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66 relations: Alcohol (drug), Allopregnanolone, AMPA receptor, AP5, Apical dendrite, Barbiturate, Beta-Methylamino-L-alanine, Biology of bipolar disorder, Channel blocker, CNQX, Cyclothiazide, Dasolampanel, David Lodge (neuroscientist), Diazoxide, Domoic acid, Enflurane, Evans Blue (dye), Excitatory synapse, Glutamate (neurotransmitter), Glutamate receptor, Glutamate transporter, GRIA2, GRIA3, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, Halothane, Ibotenic acid, Index of biochemistry articles, Ionotropic glutamate receptor, Kainic acid, Kaitocephalin, Kar, Lacosamide, Licostinel, Ligand-gated ion channel, List of MeSH codes (D12.776.543), Long-term depression, LY-404,039, Molecular neuroscience, Mossy fiber (hippocampus), NBQX, Neurotransmitter, Nitrous oxide, NMDA receptor, NS102, Omigapil, ..., Philanthotoxin, Pregnenolone sulfate, Proline, Quinoxalinedione, Quisqualamine, Quisqualic acid, Receptor (biochemistry), Riluzole, Selurampanel, SGK1, Silent synapse, Tezampanel, Theanine, UBP-302, 5-Fluorowillardiine, 5-Iodowillardiine. Expand index (16 more) »
Alcohol (drug)
Alcohol, also known by its chemical name ethanol, is a psychoactive substance or drug that is the active ingredient in alcoholic beverages such as beer, wine, and distilled spirits (hard liquor).
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Allopregnanolone
Allopregnanolone, also known as 5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), as well as brexanolone, is an endogenous inhibitory pregnane neurosteroid.
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AMPA receptor
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS).
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AP5
AP5 or APV ((2R)-amino-5-phosphonovaleric acid; (2R)-amino-5-phosphonopentanoate) is a selective NMDA receptor antagonist that competitively inhibits the ligand (glutamate) binding site of NMDA receptors.
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Apical dendrite
An apical dendrite is a dendrite that emerges from the apex of a pyramidal cell.
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Barbiturate
A barbiturate is a drug that acts as a central nervous system depressant, and can therefore produce a wide spectrum of effects, from mild sedation to death.
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Beta-Methylamino-L-alanine
β-Methylamino-L-alanine, or BMAA, is a non-proteinogenic amino acid produced by cyanobacteria.
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Biology of bipolar disorder
Bipolar disorder is an affective disorder characterized by periods of elevated and depressed mood.
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Channel blocker
A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell.
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CNQX
CNQX or cyanquixaline (6-cyano-7-nitroquinoxaline-2,3-dione) is a competitive AMPA/kainate receptor antagonist.
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Cyclothiazide
Cyclothiazide (Anhydron, Acquirel, Doburil, Fluidil, Renazide, Tensodiural, Valmiran) is a benzothiadiazide (thiazide) diuretic and antihypertensive that was originally introduced in the United States in 1963 by Eli Lilly and was subsequently also marketed in Europe and Japan.
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Dasolampanel
Dasolampanel (INN, USAN, code name NGX-426) is an orally bioavailable analog of tezampanel and thereby competitive antagonist of the AMPA and kainate receptors which was under development by Raptor Pharmaceuticals/Torrey Pines Therapeutics for the treatment of chronic pain conditions including neuropathic pain and migraine.
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David Lodge (neuroscientist)
David Lodge FRS is a Research Fellow in the Department of Physiology and Pharmacology at the University of Bristol.
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Diazoxide
Diazoxide (INN; brand name Proglycem) is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions.
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Domoic acid
Domoic acid (DA) is a kainic acid analog neurotoxin that causes amnesic shellfish poisoning (ASP).
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Enflurane
Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether.
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Evans Blue (dye)
T-1824 or Evans blue, often incorrectly rendered as Evan's blue, is an azo dye that has a very high affinity for serum albumin.
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Excitatory synapse
An excitatory synapse is a synapse in which an action potential in a presynaptic neuron increases the probability of an action potential occurring in a postsynaptic cell.
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Glutamate (neurotransmitter)
In neuroscience, glutamate refers to the anion of glutamic acid in its role as a neurotransmitter: a chemical that nerve cells use to send signals to other cells.
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Glutamate receptor
Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.
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Glutamate transporter
Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane.
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GRIA2
Glutamate ionotropic receptor AMPA type subunit 2 (ionotropic glutamate receptor 2) is a protein that in humans is encoded by the GRIA2 (or GLUR2) gene.
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GRIA3
Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene.
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GRID2
Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ2, is a protein that in humans is encoded by the GRID2 gene.
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GRIK1
Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene.
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GRIK2
Glutamate ionotropic receptor kainate type subunit 2 (ionotropic glutamate receptor 6) is a protein that in humans is encoded by the GRIK2 (or GLUR6) gene.
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GRIK3
Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.
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GRIK4
GRIK4 (glutamate receptor, ionotropic, kainate 4) is a kainate receptor subtype belonging to the family of ligand-gated ion channels which is encoded by the gene.
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GRIK5
Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.
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Halothane
Halothane, sold under the brandname Fluothane among others, is a general anesthetic.
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Ibotenic acid
Ibotenic acid or (S)-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid, also referred to as ibotenate, is a chemical compound and psychoactive drug which occurs naturally in Amanita muscaria and related species of mushrooms typically found in the temperate and boreal regions of the northern hemisphere.
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Index of biochemistry articles
Biochemistry is the study of the chemical processes in living organisms.
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Ionotropic glutamate receptor
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.
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Kainic acid
Kainic acid, or kainate, is an acid that naturally occurs in some seaweed.
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Kaitocephalin
Kaitocephalin is a non-selective ionotropic glutamate receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate.
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Kar
Kar or KAR may refer to: __notoc__.
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Lacosamide
Lacosamide (INN, formerly known as erlosamide, harkeroside, SPM 927, or ADD 234037), is a medication for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.
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Licostinel
Licostinel (INN) (code name ACEA-1021) is a competitive, silent antagonist of the glycine site of the NMDA receptor (Kb.
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Ligand-gated ion channel
Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
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List of MeSH codes (D12.776.543)
This is a sub-part (membrane proteins only) of List of MeSH codes (D12.776), itself a part of the list of the "D" codes for MeSH.
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Long-term depression
Long-term depression (LTD), in neurophysiology, is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus.
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LY-404,039
LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3.
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Molecular neuroscience
Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals.
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Mossy fiber (hippocampus)
In the hippocampus, the mossy fiber pathway consists of unmyelinated axons projecting from granule cells in the dentate gyrus that terminate on modulatory hilar mossy cells and in Cornu Ammonis area 3 (CA3), a region involved in encoding short-term memory.
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NBQX
NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoquinoxaline) is an AMPA receptor antagonist.
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Neurotransmitter
Neurotransmitters are endogenous chemicals that enable neurotransmission.
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Nitrous oxide
Nitrous oxide, commonly known as laughing gas or nitrous, is a chemical compound, an oxide of nitrogen with the formula.
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NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
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NS102
NS102 is a kainate receptor antagonist.
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Omigapil
Omigapil (TCH346 or CGP3466) is a drug that was developed by Novartis and tested in clinical trials for its ability to help treat Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).
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Philanthotoxin
Philanthotoxins are components of the venom of the Egyptian solitary wasp Philanthus triangulum, commonly known as the European beewolf.
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Pregnenolone sulfate
Pregnenolone sulfate (PS, PREGS) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone.
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Proline
Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins.
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Quinoxalinedione
Quinoxalinedione is an organic compound with the formula C6H4(NH)2(CO)2.
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Quisqualamine
Quisqualamine is the α-decarboxylated analogue of quisqualic acid, as well as a relative of the neurotransmitters glutamate and γ-aminobutyric acid (GABA).
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Quisqualic acid
Quisqualic acid is an agonist of the AMPA, kainate, and group I metabotropic glutamate receptors.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Riluzole
Riluzole (marketed as Rilutek and Teglutik) is a drug used to treat amyotrophic lateral sclerosis.
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Selurampanel
Selurampanel (INN, code name BGG492) is a drug closely related to the quinoxalinedione series which acts as a competitive antagonist of the AMPA and kainate receptors and, as of 2015, is being investigated in clinical trials by Novartis for the treatment of epilepsy.
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SGK1
Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.
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Silent synapse
In neuroscience, a silent synapse is an excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type glutamate receptors but no AMPA-type glutamate receptors.
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Tezampanel
Tezampanel (INN, USAN) (code names LY-293,558, NGX-424) is a drug originally developed by Eli Lilly which acts as a competitive antagonist of the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainate receptor.
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Theanine
Theanine, also known as L-γ-glutamylethylamide and N5-ethyl-L-glutamine, is an amino acid analogue of the proteinogenic amino acids L-glutamate and L-glutamine and is found primarily in particular plant and fungal species.
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UBP-302
UBP-302 is a highly selective kainate receptor antagonist used in the study of many neurological processes.
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5-Fluorowillardiine
5-Fluorowillardiine is a selective agonist for the AMPA receptor, with only limited effects at the kainate receptor.
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5-Iodowillardiine
5-Iodowillardiine is a selective agonist for the kainate receptor, with only limited effects at the AMPA receptor.
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Kainate receptors, Kainic acid receptor, Kainic acid receptors, Receptors, kainic acid.
References
[1] https://en.wikipedia.org/wiki/Kainate_receptor
