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Cortactin

Index Cortactin

Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. [1]

47 relations: Actin, ACTR3, Arp2/3 complex, ARPC2, Cell membrane, Cell migration, Chemotaxis, Clathrin, CTNND1, Cytoplasm, Cytoskeleton, Cytoskeleton (journal), Dynamin, Endocytosis, Epithelium, Extracellular signal–regulated kinases, FER (gene), Focal adhesion, Gelsolin, Gene, Growth factor, Invadopodia, KCNA2, Lamellipodium, Macrophage, Microfilament, Minimally invasive procedures, Monomer, Neoplasm, Nucleation, Pathogen, Phosphorylation, Polymerization, Protein, Protein–protein interaction, Proto-oncogene tyrosine-protein kinase Src, Receptor tyrosine kinase, Serine/threonine-specific protein kinase, SH3 domain, SHANK2, Transferrin, Treadmilling, Tyrosine kinase, Villin, WASL (gene), WIPF1, Wiskott–Aldrich syndrome protein.

Actin

Actin is a family of globular multi-functional proteins that form microfilaments.

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ACTR3

Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene.

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Arp2/3 complex

Arp2/3 complex is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton.

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ARPC2

Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene.

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Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).

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Cell migration

Cell migration is a central process in the development and maintenance of multicellular organisms.

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Chemotaxis

Chemotaxis (from chemo- + taxis) is the movement of an organism in response to a chemical stimulus.

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Clathrin

Clathrin is a protein that plays a major role in the formation of coated vesicles.

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CTNND1

Catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene.

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Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

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Cytoskeleton

A cytoskeleton is present in all cells of all domains of life (archaea, bacteria, eukaryotes).

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Cytoskeleton (journal)

Cytoskeleton is a peer-reviewed scientific journal covering cytoskeletal research.

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Dynamin

Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell.

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Endocytosis

Endocytosis is a form of bulk transport in which a cell transports molecules (such as proteins) into the cell (endo- + cytosis) by engulfing them in an energy-using process.

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Epithelium

Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.

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Extracellular signal–regulated kinases

In molecular biology, extracellular signal–regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.

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FER (gene)

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.

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Focal adhesion

In cell biology, focal adhesions (also cell–matrix adhesions or FAs) are large macromolecular assemblies through which mechanical force and regulatory signals are transmitted between the extracellular matrix (ECM) and an interacting cell.

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Gelsolin

Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Growth factor

A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.

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Invadopodia

Invadopodia are actin-rich protrusions of the plasma membrane that are associated with degradation of the extracellular matrix in cancer invasiveness and metastasis.

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KCNA2

Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene.

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Lamellipodium

The lamellipodium (plural lamellipodia) (from Latin lamina, "thin sheet"; pod, "foot") is a cytoskeletal protein actin projection on the leading edge of the cell.

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Macrophage

Macrophages (big eaters, from Greek μακρός (makrós).

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Microfilament

Microfilaments, also called actin filaments, are filaments in the cytoplasm of eukaryotic cells that form part of the cytoskeleton.

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Minimally invasive procedures

Minimally invasive procedures (also known as minimally invasive surgeries) encompass surgical techniques that limit the size of incisions needed and so lessen wound healing time, associated pain and risk of infection.

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Monomer

A monomer (mono-, "one" + -mer, "part") is a molecule that "can undergo polymerization thereby contributing constitutional units to the essential structure of a macromolecule".

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Nucleation

Nucleation is the first step in the formation of either a new thermodynamic phase or a new structure via self-assembly or self-organization.

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Pathogen

In biology, a pathogen (πάθος pathos "suffering, passion" and -γενής -genēs "producer of") or a '''germ''' in the oldest and broadest sense is anything that can produce disease; the term came into use in the 1880s.

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Phosphorylation

In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.

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Polymerization

In polymer chemistry, polymerization is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Proto-oncogene tyrosine-protein kinase Src

Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.

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Receptor tyrosine kinase

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.

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Serine/threonine-specific protein kinase

A serine/threonine protein kinase is a kinase enzyme that phosphorylates the OH group of serine or threonine (which have similar sidechains).

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SH3 domain

The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues.

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SHANK2

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene.

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Transferrin

Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron (Fe) in biological fluids.

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Treadmilling

Treadmilling is a phenomenon observed in many cellular cytoskeletal filaments, especially in actin filaments and microtubules.

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Tyrosine kinase

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.

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Villin

Villin is a 92.5 kDa tissue-specific actin-binding protein associated with the actin core bundle of the brush border.

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WASL (gene)

Neural Wiskott-Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene.

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WIPF1

WAS/WASL-interacting protein family member 1 is a protein that in humans is encoded by the WIPF1 gene.

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Wiskott–Aldrich syndrome protein

The Wiskott–Aldrich Syndrome protein (WASp) is a 502-amino acid protein expressed in cells of the hematopoietic system.

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Redirects here:

CTTN, CTTN (gene).

References

[1] https://en.wikipedia.org/wiki/Cortactin

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