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6-Pyruvoyltetrahydropterin synthase and 6-Pyruvoyltetrahydropterin synthase deficiency

Shortcuts: Differences, Similarities, Jaccard Similarity Coefficient, References.

Difference between 6-Pyruvoyltetrahydropterin synthase and 6-Pyruvoyltetrahydropterin synthase deficiency

6-Pyruvoyltetrahydropterin synthase vs. 6-Pyruvoyltetrahydropterin synthase deficiency

In enzymology, a 6-pyruvoyltetrahydropterin synthase (PTPS) is an enzyme that catalyzes the following chemical reaction: 7,8-Dihydroneopterin triphosphate \rightleftharpoons 6-pyruvoyltetrahydropterin + triphosphate This reaction is the second step (shown above) in the biosynthesis of Tetrahydrobiopterin from GTP, which is used as a cofactor in the synthesis of Aromatic amino acid Monooxygenases and Nitric oxide synthase PTPS converts 7,8-Dihydroneopterin triphosphate to 6-pyruvoyltetrahydropterin (PTP) through the loss of the triphosphate group, a stereospecific reduction of the double bond between the top right nitrogen and carbon in the ring on the ightht, The oxidation of the hydroxyl groups located on the first and second carbons of the side chain, and an internal base-catalyzed hydrogen tnsfer. 6-pyruvoyltetrahydropterin synthase (PTPS) can be found in the cytoplasm as well as the nucleus of cells according to immunohistochemical studies conducted. 6-Pyruvoyltetrahydropterin synthase deficiency is an autosomal recessive disorder that causes malignant hyperphenylalaninemia due to tetrahydrobiopterin deficiency.

Similarities between 6-Pyruvoyltetrahydropterin synthase and 6-Pyruvoyltetrahydropterin synthase deficiency

6-Pyruvoyltetrahydropterin synthase and 6-Pyruvoyltetrahydropterin synthase deficiency have 4 things in common (in Unionpedia): Dystonia, Epileptic seizure, Hyperphenylalaninemia, Tetrahydrobiopterin.

Dystonia

Dystonia is a neurological movement disorder syndrome in which sustained or repetitive muscle contractions result in twisting and repetitive movements or abnormal fixed postures.

6-Pyruvoyltetrahydropterin synthase and Dystonia · 6-Pyruvoyltetrahydropterin synthase deficiency and Dystonia · See more »

Epileptic seizure

An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

6-Pyruvoyltetrahydropterin synthase and Epileptic seizure · 6-Pyruvoyltetrahydropterin synthase deficiency and Epileptic seizure · See more »

Hyperphenylalaninemia

Hyperphenylalaninemia is a medical condition characterized by mildly or strongly elevated concentrations of the amino acid phenylalanine in the blood.

6-Pyruvoyltetrahydropterin synthase and Hyperphenylalaninemia · 6-Pyruvoyltetrahydropterin synthase deficiency and Hyperphenylalaninemia · See more »

Tetrahydrobiopterin

Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases.

6-Pyruvoyltetrahydropterin synthase and Tetrahydrobiopterin · 6-Pyruvoyltetrahydropterin synthase deficiency and Tetrahydrobiopterin · See more »

The list above answers the following questions

6-Pyruvoyltetrahydropterin synthase and 6-Pyruvoyltetrahydropterin synthase deficiency Comparison

6-Pyruvoyltetrahydropterin synthase has 36 relations, while 6-Pyruvoyltetrahydropterin synthase deficiency has 28. As they have in common 4, the Jaccard index is 6.25% = 4 / (36 + 28).

References

This article shows the relationship between 6-Pyruvoyltetrahydropterin synthase and 6-Pyruvoyltetrahydropterin synthase deficiency. To access each article from which the information was extracted, please visit:

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