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64 relations: Adenocarcinoma of the lung, AEE788, Breast development, C-Met inhibitor, Cabozantinib, CBL (gene), CBLL1, CDH1 (gene), Clear-cell ovarian carcinoma, Crizotinib, Dependence receptor, Dihexa, Ectodysplasin A, Emibetuzumab, ErbB, Erlotinib, Foretinib, G0 phase, Gene duplication, George Vande Woude, Gestational diabetes, Glesatinib, GLMN, Glycosaminoglycan, GRB2, Hepatocyte growth factor, Heritability of autism, Hormonal breast enhancement, Index of genetics articles, Internalin, KHDRBS1, List of MeSH codes (D08), List of MeSH codes (D12.776), List of MeSH codes (D12.776.543), List of OMIM disorder codes, Listeria monocytogenes, LRIG1, Lung cancer, Merestinib, Mesothelioma, Met, Migration inducting gene 7, Mir-199 microRNA precursor, MST1R, Myogenesis, Non-small-cell lung carcinoma, Oncoantigen, Pancreatic cancer, Protein kinase domain, Protein kinase inhibitor, ..., PTPRM, RANBP9, Receptor tyrosine kinase, Renal cell carcinoma, Rhabdomyosarcoma, Savolitinib, Sema domain, Stem cell marker, Teva Pharmaceutical Industries, Tivantinib, TP53-inducible glycolysis and apoptosis regulator, Tpr-met fusion protein, Tyrosine kinase, Van Andel Institute. Expand index (14 more) »
Adenocarcinoma of the lung
Adenocarcinoma of the lung (also known as pulmonary adenocarcinoma) is the most common type of lung cancer, and is characterized by distinct cellular and molecular features including gland and/or duct formation and/or production of significant amounts of mucus.
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AEE788
AEE788 is a multitargeted human epidermal receptor (HER) 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, 77, 59 nM for EGFR, ErbB2, KDR, and Flt-1.
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Breast development
Breast development, also known as mammogenesis, is a complex biological process in primates that takes place throughout a female's life.
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C-Met inhibitor
c-Met inhibitors are a class of small molecules that inhibit the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF).
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Cabozantinib
Cabozantinib, sold under the brand-name Cabometyx and Cometriq, is a medication used to treat medullary thyroid cancer and a second line treatment for renal cell carcinoma among others.
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CBL (gene)
Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination.
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CBLL1
The E3 ubiquitin-protein ligase Hakai (HAKAI) also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1 (CBLL1) is an enzyme that in humans is encoded by the CBLL1 gene.
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CDH1 (gene)
Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene.
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Clear-cell ovarian carcinoma
Clear cell ovarian carcinoma is one of several subtypes of ovarian carcinoma.
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Crizotinib
Crizotinib (trade name Xalkori, Pfizer) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.
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Dependence receptor
In cellular biology, dependence receptors are proteins that mediate programmed cell death by monitoring the absence of certain trophic factors (or, equivalently, the presence of anti-trophic factors) that otherwise serve as ligands (interactors) for the dependence receptors.
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Dihexa
Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met.
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Ectodysplasin A
Ectodysplasin A (EDA) is a protein that in humans is encoded by the EDA gene.
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Emibetuzumab
Emibetuzumab (INN) (LY2875358) is a humanized monoclonal antibody designed for the treatment of cancer.
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ErbB
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.
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Erlotinib
Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer.
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Foretinib
Foretinib is an experimental drug candidate for the treatment of cancer.
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G0 phase
The G0 phase describes a cellular state outside of the replicative cell cycle.
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Gene duplication
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.
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George Vande Woude
George F. Vande Woude is a scientist and former director at Van Andel Research Institute in Michigan studying breast cancer.
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Gestational diabetes
Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy.
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Glesatinib
Glesatinib (MGCD265) is an experimental anti-cancer drug.
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GLMN
Glomulin is a protein that in humans is encoded by the GLMN gene.
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Glycosaminoglycan
Glycosaminoglycans (GAGs) or mucopolysaccharides are long unbranched polysaccharides consisting of a repeating disaccharide unit.
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GRB2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication.
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Hepatocyte growth factor
Hepatocyte growth factor (HGF) (or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells. It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration, and in wound healing.
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Heritability of autism
The heritability of autism is the proportion of differences in expression of autism that can be explained by genetic variation; if the heritability of a condition is high, then the condition is considered to be primarily genetic.
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Hormonal breast enhancement
Hormonal breast enhancement or augmentation is a highly experimental potential medical treatment for the breasts in which hormones or hormonal agents such as estrogen, progesterone, growth hormone (GH), and insulin-like growth factor 1 (IGF-1) are utilized or manipulated to produce breast enlargement in women.
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Index of genetics articles
Genetics (from Ancient Greek γενετικός genetikos, “genite” and that from γένεσις genesis, “origin”), a discipline of biology, is the science of heredity and variation in living organisms.
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Internalin
Internalins are surface proteins found on Listeria monocytogenes.
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KHDRBS1
KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene.
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List of MeSH codes (D08)
This is the fourth part of the list of the "D" codes for MeSH.
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List of MeSH codes (D12.776)
This is part of the list of the "D" codes for MeSH.
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List of MeSH codes (D12.776.543)
This is a sub-part (membrane proteins only) of List of MeSH codes (D12.776), itself a part of the list of the "D" codes for MeSH.
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List of OMIM disorder codes
This is a list of disorder codes in the Online Mendelian Inheritance in Man (OMIM) database.
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Listeria monocytogenes
Listeria monocytogenes is the species of pathogenic bacteria that causes the infection listeriosis.
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LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.
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Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
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Merestinib
Merestinib (LY2801653) is an experimental cancer drug in development by Eli Lilly.
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Mesothelioma
Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium).
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Met
Met, MET, The Met or The MET may refer to:to.
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Migration inducting gene 7
Migration inducting gene 7 (Mig-7 or Mig7) is a gene.
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Mir-199 microRNA precursor
The miR-199 microRNA precursor is a short non-coding RNA gene involved in gene regulation.
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MST1R
Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.
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Myogenesis
Myogenesis is the formation of muscular tissue, particularly during embryonic development.
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Non-small-cell lung carcinoma
Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC).
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Oncoantigen
An oncoantigen is a surface or soluble tumor antigen that supports tumor growth.
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Pancreatic cancer
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.
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Protein kinase domain
The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases.
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Protein kinase inhibitor
A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases.
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PTPRM
Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.
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RANBP9
Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene.
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Receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
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Renal cell carcinoma
Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine.
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Rhabdomyosarcoma
Rhabdomyosarcoma, or RMS, is an aggressive and highly malignant form of cancer that develops from skeletal (striated) muscle cells that have failed to fully differentiate.
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Savolitinib
Savolitinib is an experimental small molecule inhibitor of c-Met.
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Sema domain
The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance.
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Stem cell marker
Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells.
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Teva Pharmaceutical Industries
Teva Pharmaceutical Industries Ltd. (טבע תעשיות פרמצבטיות בע"מ) is an Israeli multinational pharmaceutical company headquartered in Petah Tikva, Israel.
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Tivantinib
Tivantinib (ARQ197; by Arqule, Inc.) is an experimental small molecule anti-cancer drug.
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TP53-inducible glycolysis and apoptosis regulator
The TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by the C12orf5 gene.
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Tpr-met fusion protein
Tpr-Met fusion protein is an oncogene fusion protein consisting of TPR and MET.
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Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.
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Van Andel Institute
Van Andel Institute (VAI) is a 501(c)(3) nonprofit biomedical research and science education organization in Grand Rapids, Michigan.
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Redirects here:
C-MET, HGFR, Hepatocyte growth factor receptor, Hgfr, MET (gene), MET kinase, Met proto-oncogene, Proto-oncogene proteins c-met, RCCP2, Rccp2.
References
[1] https://en.wikipedia.org/wiki/C-Met
