DNA methylation in cancer

DNA methylation in cancer plays a variety of roles, helping to change the healthy regulation of gene expression to a disease pattern. ^[1]

8 relations: Carcinogenesis, DNA methylation, Hepatitis B virus, Inflammation, Malignant transformation, Promoter (genetics), Regulation of transcription in cancer, TOP1.

Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.

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DNA methylation

DNA methylation is a process by which methyl groups are added to the DNA molecule.

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Hepatitis B virus

Hepatitis B virus, abbreviated HBV, is a double stranded DNA virus, a species of the genus Orthohepadnavirus, and a member of the Hepadnaviridae family of viruses.

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Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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Malignant transformation

Malignant transformation is the process by which cells acquire the properties of cancer.

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Promoter (genetics)

In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.

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Regulation of transcription in cancer

Generally, in progression to cancer, hundreds of genes are silenced or activated.

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TOP1

DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.

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References

[1] https://en.wikipedia.org/wiki/DNA_methylation_in_cancer

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