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134 relations: Adipokine, Adipose tissue macrophages, Allergy, Alloimmunity, Anne O'Garra, Anti inflammatory agents in breast milk, Apremilast, Asthma, Autoimmune lymphoproliferative syndrome, Biology of depression, Butyric acid, CARD9, Caspase 6, CCL16, CCL18, CCL2, CCL20, CD25 deficiency, CD4+ T cells and antitumor immunity, Chronic active EBV infection, Chronic fatigue syndrome, Chronic myelomonocytic leukemia, Cinobufagin, Clonal anergy, Cortisol, Cytokine, Development of analogs of thalidomide, DNA vaccination, Epigenetic therapy, Esculentin-2CHa, FGL2, Fiona Powrie, Galectin-1, Galectin-4, Hangover, Heligmosomoides polygyrus, Helminthic therapy, Herpesviridae, HMOX1, Human T-lymphotropic virus 1, Hypothalamic–pituitary–adrenal axis, IL-10, IL-10 family, IL1A, Immune tolerance, Immunoglobulin therapy, Immunologic activation, Immunotherapy, IMP321, Index of immunology articles, ..., Inflammation, Interleukin, Interleukin 10, Interleukin 10 receptor, alpha subunit, Interleukin 19, Interleukin 20, Interleukin 22, Interleukin 24, Interleukin 26, Interleukin 27, Interleukin 4, Interleukin 6, Intestinal mucosal barrier, JAK-STAT signaling pathway, Janus kinase 1, Kari Nadeau, Keratinocyte, Langerhans cell, Leishmania donovani, Lentiviral vector in gene therapy, Lipopolysaccharide, List of MeSH codes (D12.644), List of MeSH codes (D12.776), List of MeSH codes (D23), Lyme disease microbiology, Macrophage, Macrophage polarization, Macrophage-activating factor, Mesangial proliferative glomerulonephritis, Microbial drug delivery, Microglia, Morphine, Mosquito, Mouse model of colorectal and intestinal cancer, Multiple organ dysfunction syndrome, Myeloid-derived suppressor cell, Myokine, Nasal-associated lymphoid tissue, Natural killer cell, Neointimal hyperplasia, Nonylphenol, Outline of immunology, Pathophysiology of multiple sclerosis, Peripheral tolerance, Pharmacology of antidepressants, Pomalidomide, Post-transplant lymphoproliferative disorder, Proinflammatory cytokine, Psoriasis, Psoriatic arthritis, Regulatory B cells, Regulatory macrophages, Regulatory T cell, Rome process, Sarcoidosis, Sepsis, Serum amyloid A1, SOCS2, Specialized pro-resolving mediators, Subdural hematoma, Superantigen, Syndemic, T cell, T helper 3 cell, T helper cell, TCIRG1, Th 9 cell, TIGIT, TLR2, TLR4, Tolerogenic therapy, Transforming growth factor beta, Trichobilharzia regenti, Trichuris suis, Tumor microenvironment, Tumor-associated macrophage, Type II cytokine receptor, Tyrosine kinase 2, U937 (cell line), Unfolded protein response, University of London, Uveitis, Very early onset inflammatory bowel disease, Virokine. Expand index (84 more) »
Adipokine
The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling proteins) secreted by adipose tissue.
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Adipose tissue macrophages
Adipose tissue macrophages (abbr. ATMs) comprise tissue resident macrophages present in adipose tissue.
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Allergy
Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment.
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Alloimmunity
Alloimmunity (sometimes called isoimmunity) is an immune response to nonself antigens from members of the same species, which are called alloantigens or isoantigens.
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Anne O'Garra
Anne O'Garra FRS FMedSci (born 1954) is a British immunologist who has made important discoveries on the mechanism of action of Interleukin 10.
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Anti inflammatory agents in breast milk
The anti-inflammatory components in breast milk are those bioactive substances that confer or increase the anti-inflammatory response in a breastfeeding infant.
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Apremilast
Apremilast, brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis.
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Asthma
Asthma is a common long-term inflammatory disease of the airways of the lungs.
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Autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome,Straus SE, Jaffe ES, Puck JM et al.
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Biology of depression
Scientific studies have found that numerous brain areas show altered activity in patients suffering from depression, and this has encouraged advocates of various theories that seek to identify a biochemical origin of the disease, as opposed to theories that emphasize psychological or situational causes.
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Butyric acid
Butyric acid (from βούτῡρον, meaning "butter"), also known under the systematic name butanoic acid, abbreviated BTA, is a carboxylic acid with the structural formula CH3CH2CH2-COOH.
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CARD9
Caspase recruitment domain-containing protein 9 is an adaptor protein which in humans is encoded by the CARD9 gene.
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Caspase 6
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene.
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CCL16
Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1).
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CCL18
Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family.
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CCL2
For the ICAO airport code see Candle Lake Airpark, for the diradical compound see Dichlorocarbene. The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2.
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CCL20
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family.
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CD25 deficiency
CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene.
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CD4+ T cells and antitumor immunity
Understanding of the antitumor immunity role of CD4+ T cells has grown substantially since the late 1990s.
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Chronic active EBV infection
Chronic active EBV infection (CAEBV) or in its expanded form, chronic active Epstein-Barr virus infection is a very rare and often fatal complication of Epstein-Barr virus (EBV) infection that most often occurs in children or adolescents of Asian or South American lineage, although cases in Hispanics, Europeans and Africans have been reported.
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Chronic fatigue syndrome
Chronic fatigue syndrome (CFS), also referred to as myalgic encephalomyelitis (ME), is a medical condition characterized by long-term fatigue and other symptoms that limit a person's ability to carry out ordinary daily activities.
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Chronic myelomonocytic leukemia
Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming cells of the bone marrow.
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Cinobufagin
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans.
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Clonal anergy
Anergy is a term in immunobiology that describes a lack of reaction by the body's defense mechanisms to foreign substances, and consists of a direct induction of peripheral lymphocyte tolerance.
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Cortisol
Cortisol is a steroid hormone, in the glucocorticoid class of hormones.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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Development of analogs of thalidomide
The development of analogs of thalidomide was precipitated by the discovery of the anti-angiogenic and anti-inflammatory properties of the drug yielding a new way of fighting cancer as well as some inflammatory diseases after it had been banned in 1961.
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DNA vaccination
DNA vaccination is a technique for protecting against disease by injection with genetically engineered DNA so cells directly produce an antigen, producing a protective immunological response.
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Epigenetic therapy
Epigenetic therapy is the use of drugs or other epigenome-influencing techniques to treat medical conditions.
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Esculentin-2CHa
Esculentin-2CHa (from Latin ēsculentus (“edible; nutritious; full of food”)) is an antimicrobial peptide located outside the epithelial cell’s membrane of the skin of many species of amphibians, such as Rana chiricahuensis.
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FGL2
Fibrinogen-like protein 2, also known as FGL2, is a protein which in humans is encoded by the FGL2 gene.
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Fiona Powrie
Fiona Magaret Powrie (born 1963) FRS FMedSci is currently the head of the Kennedy Institute of Rheumatology at the University of Oxford.
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Galectin-1
Galectin-1 is a protein that in humans is encoded by the LGALS1 gene.
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Galectin-4
Galectin-4 is a protein that in humans is encoded by the LGALS4 gene.
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Hangover
A hangover is the experience of various unpleasant physiological and psychological effects following the consumption of alcohol, such as wine, beer and distilled spirits.
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Heligmosomoides polygyrus
Heligmosomoides polygyrus, previously named Nematospiroides dubius, is a naturally occurring intestinal roundworm of rodents.
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Helminthic therapy
Helminthic therapy, an experimental type of immunotherapy, is the treatment of autoimmune diseases and immune disorders by means of deliberate infestation with a helminth or with the ova of a helminth.
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Herpesviridae
Herpesviridae is a large family of DNA viruses that cause diseases in animals, including humans.
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HMOX1
HMOX1 (heme oxygenase (decycling) 1) is a human gene that encodes for the enzyme heme oxygenase 1.
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Human T-lymphotropic virus 1
Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases.
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Hypothalamic–pituitary–adrenal axis
The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus, the pituitary gland (a pea-shaped structure located below the thalamus), and the adrenal (also called "suprarenal") glands (small, conical organs on top of the kidneys).
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IL-10
Il-10 may refer to.
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IL-10 family
The IL10 family is a family of interleukins.
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IL1A
Interleukin 1 alpha (IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene.
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Immune tolerance
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in given organism.It is induced by prior exposure to that specific antigen.
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Immunoglobulin therapy
Immunoglobulin therapy, also known as normal human immunoglobulin (NHIG), is the use of a mixture of antibodies (immunoglobulins) to treat a number of health conditions.
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Immunologic activation
In immunology, activation is the transition of leucocytes and other cell types involved in the immune system.
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Immunotherapy
Immunotherapy is the "treatment of disease by inducing, enhancing, or suppressing an immune response".
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IMP321
IMP321 is a large molecule cancer drug being developed by the clinical stage biotechnology company Prima BioMed (Nasdaq: IMMP).
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Index of immunology articles
Immunology is the study of the immune system during health and disease.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Interleukin
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that were first seen to be expressed by white blood cells (leukocytes).
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Interleukin 10
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine.
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Interleukin 10 receptor, alpha subunit
Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor.
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Interleukin 19
Interleukin 19 (IL19) is a protein that in humans is encoded by the IL19 gene.
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Interleukin 20
Interleukin 20 (IL20) is a protein that in humans is encoded by the IL20 gene.
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Interleukin 22
Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene.
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Interleukin 24
Interleukin 24 (IL-24) is a protein that in humans is encoded by the IL24 gene.
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Interleukin 26
Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene.
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Interleukin 27
Interleukin 27 (IL-27) is a member of the IL-12 cytokine family.
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Interleukin 4
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells.
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Interleukin 6
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.
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Intestinal mucosal barrier
The intestinal mucosal barrier, also referred to as intestinal barrier, refers to the property of the intestinal mucosa that ensures adequate containment of undesirable luminal contents within the intestine while preserving the ability to absorb nutrients.
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JAK-STAT signaling pathway
The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation.
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Janus kinase 1
JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines.
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Kari Nadeau
Kari Nadeau is a physician-scientist focused on allergy and asthma treatment at Stanford University School of Medicine.
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Keratinocyte
A keratinocyte is the predominant cell type in the epidermis, the outermost layer of the skin, constituting 90% of the cells found there.
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Langerhans cell
Langerhans cells are dendritic cells (antigen-presenting immune cells) of the skin, and contain organelles called Birbeck granules.
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Leishmania donovani
Leishmania donovani is a species of intracellular parasites belonging to the genus Leishmania, a group of haemoflagellate kinetoplastids that cause the disease leishmaniasis.
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Lentiviral vector in gene therapy
Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentivirus.
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Lipopolysaccharide
Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.
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List of MeSH codes (D12.644)
This is part of the list of the "D" codes for MeSH.
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List of MeSH codes (D12.776)
This is part of the list of the "D" codes for MeSH.
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List of MeSH codes (D23)
This is the fourth part of the list of the "D" codes for MeSH.
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Lyme disease microbiology
Lyme disease, or borreliosis, is caused by spirochetal bacteria from the genus Borrelia, which has 52 known species.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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Macrophage polarization
Macrophage polarization is a process by which macrophage expresses different functional programs in response to microenvironmental signals.
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Macrophage-activating factor
A macrophage-activating factor (MAF) is a lymphokine or other receptor based signal that primes macrophages towards cytotoxicity to tumors, cytokine secretion, or clearance of pathogens.
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Mesangial proliferative glomerulonephritis
Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the mesangium.
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Microbial drug delivery
Microbial drug delivery is an emerging form of drug administration characterized by the use of commensal microbes that have been genetically modified to produce medications for chronic diseases in humans.
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Microglia
Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord.
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Morphine
Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals.
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Mosquito
Mosquitoes are small, midge-like flies that constitute the family Culicidae.
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Mouse model of colorectal and intestinal cancer
Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated, fed a modified diet, or challenged with chemicals to develop malignancies in the gastrointestinal tract.
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Multiple organ dysfunction syndrome
Multiple organ dysfunction syndrome (MODS), also known as multiple organ failure (MOF), total organ failure (TOF) or multisystem organ failure (MSOF), is altered organ function in an acutely ill patient requiring medical intervention to achieve homeostasis.
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Myeloid-derived suppressor cell
MDSC (myeloid-derived suppressor cells) are a heterogenous group of immune cells from the myeloid lineage (a family of cells that originate from bone marrow stem cells).
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Myokine
A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions.
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Nasal-associated lymphoid tissue
Nasal- or nasopharynx- associated lymphoid tissue (NALT) represents immune system of nasal mucosa and is a part of mucosa-associated lymphoid tissue (MALT) in mammals.
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Natural killer cell
Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system.
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Neointimal hyperplasia
Neointimal hyperplasia refers to proliferation and migration of vascular smooth muscle cells primarily in the tunica intima, resulting in the thickening of arterial walls and decreased arterial lumen space.
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Nonylphenol
Nonylphenols, from the Latin nōnus (number 9) and phenol, are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail.
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Outline of immunology
The following outline is provided as an overview of and topical guide to immunology: Immunology is the study of all aspects of the immune system in all organisms.
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Pathophysiology of multiple sclerosis
Multiple sclerosis is an inflammatory demyelinating disease of the CNS in which activated immune cells invade the central nervous system and cause inflammation, neurodegeneration, and tissue damage.
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Peripheral tolerance
Peripheral tolerance is the second branch of immunological tolerance, after central tolerance.
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Pharmacology of antidepressants
The pharmacology of antidepressants is not entirely clear.
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Pomalidomide
Pomalidomide (INN; marketed as Pomalyst in the U.S. and Imnovid in the EU and Russia) is a derivative of thalidomide marketed by Celgene.
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Post-transplant lymphoproliferative disorder
Post-transplant lymphoproliferative disorder (PTLD) is the name given to a B-cell proliferation due to therapeutic immunosuppression after organ transplantation.
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Proinflammatory cytokine
A proinflammatory cytokine or more simply an inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation.
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Psoriasis
Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin.
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Psoriatic arthritis
Psoriatic arthritis is a long-term inflammatory arthritis that occurs in people affected by the autoimmune disease psoriasis.
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Regulatory B cells
Regulatory B cells (Bregs) represent a small population of B cells which participates in immunomodulations and in suppression of immune responses.
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Regulatory macrophages
Regulatory macrophages (Mregs) represent one of basic macrophage population according fundamental macrophage function.
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Regulatory T cell
The regulatory T cells (Tregs), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease.
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Rome process
The Rome process and Rome criteria are an international effort to create scientific data to help in the diagnosis and treatment of functional gastrointestinal disorders, such as irritable bowel syndrome, functional dyspepsia and rumination syndrome.
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Sarcoidosis
Sarcoidosis is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomas.
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Sepsis
Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.
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Serum amyloid A1
Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene.
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SOCS2
Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.
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Specialized pro-resolving mediators
Specialized pro-resolving mediators (SPM, also termed specialized proresolving mediators) are a large and growing class of cell signaling molecules formed in cells by the metabolism of polyunsaturated fatty acids (PUFA) by one or a combination of lipoxygenase, cyclooxygenase, and cytochrome P450 monooxygenase enzymes.
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Subdural hematoma
A subdural hematoma (SDH), is a type of hematoma, usually associated with traumatic brain injury.
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Superantigen
Superantigens (SAgs) are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release.
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Syndemic
A syndemic or synergistic epidemic is the aggregation of two or more concurrent or sequential epidemics or disease clusters in a population with biological interactions, which exacerbate the prognosis and burden of disease.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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T helper 3 cell
T helper 3 cells (Th3) are white blood cells of the lymphocyte type.
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T helper cell
The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.
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TCIRG1
V-type proton ATPase 116 kDa subunit a isoform 3 is an enzyme that in humans is encoded by the TCIRG1 gene.
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Th 9 cell
In cell biology, TH9 cells (T helper type 9 cells, CD4+IL-9+IL-13−IFNγ −) are a sub-population of CD4+T cells that produce interleukin-9 (IL-9).
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TIGIT
TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is an immune receptor present on some T cells and Natural Killer Cells(NK).
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TLR2
Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene.
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TLR4
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene.
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Tolerogenic therapy
Tolerogenic therapy aims to induce immune tolerance where there is pathological or undesirable activation of the normal immune response.
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Transforming growth factor beta
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages.
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Trichobilharzia regenti
Trichobilharzia regenti is a neuropathogenic parasitic flatworm of birds which also causes cercarial dermatitis in humans.
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Trichuris suis
Trichuris suis is a whipworm; the variations in thickness of the anterior and posterior segments give the parasite the characteristic “whip-like” appearance.
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Tumor microenvironment
The tumor microenvironment (TME) is the cellular environment in which the tumor exists, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules and the extracellular matrix (ECM).
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Tumor-associated macrophage
Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors.
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Type II cytokine receptor
Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines.
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Tyrosine kinase 2
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.
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U937 (cell line)
U937 cells are a model cell line used in biomedical research.
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Unfolded protein response
The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress.
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University of London
The University of London (abbreviated as Lond. or more rarely Londin. in post-nominals) is a collegiate and a federal research university located in London, England.
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Uveitis
Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the outer fibrous layer composed of the sclera and cornea.
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Very early onset inflammatory bowel disease
Very early onset inflammatory bowel disease (VEOIBD) is a type of IBD specific to patients younger than 6 years of age.
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Virokine
Virokines are proteins encoded by some large DNA viruses that are secreted by the host cell and serve to evade the host's immune system.
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Redirects here:
IL10 (gene), Interleukin-10, Pegilodecakin.
References
[1] https://en.wikipedia.org/wiki/Interleukin_10
