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CYP3A4 and Spironolactone

Shortcuts: Differences, Similarities, Jaccard Similarity Coefficient, References.

Difference between CYP3A4 and Spironolactone

CYP3A4 vs. Spironolactone

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine. Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.

Similarities between CYP3A4 and Spironolactone

CYP3A4 and Spironolactone have 29 things in common (in Unionpedia): Agonist, Androgen, Antiandrogen, Antidepressant, Antimineralocorticoid, Beta blocker, Bicalutamide, Bioavailability, Biological half-life, Dietary supplement, Enzyme, Eplerenone, Fetus, Finasteride, Glucocorticoid, Hepatotoxicity, Hydroxylation, Immunosuppression, Intravenous therapy, Ketoconazole, Ligand (biochemistry), Potency (pharmacology), Pregnane X receptor, Prodrug, Selective estrogen receptor modulator, Sex steroid, Tamoxifen, Testosterone, Transcription (biology).

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

Agonist and CYP3A4 · Agonist and Spironolactone · See more »

Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

Androgen and CYP3A4 · Androgen and Spironolactone · See more »

Antiandrogen

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.

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Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Antimineralocorticoid

An antimineralocorticoid, MCRA, or an aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors.

Antimineralocorticoid and CYP3A4 · Antimineralocorticoid and Spironolactone · See more »

Beta blocker

Beta blockers, also written β-blockers, are a class of medications that are particularly used to manage abnormal heart rhythms, and to protect the heart from a second heart attack (myocardial infarction) after a first heart attack (secondary prevention).

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Bicalutamide

Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer.

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Bioavailability

In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.

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Biological half-life

The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.

Biological half-life and CYP3A4 · Biological half-life and Spironolactone · See more »

Dietary supplement

A dietary supplement is a manufactured product intended to supplement the diet when taken by mouth as a pill, capsule, tablet, or liquid.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Eplerenone

Eplerenone is a steroidal antimineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure.

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Fetus

A fetus is a stage in the prenatal development of viviparous organisms.

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Finasteride

Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used mainly to treat an enlarged prostate or scalp hair loss in men.

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Glucocorticoid

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones.

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Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

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Hydroxylation

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.

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Immunosuppression

Immunosuppression is a reduction of the activation or efficacy of the immune system.

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Intravenous therapy

Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).

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Ketoconazole

Ketoconazole is a synthetic imidazole antifungal drug used primarily to treat fungal infections.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

CYP3A4 and Ligand (biochemistry) · Ligand (biochemistry) and Spironolactone · See more »

Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

CYP3A4 and Potency (pharmacology) · Potency (pharmacology) and Spironolactone · See more »

Pregnane X receptor

In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1, group I, member 2) gene.

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Prodrug

A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.

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Selective estrogen receptor modulator

Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).

CYP3A4 and Selective estrogen receptor modulator · Selective estrogen receptor modulator and Spironolactone · See more »

Sex steroid

Sex steroids, also known as gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate androgen or estrogen receptors.

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Tamoxifen

Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.

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Testosterone

Testosterone is the primary male sex hormone and an anabolic steroid.

CYP3A4 and Testosterone · Spironolactone and Testosterone · See more »

Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

CYP3A4 and Transcription (biology) · Spironolactone and Transcription (biology) · See more »

The list above answers the following questions

CYP3A4 and Spironolactone Comparison

CYP3A4 has 307 relations, while Spironolactone has 346. As they have in common 29, the Jaccard index is 4.44% = 29 / (307 + 346).

References

This article shows the relationship between CYP3A4 and Spironolactone. To access each article from which the information was extracted, please visit:

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