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Antiestrogen

Index Antiestrogen

Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body. [1]

136 relations: Abiraterone acetate, Acefluranol, Afimoxifene, Aggressive fibromatosis, Aminoglutethimide, Anastrozole, Androgen insensitivity syndrome, Anordiol, Anordrin, Antiandrogen, Antigonadotropin, Antihormone therapy, Antineoplastic resistance, Antiprogestogen, Baicalein, Boerhavia diffusa, Breast atrophy, Breast cancer management, Breast hypertrophy, Broparestrol, Catechol estrogen, Chlormadinone acetate, Chlorotrianisene, Clometerone, Clomifenoxide, Cyproterone acetate, Cytestrol acetate, D-15414, Danazol, Delmadinone acetate, Depressogenic, Desogestrel, Dimepregnen, Drostanolone propionate, Dydrogesterone, Elacestrant, Enclomifene, Epitiostanol, ER-X, ERX-11, Estetrol (medication), Estradiol (medication), Estradiol sulfamate, Estriol, Estriol (medication), Estrogen (medication), Estrogen deprivation therapy, Estrogen receptor, Estrogen receptor alpha, Estrogen receptor beta, ..., Estrogen-dependent condition, Etacstil, Ethamoxytriphetol, Exemestane, Fadrozole, Flumedroxone acetate, Flushing (physiology), Flutamide, Formestane, Fulvestrant, Gestodene, Gestonorone caproate, Gestrinone, Glyceollin, Glyceollin I, Glyceollin III, Glycinol (pterocarpan), Gold nanoparticles in chemotherapy, High-dose estrogen, HSD17B2, ICI-164384, Index of oncology articles, John Katzenellenbogen, Larry Bigbie, Letrozole, List of banned substances in baseball, List of Major League Baseball players named in the Mitchell Report, List of MeSH codes (D06), List of MeSH codes (D16), Lunamarine, Male infertility, Medroxyprogesterone acetate, Megestrol acetate, Mepitiostane, Metandienone, Methylepitiostanol, MIBE, Nafoxidine, Nandrolone decanoate, Nandrolone phenylpropionate, NCAA drug testing, Nitromifene, NNC 45-0095, Nomegestrol acetate, Norendoxifen, Ormeloxifene, Peripherally selective drug, Pharmacology of bicalutamide, Progesterone (medication), Progestin, Progonadotropin, Prolactin modulator, Raloxifene, Rimostil, RU-16117, Segesterone acetate, Selective estrogen receptor modulator, Sex effects of water pollution, Sex hormone receptor, Sex-hormonal agent, Side effects of bicalutamide, Sivifene, Spironolactone, Steroidal alkaloid, Teratospermia, Testolactone, Tibolone, Timeline of cancer treatment development, Tissue selectivity, Toremifene, Transgender hormone therapy (female-to-male), Trimegestone, Trimethyltrienolone, Triparanol, Triphenylethanol, Triphenylethylene, UFC 200, WAY-204688, ZB716, Zuclomifene, 1-Keto-1,2,3,4-tetrahydrophenanthrene, 16α-Hydroxyestrone, 2,3,7,8-Tetrachlorodibenzodioxin, 4'-Hydroxynorendoxifen, 7,8-Dihydroxyflavone, 7β-Hydroxy-DHEA. Expand index (86 more) »

Abiraterone acetate

Abiraterone acetate, sold under the brand name Zytiga among others, is an antiandrogen medication which is used in the treatment of prostate cancer.

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Acefluranol

Acefluranol (developmental code name BX-591), also known as 2,3-bis(3,4-diacetoxy-5-fluorophenyl)pentane, is a nonsteroidal antiestrogen of the stilbestrol group that was never marketed.

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Afimoxifene

Afimoxifene, also known as 4-hydroxytamoxifen (4-OHT, 4-HT, OHTAM, others), is a selective estrogen receptor modulator (SERM) of the triphenylethylene group and the major active metabolite of tamoxifen.

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Aggressive fibromatosis

Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors.

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Aminoglutethimide

Aminoglutethimide is an anti-steroid drug marketed under the tradename Cytadren by Novartis around the world.

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Anastrozole

Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer.

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Androgen insensitivity syndrome

Androgen insensitivity syndrome (AIS) is an intersex condition in which there is a partial or complete inability of many cells in the affected genetic male to respond to androgenic hormones.

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Anordiol

Anordiol, or anordriol, also known as 2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol, is a synthetic steroid-like mixed estrogen and antiestrogen and an active metabolite of anordrin, a postcoital contraceptive that is marketed and used in China.

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Anordrin

Anordrin (former developmental code name AF-53), also known as 2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol dipropionate, is a synthetic, steroidal selective estrogen receptor modulator (SERM) which is used in China as an emergency contraceptive.

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Antiandrogen

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.

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Antigonadotropin

An antigonadotropin is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

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Antihormone therapy

Antihormone therapy is a type of hormone therapy that suppresses selected hormones or their effects, in contrast with hormone replacement therapy, which encourages hormone activity.

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Antineoplastic resistance

Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the multiple drug resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies.

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Antiprogestogen

Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body.

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Baicalein

Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora.

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Boerhavia diffusa

Boerhavia diffusa is a species of flowering plant in the four o'clock family which is commonly known as punarnava (meaning that which rejuvenates or renews the body in Ayurveda), red spiderling, spreading hogweed, or tarvine.

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Breast atrophy

Breast atrophy is the normal or spontaneous atrophy or shrinkage of the breasts.

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Breast cancer management

Breast cancer management takes different approaches depending on physical and biological characteristics of the disease, as well as the age, over-all health and personal preferences of the patient.

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Breast hypertrophy

Breast hypertrophy is a rare medical condition of the breast connective tissues in which the breasts become excessively large.

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Broparestrol

Broparestrol (brand names Acnestrol, Longestrol; former developmental code name LN-107), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (BDPE), is a synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that has been used in Europe as a dermatological agent and for the treatment of breast cancer.

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Catechol estrogen

A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure.

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Chlormadinone acetate

Chlormadinone acetate (CMA), sold under the brand names Belara, Lutéran, and Prostal among others, is a progestin and antiandrogen medication which is used in birth control pills to prevent pregnancy, as a component of menopausal hormone therapy, and in the treatment of gynecological disorders as well as androgen-dependent conditions like enlarged prostate and prostate cancer in men and acne and hirsutism in women.

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Chlorotrianisene

Chlorotrianisene (CTA), also known as tri-p-anisylchloroethylene (TACE) and sold under the brand name Tace among others, is a nonsteroidal estrogen related to diethylstilbestrol (DES) which was previously used in the treatment of menopausal symptoms and estrogen deficiency in women and prostate cancer in men, among other indications, but has since been discontinued and is now no longer available.

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Clometerone

Clometerone (developmental code name L-38000), or clometherone, also known as 6α-chloro-16α-methylprogesterone, is a synthetic pregnane steroid and derivative of progesterone which was reported in 1962 and is described as an antiestrogen and antiandrogen but was never marketed.

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Clomifenoxide

Clomifenoxide (INN), also known as clomifene N-oxide, is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that is described as an antiestrogen and "gonad stimulant" and was never marketed.

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Cyproterone acetate

Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol (EE) under the brand names Diane or Diane-35 among others, is an antiandrogen and progestogen which is used in the treatment of androgen-dependent conditions like acne, excessive hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender women, and in birth control pills.

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Cytestrol acetate

Cytestrol acetate is a steroidal antiestrogen and an alkylating antineoplastic agent (i.e., chemotherapeutic) which was developed for the treatment of breast cancer but was never marketed.

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D-15414

D-15414 is a nonsteroidal weak estrogen of the 2-phenylindole group which was never marketed.

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Danazol

Danazol, sold under the brand name Danocrine among others, is a medication which is used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema, and other conditions.

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Delmadinone acetate

Delmadinone acetate (DMA), sold under the brand name Tardak among others, is a progestin and antiandrogen which is used in veterinary medicine to treat androgen-dependent conditions such as benign prostatic hyperplasia.

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Depressogenic

A depressogenic substance (or depressogen) is one that causes or can cause depression, usually as a side effect.

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Desogestrel

Desogestrel, sold under the brand names Cerazette and Mircette among many others, is a progestin medication which is used in birth control pills for women.

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Dimepregnen

Dimepregnen (INN, BAN) (developmental code name ST-1411), or 6α,16α-dimethylpregn-4-en-3β-ol-20-one, is a pregnene steroid described as an antiestrogen that was synthesized in 1968 and was never marketed.

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Drostanolone propionate

Drostanolone propionate, or dromostanolone propionate, sold under the brand names Drolban, Masteril, and Masteron among others, is an androgen and anabolic steroid (AAS) medication which was used to treat breast cancer in women but is now no longer marketed.

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Dydrogesterone

Dydrogesterone, sold under the brand name Duphaston among others, is a progestin medication which is used for a variety of indications, including threatened or recurrent miscarriage during pregnancy, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhea, irregular cycles, premenstrual syndrome, and as a component of menopausal hormone therapy.

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Elacestrant

Elacestrant (INN) (developmental code names RAD-1901, ER-306323) is a nonsteroidal combined selective estrogen receptor modulator (SERM) and selective estrogen receptor degrader (SERD) (described as a "SERM/SERD hybrid (SSH)") that was discovered by Eisai and is under development by Radius Health and Takeda for the treatment of menopausal vasomotor symptoms (hot flashes) and estrogen receptor (ER)-positive advanced breast cancer, as well as endometrial cancer and kidney cancer.

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Enclomifene

Enclomifene (tentative brand name Androxal), or enclomiphene, is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that is under development for the treatment of male hypogonadism.

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Epitiostanol

Epitiostanol, sold under the brand name Thiodrol, is an injected antiestrogen and anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which was described in the literature in 1965 and has been marketed in Japan as an antineoplastic agent for the treatment of breast cancer since 1977.

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ER-X

ER-X is a membrane-associated receptor that is bound and activated by 17α-estradiol and 17β-estradiol and is a putative membrane estrogen receptor (mER).

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ERX-11

ERX-11, also known as ERα coregulator-binding modulator-11, is a novel antiestrogen and experimental hormonal antineoplastic agent which is being researched for the potential treatment of estrogen receptor-positive breast cancer.

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Estetrol (medication)

Estetrol, tentative brand names Donesta (alone) and Estelle (with drospirenone), is an estrogen medication and naturally occurring steroid hormone which is under development for use as a birth control pill in combination with a progestin, in menopausal hormone therapy to treat symptoms such as vaginal atrophy, hot flashes, and bone loss, and for the treatment of breast cancer, prostate cancer, osteoarthritis, and migraine.

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Estradiol (medication)

Estradiol, also spelled oestradiol, is a medication and naturally occurring steroid hormone.

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Estradiol sulfamate

Estradiol sulfamate (E2MATE; developmental code names J995, PGL-2, PGL-2001, ZK-190628), or estradiol-3-O-sulfamate, is a synthetic estrogen and steroid sulfatase (STS) inhibitor which is under development for the treatment of endometriosis.http://adisinsight.springer.com/drugs/800026648 It is the 3-sulfamate ester of estradiol, and in terms of its estrogenic activity, acts as a prodrug of estradiol. The drug shows profoundly reduced susceptibility to first-pass metabolism relative to estradiol, and was the first "potent" estradiol prodrug to be discovered. As of 2017, E2MATE is in phase II clinical trials for endometriosis. The drug has also been clinically investigated for potential use in hormone replacement therapy. Unlike estradiol and other estradiol esters, due to its unique sulfamate ester, E2MATE is not hydrolyzed during first-pass metabolism, and is instead cleaved into estradiol systemically. E2MATE itself shows no affinity for the estrogen receptor or estrogenic activity in vitro, requiring hydrolysis into estradiol for its estrogenicity. In accordance, the systemic potency of oral E2MATE is increased approximately 100-fold relative to that of oral estradiol, whereas its hepatotropic activity is increased only marginally, by about 2- to 3-fold. As such, E2MATE has virtually absent effects on estrogen-modulated liver functions with oral administration at typical dosages equivalent to those of estradiol and behaves much like parenterally or transdermally administered estradiol, thereby combining the advantages of transdermal estradiol with the convenience of oral administration. Unfortunately, it has been found that E2MATE, without being hydrolyzed first, can be converted by 17β-hydroxysteroid dehydrogenase into estrone sulfamate (EMATE), analogously to conversion of estradiol into estrone. Moreover, EMATE is the dominant fraction found in circulation, and EMATE is hydrolyzed into estrone, which is a far less potent estrogen than estradiol. In relation to these findings, according to Elger et al., "In spite of high levels of and EMATE in the circulation, only insignificant levels and no estrogenic effects were generated in humans (W. Elger, unpublished data)." As such, E2MATE and EMATE are actually not clinically effective as estrogens, and the researchers have subsequently developed new 17-sulfonamide ester estradiol prodrugs, such as EC508, that are not STS inhibitors and that cannot be transformed into the corresponding estrone variants. In addition to its estrogenic activity, E2MATE has been found to act as a potent and irreversible inhibitor of STS. This enzyme is responsible for the transformation of hormonally inactive steroid sulfates into their hormonally active forms, for instance hydrolysis of estrone sulfate into estrone. Inhibition of STS appears to be the basis for E2MATE's clinical development for endometriosis, as STS is expressed in the endometrium and the severity of endometriosis has been found to correlate with STS expression. In a clinical study, E2MATE was found to inhibit endometrial STS activity by 91% in premenopausal women, while circulating levels of estradiol were not affected, implying potential tissue-selective antiestrogenic effects of E2MATE in the endometrium.

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Estriol

Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone.

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Estriol (medication)

Estriol, sold under the brand name Ovestin among others, is an estrogen medication and naturally occurring steroid hormone which is used in menopausal hormone therapy.

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Estrogen (medication)

An estrogen is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.

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Estrogen deprivation therapy

Estrogen deprivation therapy is a form of hormone therapy that is used in the treatment of breast cancer.

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Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

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Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.

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Estrogen receptor beta

Estrogen receptor beta (ER-β), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is one of two main types of estrogen receptor, a nuclear receptor which is activated by the sex hormone estrogen.

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Estrogen-dependent condition

An estrogen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of estrogenic activity in the body.

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Etacstil

Etacstil (developmental code names GW-5638, DPC974) is an orally active, nonsteroidal, combined selective estrogen receptor modulator (SERM) and selective estrogen receptor degrader (SERD) that was developed for the treatment of estrogen receptor-positive breast cancer.

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Ethamoxytriphetol

Ethamoxytriphetol (developmental code name MER-25) is a synthetic nonsteroidal antiestrogen that was studied clinically in the late 1950s and early 1960s but was never marketed.

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Exemestane

Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer.

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Fadrozole

Fadrozole, sold under the brand name Afema (by Novartis), is a selective, nonsteroidal aromatase inhibitor which is or has been used in Japan for the treatment of breast cancer.

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Flumedroxone acetate

Flumedroxone acetate, sold under the brand names Demigran and Leomigran, is a progestogen medication which is or has been used as an antimigraine agent.

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Flushing (physiology)

For a person to flush is to become markedly red in the face and often other areas of the skin, from various physiological conditions.

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Flutamide

Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer.

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Formestane

Formestane, sold under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women.

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Fulvestrant

Fulvestrant, sold under the brand name Faslodex among others, is a medication used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression as well as HR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrine therapy.

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Gestodene

Gestodene, sold under the brand names Femodene and Minulet among others, is a progestin medication which is used in birth control pills for women.

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Gestonorone caproate

Gestonorone caproate, also known as gestronol hexanoate or norhydroxyprogesterone caproate and sold under the brand names Depostat and Primostat, is a progestin medication which is used in the treatment of enlarged prostate and endometrial cancer.

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Gestrinone

Gestrinone, sold under the brand names Dimetrose and Nemestran among others, is a medication which is used in the treatment of endometriosis.

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Glyceollin

Glyceollins are a family of prenylated pterocarpan found in ineffective types of nodule in soybean in response to symbiotic infection.

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Glyceollin I

Glyceollin I is a glyceollin, a type of prenylated pterocarpan.

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Glyceollin III

Glyceollin III is a glyceollin, a type of pterocarpan, found in the soybean (Glycine max).

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Glycinol (pterocarpan)

Glycinol is a pterocarpan, a type of natural phenol.

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Gold nanoparticles in chemotherapy

This article is about gold nanoparticles in chemotherapy and radiotherapy.

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High-dose estrogen

High-dose estrogen (HDE) is a type of hormone therapy in which high doses of estrogens are given.

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HSD17B2

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2 gene.

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ICI-164384

ICI-164384, also known as N-n-butyl-N-methyl-11-(3,17β-dihydroxyestra-1,3,5(10)-trien-7α-yl)undecanamide, is a steroidal antiestrogen and a synthetic derivative of estradiol which is closely related to fulvestrant and was never marketed.

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Index of oncology articles

This is a list of terms related to oncology.

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John Katzenellenbogen

John Albert Katzenellenbogen (born May 10, 1944) is an American Professor of Chemistry at the University of Illinois at Urbana-Champaign.

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Larry Bigbie

Larry Robert Bigbie (born November 4, 1977) is a former Major League Baseball first baseman and outfielder.

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Letrozole

Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor which is used in the treatment of hormonally-responsive breast cancer after surgery.

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List of banned substances in baseball

Major League Baseball's drug policy prohibits players from using, possessing, selling, facilitating the sale of, distributing, or facilitating the distribution of any Drug of Abuse and/or Steroid.

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List of Major League Baseball players named in the Mitchell Report

The List of Major League Baseball players named in the Mitchell Report includes active and former Major League players as well as free agents.

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List of MeSH codes (D06)

This is the fourth part of the list of the "D" codes for MeSH.

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List of MeSH codes (D16)

This is the fourth part of the list of the "D" codes for MeSH.

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Lunamarine

Lunamarine (punarnavine) is a quinolone alkaloid present in Boerhavia diffusa (punarnava).

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Male infertility

Male infertility refers to a male's inability to cause pregnancy in a fertile female.

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Medroxyprogesterone acetate

Medroxyprogesterone acetate (MPA), sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type.

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Megestrol acetate

Megestrol acetate (MGA), sold under the brand name Megace among others, is a progestin medication which is used mainly as an appetite stimulant to treat wasting syndromes such as cachexia.

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Mepitiostane

Mepitiostane, sold under the brand name Thioderon, is an orally active antiestrogen and anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which is marketed in Japan as an antineoplastic agent for the treatment of breast cancer.

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Metandienone

Metandienone, also known as methandienone or methandrostenolone and sold under the brand name Dianabol among others, is an androgen and anabolic steroid (AAS) medication which is mostly no longer used.

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Methylepitiostanol

Methylepitiostanol, known by the nicknames Epistane, Hemapolin, Havoc, and Epi Plex, is a synthetic and orally active anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which was first described in the literature in 1974 but was never marketed for medical use.

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MIBE

MIBE is a synthetic, nonsteroidal antiestrogen that acts as a dual antagonist of the ERα and the GPER.

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Nafoxidine

Nafoxidine (INN) (developmental code names U-11,000A, NSC-70735), or nafoxidine hydrochloride (USAN), is a nonsteroidal selective estrogen receptor modulator (SERM) or partial antiestrogen of the triphenylethylene group that was developed for the treatment of advanced breast cancer by Upjohn in the 1970s but was never marketed.

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Nandrolone decanoate

Nandrolone decanoate, sold under the brand name Deca-Durabolin among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women.

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Nandrolone phenylpropionate

Nandrolone phenylpropionate (NPP), or nandrolone phenpropionate, sold under the brand name Durabolin among others, is an androgen and anabolic steroid (AAS) medication which has been used primarily in the treatment of breast cancer and osteoporosis in women.

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NCAA drug testing

The NCAA adopted a drug testing program in 1986, the year after the executive committee formed the Special NCAA Committee on Drug Testing.

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Nitromifene

Nitromifene (INN; also as the citrate salt nitromifene citrate (USAN), developmental code names CI-728, CN-5518, CN-55945) is a nonsteroidal selective estrogen receptor modulator (SERM) related to triphenylethylenes like tamoxifen that was never marketed.

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NNC 45-0095

NC 45-0095 is a synthetic nonsteroidal selective estrogen receptor modulator (SERM) which was under development by Novo Nordisk for the treatment of postmenopausal osteoporosis but was never marketed.

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Nomegestrol acetate

Nomegestrol acetate (NOMAC), sold under the brand names Lutenyl and Zoely among others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.

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Norendoxifen

Norendoxifen, also known as N,N-didesmethyl-4-hydroxytamoxifen, is a nonsteroidal aromatase inhibitor (AI) of the triphenylethylene group that was never marketed.

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Ormeloxifene

Ormeloxifene, also known as centchroman, is one of the selective estrogen receptor modulators, or SERMs, a class of medication which acts on the estrogen receptor.

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Peripherally selective drug

Peripherally selective drugs have their primary mechanism of action outside of the central nervous system (CNS), usually because they are excluded from the CNS by the blood-brain barrier.

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Pharmacology of bicalutamide

The pharmacology of bicalutamide, a nonsteroidal antiandrogen (NSAA), has been well-characterized.

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Progesterone (medication)

Progesterone is a medication and naturally occurring steroid hormone.

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Progestin

A progestin is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.

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Progonadotropin

A progonadotropin, or hypergonadotropin, also known as a gonad stimulant, is a type of drug which increases the secretion of one or both of the major gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

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Prolactin modulator

A prolactin modulator is a drug which modulates the secretion of the pituitary hormone prolactin from the anterior pituitary gland.

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Raloxifene

Raloxifene, developed by Eli Lilly in 1997 and sold under the brand name Evista among others, is a medication which is used in the prevention and treatment of osteoporosis in postmenopausal women and to reduce the risk of breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer.

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Rimostil

Rimostil (developmental code name P-081) is a dietary supplement and extract of isoflavones from red clover which was under development by Kazia Therapeutics (formerly Novogen) for the prevention of postmenopausal osteoporosis and cardiovascular disease and for the treatment of menopausal symptoms and hyperlipidemia but was never approved for medical use.

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RU-16117

RU-16117 is an estrogen medication which was investigated for the potential treatment of symptoms of estrogen deficiency such as hot flashes and osteoporosis in women but was never marketed.

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Segesterone acetate

Segesterone acetate (SGA), sold under the brand names Nestorone and Elcometrine, is a progestin medication which is used in birth control and in the treatment of endometriosis in Brazil and other South American countries.

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Selective estrogen receptor modulator

Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).

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Sex effects of water pollution

Sex is influenced by water pollutants that are encountered in everyday life.

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Sex hormone receptor

The sex hormone receptors, or sex steroid receptors, are a group of steroid hormone receptors that interact with the sex hormones, the androgens, estrogens, and progestogens, as well as with sex-hormonal agents such as anabolic steroids, progestins, and antiestrogens.

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Sex-hormonal agent

A sex-hormonal agent, also known as a sex-hormone receptor modulator, is a type of hormonal agent which specifically modulates the effects of sex hormones and of their biological targets, the sex hormone receptors.

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Side effects of bicalutamide

The side effects of bicalutamide, a nonsteroidal antiandrogen (NSAA), including its frequent and rare side effects, have been well-studied and characterized.

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Sivifene

Sivifene (INN, USAN; developmental code name A-007) is a small-molecule antineoplastic agent and immunomodulator that was under development in the 2000s by Tigris Pharmaceuticals (now Kirax Corporation) as a topical treatment for cutaneous cancer metastases.

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Spironolactone

Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.

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Steroidal alkaloid

Steroidal alkaloids have organic ring backbones which feature nitrogen-based functional groups.

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Teratospermia

Teratospermia or teratozoospermia is a condition characterized by the presence of sperm with abnormal morphology that affects fertility in males.

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Testolactone

Testolactone (brand name Teslac) is a non-selective, irreversible, steroidal aromatase inhibitor which is used as an antineoplastic drug to treat advanced-stage breast cancer.

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Tibolone

Tibolone, sold under the brand names Livial and Tibofem among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis.

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Timeline of cancer treatment development

This is a historical timeline of the development and progress of cancer treatments, which includes time of discovery, progress, and approval of the treatments.

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Tissue selectivity

Tissue selectivity is a topic in distribution (pharmacology) and a property of some drugs.

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Toremifene

Toremifene, sold under the brand name Fareston among others, is a medication which is used in the treatment of advanced breast cancer in postmenopausal women.

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Transgender hormone therapy (female-to-male)

Transgender hormone therapy of the female-to-male (FTM) type, also known as masculinizing hormone therapy, is a form of hormone replacement therapy (HRT) and sex reassignment therapy which is used to change the secondary sexual characteristics of transgender people from feminine (or androgynous) to masculine.

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Trimegestone

Trimegestone, sold under the brand names Ondeva and Totelle among others, is a progestin medication which is used in menopausal hormone therapy and in the prevention of postmenopausal osteoporosis.

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Trimethyltrienolone

Trimethyltrienolone (TMT), also known by its developmental code name R-2956 or RU-2956, is an antiandrogen medication which was never introduced for medical use but has been used in scientific research.

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Triparanol

Triparanol (INN, BAN) (brand and developmental code names MER/29, as well as many other brand names), patented in 1959 and introduced in the United States in 1960, was the first synthetic cholesterol-lowering drug.

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Triphenylethanol

Triphenylethanol, or 1,1,2-triphenylethanol, is an organic compound related to triphenylethylene.

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Triphenylethylene

Triphenylethylene (TPE) is a simple aromatic hydrocarbon that possesses weak estrogenic activity.

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UFC 200

UFC 200: Tate vs.

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WAY-204688

WAY-204688, also known as SIM-688, is a synthetic nonsteroidal estrogen and nuclear factor κB (NF-κB) inhibitor which was originated by ArQule and Wyeth and was under development by Wyeth for the treatment of rheumatoid arthritis, non-specific inflammation, and sepsis but was never marketed.

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ZB716

ZB716, also known as fulvestrant-3-boronic acid, is a synthetic, steroidal, orally active antiestrogen which is under development for the treatment of estrogen receptor (ER)-positive metastatic breast cancer.

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Zuclomifene

Zuclomifene (INN; or zuclomiphene (USAN)) is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was never marketed.

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1-Keto-1,2,3,4-tetrahydrophenanthrene

1-Keto-1,2,3,4-tetrahydrophenanthrene (THP-1), or 1,2,3,4-tetrahydrophenanthren-1-one, is a synthetic steroid-like compound which was reported to be the first synthetic estrogen, or the first synthetic compound identified with estrogenic activity.

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16α-Hydroxyestrone

16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-trien-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol.

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2,3,7,8-Tetrachlorodibenzodioxin

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a polychlorinated dibenzo''-p-''dioxin (sometimes shortened, though inaccurately, to simply "dioxin") with the chemical formula.

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4'-Hydroxynorendoxifen

4'-Hydroxynorendoxifen is a synthetic, nonsteroidal antiestrogen of the triphenylethylene group.

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7,8-Dihydroxyflavone

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves.

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7β-Hydroxy-DHEA

7β-Hydroxydehydroepiandrosterone (7β-hydroxy-DHEA; 7β-OH-DHEA), also known as 3β,7β-dihydroxyandrost-4-ene-17-one, is an endogenous, naturally occurring steroid and a metabolite of dehydroepiandrosterone (DHEA).

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Anti-estrogen, Anti-estrogenic, Anti-estrogens, Antiestrogenic, Antiestrogens, ER antagonist, ER antagonists, ER blocker, ER blockers, Estradiol antagonist, Estradiol antagonists, Estradiol blocker, Estradiol blockers, Estradiol receptor antagonist, Estradiol receptor antagonists, Estradiol receptor blocker, Estradiol receptor blockers, Estrogen antagonist, Estrogen antagonists, Estrogen receptor antagonist, Estrogen receptor antagonists, Estrogen receptor blocker, Estrogen receptor blockers.

References

[1] https://en.wikipedia.org/wiki/Antiestrogen

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