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37 relations: A431 cells, BCAR1, Beta-catenin, Breast cancer, Colony stimulating factor 1 receptor, Cortactin, Diabetes mellitus type 2, DOK1, Endoplasmic reticulum, Enzyme, Epidermal growth factor, Epidermal growth factor receptor, Gene, Glutathione, GRB2, Hep G2, HER2/neu, Hydrogen bond, Hydrogen peroxide, Insulin, Insulin receptor, Insulin-like growth factor 1 receptor, IRS1, Janus kinase 2, Metastasis, Obesity, P53, Protein tyrosine phosphatase, Protein–protein interaction, Proto-oncogene tyrosine-protein kinase Src, PTK2, Reactive oxygen species, Stacking (chemistry), Sulfenic acid, Tyrosine, Tyrosine kinase 2, Wild type.
A431 cells
A431 cells are a model human cell line (epidermoid carcinoma) used in biomedical research.
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BCAR1
Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.
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Beta-catenin
Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene.
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Breast cancer
Breast cancer is cancer that develops from breast tissue.
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Colony stimulating factor 1 receptor
Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS).
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Cortactin
Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery.
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Diabetes mellitus type 2
Diabetes mellitus type 2 (also known as type 2 diabetes) is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
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DOK1
Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.
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Endoplasmic reticulum
The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Epidermal growth factor
Epidermal growth factor (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR.
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Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glutathione
Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea.
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GRB2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication.
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Hep G2
Hep G2 is a human liver cancer cell line.
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HER2/neu
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene.
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Hydrogen bond
A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.
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Hydrogen peroxide
Hydrogen peroxide is a chemical compound with the formula.
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Insulin
Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.
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Insulin receptor
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.
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Insulin-like growth factor 1 receptor
The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells.
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IRS1
Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS-1 gene.
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Janus kinase 2
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase.
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Metastasis
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; it is typically spoken of as such spread by a cancerous tumor.
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Obesity
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.
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P53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
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Protein tyrosine phosphatase
Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.
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PTK2
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.
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Reactive oxygen species
Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.
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Stacking (chemistry)
In chemistry, pi stacking (also called π–π stacking) refers to attractive, noncovalent interactions between aromatic rings, since they contain pi bonds.
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Sulfenic acid
A sulfenic acid is an organosulfur compound and oxoacid with the general formula RSOH.
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Tyrosine
Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.
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Tyrosine kinase 2
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.
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Wild type
Wild type (WT) refers to the phenotype of the typical form of a species as it occurs in nature.
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Redirects here:
PTP1B, PTPN1 (gene), Protein tyrosine phosphatase 1B, Ptp1b.
References
[1] https://en.wikipedia.org/wiki/PTPN1
