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20 relations: APETx1, Brugada syndrome, Cation channel superfamily, DSP-2230, Evenamide, Funapide, GTx1-15, HEY2, Index of biophysics articles, List of investigational analgesics, List of investigational antipsychotics, Melittin, Nav1.5, Nav1.7, Nav1.9, Orphenadrine, PF-05089771, S100A10, Sodium channel, Sodium channel blocker.
APETx1
APETx1 is a peptide toxin from the venom of the sea anemone Anthopleura elegantissima.
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Brugada syndrome
Brugada syndrome (BrS) is a genetic condition that results in abnormal electrical activity within the heart, increasing the risk of sudden cardiac death.
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Cation channel superfamily
The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels.
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DSP-2230
DSP-2230 is a selective small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker which is under development by Dainippon Sumitomo Pharma for the treatment of neuropathic pain.
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Evenamide
Evenamide (developmental code names NW-3509, NW-3509A) is a selective voltage-gated sodium channel blocker, including (and not limited to) subtypes Nav1.3, Nav1.7, and Nav1.8, which is described as an antipsychotic and is under development by Newron Pharmaceuticals as an add-on therapy for the treatment of schizophrenia.
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Funapide
Funapide (INN) (former developmental code names TV-45070 and XEN402) is a novel analgesic under development by Xenon Pharmaceuticals in partnership with Teva Pharmaceutical Industries for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain.
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GTx1-15
GTx1-15 is a toxin from the Chilean tarantula venom that acts as both a voltage-gated calcium channel blocker and a voltage-gated sodium channel blocker.
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HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the HEY2 gene.
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Index of biophysics articles
This is a list of articles on biophysics.
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List of investigational analgesics
This is a list of investigational analgesics, or analgesics that are currently under development for clinical use but are not yet approved.
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List of investigational antipsychotics
This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved.
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Melittin
Melittin is the main component (40–60% of the dry weight) and the major pain producing substance of honeybee (Apis mellifera) venom.
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Nav1.5
NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit.
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Nav1.7
Nav1.7 is a sodium ion channel that in humans is encoded by the SCN9A gene.
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Nav1.9
Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated sodium ion channel protein which is encoded by the SCN11A gene on chromosome 3 in humans.
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Orphenadrine
Orphenadrine (sold under many brand names worldwide Page accessed Feb 5, 2016) is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine.
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PF-05089771
PF-05089771 is a selective, small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker under development by Pfizer as a novel analgesic.
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S100A10
S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein that is encoded by the S100A10 gene in humans and the S100a10 gene in other species.
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Sodium channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
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Sodium channel blocker
Sodium channel blockers are drugs which impair the conduction of sodium ions (Na+) through sodium channels.
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