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Index Gabapentin

Gabapentin, sold under the brand name Neurontin among others, is a medication which is used to treat epilepsy (specifically partial seizures), neuropathic pain, hot flashes, and restless legs syndrome. [1]

180 relations: Absence seizure, Active placebo, Acute intermittent porphyria, Alcohol withdrawal syndrome, Alcoholic polyneuropathy, Alcoholism, Amanda Peterson, Amyotrophic lateral sclerosis, Amyotrophic lateral sclerosis research, Analgesic, Analgesic adjuvant, Anticonvulsant, Atagabalin, ATC code N03, Atypical trigeminal neuralgia, Balance disorder, Benzodiazepine withdrawal syndrome, Bipolar II disorder, Branched-chain amino acid aminotransferase, Burn, CACNA2D1, Calcium channel blocker, Cannabis use disorder, Carpal tunnel syndrome, Central pain syndrome, Chronic prostatitis/chronic pelvic pain syndrome, Ciguatera fish poisoning, Cimetidine, Cocaine dependence, Consumer & Prescriber Grant Program, Continuing medical education, Costochondritis, COX-2 inhibitor, Curtius rearrangement, CYP2A6, CYP3A4, David Franklin (scientist), David Frederick, Dejerine–Roussy syndrome, Delta wave, Depomed, Drug Industry Documents Archive, Drug reaction with eosinophilia and systemic symptoms, Epilepsy in animals, Erythromelalgia, Essential tremor, Euphoria, Ezekiel Emanuel, Fibromyalgia, Franklin v. Parke-Davis, ..., Frontal lobe epilepsy, GABA analogue, Gabapentin enacarbil, Gabapentinoid, Gabata, Gamma-Aminobutyric acid, Generalized anxiety disorder, Geniculate ganglionitis, Glossary of chemical formulas, Hereditary coproporphyria, Hexacyclonate, Hiccup, Hofmann rearrangement, Hyperalgesia, Hyperkinesia, Hypnogram, Illusory palinopsia, Index of oncology articles, Instant Karma (House), Intermittent explosive disorder, Intractable pain, Jeavons syndrome, Ketoprofen, Knee replacement, Lacosamide, Lateral medullary syndrome, Levetiracetam, List of cytochrome P450 modulators, List of drugs known for off-label use, List of drugs: G, List of drugs: Nb-Nh, List of largest civil only pharmaceutical settlements, List of largest pharmaceutical settlements, List of off-label promotion pharmaceutical settlements, List of psychiatric medications, List of psychiatric medications by condition treated, List of psychotropic medications, List of veterinary drugs, List of whistleblowers, Lithium (medication), Lofexidine, Lossen rearrangement, Low back pain, Management of chronic headaches, Marketing of off-label use, Menopause, Meralgia paraesthetica, Migraine, Mirogabalin, Mood stabilizer, Multiple sclerosis signs and symptoms, Muscle relaxant, Myoclonus, N-type calcium channel, Necrotizing fasciitis, Neuralgia, Neuropathic pain, New daily persistent headache, NMDA receptor antagonist, Nocturnal epilepsy, Notalgia paresthetica, Nystagmus, Obsessive–compulsive disorder, Off-label use, Opioid, Orexigenic, Osama bin Laden's compound in Abbottabad, Pain management, Paresthesia, Parke-Davis, Paroxysmal extreme pain disorder, Paroxysmal sympathetic hyperactivity, PD-217,014, Pedro Cuatrecasas, Peripheral neuropathy, Pfizer, Phantom limb, Phenibut, Physical dependence, Porphyria, Post viral cerebellar ataxia, Post-traumatic epilepsy, Postherpetic neuralgia, Posttraumatic stress disorder, Pregabalin, Prevention of migraines, Primidone, Prometa, Proximal diabetic neuropathy, Psychiatric medication, Pudendal nerve entrapment, Quetiapine, Qui tam, Red ear syndrome, Referred itch, Reporting bias, Restless legs syndrome, Rolandic epilepsy, Sciatica, Sedative, Seeding trial, Sensory neuron, Shingles, Side effect, Social anxiety disorder, Somnolence, Spasmodic torticollis, STEPS trial, Stroke recovery, Substance dependence, SUNCT syndrome, Superior oblique myokymia, Syringomyelia, Tail chasing, Tarsal tunnel syndrome, Temporal lobe epilepsy, Temporomandibular joint dysfunction, Teva Pharmaceutical Industries, Thin (film), Tiagabine, Topical anesthetic, Treatment of equine lameness, Trigeminal neuralgia, Unverricht–Lundborg disease, Valnoctamide, Visceral pain, Voltage-gated calcium channel, Zenker's paralysis, 3,3-Diethyl-2-pyrrolidinone, 4-Methylpregabalin. Expand index (130 more) »

Absence seizure

Absence seizures are one of several kinds of generalized seizures.

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Active placebo

An active placebo is a placebo that produces noticeable side effects that may convince the person being treated that they are receiving a legitimate treatment, rather than an ineffective placebo.

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Acute intermittent porphyria

Acute intermittent porphyria (AIP) is a genetic metabolic disorder affecting the production of heme, the oxygen-binding prosthetic group of hemoglobin.

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Alcohol withdrawal syndrome

Alcohol withdrawal syndrome is a set of symptoms that can occur following a reduction in alcohol use after a period of excessive use.

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Alcoholic polyneuropathy

Alcoholic polyneuropathy (A.K.A alcohol leg) is a neurological disorder in which peripheral nerves throughout the body malfunction simultaneously.

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Alcoholism, also known as alcohol use disorder (AUD), is a broad term for any drinking of alcohol that results in mental or physical health problems.

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Amanda Peterson

Amanda Peterson (born Phyllis Amanda Peterson, July 8, 1971 – July 3, 2015) was an American actress, most known for her role as Cindy Mancini in the 1987 comedy film Can't Buy Me Love.

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Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND), and Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.

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Amyotrophic lateral sclerosis research

Research on amyotrophic lateral sclerosis has focused on animal models of the disease, its mechanisms, ways to diagnose and track it, and treatments.

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An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.

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Analgesic adjuvant

An analgesic adjuvant is a medication that is typically used for indications other than pain control but provides control of pain in some painful diseases.

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Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.

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Atagabalin (PD-0200,390) is a drug developed by Pfizer and related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2).

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ATC code N03


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Atypical trigeminal neuralgia

Atypical trigeminal neuralgia (ATN), or type 2 trigeminal neuralgia, is a form of trigeminal neuralgia, a disorder of the fifth cranial nerve.

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Balance disorder

A balance disorder is a disturbance that causes an individual to feel unsteady, for example when standing or walking.

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Benzodiazepine withdrawal syndrome

Benzodiazepine withdrawal syndrome—often abbreviated to benzo withdrawal—is the cluster of symptoms that emerge when a person who has taken benzodiazepines, either medically or recreationally, and has developed a physical dependence undergoes dosage reduction or discontinuation.

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Bipolar II disorder

Bipolar II disorder (BP-II; pronounced "type two bipolar" or "bipolar type two" disorder) is a bipolar spectrum disorder (see also Bipolar disorder) characterized by at least one episode of hypomania and at least one episode of major depression.

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Branched-chain amino acid aminotransferase

Branched-chain amino acid aminotransferase (BCAT), also known as branched-chain amino acid transaminase, is an aminotransferase enzyme which acts upon branched-chain amino acids (BCAAs).

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A burn is a type of injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or radiation.

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Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene.

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Calcium channel blocker

Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are several medications that disrupt the movement of calcium through calcium channels.

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Cannabis use disorder

Cannabis use disorder (CUD) (also known as cannabis or marijuana addiction) is defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and ICD-10 published by World Health Organization as the continued use of cannabis despite clinically significant impairment, ranging from mild to severe.

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Carpal tunnel syndrome

Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels through the wrist at the carpal tunnel.

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Central pain syndrome

Central pain syndrome is a neurological condition caused by damage or malfunction in the Central Nervous System (CNS) which causes a sensitization of the pain system.

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Chronic prostatitis/chronic pelvic pain syndrome

Chronic nonbacterial prostatitis or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a pelvic pain condition in men, and should be distinguished from other forms of prostatitis such as chronic bacterial prostatitis and acute bacterial prostatitis.

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Ciguatera fish poisoning

Ciguatera fish poisoning, also known simply as ciguatera, is a foodborne illness caused by eating reef fish whose flesh is contaminated with certain toxins.

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Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production.

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Cocaine dependence

Cocaine dependence is a psychological desire to use cocaine regularly.

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Consumer & Prescriber Grant Program

The Consumer & Prescriber Grant Program (also going by other names, including Attorney General Prescriber Grant Program) was a grant program established with fines paid by Pfizer in the Franklin v. Parke-Davis trial for False Claims Act violations relating to off-label use of gabapentin.

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Continuing medical education

Continuing medical education (CME) refers to a specific form of continuing education (CE) that helps those in the medical field maintain competence and learn about new and developing areas of their field.

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Costochondritis, also known as chest wall pain, costosternal syndrome, or costosternal chondrodynia is an acute and often temporary inflammation of the costal cartilage, the structure that connects each rib to the sternum at the costosternal joint.

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COX-2 inhibitor

Selective COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain.

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Curtius rearrangement

The Curtius rearrangement (or Curtius reaction or Curtius degradation), first defined by Theodor Curtius in 1885, is the thermal decomposition of an acyl azide to an isocyanate with loss of nitrogen gas.

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Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body.

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Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.

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David Franklin (scientist)

David Franklin is an American microbiologist and former fellow of Harvard Medical School who while employed by Parke-Davis filed the 1996 whistleblower lawsuit exposing their illegal promotion of Neurontin (gabapentin) for off-label uses.

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David Frederick

David Frederick (born April 9, 1961) is an appellate attorney in Washington, D.C., and is a partner with Kellogg, Hansen, Todd, Figel & Frederick, P.L.L.C.

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Dejerine–Roussy syndrome

Dejerine–Roussy syndrome or thalamic pain syndrome is a condition developed after a thalamic stroke, a stroke causing damage to the thalamus.

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Delta wave

A delta wave is a high amplitude brain wave with a frequency of oscillation between 0.5–4 hertz.

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Depomed, Inc. is an American specialty pharmaceutical company which mainly markets products for treatment in neurology, pain and diseases of the central nervous system.

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Drug Industry Documents Archive

The Drug Industry Documents Archive (DIDA) is a digital archive of pharmaceutical industry documents created and maintained by the University of California, San Francisco, Library and Center for Knowledge Management.

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Drug reaction with eosinophilia and systemic symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications.

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Epilepsy in animals

Epilepsy in animals is a group of neurological disorders characterized by seizures, caused by abnormal bursts of electrical activity in the brain.

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Erythromelalgia, formerly known as Mitchell's disease (after Silas Weir Mitchell), is a rare vascular peripheral pain disorder in which blood vessels, usually in the lower extremities or hands, are episodically blocked (frequently on and off daily), then become hyperemic and inflamed.

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Essential tremor

Essential tremor (ET, also referred to as benign tremor, familial tremor, or idiopathic tremor) is a progressive neurological disorder that is also the most common movement disorder.

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Euphoria is an affective state in which a person experiences pleasure or excitement and intense feelings of well-being and happiness.

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Ezekiel Emanuel

Ezekiel Jonathan "Zeke" Emanuel (born September 6, 1957) is an American oncologist and bioethicist and senior fellow at the Center for American Progress.

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Fibromyalgia (FM) is a medical condition characterised by chronic widespread pain and a heightened pain response to pressure.

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Franklin v. Parke-Davis

Franklin v. Parke-Davis is a lawsuit filed in 1996 against Parke-Davis, a division of Warner-Lambert Company, and eventually against Pfizer (which bought Warner-Lambert in 2000) under the qui tam provisions of the False Claims Act.

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Frontal lobe epilepsy

Frontal lobe epilepsy, or FLE, is a neurological disorder that is characterized by brief, recurring seizures that arise in the frontal lobes of the brain, often while the patient is sleeping.

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GABA analogue

A GABA analogue is a compound which is an analogue or derivative of the neurotransmitter gamma-Aminobutyric acid (GABA) (the IUPAC of which is 4-aminobutanoic acid).

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Gabapentin enacarbil

Gabapentin enacarbil (Horizant, Regnite (in Japan)) is an anticonvulsant and analgesic drug of the gabapentinoid class, and a prodrug to gabapentin.

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Gabapentinoids, also known as α2δ ligands, are a class of drugs that are derivatives of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) (i.e., GABA analogues) which block α2δ subunit-containing voltage-dependent calcium channels (VDCCs).

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Gabata may refer to.

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Gamma-Aminobutyric acid

gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.

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Generalized anxiety disorder

Generalized anxiety disorder (GAD) is an anxiety disorder characterized by excessive, uncontrollable and often irrational worry, that is, apprehensive expectation about events or activities.

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Geniculate ganglionitis

Geniculate ganglionitis or geniculate neuralgia (GN), also called nervus intermedius neuralgia, Ramsay Hunt syndrome, or Hunt's neuralgia, is a rare disorder characterized by severe paroxysmal neuralgic pain deep in the ear, that may spread to the ear canal, outer ear, mastoid or eye regions.

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Glossary of chemical formulas

This is a list of common chemical compounds with chemical formulas and CAS numbers, indexed by formula.

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Hereditary coproporphyria

Hereditary coproporphyria (HCP) is a disorder of heme biosynthesis, classified as an acute hepatic porphyria.

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Hexacyclonate (Gevilon) is a stimulant drug.

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A hiccup (also spelled hiccough) is an involuntary contraction (myoclonic jerk) of the diaphragm that may repeat several times per minute.

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Hofmann rearrangement

The Hofmann rearrangement is the organic reaction of a primary amide to a primary amine with one fewer carbon atom.

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Hyperalgesia (or; 'hyper' from Greek ὑπέρ (huper, “over”), '-algesia' from Greek algos, ἄλγος (pain)) is an increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus, stimuli which would normally not be cause for a pain reaction (ex/ eyes or brain having a painful reaction to daylight).

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Hyperkinesia, also known as hyperkinesis, refers to an increase in muscular activity that can result in excessive abnormal movements, excessive normal movements, or a combination of both.

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A hypnogram is a form of polysomnography; it is a graph that represents the stages of sleep as a function of time.

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Illusory palinopsia

Illusory palinopsia (Greek: palin for "again" and opsia for "seeing") is a subtype of palinopsia, a visual disturbance defined as the persistence or recurrence of a visual image after the stimulus has been removed.

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Index of oncology articles

This is a list of terms related to oncology.

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Instant Karma (House)

"Instant Karma" is the fourth episode of the sixth season of House.

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Intermittent explosive disorder

Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by explosive outbursts of anger and violence, often to the point of rage, that are disproportionate to the situation at hand (e.g., impulsive screaming triggered by relatively inconsequential events).

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Intractable pain

Intractable pain, also known as Intractable Pain Disease or IP, is a severe, constant pain that is not curable by any known means and which causes a bed or house-bound state and early death if not adequately treated, usually with opioids and/or interventional procedures.

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Jeavons syndrome

Jeavons syndrome is a type of epilepsy.

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Ketoprofen, (RS)-2-(3-benzoylphenyl)-propionic acid (chemical formula C16H14O3) is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects.

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Knee replacement

Knee replacement, also known as knee arthroplasty, is a surgical procedure to replace the weight-bearing surfaces of the knee joint to relieve pain and disability.

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Lacosamide (INN, formerly known as erlosamide, harkeroside, SPM 927, or ADD 234037), is a medication for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.

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Lateral medullary syndrome

Lateral medullary syndrome is a neurological disorder causing a range of symptoms due to ischemia in the lateral part of the medulla oblongata in the brainstem.

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Levetiracetam, marketed under the trade names Keppra among others, is a medication used to treat epilepsy.

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List of cytochrome P450 modulators

This is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes.

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List of drugs known for off-label use

Drugs become known for off-label use when publications begin discussing how they can be used for off-label treatment of medical conditions.

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List of drugs: G

No description.

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List of drugs: Nb-Nh

No description.

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List of largest civil only pharmaceutical settlements

The following is a list of the 21 largest civil settlements, reached between the United States Department of Justice and pharmaceutical companies from 2001 to 2017, ordered by the size of the total civil settlement.

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List of largest pharmaceutical settlements

The following is a list of the 20 largest settlements reached between the United States Department of Justice and pharmaceutical companies from 1991 to 2012, ordered by the size of the total settlement.

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List of off-label promotion pharmaceutical settlements

The following are settlements reached with US authorities against pharmaceutical companies to resolve allegations of "off-label" promotion of drugs.

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List of psychiatric medications

This is an alphabetical list of psychiatric medications used by psychiatrists and other physicians to treat mental illness or distress.

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List of psychiatric medications by condition treated

This is a list of psychiatric medications used by psychiatrists and other physicians to treat mental illness or distress.

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List of psychotropic medications

List of medications which are used to treat psychiatric conditions that are on the market in the United States (this list is incomplete; the title of the entry is "List of Psychotropic Medications" and what follows is a list of psychiatric drugs - not all psychotropic agents are used to treat psychiatric conditions. A couple of examples are 'Tramadol' and 'Morphine').

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List of veterinary drugs

This article lists veterinary pharmaceutical drugs alphabetically by name.

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List of whistleblowers

This is a list of major whistleblowers from various countries.

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Lithium (medication)

Lithium compounds, also known as lithium salts, are primarily used as a psychiatric medication.

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Lofexidine, sold under the brand name Lucemyra among others, is a medication historically used to treat high blood pressure, but more commonly used to help with the physical symptoms of opioid withdrawal.

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Lossen rearrangement

The Lossen rearrangement is the conversion of a hydroxamic acid (1) to an isocyanate (3) via the formation of an O-acyl, sulfonyl, or phosphoryl intermediate hydroxamic acid O-derivative (2) and then conversion to its conjugate base.

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Low back pain

Low back pain (LBP) is a common disorder involving the muscles, nerves, and bones of the back.

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Management of chronic headaches

Chronic headache, or chronic daily headache (CDH), is classified as experiencing fifteen or more days with a headache per month.

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Marketing of off-label use

Marketing of off-label use is advertising the use of drugs for purposes not approved by the regional government.

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Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.

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Meralgia paraesthetica

Meralgia paresthetica or meralgia paraesthetica (or Bernhardt-Roth syndrome), is numbness or pain in the outer thigh not caused by injury to the thigh, but by injury to a nerve that extends from the spinal column to the thigh.

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A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe.

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Mirogabalin (developmental code name DS-5565) is a drug developed by Daiichi Sankyo, a gabapentinoid.

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Mood stabilizer

A mood stabilizer is a psychiatric pharmaceutical drug used to treat mood disorders characterized by intense and sustained mood shifts, typically bipolar disorder type I or type II, borderline personality disorder (BPD) and schizophrenia.

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Multiple sclerosis signs and symptoms

Multiple sclerosis can cause a variety of symptoms: changes in sensation (hypoesthesia), muscle weakness, abnormal muscle spasms, or difficulty moving; difficulties with coordination and balance; problems in speech (dysarthria) or swallowing (dysphagia), visual problems (nystagmus, optic neuritis, phosphenes or diplopia), fatigue and acute or chronic pain syndromes, bladder and bowel difficulties, cognitive impairment, or emotional symptomatology (mainly major depression).

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Muscle relaxant

A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.

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Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles.

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N-type calcium channel

N-type calcium channels are voltage gated calcium channels that are distributed throughout the entire body.

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Necrotizing fasciitis

Necrotizing fasciitis (NF), commonly known as flesh-eating disease, is an infection that results in the death of the body's soft tissue.

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Neuralgia (Greek neuron, "nerve" + algos, "pain") is pain in the distribution of a nerve or nerves, as in intercostal neuralgia, trigeminal neuralgia, and glossopharyngeal neuralgia.

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Neuropathic pain

Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system.

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New daily persistent headache

New daily persistent headache (NDPH) is a primary headache syndrome which can mimic chronic migraine and chronic tension-type headache.

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NMDA receptor antagonist

NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor (NMDAR).

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Nocturnal epilepsy

Nocturnal epilepsy is a seizure disorder in which seizures occur only while sleeping.

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Notalgia paresthetica

Notalgia paraesthetica (NP) or notalgia paresthetica (also known as "Hereditary localized pruritus", "Posterior pigmented pruritic patch", and "Subscapular pruritus") is a chronic sensory neuropathy.

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Nystagmus is a condition of involuntary (or voluntary, in rare cases) eye movement, acquired in infancy or later in life, that may result in reduced or limited vision.

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Obsessive–compulsive disorder

Obsessive–compulsive disorder (OCD) is a mental disorder where people feel the need to check things repeatedly, perform certain routines repeatedly (called "rituals"), or have certain thoughts repeatedly (called "obsessions").

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Off-label use

Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.

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Opioids are substances that act on opioid receptors to produce morphine-like effects.

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An orexigenic, or appetite stimulant, is a drug, hormone, or compound that increases appetite and may induce hyperphagia.

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Osama bin Laden's compound in Abbottabad

Osama bin Laden's compound, known locally as the Waziristan Haveli (وزیرستان حویلی), was an upper-class mansion that was used as a safe house for militant Islamist Osama bin Laden, who was shot and killed there by U.S. forces on May 2, 2011.

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Pain management

Pain management, pain medicine, pain control or algiatry, is a branch of medicine employing an interdisciplinary approach for easing the suffering and improving the quality of life of those living with chronic pain The typical pain management team includes medical practitioners, pharmacists, clinical psychologists, physiotherapists, occupational therapists, physician assistants, nurses.

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Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.

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Parke-Davis is a subsidiary of the pharmaceutical company Pfizer.

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Paroxysmal extreme pain disorder

Paroxysmal extreme pain disorder (PEPD), originally named familial rectal pain syndrome, is a rare disorder whose most notable features are pain in the mandibular, ocular and rectal areas as well as flushing.

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Paroxysmal sympathetic hyperactivity

Paroxysmal sympathetic hyperactivity (PSH) is a syndrome that causes episodes of increased activity of the sympathetic nervous system.

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PD-217,014 is a drug developed by Pfizer and related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2).

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Pedro Cuatrecasas

Pedro Cuatrecasas (born 27 September 1936) is an American biochemist and an Adjunct Professor of Pharmacology & Medicine at the University of California San Diego.

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Peripheral neuropathy

Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected.

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Pfizer Inc. is an American pharmaceutical conglomerate headquartered in New York City, with its research headquarters in Groton, Connecticut.

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Phantom limb

A phantom limb is the sensation that an amputated or missing limb is still attached.

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Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic and sedative effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications.

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Physical dependence

Physical dependence is a physical condition caused by chronic use of a tolerance forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms.

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Porphyria is a group of diseases in which substances called porphyrins build up, negatively affecting the skin or nervous system.

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Post viral cerebellar ataxia

Post-viral cerebellar ataxia also known as acute cerebellitis and acute cerebellar ataxia (ACA) is a disease characterized by the sudden onset of ataxia following a viral infection.

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Post-traumatic epilepsy

Post-traumatic epilepsy (PTE) is a form of epilepsy that results from brain damage caused by physical trauma to the brain (traumatic brain injury, abbreviated TBI).

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Postherpetic neuralgia

Postherpetic neuralgia (PHN) is nerve pain which occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus (herpes zoster, also known as shingles).

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Posttraumatic stress disorder

Posttraumatic stress disorder (PTSD)Acceptable variants of this term exist; see the Terminology section in this article.

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Pregabalin, marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder.

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Prevention of migraines

Preventive (also called prophylactic) treatment of migraines can be an important component of migraine management.

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Primidone (INN, BAN, USP) is an anticonvulsant of the barbiturate class.

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Prometa is a treatment protocol used primarily for methamphetamine addiction, although it has also been claimed to be effective for dependence on alcohol or cocaine.

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Proximal diabetic neuropathy

Proximal diabetic neuropathy, more commonly known as diabetic amyotrophy, is a nerve disorder that results as a complication of diabetes mellitus.

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Psychiatric medication

A psychiatric medication is a licensed psychoactive drug taken to exert an effect on the chemical makeup of the brain and nervous system.

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Pudendal nerve entrapment

Pudendal nerve entrapment (PNE), also known as Alcock canal syndrome, is an uncommon source of chronic pain, in which the pudendal nerve (located in the pelvis) is entrapped or compressed.

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Quetiapine, marketed as Seroquel among other names, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.

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Qui tam

In common law, a writ of qui tam is a writ whereby a private individual who assists a prosecution can receive all or part of any penalty imposed.

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Red ear syndrome

Red ear syndrome (RES) is a rare disorder of unknown etiology which was originally described in 1994.

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Referred itch

Referred itch is the phenomenon in which a stimulus applied in one region of the body is felt as an itch or irritation in a different part of the body.

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Reporting bias

In epidemiology, reporting bias is defined as "selective revealing or suppression of information" by subjects (for example about past medical history, smoking, sexual experiences).

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Restless legs syndrome

Restless legs syndrome (RLS) is a disorder that causes a strong urge to move one's legs.

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Rolandic epilepsy

Benign Rolandic epilepsy or benign childhood epilepsy with centrotemporal spikes (BCECTS) is the most common epilepsy syndrome in childhood.

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Sciatica is a medical condition characterized by pain going down the leg from the lower back.

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A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.

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Seeding trial

A seeding trial or marketing trial is a form of marketing, conducted in the name of research, designed to target product sampling towards selected consumers.

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Sensory neuron

Sensory neurons also known as afferent neurons are neurons that convert a specific type of stimulus, via their receptors, into action potentials or graded potentials.

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Shingles, also known as herpes zoster, is a viral disease characterized by a painful skin rash with blisters in a localized area.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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Social anxiety disorder

Social anxiety disorder (SAD), also known as social phobia, is an anxiety disorder characterized by a significant amount of fear in one or more social situations, causing considerable distress and impaired ability to function in at least some parts of daily life.

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Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).

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Spasmodic torticollis

Spasmodic torticollis is an extremely painful chronic neurological movement disorder causing the neck to involuntarily turn to the left, right, upwards, and/or downwards.

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STEPS trial

The STEPS trial (an acronym for Study of Neurontin: Titrate to Efficacy, Profile of Safety) was a clinical trial sponsored by Parke-Davis (now Pfizer) to evaluate the anticonvulsant Neurontin.

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Stroke recovery

The primary goals of stroke management are to reduce brain injury and promote maximum patient recovery.

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Substance dependence

Substance dependence also known as drug dependence is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use.

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SUNCT syndrome

Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT syndrome), is a rare headache disorder that belongs to the group of headaches called trigeminal autonomic cephalalgia (TACs).

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Superior oblique myokymia

Superior oblique myokymia is a neurological disorder affecting vision and was named by Hoyt and Keane in 1970.

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Syringomyelia is a generic term referring to a disorder in which a cyst or cavity forms within the spinal cord.

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Tail chasing

Tail chasing is a behaviour exhibited in dogs that is characterized by spinning in tight circles in either direction, and can be slow and focused on the tail or fast and unfocused.

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Tarsal tunnel syndrome

Tarsal tunnel syndrome (TTS), also known as posterior tibial neuralgia, is a compression neuropathy and painful foot condition in which the tibial nerve is compressed as it travels through the tarsal tunnel.

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Temporal lobe epilepsy

Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes.

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Temporomandibular joint dysfunction

Temporomandibular joint dysfunction (TMD, TMJD) is an umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull).

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Teva Pharmaceutical Industries

Teva Pharmaceutical Industries Ltd. (טבע תעשיות פרמצבטיות בע"מ) is an Israeli multinational pharmaceutical company headquartered in Petah Tikva, Israel.

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Thin (film)

Thin (often styled as THIN) is a 2006 cinéma vérité documentary film directed by Lauren Greenfield and distributed by HBO.

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Tiagabine (trade name Gabitril) is an anticonvulsant medication used in the treatment of epilepsy that is produced by Cephalon.

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Topical anesthetic

A topical anesthetic is a local anesthetic that is used to numb the surface of a body part.

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Treatment of equine lameness

The treatment of equine lameness is a complex subject.

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Trigeminal neuralgia

Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve.

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Unverricht–Lundborg disease

Unverricht–Lundborg disease (abbreviated ULD or EPM1) is the most common form of an uncommon group of genetic epilepsy disorders called the progressive myoclonus epilepsies.

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Valnoctamide (INN, USAN) has been used in France as a sedative-hypnotic since 1964.

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Visceral pain

Visceral pain is pain that results from the activation of nociceptors of the thoracic, pelvic, or abdominal viscera (organs).

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Voltage-gated calcium channel

Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the calcium ion Ca2+.

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Zenker's paralysis

Zenker’s paralysis, also known as peroneal nerve paralysis or palsy, is a paralysis on common fibular nerve that affects patient’s ability to lift the foot at the ankle.

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3,3-Diethyl-2-pyrrolidinone (DEABL) is an anticonvulsant drug most closely related to pyrithyldione and gabapentin.

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4-Methylpregabalin is a drug developed by Pfizer and related to pregabalin, which similarly acts as an analgesic with effectiveness against difficult to treat "atypical" pain syndromes such as neuropathic pain.

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Redirects here:

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[1] https://en.wikipedia.org/wiki/Gabapentin

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