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Gabaculine

Index Gabaculine

Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor. [1]

8 relations: Effective dose (pharmacology), Epilepsy, GABA reuptake inhibitor, GABA transaminase, Gamma-Aminobutyric acid, Median lethal dose, Neurotoxin, Streptomyces.

Effective dose (pharmacology)

An effective dose (ED) in pharmacology is the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it.

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Epilepsy

Epilepsy is a group of neurological disorders characterized by epileptic seizures.

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GABA reuptake inhibitor

A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs).

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GABA transaminase

A GABA transaminase is an enzyme that catalyzes two reactions.

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Gamma-Aminobutyric acid

gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.

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Median lethal dose

In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a measure of the lethal dose of a toxin, radiation, or pathogen.

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Neurotoxin

Neurotoxins are toxins that are poisonous or destructive to nerve tissue (causing neurotoxicity).

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Streptomyces

Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae.

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References

[1] https://en.wikipedia.org/wiki/Gabaculine

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