51 relations: Base excision repair, Biological effects of radiation on the epigenome, Bisulfite sequencing, Cancer epigenetics, Combined bisulfite restriction analysis, CpG island hypermethylation, CpG site, Cytosine, Deamination, DNA, DNA damage theory of aging, DNA demethylation, DNA glycosylase, DNA methylation, DNA methyltransferase, DNA sequencing, Epigenetics, Epitranscriptome, List of MeSH codes (D03), MBD4, Methylated DNA immunoprecipitation, Methylation, Methyltransferase, Multisite-specific tRNA:(cytosine-C5)-methyltransferase, Mutagenesis, Mutation, Mutational signatures, Neonatal diabetes mellitus, Neuroepigenetics, NSUN2, Nucleic acid analogue, Nucleobase, OGT (gene), Promoter (genetics), Protein O-GlcNAc transferase, Regulation of transcription in cancer, Sodium bisulfite, Succinic acid, Tet methylcytosine dioxygenase 1, Third-generation sequencing, Transition (genetics), Treat Baldwin Johnson, TRNA (cytosine34-C5)-methyltransferase, TRNA (cytosine38-C5)-methyltransferase, Tuberculinic acid, Very short patch repair, 16S rRNA (cytosine1407-C5)-methyltransferase, 16S rRNA (cytosine967-C5)-methyltransferase, 23S rRNA (cytosine1962-C5)-methyltransferase, 5-Hydroxymethylcytosine, ..., 5-Methylcytidine. Expand index (1 more) » « Shrink index
In biochemistry and genetics, base excision repair (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle.
Ionizing radiation can cause biological effects which are passed on to offspring through the epigenome.
Bisulfite sequencing (also known as bisulphite sequencing) is the use of bisulfite treatment of DNA to determine its pattern of methylation.
Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence.
Combined Bisulfite Restriction Analysis (or COBRA) is a molecular biology technique that allows for the sensitive quantification of DNA methylation levels at a specific genomic locus on a DNA sequence in a small sample of genomic DNA.
CpG island hypermethylation is an epigenetic control aberration that is important for gene inactivation in cancer cells.
The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction.
Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).
Deamination is the removal of an amine group from a protein molecule.
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damages.
DNA demethylation is the process of removal of a methyl group from nucleotides in DNA.
DNA glycosylases are a family of enzymes involved in base excision repair, classified under EC number EC 3.2.2.
DNA methylation is a process by which methyl groups are added to the DNA molecule.
In biochemistry, the DNA methyltransferase (DNA MTase) family of enzymes catalyze the transfer of a methyl group to DNA.
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
Within the field of molecular biology, the epitranscriptome includes all the biochemical modifications of the RNA (the transcriptome) within a cell.
This is the fourth part of the list of the "D" codes for MeSH.
Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.
Methylated DNA immunoprecipitation (MeDIP or mDIP) is a large-scale (chromosome- or genome-wide) purification technique in molecular biology that is used to enrich for methylated DNA sequences.
In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.
Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features.
Multisite-specific tRNA:(cytosine-C5)-methyltransferase (multisite-specific tRNA:m5C-methyltransferase, TRM4 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine-C5)-methyltransferase.
Mutagenesis is a process by which the genetic information of an organism is changed, resulting in a mutation.
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
Mutational signatures (also known as "Alexandrov signatures") are characteristic combinations of mutation types arising from specific mutagenesis processes such as DNA replication infidelity, exogenous and endogenous genotoxins exposures, defective DNA repair pathways and DNA enzymatic editing.
Neonatal diabetes mellitus (NDM) is defined as a disease that affects an infant and their body's ability to produce or use insulin.
Neuroepigenetics is the study of how epigenetic changes to genes affect the nervous system.
NOP2/Sun domain family, member 2 is a protein that in humans is encoded by the NSUN2 gene.
Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.
Nucleobases, also known as nitrogenous bases or often simply bases, are nitrogen-containing biological compounds that form nucleosides, which in turn are components of nucleotides, with all of these monomers constituting the basic building blocks of nucleic acids.
UDP-N-acetylglucosamine—peptide N-acetylglucosaminyltransferase, also known as O-linked β-N-acetylglucosamine transferase and O-GlcNAc transferase, OGT is an enzyme that in humans is encoded by the OGT gene.
In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.
O-GlcNAc transferase (O-GlcNAc transferase, OGTase, O-linked N-acetylglucosaminyltransferase, uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase, protein O-linked beta-N-acetylglucosamine transferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase.
Generally, in progression to cancer, hundreds of genes are silenced or activated.
Sodium bisulfite (or sodium bisulphite) (sodium hydrogen sulfite) is a chemical compound with the chemical formula NaHSO3.
Succinic acid is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2.
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes that in humans is encoded by the TET1 gene.
Third-generation sequencing (also known as long-read sequencing) is a class of DNA sequencing methods currently under active development.
In genetics, a transition is a point mutation that changes a purine nucleotide to another purine (A ↔ G) or a pyrimidine nucleotide to another pyrimidine (C ↔ T).
Treat Baldwin Johnson (1875-1947) was an American chemist, born at Bethany, Connecticut.
TRNA (cytosine34-C5)-methyltransferase (hTrm4 Mtase, hTrm4 methyltransferase, hTrm4 (gene), tRNA:m5C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase.
TRNA (cytosine38-C5)-methyltransferase (hDNMT2 (gene), DNMT2 (gene), TRDMT1 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase.
Tuberculinic acid is a noncanonical nucleic acid initially identified as the poison of Tubercle bacillus (.
Very short patch (VSP) repair is a DNA repair system that removes GT mismatches created by the deamination of 5-methylcytosine to thymine.
16S rRNA (cytosine1407-C5)-methyltransferase (RNA m5C methyltransferase YebU, RsmF, YebU) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytosine1407-C5)-methyltransferase.
16S rRNA (cytosine967-C5)-methyltransferase (rsmB (gene), fmu (gene), 16S rRNA m5C967 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytosine967-C5)-methyltransferase.
23S rRNA (cytosine1962-C5)-methyltransferase (RlmI, rRNA large subunit methyltransferase I, YccW) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytosine1962-C5)-methyltransferase.
5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base derived from cytosine.
5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine.