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62 relations: Acute generalized exanthematous pustulosis, Acyclic diene metathesis, ADMET, Advanced Chemistry Development, Albert P. Li, Aureus Sciences, Bioavailability, Biological activity, Biopharmaceutics Classification System, Center for Pharmaceutical Research and Innovation, Chemical database, Chemical Diversity, ChemMedChem, Combinatorial chemistry, Computational Resource for Drug Discovery, Discovery Studio, Distribution (pharmacology), Drug design, Drug discovery, Drug interaction, Drug intolerance, Drug reaction with eosinophilia and systemic symptoms, DrugBank, Elimination (pharmacology), Ethylmercury, Expert Opinion on Drug Metabolism & Toxicology, First pass effect, Forensic toxicology, Future Medicinal Chemistry, Galenic formulation, Gerhard Ecker, Glycorandomization, History of diabetes, IdMOC, IIT Research Institute, Insulin analog, Lead Finder, Liberation (pharmacology), Lipinski's rule of five, Metalloprotease inhibitor, Molecular Discovery, Molecule mining, Organic-anion-transporting polypeptide, Para-Aminoblebbistatin, Partition coefficient, Pharmacodynamics, Pharmacoepigenetics, Pharmacokinetics, Pre-clinical development, Prodrug, ..., Quantitative structure–activity relationship, Radioactivity in the life sciences, Route of administration, Severe cutaneous adverse reactions, Simcyp, Simcyp Simulator, Simulations Plus, Stevens–Johnson syndrome, Thebacon, Toxgnostics, Turing Pharmaceuticals, Wolfe Laboratories. Expand index (12 more) »
Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) (also known as pustular drug eruption and toxic pustuloderma) is a rare skin reaction that in 90% of cases is related to medication administration.
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Acyclic diene metathesis
Acyclic diene metathesis or ADMET (distinguish from ADME) is a special type of olefin metathesis used to polymerize terminal dienes to polyenes: The new double bonds formed can be in cis- or trans-configuration, the exact ratio depends on the monomer and catalyst structures.
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ADMET
ADMET may refer to.
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Advanced Chemistry Development
Advanced Chemistry Development, Inc., (ACD/Labs) specializes in software for small molecule chemistry R&D.
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Albert P. Li
Albert P. Li is President and CEO of In Vitro ADMET Laboratories (IVAL), Columbia, MD and Malden, MA.
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Aureus Sciences
Aureus Sciences (founded as Aureus Pharma) was a research-based company which sold software to the pharmaceutical industry for drug development.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Biological activity
In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.
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Biopharmaceutics Classification System
The Biopharmaceutics Classification System is a system to differentiate the drugs on the basis of their solubility and permeability.
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Center for Pharmaceutical Research and Innovation
The Center for Pharmaceutical Research and Innovation (CPRI) is a University of Kentucky-based research center established by the University of Kentucky College of Pharmacy in 2012 to facilitate academic translational research and drug discovery/drug development.
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Chemical database
A chemical database is a database specifically designed to store chemical information.
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Chemical Diversity
Chemical Diversity (ChemDiv) is a contract research organization headquartered in San Diego, California, with subsidiaries in Russia and Ukraine.
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ChemMedChem
ChemMedChem is a monthly peer-reviewed medicinal chemistry journal.
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Combinatorial chemistry
Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process.
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Computational Resource for Drug Discovery
Computational Resources for Drug Discovery (CRDD) is one of the important silico modules of Open Source for Drug Discovery (OSDD).
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Discovery Studio
Discovery Studio is a suite of software for simulating small molecule and macromolecule systems.
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Distribution (pharmacology)
Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.
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Drug design
Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.
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Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
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Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together.
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Drug intolerance
Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses.
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Drug reaction with eosinophilia and systemic symptoms
Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications.
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DrugBank
The DrugBank database is a comprehensive, freely accessible, online database containing information on drugs and drug targets.
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Elimination (pharmacology)
In pharmacology the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite.
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Ethylmercury
Ethylmercury (sometimes ethyl mercury) is a cation composed of an organic CH3CH2- species (an ethyl group) bound to a mercury(II) centre, making it a type of organometallic cation, and giving it a chemical formula is C2H5Hg+.
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Expert Opinion on Drug Metabolism & Toxicology
Expert Opinion on Drug Metabolism & Toxicology is a monthly peer-reviewed medical journal publishing review articles on ADME-Tox.
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First pass effect
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.
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Forensic toxicology
Forensic toxicology is the use of toxicology and other disciplines such as analytical chemistry, pharmacology and clinical chemistry to aid medical or legal investigation of death, poisoning, and drug use.
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Future Medicinal Chemistry
Future Medicinal Chemistry is a peer-reviewed medical journal covering all aspects of medicinal chemistry, including drug discovery, pharmacology, in silico drug design, structural characterization techniques, ADME-Tox investigations, and science policy, economic and intellectual property issues.
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Galenic formulation
Galenic formulation deals with the principles of preparing and compounding medicines in order to optimize their absorption.
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Gerhard Ecker
Gerhard F. Ecker is an Austrian medicinal chemist and expert in the fields of Pharmacoinformatics at the University of Vienna.
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Glycorandomization
Glycorandomization, is a drug discovery and drug development technology platform to enable the rapid diversification of bioactive small molecules, drug leads and/or approved drugs through the attachment of sugars.
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History of diabetes
Diabetes is one of the first diseases described with an Egyptian manuscript from c. 1500 BCE mentioning “too great emptying of the urine.” The first described cases are believed to be of type 1 diabetes.
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IdMOC
Integrated discrete Multiple Organ Culture (IdMOC) is an in vitro, cell culture based experimental model for the study of intercellular communication.
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IIT Research Institute
IIT Research Institute (IITRI),Greenbaum & Wheeler (1967), cover sheet (technical paper).
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Insulin analog
An insulin analog is an altered form of insulin, different from any occurring in nature, but still available to the human body for performing the same action as human insulin in terms of glycemic control.
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Lead Finder
Lead Finder software is a computational chemistry application for modeling protein-ligand interactions.
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Liberation (pharmacology)
Liberation is the first step in the process by which medication enters the body and liberates the active ingredient that has been administered.
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Lipinski's rule of five
Lipinski's rule of five also known as the Pfizer's rule of five or simply the rule of five (RO5) is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would make it a likely orally active drug in humans.
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Metalloprotease inhibitor
Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs).
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Molecular Discovery
Molecular Discovery Ltd is a software company working in the area of drug discovery.
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Molecule mining
This page describes mining for molecules.
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Organic-anion-transporting polypeptide
An organic-anion-transporting polypeptide (OATP) is a membrane transport protein or 'transporter' that mediates the transport of mainly organic anions across the cell membrane.
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Para-Aminoblebbistatin
para-Aminoblebbistatin is a water-soluble, non-fluorescent, photostable myosin II inhibitor, developed from blebbistatin.
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Partition coefficient
In the physical sciences, a partition-coefficient (P) or distribution-coefficient (D) is the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Pharmacoepigenetics
Pharmacoepigenetics is an emerging field that studies the underlying epigenetic marking patterns that lead to variation in an individual's response to medical treatment.
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Pharmacokinetics
Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered to a living organism.
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Pre-clinical development
In drug development, preclinical development, also named preclinical studies and nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) can begin, and during which important feasibility, iterative testing and drug safety data are collected.
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Prodrug
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
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Quantitative structure–activity relationship
Quantitative structure–activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering.
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Radioactivity in the life sciences
Radioactivity is generally used in life sciences for highly sensitive and direct measurements of biological phenomena, and for visualizing the location of biomolecules radiolabelled with a radioisotope.
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Route of administration
A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body.
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Severe cutaneous adverse reactions
Severe cutaneous adverse reactions or SCARs are a group of potentially lethal adverse drug reactions that involve the skin and mucous membranes of various body openings such as the eyes, ears, and inside the nose, mouth, and lips.
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Simcyp
Simcyp Limited is a research-based company which provides modelling and simulation software to the pharmaceutical industry for use during drug development.
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Simcyp Simulator
The Simcyp population-based ADME simulator is a modelling and simulation platform used by the pharmaceutical industry in drug discovery and development.
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Simulations Plus
Simulations Plus, Inc. develops absorption, distribution, metabolism, excretion, and toxicity (ADMET) modeling and simulation software for the pharmaceutical and biotechnology, industrial chemicals, cosmetics, food ingredients, and herbicide industries.
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Stevens–Johnson syndrome
Stevens–Johnson syndrome (SJS) is a type of severe skin reaction.
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Thebacon
Thebacon (INN; pronounced), or dihydrocodeinone enol acetate, is a semisynthetic opioid that is similar to hydrocodone and is most commonly synthesised from thebaine.
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Toxgnostics
Toxgnostics is part of Personalized medicine as it describes the guiding principles for the discovery of pharmacogenomic biomarker tests, also referred to as companion diagnostic tests, which identify if an individual patient is likely to suffer severe drug toxicity from treatment with a specific therapeutic agent.
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Turing Pharmaceuticals
Turing Pharmaceuticals is a pharmaceutical company incorporated in Zug, Switzerland, with offices in New York City.
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Wolfe Laboratories
Wolfe Laboratories, Inc. (WLI) is a contract research organization (CRO) headquartered in Woburn, Massachusetts.
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References
[1] https://en.wikipedia.org/wiki/ADME
