Faster access than browser!
189 relations: Abemaciclib, Actinium, ADAM (protein), ADAM10, Adenocarcinoma in situ of the lung, Adenocarcinoma of the lung, AEE788, Afatinib, AKT1, AKT2, Anatomical pathology, Angiomotin, Ann Marie Rogers, Antibody-vaccine engineered construct, Antineoplastic resistance, Apocrine, Autocrine signalling, BAG3, Barrett's esophagus, Beta-catenin, Bi-specific T-cell engager, Biological response modifiers, Biomarker (medicine), Biopharmaceutical, BRCA mutation, Breast cancer, Breast cancer classification, Breast cancer management, Buparlisib, C-jun, C7orf43, Calu-3, Cancer biomarker, Cancer epigenetics, Canertinib, CCDC180, CD16, CDK inhibitor, Celltrion, Cerulenin, Chemotherapy regimen, Chimeric antigen receptor, Chordoma, Chromosome 17, Circulating tumor cell, Copanlisib, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Darlene Nipper, Dennis Slamon, ..., DENR (gene), Digital pathology, DLG4, DNAJA3, Dock7, Embryonal fyn-associated substrate, Endometrial cancer, Enzyme-linked receptor, Epidermal growth factor receptor, ErbB, ERBB3, Erbin (protein), Ertumaxomab, Extracellular signal–regulated kinases, FHIT, Fluorescence in situ hybridization, FOXO4, Friedrich Miescher Institute for Biomedical Research, Gene duplication, Genentech, Glucose-6-phosphate isomerase, Glycoprotein 130, GRB2, GRB7, GT198, Halozyme, Inc., Health in Ghana, Heat shock protein 90kDa alpha (cytosolic), member A1, Her, Heterogeneous ribonucleoprotein particle, Histone deacetylase inhibitor, HOTAIR, Hyaluronan-mediated motility receptor, Immune checkpoint, ImmunoGen, Immunohistochemistry, Immutep, IMP321, Imugene, Index of biochemistry articles, Index of oncology articles, Invasive carcinoma of no special type, Keratin 5, Laboratory Syrian hamster, Lapatinib, Lentiviral vector in gene therapy, List of antineoplastic agents, List of breast cancer cell lines, List of human clusters of differentiation, List of MeSH codes (D08), List of MeSH codes (D12.776), List of MeSH codes (D12.776.543), List of MeSH codes (D23), List of MeSH codes (G14), List of OMIM disorder codes, List of therapeutic monoclonal antibodies, List of Washington & Jefferson College alumni, Lobular carcinoma in situ, Lung cancer, MACF1, Male breast cancer, MammaPrint, Margetuximab, MCF-7, Mechanism of action, Merrimack Pharmaceuticals, Mertansine, Michael Stratton, Microvesicles, Mir-181 microRNA precursor, Molecular Partners, Monoclonal antibody, Monoclonal antibody therapy, Mouse models of breast cancer metastasis, MTOR inhibitors, MUC1, Mucin 4, National Breast Cancer Coalition, Neratinib, Neu (disambiguation), Neuregulin, Neuregulin 1, Neuregulin 3, NeuVax, Neuvenge, Non-small-cell lung carcinoma, Olaparib, Oncoantigen, Oncogene, ONT-380, Ovarian cancer, Patient derived xenograft, Pediatric ependymoma, Personalized medicine, Pertuzumab, PICK1, PIK3R2, PLCG1, Polysomy, Potato carboxypeptidase inhibitor, Poziotinib, PRKCD, Protein kinase domain, Protein kinase inhibitor, Psoralen, PTPN1, PTPRK, Quinazoline, Ribociclib, Sandra M. Swain, Selective estrogen receptor modulator, Sheddase, Signal transduction, Single-chain variable fragment, Single-domain antibody, SKBR3, Spectrum Pharmaceuticals, STARD3, Stomach cancer, Stuart A. Aaronson, Tamoxifen, Targeted therapy, Tesetaxel, Timeline of brain cancer, TopoTarget, Trastuzumab, Trastuzumab emtansine, Treatment of cancer, Trifunctional antibody, Triple-negative breast cancer, Tucatinib, Tumor antigen vaccine, Tyrosine kinase, Tyrosine-kinase inhibitor, Ursula Wiedermann, Uterine serous carcinoma, Vadimezan, ViroMed, Zinc finger transcription factor. Expand index (139 more) »
Abemaciclib
Abemaciclib (trade name Verzenio) is a drug for the treatment of advanced or metastatic breast cancers.
New!!: HER2/neu and Abemaciclib · See more »
Actinium
Actinium is a chemical element with symbol Ac and atomic number 89.
New!!: HER2/neu and Actinium · See more »
ADAM (protein)
ADAMs (short for a disintegrin and metalloproteinase) are a family of transmembrane and secreted metalloendopeptidases.
New!!: HER2/neu and ADAM (protein) · See more »
ADAM10
A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene.
New!!: HER2/neu and ADAM10 · See more »
Adenocarcinoma in situ of the lung
In situ pulmonary adenocarcinoma (AIS)—previously included in the category of "bronchioloalveolar carcinoma" (BAC)—is a subtype of lung adenocarcinoma.
New!!: HER2/neu and Adenocarcinoma in situ of the lung · See more »
Adenocarcinoma of the lung
Adenocarcinoma of the lung (also known as pulmonary adenocarcinoma) is the most common type of lung cancer, and is characterized by distinct cellular and molecular features including gland and/or duct formation and/or production of significant amounts of mucus.
New!!: HER2/neu and Adenocarcinoma of the lung · See more »
AEE788
AEE788 is a multitargeted human epidermal receptor (HER) 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, 77, 59 nM for EGFR, ErbB2, KDR, and Flt-1.
New!!: HER2/neu and AEE788 · See more »
Afatinib
Afatinib, sold under the brand name Gilotrif among others, is a medication used to treat non-small cell lung carcinoma (NSCLC).
New!!: HER2/neu and Afatinib · See more »
AKT1
RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene.
New!!: HER2/neu and AKT1 · See more »
AKT2
RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.
New!!: HER2/neu and AKT2 · See more »
Anatomical pathology
Anatomical pathology (Commonwealth) or Anatomic pathology (U.S.) is a medical specialty that is concerned with the diagnosis of disease based on the macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
New!!: HER2/neu and Anatomical pathology · See more »
Angiomotin
Angiomotin (AMOT) is a protein that in humans is encoded by the AMOT gene.
New!!: HER2/neu and Angiomotin · See more »
Ann Marie Rogers
Ann Marie Rogers (died 2 March 2009) was a British campaigner who fought a successful landmark court battle to receive the breast cancer drug Herceptin on the NHS.
New!!: HER2/neu and Ann Marie Rogers · See more »
Antibody-vaccine engineered construct
Antibody-vaccine engineered construct abbreviated AVEC is a biomolecularly engineered molecule consisting of the two main components: (1) antibody; (2) vaccine.
New!!: HER2/neu and Antibody-vaccine engineered construct · See more »
Antineoplastic resistance
Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the multiple drug resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies.
New!!: HER2/neu and Antineoplastic resistance · See more »
Apocrine
Apocrine is a term used to classify exocrine glands in the study of histology.
New!!: HER2/neu and Apocrine · See more »
Autocrine signalling
Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell.
New!!: HER2/neu and Autocrine signalling · See more »
BAG3
BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene.
New!!: HER2/neu and BAG3 · See more »
Barrett's esophagus
Barrett's esophagus refers to an (abnormal) change in the cells of the lower portion of the esophagus. It is characterized by the replacement of the normal stratified squamous epithelium lining of the esophagus by simple columnar epithelium with goblet cells (which are usually found lower in the gastrointestinal tract). The medical significance of Barrett's esophagus is its strong association (0.1 per 1 cm Prague C>M> total segment length per patient-year) with esophageal adenocarcinoma, a very often deadly cancer, because of which it is considered to be a premalignant condition. The main cause of Barrett's esophagus is thought to be an adaptation to chronic acid exposure from reflux esophagitis The incidence of esophageal adenocarcinoma has increased substantially in the Western world in recent years. The condition is found in 5–15% of patients who seek medical care for heartburn (gastroesophageal reflux disease), although a large subgroup of patients with Barrett's esophagus do not have symptoms. Diagnosis requires endoscopy (more specifically, esophagogastroduodenoscopy, a procedure in which a fibreoptic cable is inserted through the mouth to examine the esophagus, stomach, and duodenum) and biopsy. The cells of Barrett's esophagus, after biopsy, are classified into four general categories: nondysplastic, low-grade dysplasia, high-grade dysplasia, and frank carcinoma. High-grade dysplasia and early stages of adenocarcinoma can be treated by endoscopic resection and new endoscopic therapies such as radiofrequency ablation, whereas advanced stages (submucosal) are generally advised to undergo surgical treatment. Nondysplastic and low-grade patients are generally advised to undergo annual observation with endoscopy, with radiofrequency ablation as a therapeutic option. In high-grade dysplasia, the risk of developing cancer might be at 10% per patient-year or greater. The condition is named after the Australian-born British thoracic surgeon Norman Barrett (1903–1979), who described it in 1950. Those with the eating disorder bulimia are more likely to develop Barrett’s esophagus because bulimia can cause severe acid reflux, and because purging also floods the esophagus with acid.
New!!: HER2/neu and Barrett's esophagus · See more »
Beta-catenin
Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene.
New!!: HER2/neu and Beta-catenin · See more »
Bi-specific T-cell engager
Bi-specific T-cell engagers (BiTEs) are a class of artificial bispecific monoclonal antibodies that are investigated for the use as anti-cancer drugs.
New!!: HER2/neu and Bi-specific T-cell engager · See more »
Biological response modifiers
Biological response modifiers (BRMs) are substances that modify immune responses.
New!!: HER2/neu and Biological response modifiers · See more »
Biomarker (medicine)
In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state.
New!!: HER2/neu and Biomarker (medicine) · See more »
Biopharmaceutical
A biopharmaceutical, also known as a biologic(al) medical product, biological, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources.
New!!: HER2/neu and Biopharmaceutical · See more »
BRCA mutation
A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes.
New!!: HER2/neu and BRCA mutation · See more »
Breast cancer
Breast cancer is cancer that develops from breast tissue.
New!!: HER2/neu and Breast cancer · See more »
Breast cancer classification
Breast cancer classification divides breast cancer into categories according to different schemes criteria and serving a different purpose.
New!!: HER2/neu and Breast cancer classification · See more »
Breast cancer management
Breast cancer management takes different approaches depending on physical and biological characteristics of the disease, as well as the age, over-all health and personal preferences of the patient.
New!!: HER2/neu and Breast cancer management · See more »
Buparlisib
Buparlisib (INN, codenamed BKM120) is an investigational small molecule orally-available pan-class I phosphoinositide 3-kinase inhibitor.
New!!: HER2/neu and Buparlisib · See more »
C-jun
c-Jun is a protein that in humans is encoded by the JUN gene.
New!!: HER2/neu and C-jun · See more »
C7orf43
C7orf43 (Chromosome 7 Open reading frame 43) is a protein that in human is encoded by the gene C7orf43.
New!!: HER2/neu and C7orf43 · See more »
Calu-3
Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development.
New!!: HER2/neu and Calu-3 · See more »
Cancer biomarker
A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body.
New!!: HER2/neu and Cancer biomarker · See more »
Cancer epigenetics
Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence.
New!!: HER2/neu and Cancer epigenetics · See more »
Canertinib
Canertinib (CI-1033) is an experimental drug candidate for the treatment of cancer.
New!!: HER2/neu and Canertinib · See more »
CCDC180
Coiled-coil domain containing protein 180 (CCDC180) is a protein that in humans is encoded by the CCDC180 gene.
New!!: HER2/neu and CCDC180 · See more »
CD16
CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.
New!!: HER2/neu and CD16 · See more »
CDK inhibitor
A CDK (cyclin-dependent kinase) inhibitor is any chemical that inhibits the function of CDKs.
New!!: HER2/neu and CDK inhibitor · See more »
Celltrion
Celltrion is a biopharmaceutical company headquartered in Incheon, South Korea.
New!!: HER2/neu and Celltrion · See more »
Cerulenin
Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis.
New!!: HER2/neu and Cerulenin · See more »
Chemotherapy regimen
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations.
New!!: HER2/neu and Chemotherapy regimen · See more »
Chimeric antigen receptor
Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors) are engineered receptors that combine a new specificity with an immune cell to target cancer cells.
New!!: HER2/neu and Chimeric antigen receptor · See more »
Chordoma
Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord.
New!!: HER2/neu and Chordoma · See more »
Chromosome 17
Chromosome 17 is one of the 23 pairs of chromosomes in humans.
New!!: HER2/neu and Chromosome 17 · See more »
Circulating tumor cell
Circulating tumor cells (CTCs) are cells that have shed into the vasculature or lymphatics from a primary tumor and are carried around the body in the blood circulation.
New!!: HER2/neu and Circulating tumor cell · See more »
Copanlisib
Copanlisib (trade name Aliqopa; codenamed BAY 80-6946) is a drug which is approved by US FDA for the treatment of adult patients experiencing relapsed follicular lymphoma who have received at least two prior systemic therapies.
New!!: HER2/neu and Copanlisib · See more »
Cyclin-dependent kinase 4
Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene.
New!!: HER2/neu and Cyclin-dependent kinase 4 · See more »
Cyclin-dependent kinase 6
Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.
New!!: HER2/neu and Cyclin-dependent kinase 6 · See more »
Darlene Nipper
Darlene Nipper is an American lesbian, gay, bisexual and transgender (LGBT) rights activist and the deputy executive director of the National Gay and Lesbian Task Force since 2008.
New!!: HER2/neu and Darlene Nipper · See more »
Dennis Slamon
Dennis Joseph Slamon (born August 8, 1948), is an American oncologist and chief of the division of Hematology-Oncology at UCLA.
New!!: HER2/neu and Dennis Slamon · See more »
DENR (gene)
Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene.
New!!: HER2/neu and DENR (gene) · See more »
Digital pathology
Digital pathology is an image-based information environment which is enabled by computer technology that allows for the management of information generated from a digital slide.
New!!: HER2/neu and Digital pathology · See more »
DLG4
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.
New!!: HER2/neu and DLG4 · See more »
DNAJA3
DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16.
New!!: HER2/neu and DNAJA3 · See more »
Dock7
Dock7 (Dedicator of cytokinesis 7), also known as Zir2, is a large (~240 kDa) protein involved in intracellular signalling networks.
New!!: HER2/neu and Dock7 · See more »
Embryonal fyn-associated substrate
Embryonal fyn-associated substrate is a protein that in humans is encoded by the EFS gene.
New!!: HER2/neu and Embryonal fyn-associated substrate · See more »
Endometrial cancer
Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).
New!!: HER2/neu and Endometrial cancer · See more »
Enzyme-linked receptor
An enzyme-linked receptor, also known as a catalytic receptor, is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side.
New!!: HER2/neu and Enzyme-linked receptor · See more »
Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
New!!: HER2/neu and Epidermal growth factor receptor · See more »
ErbB
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.
New!!: HER2/neu and ErbB · See more »
ERBB3
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.
New!!: HER2/neu and ERBB3 · See more »
Erbin (protein)
Erbb2 interacting protein (ERBB2IP) also known as Erbin is a protein which in humans is encoded by the ERBB2IP gene.
New!!: HER2/neu and Erbin (protein) · See more »
Ertumaxomab
Ertumaxomab (trade name Rexomun) is a rat-murine hybrid monoclonal antibody designed to treat some types of cancer.
New!!: HER2/neu and Ertumaxomab · See more »
Extracellular signal–regulated kinases
In molecular biology, extracellular signal–regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.
New!!: HER2/neu and Extracellular signal–regulated kinases · See more »
FHIT
Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene.
New!!: HER2/neu and FHIT · See more »
Fluorescence in situ hybridization
Fluorescent in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity.
New!!: HER2/neu and Fluorescence in situ hybridization · See more »
FOXO4
Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene.
New!!: HER2/neu and FOXO4 · See more »
Friedrich Miescher Institute for Biomedical Research
The Friedrich Miescher Institute for Biomedical Research (FMI) is a world-class center for basic research in life sciences based in Basel, Switzerland.
New!!: HER2/neu and Friedrich Miescher Institute for Biomedical Research · See more »
Gene duplication
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.
New!!: HER2/neu and Gene duplication · See more »
Genentech
Genentech, Inc., is a biotechnology corporation which became a subsidiary of Roche in 2009.
New!!: HER2/neu and Genentech · See more »
Glucose-6-phosphate isomerase
Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme that in humans is encoded by the GPI gene on chromosome 19.
New!!: HER2/neu and Glucose-6-phosphate isomerase · See more »
Glycoprotein 130
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.
New!!: HER2/neu and Glycoprotein 130 · See more »
GRB2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication.
New!!: HER2/neu and GRB2 · See more »
GRB7
Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene.
New!!: HER2/neu and GRB7 · See more »
GT198
GT198 is a human oncogene (gene symbol PSMC3IP, alias TBPIP or Hop2) located within the BRCA1 locus at chromosome 17q21.
New!!: HER2/neu and GT198 · See more »
Halozyme, Inc.
Halozyme Therapeutics is a U.S. biotechnology company that develops novel oncology therapies designed to target the tumor microenvironment and licenses a novel drug delivery technology through corporate partnerships.
New!!: HER2/neu and Halozyme, Inc. · See more »
Health in Ghana
Health in Ghana includes the healthcare systems on prevention, care and treatment of diseases and other maladies.
New!!: HER2/neu and Health in Ghana · See more »
Heat shock protein 90kDa alpha (cytosolic), member A1
Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene.
New!!: HER2/neu and Heat shock protein 90kDa alpha (cytosolic), member A1 · See more »
Her
Her is the objective form of the pronoun she in Modern English.
New!!: HER2/neu and Her · See more »
Heterogeneous ribonucleoprotein particle
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA (pre-mRNA).
New!!: HER2/neu and Heterogeneous ribonucleoprotein particle · See more »
Histone deacetylase inhibitor
Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases.
New!!: HER2/neu and Histone deacetylase inhibitor · See more »
HOTAIR
HOTAIR (for HOX transcript antisense RNA) is a human gene located on chromosome 12.
New!!: HER2/neu and HOTAIR · See more »
Hyaluronan-mediated motility receptor
Hyaluronan-mediated motility receptor (HMMR), also known as RHAMM (Receptor for Hyaluronan Mediated Motility) is a protein which in humans is encoded by the HMMR gene.
New!!: HER2/neu and Hyaluronan-mediated motility receptor · See more »
Immune checkpoint
Immune checkpoints are regulators of the immune system.
New!!: HER2/neu and Immune checkpoint · See more »
ImmunoGen
ImmunoGen, Inc. is a biotechnology company focused on the development of antibody-drug conjugate (ADC) therapeutics for the treatment of cancer.
New!!: HER2/neu and ImmunoGen · See more »
Immunohistochemistry
Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues.
New!!: HER2/neu and Immunohistochemistry · See more »
Immutep
Immutep Ltd (formerly Prima Biomed) is a biotechnology company working primarily in the field of cancer immunotherapy.
New!!: HER2/neu and Immutep · See more »
IMP321
IMP321 is a large molecule cancer drug being developed by the clinical stage biotechnology company Prima BioMed (Nasdaq: IMMP).
New!!: HER2/neu and IMP321 · See more »
Imugene
Imugene Ltd is a biotechnology company working in cancer immunotherapy.
New!!: HER2/neu and Imugene · See more »
Index of biochemistry articles
Biochemistry is the study of the chemical processes in living organisms.
New!!: HER2/neu and Index of biochemistry articles · See more »
Index of oncology articles
This is a list of terms related to oncology.
New!!: HER2/neu and Index of oncology articles · See more »
Invasive carcinoma of no special type
Invasive carcinoma of no special type (NST) also known as invasive ductal carcinoma or ductal NOS and previously known as invasive ductal carcinoma, not otherwise specified (NOS) is a group of breast cancers that do not have the "specific differentiating features".
New!!: HER2/neu and Invasive carcinoma of no special type · See more »
Keratin 5
Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene.
New!!: HER2/neu and Keratin 5 · See more »
Laboratory Syrian hamster
Syrian hamsters (Mesocricetus auratus) are one of several rodents used in animal testing.
New!!: HER2/neu and Laboratory Syrian hamster · See more »
Lapatinib
Lapatinib (INN), used in the form of lapatinib ditosylate (USAN) (trade names Tykerb and Tyverb) is an orally active drug for breast cancer and other solid tumours.
New!!: HER2/neu and Lapatinib · See more »
Lentiviral vector in gene therapy
Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentivirus.
New!!: HER2/neu and Lentiviral vector in gene therapy · See more »
List of antineoplastic agents
This is a list of antineoplastic agents used to treat cancer.
New!!: HER2/neu and List of antineoplastic agents · See more »
List of breast cancer cell lines
Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease.
New!!: HER2/neu and List of breast cancer cell lines · See more »
List of human clusters of differentiation
The following is a list of human clusters of differentiation (or CD) molecules.
New!!: HER2/neu and List of human clusters of differentiation · See more »
List of MeSH codes (D08)
This is the fourth part of the list of the "D" codes for MeSH.
New!!: HER2/neu and List of MeSH codes (D08) · See more »
List of MeSH codes (D12.776)
This is part of the list of the "D" codes for MeSH.
New!!: HER2/neu and List of MeSH codes (D12.776) · See more »
List of MeSH codes (D12.776.543)
This is a sub-part (membrane proteins only) of List of MeSH codes (D12.776), itself a part of the list of the "D" codes for MeSH.
New!!: HER2/neu and List of MeSH codes (D12.776.543) · See more »
List of MeSH codes (D23)
This is the fourth part of the list of the "D" codes for MeSH.
New!!: HER2/neu and List of MeSH codes (D23) · See more »
List of MeSH codes (G14)
The following is a list of the "G" codes for MeSH.
New!!: HER2/neu and List of MeSH codes (G14) · See more »
List of OMIM disorder codes
This is a list of disorder codes in the Online Mendelian Inheritance in Man (OMIM) database.
New!!: HER2/neu and List of OMIM disorder codes · See more »
List of therapeutic monoclonal antibodies
This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent cell.
New!!: HER2/neu and List of therapeutic monoclonal antibodies · See more »
List of Washington & Jefferson College alumni
Washington & Jefferson College is a private liberal arts college in Washington, Pennsylvania, which is located in the Pittsburgh metropolitan area.
New!!: HER2/neu and List of Washington & Jefferson College alumni · See more »
Lobular carcinoma in situ
Lobular carcinoma in situ (LCIS) is an incidental microscopic finding with characteristic cellular morphology and multifocal tissue patterns.
New!!: HER2/neu and Lobular carcinoma in situ · See more »
Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
New!!: HER2/neu and Lung cancer · See more »
MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 is a protein that in humans is encoded by the MACF1 gene.
New!!: HER2/neu and MACF1 · See more »
Male breast cancer
Male breast cancer (male breast neoplasm) is a rare cancer in males that originates from the breast.
New!!: HER2/neu and Male breast cancer · See more »
MammaPrint
MammaPrint is a prognostic and predictive diagnostic test for early stage breast cancer patients that assess the risk that a tumor will metastasize to other parts of the body.
New!!: HER2/neu and MammaPrint · See more »
Margetuximab
Margetuximab is a chimeric IgG monoclonal antibody against HER2 designed for the treatment of cancer.
New!!: HER2/neu and Margetuximab · See more »
MCF-7
MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old Caucasian woman.
New!!: HER2/neu and MCF-7 · See more »
Mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.
New!!: HER2/neu and Mechanism of action · See more »
Merrimack Pharmaceuticals
Merrimack Pharmaceuticals is a pharmaceutical company based in Cambridge, Massachusetts, United States.
New!!: HER2/neu and Merrimack Pharmaceuticals · See more »
Mertansine
Mertansine, also called DM1 (and in some of its forms emtansine), is a thiol-containing maytansinoid that for therapeutic purposes is attached to a monoclonal antibody through reaction of the thiol group with a linker structure to create an antibody-drug conjugate (ADC).
New!!: HER2/neu and Mertansine · See more »
Michael Stratton
Sir Michael Rudolf Stratton, (born 22 June 1957) is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute.
New!!: HER2/neu and Michael Stratton · See more »
Microvesicles
Microvesicles (circulating microvesicles, or microparticles) are a type of extracellular vesicle, between 50 and 1,000 nanometers (nm) in diameter, found in many types of body fluids as well as the interstitial space between cells.
New!!: HER2/neu and Microvesicles · See more »
Mir-181 microRNA precursor
In molecular biology miR-181 microRNA precursor is a small non-coding RNA molecule.
New!!: HER2/neu and Mir-181 microRNA precursor · See more »
Molecular Partners
Molecular Partners AG is a clinical-stage biopharmaceutical company based in Zurich, Switzerland.
New!!: HER2/neu and Molecular Partners · See more »
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
New!!: HER2/neu and Monoclonal antibody · See more »
Monoclonal antibody therapy
Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies (mAb) to bind monospecifically to certain cells or proteins.
New!!: HER2/neu and Monoclonal antibody therapy · See more »
Mouse models of breast cancer metastasis
Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammary tumor leading to distant focal lesions of mammary epithelium.
New!!: HER2/neu and Mouse models of breast cancer metastasis · See more »
MTOR inhibitors
mTOR inhibitors are a class of drugs that inhibit the mechanistic target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs).
New!!: HER2/neu and MTOR inhibitors · See more »
MUC1
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans.
New!!: HER2/neu and MUC1 · See more »
Mucin 4
Mucin 4 (MUC 4) is a mucin protein that in humans is encoded by the MUC4 gene.
New!!: HER2/neu and Mucin 4 · See more »
National Breast Cancer Coalition
The National Breast Cancer Coalition (NBCC) is a grassroots advocacy organization that seeks to improve public policies surrounding breast cancer research, diagnosis and treatment.
New!!: HER2/neu and National Breast Cancer Coalition · See more »
Neratinib
Neratinib (INN; trade name Nerlynx; development code HKI-272) is a tyrosine kinase inhibitor anticancer drug.
New!!: HER2/neu and Neratinib · See more »
Neu (disambiguation)
Neu! is a German krautrock band.
New!!: HER2/neu and Neu (disambiguation) · See more »
Neuregulin
Neuregulins or neuroregulins are a family of four structurally related proteins that are part of the EGF family of proteins.
New!!: HER2/neu and Neuregulin · See more »
Neuregulin 1
Neuregulin 1 or NRG1 is a cell adhesion molecule that in humans is encoded by the NRG1 gene.
New!!: HER2/neu and Neuregulin 1 · See more »
Neuregulin 3
Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene.
New!!: HER2/neu and Neuregulin 3 · See more »
NeuVax
NeuVax is a peptide vaccine aimed at preventing or delaying the recurrence of breast cancer in cancer survivors who achieve remission after standard of care treatment (e.g., surgery, radiation, chemotherapy).
New!!: HER2/neu and NeuVax · See more »
Neuvenge
Neuvenge, Lapuleucel-T (APC 8024), is a therapeutic cancer vaccine (TCV) in development (clinical trial) by Dendreon (DNDN).
New!!: HER2/neu and Neuvenge · See more »
Non-small-cell lung carcinoma
Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC).
New!!: HER2/neu and Non-small-cell lung carcinoma · See more »
Olaparib
Olaparib (AZD-2281, trade name Lynparza) is an FDA-approved targeted therapy for cancer, developed by scientists at the University of Cambridge, including Steve Jackson, KuDOS Pharmaceuticals, and later by AstraZeneca.
New!!: HER2/neu and Olaparib · See more »
Oncoantigen
An oncoantigen is a surface or soluble tumor antigen that supports tumor growth.
New!!: HER2/neu and Oncoantigen · See more »
Oncogene
An oncogene is a gene that has the potential to cause cancer.
New!!: HER2/neu and Oncogene · See more »
ONT-380
ONT-380 is a small molecule HER2-selective tyrosine kinase inhibitor.
New!!: HER2/neu and ONT-380 · See more »
Ovarian cancer
Ovarian cancer is a cancer that forms in or on an ovary.
New!!: HER2/neu and Ovarian cancer · See more »
Patient derived xenograft
Patient derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse.
New!!: HER2/neu and Patient derived xenograft · See more »
Pediatric ependymoma
Pediatric ependymomas are similar in nature to the adult form of ependymoma in that they are thought to arise from radial glial cells lining the ventricular system.
New!!: HER2/neu and Pediatric ependymoma · See more »
Personalized medicine
Personalized medicine, also termed precision medicine, is a medical procedure that separates patients into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease.
New!!: HER2/neu and Personalized medicine · See more »
Pertuzumab
Pertuzumab (also called 2C4, trade name Perjeta) is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer.
New!!: HER2/neu and Pertuzumab · See more »
PICK1
Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.
New!!: HER2/neu and PICK1 · See more »
PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.
New!!: HER2/neu and PIK3R2 · See more »
PLCG1
Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.
New!!: HER2/neu and PLCG1 · See more »
Polysomy
Polysomy is a condition found in many species, including fungi, plants, insects, and mammals, in which an organism has at least one more chromosome than normal, i.e., there may be three or more copies of the chromosome rather than the expected two copies.
New!!: HER2/neu and Polysomy · See more »
Potato carboxypeptidase inhibitor
Potato carboxypeptidase inhibitor (PCI) is a naturally occurring protease inhibitor peptide in potatoes that can form complexes with several metallo-carboxypeptidases, inhibiting them in a strong competitive way with a Ki in the nanomolar range.
New!!: HER2/neu and Potato carboxypeptidase inhibitor · See more »
Poziotinib
Poziotinib (NOV120101, HM781-36B) is a drug in development by Hanmi Pharmaceutical (in South Korea), Luye Pharma (China), and Spectrum Pharmaceuticals (rest of world) for various cancers.
New!!: HER2/neu and Poziotinib · See more »
PRKCD
Protein kinase C delta type (or PKC-δ) is an enzyme that in humans is encoded by the PRKCD gene.
New!!: HER2/neu and PRKCD · See more »
Protein kinase domain
The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases.
New!!: HER2/neu and Protein kinase domain · See more »
Protein kinase inhibitor
A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases.
New!!: HER2/neu and Protein kinase inhibitor · See more »
Psoralen
Psoralen (also called psoralene) is the parent compound in a family of natural products known as furocoumarins.
New!!: HER2/neu and Psoralen · See more »
PTPN1
Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family.
New!!: HER2/neu and PTPN1 · See more »
PTPRK
Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene.
New!!: HER2/neu and PTPRK · See more »
Quinazoline
Quinazoline is an organic compound with the formula C8H6N2.
New!!: HER2/neu and Quinazoline · See more »
Ribociclib
Ribociclib (trade name Kisqali) is an inhibitor of cyclin D1/CDK4 and CDK6, and is used for the treatment of certain kinds of breast cancer.
New!!: HER2/neu and Ribociclib · See more »
Sandra M. Swain
Sandra M. Swain is an American oncologist, breast cancer specialist and clinical translational researcher.
New!!: HER2/neu and Sandra M. Swain · See more »
Selective estrogen receptor modulator
Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).
New!!: HER2/neu and Selective estrogen receptor modulator · See more »
Sheddase
Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface.
New!!: HER2/neu and Sheddase · See more »
Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
New!!: HER2/neu and Signal transduction · See more »
Single-chain variable fragment
A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids.
New!!: HER2/neu and Single-chain variable fragment · See more »
Single-domain antibody
A single-domain antibody (sdAb) is an antibody fragment consisting of a single monomeric variable antibody domain.
New!!: HER2/neu and Single-domain antibody · See more »
SKBR3
SkBr3 (also known as SK-BR-3) is a breast cancer cell line isolated by the Memorial Sloan–Kettering Cancer Center in 1970 that is used in therapeutic research, especially in context of HER2 targeting.
New!!: HER2/neu and SKBR3 · See more »
Spectrum Pharmaceuticals
Spectrum Pharmaceuticals is an American biopharmaceutical company.
New!!: HER2/neu and Spectrum Pharmaceuticals · See more »
STARD3
StAR-related lipid transfer domain protein 3 (STARD3) also known as metastatic lymph node 64 protein (MLN64) is a late endosomal integral membrane protein involved in cholesterol transport.
New!!: HER2/neu and STARD3 · See more »
Stomach cancer
Stomach cancer, also known as gastric cancer, is cancer developing from the lining of the stomach.
New!!: HER2/neu and Stomach cancer · See more »
Stuart A. Aaronson
Stuart A. Aaronson, M.D., is an American author and internationally recognized cancer biologist.
New!!: HER2/neu and Stuart A. Aaronson · See more »
Tamoxifen
Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.
New!!: HER2/neu and Tamoxifen · See more »
Targeted therapy
Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy.
New!!: HER2/neu and Targeted therapy · See more »
Tesetaxel
Tesetaxel is an orally administered taxane being investigated as a chemotherapy agent for various types of cancer, including breast cancer, gastric cancer, colorectal cancer, and other solid tumors.
New!!: HER2/neu and Tesetaxel · See more »
Timeline of brain cancer
This is a timeline of brain cancer, describing especially major discoveries, advances in treatment and major organizations.
New!!: HER2/neu and Timeline of brain cancer · See more »
TopoTarget
TopoTarget was a Copenhagen-based biotechnology company focused on the discovery and development of drugs and therapies to treat cancer.
New!!: HER2/neu and TopoTarget · See more »
Trastuzumab
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer.
New!!: HER2/neu and Trastuzumab · See more »
Trastuzumab emtansine
Trastuzumab emtansine also known as ado-trastuzumab emtansine and sold under the trade name Kadcyla, is an antibody-drug conjugate consisting of the monoclonal antibody trastuzumab (Herceptin) linked to the cytotoxic agent emtansine (DM1).
New!!: HER2/neu and Trastuzumab emtansine · See more »
Treatment of cancer
Cancer can be treated by surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy (including immunotherapy such as monoclonal antibody therapy) and synthetic lethality.
New!!: HER2/neu and Treatment of cancer · See more »
Trifunctional antibody
A trifunctional antibody is a monoclonal antibody with binding sites for two different antigens, typically CD3 and a tumor antigen, making it a type of bispecific monoclonal antibody.
New!!: HER2/neu and Trifunctional antibody · See more »
Triple-negative breast cancer
Triple-negative breast cancer (sometimes abbreviated TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) and Her2/neu.
New!!: HER2/neu and Triple-negative breast cancer · See more »
Tucatinib
Tucatinib (ARRY-380) is an experimental small molecule inhibitor of HER2 in development for the treatment of cancer.
New!!: HER2/neu and Tucatinib · See more »
Tumor antigen vaccine
According to the National Cancer Institute, a tumor antigen vaccine is a "vaccine made of cancer cells, parts of cancer cells, or pure tumor antigens (substances isolated from tumor cells)".
New!!: HER2/neu and Tumor antigen vaccine · See more »
Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.
New!!: HER2/neu and Tyrosine kinase · See more »
Tyrosine-kinase inhibitor
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases.
New!!: HER2/neu and Tyrosine-kinase inhibitor · See more »
Ursula Wiedermann
Ursula Wiedermann is an Austrian medical scientist who has made significant contributions in the field of allergies and of cancer immunotherapy.
New!!: HER2/neu and Ursula Wiedermann · See more »
Uterine serous carcinoma
Uterine serous carcinoma (USC), also known as uterine papillary serous carcinoma (UPSC) and uterine serous adenocarcinoma, is an uncommon form of endometrial cancer that typically arises in postmenopausal women.
New!!: HER2/neu and Uterine serous carcinoma · See more »
Vadimezan
Vadimezan (also known as or ASA404 and DMXAA) is a tumor-vascular disrupting agent (tumor-VDA) that attacks the blood supply of a cancerous tumor to cause tumor regression.
New!!: HER2/neu and Vadimezan · See more »
ViroMed
ViroMed Co., Ltd. (VM BioPharma in the US) is a biotechnology company located in Seoul, Korea with US presence in Atlanta and the San Francisco Bay Area.
New!!: HER2/neu and ViroMed · See more »
Zinc finger transcription factor
Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a variety of transcription-factor effector-domains that exert their modulatory effect in the vicinity of any sequence to which the protein domain binds.
New!!: HER2/neu and Zinc finger transcription factor · See more »
Redirects here:
C-erb b-2, C-erbB-2, CD340, ERBB2, ERBB2 (gene), Erb B2, Erb-B2, Erb2, ErbB 2, ErbB-2, ErbB-2 receptor, ErbB2, Erbb-2 receptor, Genes, erbb-2, HER-2, HER-2/Neu, HER2, HER2 positive, HER2 receptor, HER2 receptor positive, HER2-positive breast cancer, HER2/neu gene, Her-2 neu, Her2, Her2/neu, Her2neu, Human epidermal growth factor receptor 2, Receptor, erbb-2.
References
[1] https://en.wikipedia.org/wiki/HER2/neu
