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50 relations: Adenosine diphosphate ribose, ADP-ribosylation, ADP-ribosyltransferase, Alan Ashworth, Aplysia, Apoptosis, Arenobufagin, Biological effects of radiation on the epigenome, Caspase, Centenarian, Cytotoxic T cell, Dauricine, DNA damage theory of aging, Epigenetics, Ferroptosis, FUS (gene), Granzyme B, High-grade serous carcinoma, Indole-3-acetic acid, List of EC numbers (EC 2), List of MeSH codes (D08), Longevity, Louise McCullough, Macro domain, Mammal, Maximum life span, Mensacarcin, MRN complex, Nicotinamide adenine dinucleotide, Nicotinamide mononucleotide, Olaparib, Ovarian cancer, PARP, PARP inhibitor, PARP1, PARP2, PD-1 and PD-L1 inhibitors, Pentosyltransferase, Proliferating cell nuclear antigen, Proteasome, Safingol, Seed, Streptozotocin, Takashi Sugimura, Talazoparib, TRPM2, WWE protein domain, XRCC1, Zinc, 3-Aminobenzamide.
Adenosine diphosphate ribose
Adenosine diphosphate ribose is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase.
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ADP-ribosylation
ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein.
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ADP-ribosyltransferase
ADP-ribosyltransferase may refer to.
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Alan Ashworth
Alan Ashworth, FRS (born 1960 in Bolton, Lancashire) is a British molecular biologist, noted for his work on genes involved in cancer susceptibility.
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Aplysia
Aplysia is a genus of medium-sized to extremely large sea slugs, specifically sea hares, which are one clade of large sea slugs, marine gastropod mollusks.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Arenobufagin
Arenobufagin is a cardiotoxic bufanolide steroid secreted by the Argentine toad Bufo arenarum.
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Biological effects of radiation on the epigenome
Ionizing radiation can cause biological effects which are passed on to offspring through the epigenome.
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Caspase
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.
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Centenarian
A centenarian is a person who lives to or beyond the age of 100 years.
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Cytotoxic T cell
A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.
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Dauricine
Dauricine is a plant metabolite, chemically classified as a phenol, an aromatic ether, and an isoquinoline alkaloid.
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DNA damage theory of aging
The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damages.
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Epigenetics
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
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Ferroptosis
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.
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FUS (gene)
RNA-binding protein FUS/TLS (Fused in Sarcoma/Translocated in Sarcoma) is a protein that in humans is encoded by the FUS gene.
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Granzyme B
Granzyme B is a serine protease most commonly found in the granules of cytotoxic lymphocytes (CTLs), natural killer cells (NK cells) and cytotoxic T cells.
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High-grade serous carcinoma
High-grade serous carcinoma (HGSC) is a type of tumour that arises from the serous epithelial layer in the abdominopelvic cavity and is mainly found in the ovary.
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Indole-3-acetic acid
Indole-3-acetic acid (IAA, 3-IAA) is the most common, naturally occurring, plant hormone of the auxin class.
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List of EC numbers (EC 2)
This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.
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List of MeSH codes (D08)
This is the fourth part of the list of the "D" codes for MeSH.
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Longevity
The word "longevity" is sometimes used as a synonym for "life expectancy" in demography.
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Louise McCullough
Louise McCullough M.D., Ph.D is a practicing vascular neurologist and professor who is actively engaged in stroke research at the University of Texas Health Science Center in Houston, Texas (UCHC) in the United States.
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Macro domain
In molecular biology, the Macro domain or A1pp domain is a module of about 180 amino acids which can bind ADP-ribose, an NAD metabolite, or related ligands.
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Mammal
Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.
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Maximum life span
Maximum life span (or, for humans, maximum reported age at death) is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death.
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Mensacarcin
Mensacarcin is a highly oxygenated polyketide first isolated from soil-dwelling Streptomyces bottropensis bacteria.
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MRN complex
The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast).
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Nicotinamide adenine dinucleotide
Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells.
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Nicotinamide mononucleotide
Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide.
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Olaparib
Olaparib (AZD-2281, trade name Lynparza) is an FDA-approved targeted therapy for cancer, developed by scientists at the University of Cambridge, including Steve Jackson, KuDOS Pharmaceuticals, and later by AstraZeneca.
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Ovarian cancer
Ovarian cancer is a cancer that forms in or on an ovary.
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PARP
PARP may refer to.
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PARP inhibitor
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP).
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PARP1
Poly polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly synthase 1 is an enzyme that in humans is encoded by the PARP1 gene.
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PARP2
Poly polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene.
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PD-1 and PD-L1 inhibitors
PD-1 inhibitors and PD-L1 inhibitors are a novel group of checkpoint inhibitors being developed for the treatment of cancer.
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Pentosyltransferase
Pentosyltransferases are a type of glycosyltransferase that catalyze the transfer of a pentose.
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Proliferating cell nuclear antigen
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication.
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Proteasome
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.
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Safingol
Safingol is a lyso-sphingolipid protein kinase inhibitor.
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Seed
A seed is an embryonic plant enclosed in a protective outer covering.
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Streptozotocin
Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals.
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Takashi Sugimura
is a Japanese biochemist, famous for research on chemical carcinogens.
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Talazoparib
Talazoparib (BMN-673) is an orally available poly ADP ribose polymerase (PARP) inhibitor currently in development by Pfizer for the treatment of advanced breast cancer patients with germline BRCA mutations.
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TRPM2
Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.
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WWE protein domain
The WWE domains occur in two functional classes of proteins, namely those associated with ubiquitination and those associated with poly-ADP ribosylation (PARP).
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XRCC1
DNA repair protein XRCC1 also known as X-ray repair cross-complementing protein 1 is a protein that in humans is encoded by the XRCC1 gene.
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Zinc
Zinc is a chemical element with symbol Zn and atomic number 30.
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3-Aminobenzamide
3-Aminobenzamide is a benzamide.
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Redirects here:
EC 2.4.2.30, NAD+ ADP-ribosyltransferase, NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase, Poly ADP ribose polymerase, Poly adp ribose polymerase, Poly(ADP-ribose) polymerase-1, Poly(adp-ribose) polymerases.
References
[1] https://en.wikipedia.org/wiki/Poly_(ADP-ribose)_polymerase
