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34 relations: Alpha-ketoglutarate-dependent hydroxylases, Biochemistry, Chemistry, Cholesterol 7 alpha-hydroxylase, Collagen, CYP17A1, Cytochrome P450, Detoxification, Dopamine beta-hydroxylase, Enzyme, Excretion, Hydrolase, Hydrolysis, Hydrophile, Hydroxy group, Hydroxylysine, Hydroxyproline, Hypoxia (medical), Hypoxia-inducible factors, Lime (fruit), Lipophilicity, Lysyl hydroxylase, Medication, Organic compound, Phenylalanine hydroxylase, Procollagen-proline dioxygenase, Proline, Protein, Sailor, Scurvy, Steroid, Tyrosine hydroxylase, Ultrafiltration (renal), Vitamin C.
Alpha-ketoglutarate-dependent hydroxylases
Alpha-ketoglutarate-dependent hydroxylases are non-heme, iron-containing enzymes that consume oxygen and alpha-ketoglutarate (αKG, also known as 2-oxoglutarate, or 2OG) as co-substrates.
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Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms.
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Chemistry
Chemistry is the scientific discipline involved with compounds composed of atoms, i.e. elements, and molecules, i.e. combinations of atoms: their composition, structure, properties, behavior and the changes they undergo during a reaction with other compounds.
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Cholesterol 7 alpha-hydroxylase
Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme that in humans is encoded by the CYP7A1 gene which has an important role in cholesterol metabolism.
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Collagen
Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.
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CYP17A1
Cytochrome P450 17A1, also called steroid 17α-monooxygenase, 17α-hydroxylase, 17,20-lyase, or 17,20-desmolase, is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Detoxification
Detoxification or detoxication (detox for short) is the physiological or medicinal removal of toxic substances from a living organism, including the human body, which is mainly carried out by the liver.
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Dopamine beta-hydroxylase
Dopamine beta-hydroxylase (DBH), also known as dopamine beta-monooxygenase, is an enzyme that in humans is encoded by the DBH gene.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Excretion
Excretion is the process by which metabolic waste is eliminated from an organism.
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Hydrolase
Hydrolase is a class of enzyme that is commonly used as biochemical catalysts that utilize water to break a chemical bond.
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Hydrolysis
Hydrolysis is a term used for both an electro-chemical process and a biological one.
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Hydrophile
A hydrophile is a molecule or other molecular entity that is attracted to water molecules and tends to be dissolved by water.
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Hydroxy group
A hydroxy or hydroxyl group is the entity with the formula OH.
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Hydroxylysine
Hydroxylysine (Hyl) is an amino acid with the molecular formula C6H14N2O3.
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Hydroxyproline
(2S,4R)-4-Hydroxyproline, or L-hydroxyproline (C5H9O3N), is a common non-proteinogenic amino acid, abbreviated as Hyp, e.g., in Protein Data Bank.
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Hypoxia (medical)
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.
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Hypoxia-inducible factors
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.
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Lime (fruit)
A lime (from French lime, from Arabic līma, from Persian līmū, "lemon") is a hybrid citrus fruit, which is typically round, lime green, in diameter, and contains acidic juice vesicles.
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Lipophilicity
Lipophilicity (from Greek λίπος "fat" and φίλος "friendly"), refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.
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Lysyl hydroxylase
Lysyl hydroxylases (or procollagen-lysine 5-dioxygenases) are alpha-ketoglutarate-dependent hydroxylases enzymes that catalyze the hydroxylation of lysine to hydroxylysine.
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Medication
A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
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Organic compound
In chemistry, an organic compound is generally any chemical compound that contains carbon.
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Phenylalanine hydroxylase
Phenylalanine hydroxylase (PAH) is an enzyme that catalyzes the hydroxylation of the aromatic side-chain of phenylalanine to generate tyrosine.
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Procollagen-proline dioxygenase
Procollagen-proline dioxygenase, commonly known as prolyl hydroxylase, is a member of the class of enzymes known as alpha-ketoglutarate-dependent hydroxylases.
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Proline
Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Sailor
A sailor, seaman, mariner, or seafarer is a person who navigates waterborne vessels or assists as a crewmember in their operation and maintenance.
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Scurvy
Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid).
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Steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
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Tyrosine hydroxylase
Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA).
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Ultrafiltration (renal)
In renal physiology, ultrafiltration occurs at the barrier between the blood and the filtrate in the glomerular capsule (Bowman's capsule) in the kidneys.
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Vitamin C
Vitamin C, also known as ascorbic acid and L-ascorbic acid, is a vitamin found in food and used as a dietary supplement.
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Aryl hydrocarbon hydroxylases, Beta-hydroxylation, Dehydroxylated, Dehydroxylation, Hydroxylase, Hydroxylate, Hydroxylated, Protein hydroxylation.
References
[1] https://en.wikipedia.org/wiki/Hydroxylation
