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71 relations: Adenocarcinoma, Adenocarcinoma of the lung, Antineoplastic resistance, Atypical adenomatous hyperplasia, Autoimmune lymphoproliferative syndrome, Beta-catenin, Biomarker (medicine), Bladder cancer, Blebbishield emergency program, BxPC-3, C-Raf, C12orf66, Cancer biomarker, Carcinosarcoma, Cardiofaciocutaneous syndrome, Cetuximab, Chromosome 12, Chronic myelomonocytic leukemia, Colorectal cancer, Competing endogenous RNA (CeRNA), Congenital melanocytic nevus, COSMIC cancer database, Crizotinib, Endometrial cancer, Ferdinand I of Naples, Follicular thyroid cancer, GATA1, Gene duplication, Glioma 261, Halozyme, Inc., HCT116 cells, HRAS, K-Ras(G12C) inhibitor 6, Kras, Laboratory Syrian hamster, Leukotriene B4 receptor 2, List of genetic disorders, List of grape varieties, List of OMIM disorder codes, MAPK/ERK pathway, MEK inhibitor, Molecular diagnostics, Molecular pathological epidemiology, MTOR inhibitors, Multiple myeloma, Neuroblastoma RAS viral oncogene homolog, Non-small-cell lung carcinoma, Noonan syndrome, Ovarian cancer, Pancreatic cancer, ..., Panitumumab, Pharmacogenetics, Pharmacogenomics, PIK3CG, Plasma cell dyscrasia, POLD1, PRKCI, PTK2, RALGDS, Ras subfamily, Ras superfamily, RAS-associated autoimmune leukoproliferative disorder, RASSF2, RNA-targeting small molecule drugs, ROCK1, Selumetinib, Son of Sevenless, SOS1, Synthetic lethality, Tet methylcytosine dioxygenase 1, Trk receptor. Expand index (21 more) »
Adenocarcinoma
Adenocarcinoma (plural adenocarcinomas or adenocarcinomata) is a type of cancerous tumor that can occur in several parts of the body.
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Adenocarcinoma of the lung
Adenocarcinoma of the lung (also known as pulmonary adenocarcinoma) is the most common type of lung cancer, and is characterized by distinct cellular and molecular features including gland and/or duct formation and/or production of significant amounts of mucus.
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Antineoplastic resistance
Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the multiple drug resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies.
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Atypical adenomatous hyperplasia
Atypical adenomatous hyperplasia is a subtype of pneumocytic hyperplasia in the lung.
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Autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome,Straus SE, Jaffe ES, Puck JM et al.
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Beta-catenin
Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene.
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Biomarker (medicine)
In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state.
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Bladder cancer
Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder.
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Blebbishield emergency program
Blebbishield emergency program is a process which acts as a last line of defense for cancer stem cells after induction of apoptosis where the apoptotic blebs fuse to shield the cells/nucleus from the destructive force of apoptosis by forming blebbishields.
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BxPC-3
BxPC-3 (BxPC3) is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof.
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C-Raf
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the RAF1 gene.
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C12orf66
C12orf66 is a protein that in humans is encoded by the C12orf66 gene.
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Cancer biomarker
A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body.
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Carcinosarcoma
Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer).
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Cardiofaciocutaneous syndrome
Cardiofaciocutaneous (CFC) syndrome is an extremely rare and serious genetic disorder.
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Cetuximab
Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor used for the treatment of metastatic colorectal cancer, metastatic non-small cell lung cancer and head and neck cancer.
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Chromosome 12
Chromosome 12 is one of the 23 pairs of chromosomes in humans.
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Chronic myelomonocytic leukemia
Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming cells of the bone marrow.
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Colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).
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Competing endogenous RNA (CeRNA)
In molecular biology, competing endogenous RNAs (abbreviated ceRNAs) regulate other RNA transcripts by competing for shared microRNAs (miRNAs).
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Congenital melanocytic nevus
The congenital melanocytic nevus is a type of melanocytic nevus (or mole) found in infants at birth.
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COSMIC cancer database
COSMIC is an online database of somatically acquired mutations found in human cancer.
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Crizotinib
Crizotinib (trade name Xalkori, Pfizer) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.
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Endometrial cancer
Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).
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Ferdinand I of Naples
Ferdinand I (2 June 1423 – 25 January 1494), also called Ferrante, was the King of Naples from 1458 to 1494.
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Follicular thyroid cancer
Follicular thyroid cancer or follicular thyroid carcinoma accounts for 15% of thyroid cancer and occurs more commonly in women over 50 years of age.
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GATA1
GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors.
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Gene duplication
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.
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Glioma 261
Glioma 261 (GL261) is a frequently used murine glioma model.
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Halozyme, Inc.
Halozyme Therapeutics is a U.S. biotechnology company that develops novel oncology therapies designed to target the tumor microenvironment and licenses a novel drug delivery technology through corporate partnerships.
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HCT116 cells
HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings.
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HRAS
GTPase HRas also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene.
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K-Ras(G12C) inhibitor 6
K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP.
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Kras
Kras may refer to.
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Laboratory Syrian hamster
Syrian hamsters (Mesocricetus auratus) are one of several rodents used in animal testing.
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Leukotriene B4 receptor 2
Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2, is a Integral membrane protein that is encoded by the LTB4R2 gene in humans and the Ltbr2 gene in mice.
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List of genetic disorders
The following is a list of genetic disorders and if known, type of mutation and the chromosome involved.
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List of grape varieties
This list of grape varieties includes cultivated grapes, whether used for wine, or eating as a table grape, fresh or dried (raisin, currant, sultana).
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List of OMIM disorder codes
This is a list of disorder codes in the Online Mendelian Inheritance in Man (OMIM) database.
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MAPK/ERK pathway
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
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MEK inhibitor
A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2.
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Molecular diagnostics
Molecular diagnostics is a collection of techniques used to analyse biological markers in the genome and proteomethe individual's genetic code and how their cells express their genes as proteinsby applying molecular biology to medical testing.
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Molecular pathological epidemiology
Molecular pathological epidemiology (MPE, also molecular pathologic epidemiology) is a discipline combining epidemiology and pathology.
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MTOR inhibitors
mTOR inhibitors are a class of drugs that inhibit the mechanistic target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs).
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Multiple myeloma
Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.
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Neuroblastoma RAS viral oncogene homolog
NRAS is an enzyme that in humans is encoded by the NRAS gene.
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Non-small-cell lung carcinoma
Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC).
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Noonan syndrome
Noonan syndrome (NS) is a relatively common autosomal dominant congenital disorder and is named after Jacqueline Noonan, a pediatric cardiologist.
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Ovarian cancer
Ovarian cancer is a cancer that forms in or on an ovary.
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Pancreatic cancer
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.
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Panitumumab
Panitumumab (INN), formerly ABX-EGF, is a fully human monoclonal antibody specific to the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans).
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Pharmacogenetics
Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.
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Pharmacogenomics
Pharmacogenomics is the study of the role of the genome in drug response.
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PIK3CG
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.
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Plasma cell dyscrasia
Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof.
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POLD1
The gene polymerase delta 1 (POLD1) encodes the large, POLD1/p125, catalytic subunit of the DNA polymerase delta (Polδ) complex.
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PRKCI
Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.
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PTK2
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.
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RALGDS
Ral guanine nucleotide dissociation stimulator is a protein that in humans is encoded by the RALGDS gene.
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Ras subfamily
Ras is a family of related proteins which is expressed in all animal cell lineages and organs.
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Ras superfamily
The Ras superfamily is a protein superfamily of small GTPases.
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RAS-associated autoimmune leukoproliferative disorder
RAS-associated autoimmune leukoproliferative disorder (RALD) is a rare genetic disorder of the immune system.
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RASSF2
Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.
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RNA-targeting small molecule drugs
RNA-targeting small molecules represent a class of small molecules, organic compounds with traditional drug properties (e.g., Lipinski's rule of five) that can bind to RNA secondary or tertiary structures and alter translation patterns, localization, and degradation.
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ROCK1
ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1.
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Selumetinib
Selumetinib (AZD6244) is a drug that was discovered by Array BioPharma and was licensed to AstraZeneca.
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Son of Sevenless
In cell signalling, Son of Sevenless (SOS) refers to a set of genes encoding guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases.
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SOS1
Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.
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Synthetic lethality
Synthetic lethality arises when a combination of deficiencies in the expression of two or more genes leads to cell death, whereas a deficiency in only one of these genes does not.
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Tet methylcytosine dioxygenase 1
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes that in humans is encoded by the TET1 gene.
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Trk receptor
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.
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Redirects here:
C-K-RAS, K-Ras, KRAS (gene), KRAS gene, KRAS2, KRas, RASK2, Rask2, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.
References
[1] https://en.wikipedia.org/wiki/KRAS
