Zinc · See more »

Zinc finger inhibitor

This image shows the typical structure of NCp7, which is targeted by zinc finger inhibitors when combating HIV. Zinc finger inhibitors, or zinc ejectors, are substances or compounds that interact adversely with zinc fingers and cause them to release their zinc from its binding site, disrupting the conformation of the polypeptide chain and rendering the zinc fingers ineffective, thereby preventing them from performing their associated cellular functions.

New!!: Zinc finger and Zinc finger inhibitor · See more »

Zinc finger nuclease

Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain.

New!!: Zinc finger and Zinc finger nuclease · See more »

Zinc finger transcription factor

Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a variety of transcription-factor effector-domains that exert their modulatory effect in the vicinity of any sequence to which the protein domain binds.

New!!: Zinc finger and Zinc finger transcription factor · See more »

2018

2018 has been designated as the third International Year of the Reef by the International Coral Reef Initiative.

New!!: Zinc finger and 2018 · See more »

2019

2019 (MMXIX) will be a common year starting on Tuesday of the Gregorian calendar, the 2019th year of the Common Era (CE) and Anno Domini (AD) designations, the 19th year of the 3rd millennium, the 19th year of the 21st century, and the 10th and last year of the 2010s decade.

New!!: Zinc finger and 2019 · See more »

Redirects here:

Z Finger Technique, Z finger, Z finger protein, Z finger technique, Z-finger, Z-finger protein, ZFP, Zfp, Zinc Fingers, Zinc binding protein, Zinc finger dna binding domain, Zinc finger protein, Zinc finger protein domain, Zinc finger proteins, Zinc fingers, Zinc-binding protein, Zinc-containing DNA-binding motif, Zinc-finger, Zinc-finger protein, Zink finger DNA binding domains, Zn finger, Zn finger protein, Zn-finger, Zn-finger protein.

References

[1] https://en.wikipedia.org/wiki/Zinc_finger

OutgoingIncoming
Hey! We are on Facebook now! »