5-Hydroxyeicosatetraenoic acid and Arachidonic acid

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Difference between 5-Hydroxyeicosatetraenoic acid and Arachidonic acid

5-Hydroxyeicosatetraenoic acid vs. Arachidonic acid

5-Hydroxyeicosatetraenoic acid (5-HETE, 5(S)-HETE, or 5S-HETE) is an eicosanoid, i.e. a metabolite of arachidonic acid. Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).

ALOX12

ALOX12, also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p13.3.

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ALOX15

ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products.

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Arachidonate 5-lipoxygenase

Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene.

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Arachidonic acid 5-hydroperoxide

Arachidonic acid 5-hydroperoxide (5-hydroperoxyeicosatetraenoic acid, 5-HPETE) is an intermediate in the metabolism of arachidonic acid by the ALOX5 enzyme in humans or Alox5 enzyme in other mammals.

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Aspirin

Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation.

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Cis–trans isomerism

Cis–trans isomerism, also known as geometric isomerism or configurational isomerism, is a term used in organic chemistry.

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Double bond

A double bond in chemistry is a chemical bond between two chemical elements involving four bonding electrons instead of the usual two.

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Eicosanoid

Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, 20 carbon units in length.

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Leukotriene B4

Leukotriene B4 (LTB4) is a leukotriene involved in inflammation.

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Leukotriene C4

Leukotriene C4 (LTC4) is a leukotriene.

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Leukotriene D4

Leukotriene D4 (LTD4) is one of the leukotrienes.

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Leukotriene E4

Leukotriene E4 (LTE4) is a cysteinyl leukotriene involved in inflammation.

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Lipoxin

Lipoxins (LXs or Lxs), an acronym for lipoxygenase interaction products, are bioactive autacoid metabolites of arachidonic acid made by various cell types.

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Peroxisome proliferator-activated receptor gamma

Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor that in humans is encoded by the PPARG gene.

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Phosphatidylethanolamine

Phosphatidylethanolamines are a class of phospholipids found in biological membranes.

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Phospholipase A2

Phospholipases A2 (PLA2s) are enzymes that release fatty acids from the second carbon group of glycerol.

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Phospholipid

Phospholipids are a class of lipids that are a major component of all cell membranes.

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Polyunsaturated fatty acid

Polyunsaturated fatty acids (PUFAs) are fatty acids that contain more than one double bond in their backbone.

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Prostaglandin

The prostaglandins (PG) are a group of physiologically active lipid compounds having diverse hormone-like effects in animals.

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Prostaglandin-endoperoxide synthase 2

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (The HUGO official symbol is PTGS2; HGNC ID, HGNC:9605), also known as cyclooxygenase-2 or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.

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Protein kinase B

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.

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Protein kinase C

Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.

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12-Hydroxyeicosatetraenoic acid

12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a Hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z Cis–trans isomerism configuration (Z.

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15-Hydroxyeicosatetraenoic acid

15-Hydroxyeicosatetraenoic acid (also termed 15-HETE, 15(S)-HETE, and 15S-HETE) is an eicosanoid, i.e. a metabolite of arachidonic acid.

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5-oxo-eicosatetraenoic acid

5-Oxo-eicosatetraenoic acid (i.e. 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; also termed 5-oxo-ETE and 5-oxoETE) is a Nonclassic eicosanoid metabolite of arachidonic acid and the most potent naturally occurring member of the 5-HETE family of cell signaling agents.

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