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Aprotinin

Index Aprotinin

The drug aprotinin (Trasylol, previously Bayer and now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. [1]

34 relations: Antifibrinolytic, ATC code B02, Bayer, Beta sheet, Coagulation, CU-2010 and CU-2020, Dendrotoxin, Fibrin glue, Fibrinolysis, Glued IOL, Hyperfibrinolysis, Jatene procedure, Jonathan Weissman, Kallikrein, Kunitz domain, Kurt Wüthrich, List of compounds with carbon numbers 50–100, List of drugs: An-Ap, List of drugs: Tr-Tri, List of MeSH codes (D12.776), List of withdrawn drugs, LRP1, Macromolecular docking, Martin Karplus, Miles Laboratories, Myocardial depressant factor, Oxidative folding, Pharming (genetics), Protease inhibitor (biology), Thromboelastometry, Tissue factor pathway inhibitor, Trypsin, Trypsin inhibitor, Trypsinogen.

Antifibrinolytic

Antifibrinolytics are a class of medication that are inhibitors of fibrinolysis.

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ATC code B02

B02.

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Bayer

Bayer AG is a German multinational, pharmaceutical and life sciences company.

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Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

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Coagulation

Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.

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CU-2010 and CU-2020

CU-2010 and CU-2020 are synthetic compounds that act as serine protease inhibitors.

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Dendrotoxin

Dendrotoxins are a class of presynaptic neurotoxins produced by mamba snakes (Dendroaspis) that block particular subtypes of voltage-gated potassium channels in neurons, thereby enhancing the release of acetylcholine at neuromuscular junctions.

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Fibrin glue

Fibrin glue (also called fibrin sealant) is a surgical formulation used to create a fibrin clot for hemostasis or wound healing.

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Fibrinolysis

Fibrinolysis is a process that prevents blood clots from growing and becoming problematic.

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Glued IOL

Glued IOL or Glued Intraocular lens is a new Surgical technique for implantation of a posterior chamber IOL with the use of biological glue in eyes with deficient or absent posterior capsules (Fig 1).

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Hyperfibrinolysis

The fibrinolysis system is responsible for removing blood clots.

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Jatene procedure

The Jatene procedure, arterial switch operation or arterial switch, is an open heart surgical procedure used to correct dextro-transposition of the great arteries (d-TGA); its development was pioneered by Canadian cardiac surgeon William Mustard and it was named for Brazilian cardiac surgeon Adib Jatene, who was the first to use it successfully.

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Jonathan Weissman

Jonathan S. Weissman is a Professor of Cellular Molecular Pharmacology at the University of California, San Francisco.

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Kallikrein

Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins.

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Kunitz domain

Kunitz domains are the active domains of proteins that inhibit the function of protein degrading enzymes or, more specifically, domains of Kunitz-type are protease inhibitors.

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Kurt Wüthrich

Kurt Wüthrich (born October 4, 1938 in Aarberg, Canton of Bern) is a Swiss chemist/biophysicist and Nobel Chemistry laureate, known for developing nuclear magnetic resonance (NMR) methods for studying biological macromolecules.

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List of compounds with carbon numbers 50–100

This is a partial list of molecules that contain 50 to 100 carbon atoms.

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List of drugs: An-Ap

No description.

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List of drugs: Tr-Tri

No description.

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List of MeSH codes (D12.776)

This is part of the list of the "D" codes for MeSH.

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List of withdrawn drugs

Drugs or medicines may be withdrawn from commercial markets because of risks to patients, but also because of commercial reasons (e.g. lack of demand and relatively high production costs).

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LRP1

Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis.

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Macromolecular docking

Macromolecular docking is the computational modelling of the quaternary structure of complexes formed by two or more interacting biological macromolecules.

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Martin Karplus

Martin Karplus (born March 15, 1930) is an Austrian-born American theoretical chemist.

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Miles Laboratories

Miles Laboratories was founded as the Dr.

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Myocardial depressant factor

Myocardial depressant factor (MDF) or Myocardial Toxic factor (MTF) is a low-molecular-weight peptide released from the pancreas into the blood in mammals during various shock states.

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Oxidative folding

Oxidative protein folding is a process that is responsible for the formation of disulfide bonds between cysteine residues in proteins.

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Pharming (genetics)

Pharming, a portmanteau of "farming" and "pharmaceutical", refers to the use of genetic engineering to insert genes that code for useful pharmaceuticals into host animals or plants that would otherwise not express those genes, thus creating a genetically modified organism (GMO).

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Protease inhibitor (biology)

In biology and biochemistry, protease inhibitors are molecules that inhibit the function of proteases (enzymes that aid the breakdown of proteins).

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Thromboelastometry

Thromboelastometry (TEM), previously named rotational thromboelastography (ROTEG) or rotational thromboelastometry (ROTEM), is an established viscoelastic method for hemostasis testing in whole blood.

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Tissue factor pathway inhibitor

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa).

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Trypsin

Trypsin is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyzes proteins.

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Trypsin inhibitor

A trypsin inhibitor is a type of serine protease inhibitor that reduces the biological activity of trypsin.

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Trypsinogen

Trypsinogen (EC 3.4.23.18/20/21/23/24/26) is the precursor form or zymogen of trypsin, a digestive enzyme.

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Redirects here:

ATC code B02AB01, ATCvet code QB02AB01, BPTI, Basic pancreatic trypsin inhibitor, Bovine pancreatic trypsin inhibitor, C284H432N84O79S7, Trasylol.

References

[1] https://en.wikipedia.org/wiki/Aprotinin

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