5-HT3 receptor and Nicotinic acetylcholine receptor

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Difference between 5-HT3 receptor and Nicotinic acetylcholine receptor

5-HT3 receptor vs. Nicotinic acetylcholine receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors. Nicotinic acetylcholine receptors, or nAChRs, are receptor proteins that respond to the neurotransmitter acetylcholine.

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Calcium

Calcium is a chemical element with symbol Ca and atomic number 20.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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CHRNA7

Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.

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Cys-loop receptor

The Cys-loop ligand-gated ion channel superfamily is composed of nicotinic acetylcholine, GABAA, GABAA-ρ, glycine, 5-HT3 receptors, and zinc-activated ion channel that are composed of five protein subunits that form a pentameric arrangement around a central pore.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Ibogaine

Ibogaine is a naturally occurring psychoactive substance found in plants in the Apocynaceae family such as Tabernanthe iboga, Voacanga africana and Tabernaemontana undulata.

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Ion

An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).

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Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.

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Ligand-gated ion channel

Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.

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Memantine

Memantine is used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors. It was first synthesized by Eli Lilly and Company in 1968 as a potential agent to treat diabetes; the NMDA activity was discovered in the 1980s.

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Pathophysiology

Pathophysiology or physiopathology is a convergence of pathology with physiology.

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Potassium

Potassium is a chemical element with symbol K (from Neo-Latin kalium) and atomic number 19.

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Sodium

Sodium is a chemical element with symbol Na (from Latin natrium) and atomic number 11.

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Varenicline

Varenicline (trade name Chantix and Champix), is a prescription medication used to treat nicotine addiction.

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5-HT receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.

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