Opioid antagonist and Samidorphan

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Difference between Opioid antagonist and Samidorphan

Opioid antagonist vs. Samidorphan

An opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors. Samidorphan (INN, USAN) (developmental code names ALKS-33, RDC-0313), also known as 3-carboxamido-4-hydroxynaltrexone, is an opioid antagonist that preferentially acts as an antagonist of the μ-opioid receptor (MOR).

Buprenorphine

Buprenorphine, sold under the brand name Subutex, among others, is an opioid used to treat opioid addiction, acute pain, and chronic pain.

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Buprenorphine/samidorphan

Buprenorphine/samidorphan (developmental code name ALKS-5461) is a combination drug formulation of buprenorphine and samidorphan acting as a κ-opioid receptor (KOR) antagonist which is under development by Alkermes as an adjunct to antidepressant therapy in treatment-resistant depression (TRD).

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Cocaine dependence

Cocaine dependence is a psychological desire to use cocaine regularly.

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Cyprodime

Cyprodime is an opioid antagonist from the morphinan family of drugs.

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Euphoria

Euphoria is an affective state in which a person experiences pleasure or excitement and intense feelings of well-being and happiness.

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Hallucination

A hallucination is a perception in the absence of external stimulus that has qualities of real perception.

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JDTic

JDTic is a selective, long-acting ("inactivating") antagonist of the κ-opioid receptor (KOR).

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Naltrexone

Naltrexone, sold under the brand names ReVia and Vivitrol among others, is a medication primarily used to manage alcohol or opioid dependence.

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Opioid receptor

Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.

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Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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Substance abuse

Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder.

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Substance dependence

Substance dependence also known as drug dependence is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use.

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