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NCI-60

Index NCI-60

The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity. [1]

37 relations: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A, Ambazone, Apoptosis, Apparicine, Arglabin, Aurantiamine, CD47, Cell culture, Cerevisterol, Chromosome conformation capture, Coibamide A, Copper in health, Cucurbitacin E, Discovery and development of tubulin inhibitors, Dogger Bank itch, Duocarmycin, ENOX2, Epoxyeicosatrienoic acid, Halichondrin B, K562 cells, Leukotriene B4 receptor 2, List of contaminated cell lines, List of MeSH codes (C04), M14, Mensacarcin, National Cancer Institute, NCI-60, Neothramycin, Onnamide A, Pomiferin, PTEN (gene), Rebeccamycin, Salinosporamide A, Signet ring cell carcinoma, SK-OV-3, TCF7L2, 20-Hydroxyeicosatetraenoic acid.

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A is a type II membrane protein and an enzyme – particularly a glycosyltransferase – that, in addition to the related isoenzyme B (MGAT4B), takes part in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans in Golgi apparatus.

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Ambazone

Ambazone is an oral antiseptic.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Apparicine

Apparicine is a monoterpenoid indole alkaloid.

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Arglabin

Arglabin is a sesquiterpene lactone belonging to the guaianolide subclass bearing a 5,7,5-tricyclic ring system which is known to inhibit farnesyl transferase.

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Aurantiamine

(−)-Aurantiamine is a blue fluorescence metabolite produced by the fungus Penicillium aurantiogriseum, the most common fungi found in cereals.

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CD47

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.

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Cell culture

Cell culture is the process by which cells are grown under controlled conditions, generally outside their natural environment.

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Cerevisterol

Cerevisterol (5α-ergosta-7,22-diene-3β,5,6β-triol) is a sterol.

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Chromosome conformation capture

Chromosome conformation capture techniques (often abbreviated to 3C technologies or 3C-based methods) are a set of molecular biology methods used to analyze the spatial organization of chromatin in a cell.

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Coibamide A

Coibamide A is an antiproliferative depsipeptide which was isolated from a marine Leptolyngbya cyanobacterium.

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Copper in health

Copper is an essential trace element that is vital to the health of all living things (humans, plants, animals, and microorganisms).

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Cucurbitacin E

Cucurbitacin E is a biochemical compound from the family of cucurbitacins.

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Discovery and development of tubulin inhibitors

Tubulin inhibitors are drugs that interfere directly with the tubulin system, which is in contrast to those drugs acting on DNA for cancer chemotherapy.

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Dogger Bank itch

Dogger Bank itch is a cutaneous condition characterized by a long-lasting dermatitis caused by exposure to the sea chervil, Alcyonidium diaphanum, a bryozoan.

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Duocarmycin

The duocarmycins are members of a series of related natural products first isolated from Streptomyces bacteria in 1988.

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ENOX2

ENOX2 is a gene located on the long arm of the X chromosome in humans.

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Epoxyeicosatrienoic acid

The epoxyeicosatrienoic acids or EETs are signaling molecules formed within various types of cells by the metabolism of arachidonic acid by a specific subset of Cytochrome P450 enzymes termed cytochrome P450 epoxygenases.

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Halichondrin B

Halichondrin B is a large naturally occurring polyether macrolide originally isolated from the marine sponge Halichondria okadai by Hirata and Uemura in 1986.

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K562 cells

K562 cells were the first human immortalised myelogenous leukemia cell line to be established.

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Leukotriene B4 receptor 2

Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2, is a Integral membrane protein that is encoded by the LTB4R2 gene in humans and the Ltbr2 gene in mice.

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List of contaminated cell lines

Many cell lines that are widely used for biomedical research have been contaminated and overgrown by other, more aggressive cells.

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List of MeSH codes (C04)

The following is a list of the "C" codes for MeSH.

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M14

M14, M-14, or M.14 may refer to.

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Mensacarcin

Mensacarcin is a highly oxygenated polyketide first isolated from soil-dwelling Streptomyces bottropensis bacteria.

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National Cancer Institute

The National Cancer Institute (NCI) is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services.

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NCI-60

The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity.

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Neothramycin

Neothramycin A and B Neothramycin A and B are stereoisomeric antibiotics with anticancer activity.

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Onnamide A

Onnamide A is a bioactive natural product found in Theonella swinhoei, a species of marine sponge whose genus is well known for yielding a diverse set of biologically active natural products, including the swinholides and polytheonamides.

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Pomiferin

Pomiferin is a prenylated isoflavone that can be found along with osajin in the fruits and female flowers of the osage orange tree (Maclura pomifera).

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PTEN (gene)

Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene.

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Rebeccamycin

Rebeccamycin (NSC 655649) is a weak topoisomerase I inhibitor isolated from Nocardia sp. It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases.

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Salinosporamide A

Salinosporamide A (Marizomib) is a potent proteasome inhibitor being studied as a potential anticancer agent.

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Signet ring cell carcinoma

Signet ring cell carcinoma (SRCC) is a rare form of highly malignant adenocarcinoma that produces mucin.

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SK-OV-3

SK-OV-3 (also known as SKOV-3; SK.OV.3; SKOV3; Skov3 and SKO3) is an ovarian cancer cell line derived from the ascites of a 64 year-old Caucasian female with an ovarian serous cystadenocarcinoma.

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TCF7L2

Transcription factor 7-like 2 (T-cell specific, HMG-box) also known as TCF7L2 or TCF4 is a protein acting as a transcription factor that in humans, is encoded by the TCF7L2 gene.

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20-Hydroxyeicosatetraenoic acid

20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pathway remodeling.

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Redirects here:

60 cell line assay, 60-cell-line panel, 786-O, ACHN, CCRF-CEM, Caki-1, HCC-2998, HCC2998, HL-60(TB), KM12, LOX-IMVI, Leukemia p388, List of NCI-60 Cell Lines, M14 (cell line), MCF-7/ADR-RES, MDA-MB-435, MDA-N, MOLT-4, MOLT-4 cells, NCI 60, NCI-60 panel, NCI-H226, NCI-H23, NCI-H460, NCI/ADR-RES, NCI60, OVCAR-3, OVCAR-8, P388, RPMI-7951, SF-268, SF-539, SK-MEL-28, SK-MEL-5, SK-Mel-28, SK-Mel-5, SNB-19, SW-620, U251.

References

[1] https://en.wikipedia.org/wiki/NCI-60

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