65 relations: Aaron Klug, African clawed frog, B-box zinc finger, Beta hairpin, Beta sheet, Biomolecular structure, Caenorhabditis elegans, Cell adhesion, Chromatin, Conformational change, Coordination complex, Cysteine, Cytoskeleton, DNA, DNA-binding protein, Drosophila melanogaster, EGR1, Epithelium, Eukaryote, Evolution, Extended X-ray absorption fine structure, FokI, Gal4 transcription factor, GC box, Gene, GTF3A, Histidine, Histone acetyltransferase, HIV/AIDS, Ion, Krüppel associated box, Ligand, Lipid, Maize, Molecular binding, Myelin, Nuclear receptor, Phage display, PROSITE, Protein, Protein domain, Protein engineering, Protein folding, Protein primary structure, Protein superfamily, Rat, RING finger domain, RNA, Salt bridge (protein and supramolecular), Sequence motif, ..., Steroid hormone receptor, Structural motif, Substrate (chemistry), Supersecondary structure, TAL effector, Tobacco, Transcription (biology), Transcription activator-like effector nuclease, Transcription factor, Xenopus, Zebrafish, Zinc, Zinc finger inhibitor, Zinc finger nuclease, Zinc finger transcription factor. Expand index (15 more) » « Shrink index
Sir Aaron Klug (born 11 August 1926) is a Lithuanian-born, South African-educated, British chemist and biophysicist, and winner of the 1982 Nobel Prize in Chemistry for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes.
The African clawed frog (Xenopus laevis, also known as the xenopus, African clawed toad, African claw-toed frog or the platanna) is a species of African aquatic frog of the family Pipidae.
In molecular biology the B-box-type zinc finger domain is a short protein domain of around 40 amino acid residues in length.
The beta hairpin (sometimes also called beta-ribbon or beta-beta unit) is a simple protein structural motif involving two beta strands that look like a hairpin.
The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.
Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.
Caenorhabditis elegans is a free-living (not parasitic), transparent nematode (roundworm), about 1 mm in length, that lives in temperate soil environments.
Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface.
Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.
In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.
In chemistry, a coordination complex consists of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents.
Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.
A cytoskeleton is present in all cells of all domains of life (archaea, bacteria, eukaryotes).
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA.
Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.
EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).
Evolution is change in the heritable characteristics of biological populations over successive generations.
X-ray Absorption Spectroscopy (XAS) includes both Extended X-Ray Absorption Fine Structure (EXAFS) and X-ray Absorption Near Edge Structure (XANES).
The enzyme FokI, naturally found in Flavobacterium okeanokoites, is a bacterial type IIS restriction endonuclease consisting of an N-terminal DNA-binding domain and a non-specific DNA cleavage domain at the C-terminal.
The Gal4 transcription factor is a positive regulator of gene expression of galactose-induced genes.
In molecular biology, a GC box, also known as a GSG box, is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.
Histidine (symbol His or H) is an α-amino acid that is used in the biosynthesis of proteins.
Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine.
Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).
An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).
The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 400 human zinc finger protein-based transcription factors (KRAB zinc finger proteins).
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.
Maize (Zea mays subsp. mays, from maíz after Taíno mahiz), also known as corn, is a cereal grain first domesticated by indigenous peoples in southern Mexico about 10,000 years ago.
Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other.
Myelin is a lipid-rich substance that surrounds the axon of some nerve cells, forming an electrically insulating layer.
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
Phage display is a laboratory technique for the study of protein–protein, protein–peptide, and protein–DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them.
PROSITE is a protein database.
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.
Protein engineering is the process of developing useful or valuable proteins.
Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner.
Protein primary structure is the linear sequence of amino acids in a peptide or protein.
A protein superfamily is the largest grouping (clade) of proteins for which common ancestry can be inferred (see homology).
Rats are various medium-sized, long-tailed rodents in the superfamily Muroidea.
In molecular biology, a RING (Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively).
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.
In chemistry, a salt bridge is a combination of two non-covalent interactions: hydrogen bonding and ionic bonding (Figure 1).
In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance.
Steroid hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells.
In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which also appears in a variety of other molecules.
In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.
A supersecondary structure is a compact three-dimensional protein structure of several adjacent elements of a secondary structure that is smaller than a protein domain or a subunit.
TAL (transcription activator-like) effectors (often referred to as TALEs, but not to be confused with the three amino acid loop extension homeobox class of proteins) are proteins secreted by Xanthomonas bacteria via their type III secretion system when they infect various plant species.
Tobacco is a product prepared from the leaves of the tobacco plant by curing them.
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
Transcription activator-like effector nucleases (TALEN) are restriction enzymes that can be engineered to cut specific sequences of DNA.
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
Xenopus (Gk., ξενος, xenos.
The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.
Zinc is a chemical element with symbol Zn and atomic number 30.
This image shows the typical structure of NCp7, which is targeted by zinc finger inhibitors when combating HIV. Zinc finger inhibitors, or zinc ejectors, are substances or compounds that interact adversely with zinc fingers and cause them to release their zinc from its binding site, disrupting the conformation of the polypeptide chain and rendering the zinc fingers ineffective, thereby preventing them from performing their associated cellular functions.
Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain.
Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a variety of transcription-factor effector-domains that exert their modulatory effect in the vicinity of any sequence to which the protein domain binds.
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