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Durotaxis

Index Durotaxis

Durotaxis is a form of cell migration in which cells are guided by rigidity gradients, which arise from differential structural properties of the extracellular matrix (ECM). [1]

15 relations: Cell migration, Chemotaxis, Collective cell migration, Extracellular matrix, Focal adhesion, Haptotaxis, Mechanotaxis, Microfluidic cell culture, Microfluidics, Motility, Plithotaxis, Stiffness, Stress fiber, Taxis, Traction force microscopy.

Cell migration

Cell migration is a central process in the development and maintenance of multicellular organisms.

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Chemotaxis

Chemotaxis (from chemo- + taxis) is the movement of an organism in response to a chemical stimulus.

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Collective cell migration

Collective cell migration describes the movements of group of cells and the emergence of collective behavior from cell-environment interactions and cell-cell communication.

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Extracellular matrix

In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by support cells that provides structural and biochemical support to the surrounding cells.

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Focal adhesion

In cell biology, focal adhesions (also cell–matrix adhesions or FAs) are large macromolecular assemblies through which mechanical force and regulatory signals are transmitted between the extracellular matrix (ECM) and an interacting cell.

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Haptotaxis

Haptotaxis (from Greek ἅπτω (hapto, "touch, fasten") and τάξις (taxis, "arrangement, order")) is the directional motility or outgrowth of cells, e.g. in the case of axonal outgrowth, usually up a gradient of cellular adhesion sites or substrate-bound chemoattractants (the gradient of the chemoattractant being expressed or bound on a surface, in contrast to the classical model of chemotaxis, in which the gradient develops in a soluble fluid.). These gradients are naturally present in the extracellular matrix (ECM) of the body during processes such as angiogenesis or artificially present in biomaterials where gradients are established by altering the concentration of adhesion sites on a polymer substrate.

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Mechanotaxis

Mechanotaxis refers to the directed movement of cell motility via mechanical cues (e.g., fluidic shear stress, substrate stiffness gradients, etc.). In response to fluidic shear stress, for example, cells have been shown to migrate in the direction of the fluid flow.

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Microfluidic cell culture

Microfluidic cell culture integrates knowledge from biology, biochemistry, engineering, and physics to develop devices and techniques for culturing, maintaining, analyzing, and experimenting with cells at the microscale.

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Microfluidics

Microfluidics deals with the behaviour, precise control and manipulation of fluids that are geometrically constrained to a small, typically sub-millimeter, scale at which capillary penetration governs mass transport.

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Motility

Motility is the ability of an organism to move independently, using metabolic energy.

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Plithotaxis

Plithotaxis, from the Greek, πλήΘος, denoting crowd, swarm, or throng.

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Stiffness

Stiffness is the rigidity of an object — the extent to which it resists deformation in response to an applied force.

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Stress fiber

Stress fibers are contractile actin bundles found in non-muscle cells.

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Taxis

A taxis (plural taxes) is the movement of an organism in response to a stimulus such as light or the presence of food.

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Traction force microscopy

Traction force microscopy (TFM) is an experimental method for determining the tractions on the surface of a biological cell by obtaining measurements of the surrounding displacement field within an in vitro extracellular matrix (ECM).

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References

[1] https://en.wikipedia.org/wiki/Durotaxis

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