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57 relations: A-349,821, ABT-239, Acetylcholine, Alpha-Methylhistamine, Attention deficit hyperactivity disorder, Autoreceptor, Basal ganglia, Betahistine, Burimamide, Central nervous system, Cerebral cortex, Cipralisant, Ciproxifan, Clobenpropit, Conessine, Coronary artery disease, Cyclic adenosine monophosphate, Dopamine, Endothelium, Functional selectivity, G protein, G protein–coupled receptor, Gamma-Aminobutyric acid, Gastrointestinal tract, Gi alpha subunit, Glutamic acid, Heart, Heterotrimeric G protein, Histamine, Imetit, Immepip, Immethridine, Impentamine, InterPro, Iodophenpropit, Ischemia, Ligand (biochemistry), Lung, Methimepip, Movement disorders, N-type calcium channel, Neuron, Neurotransmitter, Norepinephrine, Obesity, Orexin, Pain, Peripheral nervous system, Pitolisant, Protein isoform, ..., Proxyfan, Schizophrenia, Serotonin, Sleep disorder, Thioperamide, Tourette syndrome, VUF-5681. Expand index (7 more) »
A-349,821
A-349,821 is a potent and selective histamine H3 receptor antagonist (or possibly an inverse agonist).
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ABT-239
ABT-239 is an H3-receptor inverse agonist developed by Abbott.
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Acetylcholine
Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals, including humans, as a neurotransmitter—a chemical message released by nerve cells to send signals to other cells.
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Alpha-Methylhistamine
α-Methylhistamine is a histamine agonist selective for the receptor subtype H3.
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Attention deficit hyperactivity disorder
Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.
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Autoreceptor
An autoreceptor is a type of receptor located in the membranes of presynaptic nerve cells.
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Basal ganglia
The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.
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Betahistine
Betahistine, sold under the brand name Serc among others, is an anti-vertigo medication.
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Burimamide
Burimamide is an antagonist at the H2 and H3 histamine receptors.
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Cerebral cortex
The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.
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Cipralisant
Cipralisant (GT-2331, tentative trade name Perceptin) is an extremely potent Histamine H3 receptor ligand originally developed by Gliatech.
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Ciproxifan
Ciproxifan is an extremely potent histamine H3 inverse agonist/antagonist.
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Clobenpropit
Clobenpropit is a histamine H3 receptor antagonist.
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Conessine
Conessine is a steroid alkaloid found in a number of plant species from the Apocynaceae family, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica.
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Coronary artery disease
Coronary artery disease (CAD), also known as ischemic heart disease (IHD), refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death.
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Cyclic adenosine monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Functional selectivity
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.
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G protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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Gamma-Aminobutyric acid
gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.
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Gastrointestinal tract
The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.
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Gi alpha subunit
Gi alpha subunit (Gαi, or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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Heart
The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.
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Heterotrimeric G protein
"G protein" usually refers to the membrane-associated heterotrimeric G proteins, sometimes referred to as the "large" G proteins (as opposed to the subclass of smaller, monomeric small GTPases).
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Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
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Imetit
Imetit is a histamine H3 receptor agonist.
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Immepip
Immepip is a histamine H3 receptor agonist.
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Immethridine
Immethridine is a histamine agonist selective for the H3 subtype.
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Impentamine
Impentamine is a histamine antagonist selective for the H3 subtype.
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InterPro
InterPro is a database of protein families, domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences in order to functionally characterise them.
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Iodophenpropit
Iodophenpropit is a histamine antagonist which binds selectively to the H3 subtype.
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Ischemia
Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Lung
The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.
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Methimepip
Methimepip is a histamine agonist which is highly selective for the H3 subtype.
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Movement disorders
Movement disorders are clinical syndromes with either an excess of movement or a paucity of voluntary and involuntary movements, unrelated to weakness or spasticity.
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N-type calcium channel
N-type calcium channels are voltage gated calcium channels that are distributed throughout the entire body.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Neurotransmitter
Neurotransmitters are endogenous chemicals that enable neurotransmission.
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Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
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Obesity
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.
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Orexin
Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite.
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Pain
Pain is a distressing feeling often caused by intense or damaging stimuli.
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Peripheral nervous system
The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).
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Pitolisant
Pitolisant, also known as tiprolisant, and sold under the brand name Wakix, is a potent and selective inverse agonist of the histamine H3 receptor (Ki.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Proxyfan
Proxyfan is a histamine H3 receptor ligand which is a "protean agonist", producing different effects ranging from full agonist, to antagonist, to inverse agonist in different tissues, depending on the level of constitutive activity of the histamine H3 receptor.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Sleep disorder
A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal.
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Thioperamide
Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier.
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Tourette syndrome
Tourette syndrome (TS or simply Tourette's) is a common neuropsychiatric disorder with onset in childhood, characterized by multiple motor tics and at least one vocal (phonic) tic.
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VUF-5681
VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H3 subtype.
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Redirects here:
H3 receptor, HRH3, HRH3 (gene), H₃ receptor, Receptors, histamine h3.
References
[1] https://en.wikipedia.org/wiki/Histamine_H3_receptor
