Communication

9 relations: Discovery and development of tubulin inhibitors, Eribulin, Halichondria, List of compounds with carbon numbers 50–100, Marine pharmacognosy, Okadaic acid, Sponge, Sponge isolates, Yoshito Kishi.

Discovery and development of tubulin inhibitors

Tubulin inhibitors are drugs that interfere directly with the tubulin system, which is in contrast to those drugs acting on DNA for cancer chemotherapy.

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Eribulin

Eribulin is an anticancer drug marketed by Eisai Co. under the trade name Halaven.

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Halichondria

Halichondria is a genus of marine demosponges belonging to the family Halichondriidae.

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List of compounds with carbon numbers 50–100

This is a partial list of molecules that contain 50 to 100 carbon atoms.

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Marine pharmacognosy

''Halichondria'' produces the eribulin ('''Halaven''') precursor halichondrin B For many years, traditional Western pharmacognosy focused on the investigation and identification of medically important plants and animals in the terrestrial environment, although many marine organisms were used in Traditional Chinese Medicine.

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Okadaic acid

Okadaic acid, C44H68O13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish.

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Sponge

Sponges, the members of the phylum Porifera (meaning "pore bearer"), are a basal Metazoa clade as sister of the Diploblasts.

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Sponge isolates

''Halichondria'' produces the eribulin ('''Halaven''') precursor halichondrin B Lacking an immune system, protective shell, or mobility, sponges have developed an ability to synthesize a variety of unusual compounds for survival.

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Yoshito Kishi

is the Morris Loeb Professor of Chemistry at Harvard University.

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Redirects here:

Halichondrin.

References

[1] https://en.wikipedia.org/wiki/Halichondrin_B

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