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Chromosome conformation capture

Index Chromosome conformation capture

Chromosome conformation capture techniques (often abbreviated to 3C technologies or 3C-based methods) are a set of molecular biology methods used to analyze the spatial organization of chromatin in a cell. [1]

17 relations: Bioinformatics, ChIA-PET, Chromatin, Chromosome territories, Circuit topology, Erez Lieberman Aiden, Gene desert, Genome architecture mapping, Hi-C (disambiguation), Nuclear organization, Paired-end tag, Polycomb Group Proteins and Cancer, Single cell epigenomics, Topologically associating domain, Transcription factories, University of Massachusetts Medical School, 3C.

Bioinformatics

Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data.

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ChIA-PET

Chromatin Interaction Analysis by Paired-End Tag Sequencing (ChIA-PET) is a technique that incorporates chromatin immunoprecipitation (ChIP)-based enrichment, chromatin proximity ligation, Paired-End Tags, and High-throughput sequencing to determine de novo long-range chromatin interactions genome-wide.

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Chromatin

Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.

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Chromosome territories

In cell biology, chromosome territories are regions of the nucleus preferentially occupied by particular chromosomes.

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Circuit topology

The circuit topology of a linear polymer refers to arrangement of its intra-molecular contacts.

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Erez Lieberman Aiden

Erez Lieberman Aiden (born 1980), formerly known as Erez Lieberman, is an American research scientist active in multiple fields related to applied mathematics.

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Gene desert

Gene deserts are regions of the genome that are devoid of protein-coding genes.

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Genome architecture mapping

In molecular biology, genome architecture mapping (GAM) is a cryosectioning method to map colocalized DNA regions in a ligation independent manner.

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Hi-C (disambiguation)

Hi-C may refer to.

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Nuclear organization

Nuclear organization refers to the spatial distribution of chromatin within a cell nucleus.

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Paired-end tag

Paired-end tags (PET) (sometimes "Paired-End diTags", or simply "ditags") are the short sequences at the 5’ and 3’ ends of a DNA fragment which are unique enough that they (theoretically) exist together only once in a genome, therefore making the sequence of the DNA in between them available upon search (if full-genome sequence data is available) or upon further sequencing (since tag sites are unique enough to serve as primer annealing sites).

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Polycomb Group Proteins and Cancer

The Polycomb-group proteins (PcGs) are a family of proteins that use epigenetic mechanisms to maintain or repress expression of their target genes.

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Single cell epigenomics

Single cell epigenomics is the study of epigenomics (the complete set of epigenetic modifications on the genetic material of a cell) in individual cells by single cell sequencing.

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Topologically associating domain

A topologically associating domain (TAD) is a self-interacting genomic region, meaning that DNA sequences within a TAD physically interact with each other more frequently than with sequences outside the TAD.

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Transcription factories

In genetics, transcription factories describe the discrete sites where transcription occurs in the nucleus.

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University of Massachusetts Medical School

The University of Massachusetts Medical School (UMMS) is one of five campuses of the University of Massachusetts (UMass) system.

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3C

3C may refer to: In astronomy.

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Redirects here:

Chromosome comformation capture, Hi-C (experiment).

References

[1] https://en.wikipedia.org/wiki/Chromosome_conformation_capture

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