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Proopiomelanocortin

Index Proopiomelanocortin

Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. [1]

54 relations: ACTH receptor, Addison's disease, Adrenocorticotropic hormone, Agouti-related peptide, Alpha-Melanocyte-stimulating hormone, Appetite, Arcuate nucleus, Beta-Endorphin, Beta-Melanocyte-stimulating hormone, Bupropion/naltrexone, Corticotropic cell, Corticotropin-like intermediate peptide, Corticotropin-releasing hormone, Corticotropin-releasing hormone receptor 1, Eating disorder, Endorphins, Enkephalin, Gamma-Melanocyte-stimulating hormone, Genetics of obesity, Hyperpigmentation, Hypothalamic–pituitary–adrenal axis, Labrador Retriever, Leptin, Lipotropin, List of MeSH codes (D06), List of MeSH codes (D12.644), List of MeSH codes (D12.776), List of OMIM disorder codes, List of opioids, Lorcaserin, Melanocortin, Melanocortin 4 receptor, Melanocyte-stimulating hormone, Melanotroph, N-Terminal peptide of proopiomelanocortin, Neurotransmitter, Nisoxetine, Nonsense-mediated decay, Nonylphenol, Nutriepigenomics, Obesity, Opioid, Opioid peptide, Pathophysiology of obesity, Peptide, Pituitary gland, Pituitary pars intermedia dysfunction, Prodynorphin, Proenkephalin, Proprotein convertase 1, ..., Protein precursor, Proteolysis, Red hair, Teleost leptins. Expand index (4 more) »

ACTH receptor

The adrenocorticotropic hormone receptor or ACTH receptor also known as the melanocortin receptor 2 or MC2 receptor is a type of melanocortin receptor (type 2) which is specific for ACTH.

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Addison's disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones.

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Adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.

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Agouti-related peptide

Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron.

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Alpha-Melanocyte-stimulating hormone

α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure and the amino acid sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2.

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Appetite

Appetite is the desire to eat food, sometimes due to hunger.

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Arcuate nucleus

The arcuate nucleus of the hypothalamus (also known as ARH, ARC, or infundibular nucleus) is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence.

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Beta-Endorphin

β-Endorphin is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central nervous system and peripheral nervous system.

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Beta-Melanocyte-stimulating hormone

β-Melanocyte-stimulating hormone (β-MSH) is an endogenous peptide hormone and neuropeptide.

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Bupropion/naltrexone

Bupropion/naltrexone is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses.

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Corticotropic cell

Corticotropes (or corticotrophs) are basophilic cells in the anterior pituitary that produce melanocyte-stimulating hormone, adrenocorticotropic hormone (ACTH) and lipotropin.

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Corticotropin-like intermediate peptide

Corticotropin-like intermediate peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe.

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Corticotropin-releasing hormone

Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in the stress response.

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Corticotropin-releasing hormone receptor 1

Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name.

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Eating disorder

An eating disorder is a mental disorder defined by abnormal eating habits that negatively affect a person's physical or mental health.

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Endorphins

Endorphins (contracted from "endogenous morphine") are endogenous opioid neuropeptides and peptide hormones in humans and other animals.

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Enkephalin

An enkephalin (occasionally spelled encephalin) is a pentapeptide involved in regulating nociception in the body.

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Gamma-Melanocyte-stimulating hormone

γ-Melanocyte-stimulating hormone (γ-MSH) is an endogenous peptide hormone and neuropeptide.

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Genetics of obesity

Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors.

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Hyperpigmentation

Hyperpigmentation is the darkening of an area of skin or nails caused by increased melanin.

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Hypothalamic–pituitary–adrenal axis

The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus, the pituitary gland (a pea-shaped structure located below the thalamus), and the adrenal (also called "suprarenal") glands (small, conical organs on top of the kidneys).

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Labrador Retriever

The Labrador Retriever, or just Labrador, is a type of retriever-gun dog.

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Leptin

Leptin (from Greek λεπτός leptos, "thin"), "the hormone of energy expenditure", is a hormone predominantly made by adipose cells that helps to regulate energy balance by inhibiting hunger.

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Lipotropin

Lipotropin is a hormone produced by the cleavage of pro-opiomelanocortin (POMC).

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List of MeSH codes (D06)

This is the fourth part of the list of the "D" codes for MeSH.

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List of MeSH codes (D12.644)

This is part of the list of the "D" codes for MeSH.

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List of MeSH codes (D12.776)

This is part of the list of the "D" codes for MeSH.

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List of OMIM disorder codes

This is a list of disorder codes in the Online Mendelian Inheritance in Man (OMIM) database.

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List of opioids

This is a list of opioids, opioid antagonists and inverse agonists.

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Lorcaserin

Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development, is a weight-loss drug developed by Arena Pharmaceuticals.

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Melanocortin

The melanocortins are a group of peptide hormones which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH), and are derived from proopiomelanocortin (POMC) in the pituitary gland.

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Melanocortin 4 receptor

Melanocortin 4 receptor is a protein that in humans is encoded by the MC4R gene.

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Melanocyte-stimulating hormone

The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides consisting of α-melanocyte-stimulating hormone (α-MSH), β-melanocyte-stimulating hormone (β-MSH), and γ-melanocyte-stimulating hormone (γ-MSH) that are produced by cells in the pars intermedia of the anterior lobe of the pituitary gland.

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Melanotroph

A melanotroph (or melanotrope) is a cell in the pituitary gland that generates melanocyte-stimulating hormone from its precursor pro-opiomelanocortin.

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N-Terminal peptide of proopiomelanocortin

The N-terminal peptide/fragment of proopiomelanocortin (NPP; N-POMC), also known as pro-γ-MSH, is a naturally occurring, endogenous metabolite of the polypeptide proopiomelanocortin (POMC).

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Nisoxetine

Nisoxetine, originally synthesized in the Lilly research laboratories during the early 1970s, is a potent and selective inhibitor for the reuptake of norepinephrine (noradrenaline) into synapses.

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Nonsense-mediated decay

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes.

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Nonylphenol

Nonylphenols, from the Latin nōnus (number 9) and phenol, are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail.

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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications.

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Obesity

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

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Opioid

Opioids are substances that act on opioid receptors to produce morphine-like effects.

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Opioid peptide

Opioid peptides are peptides that bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides.

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Pathophysiology of obesity

There are many possible pathophysiological mechanisms involved in the development and maintenance of obesity.

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Peptide

Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.

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Pituitary gland

An explanation of the development of the pituitary gland (Hypophysis cerebri) & the congenital anomalies. In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing in humans.

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Pituitary pars intermedia dysfunction

Pituitary pars intermedia dysfunction (PPID), or equine Cushing's disease, is an endocrine disease affecting the pituitary gland of horses.

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Prodynorphin

Prodynorphin, also known as proenkephalin B, is an opioid polypeptide hormone involved with chemical signal transduction and cell communication.

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Proenkephalin

Proenkephalin (PENK), formerly known as proenkephalin A (since proenkephalin B was renamed prodynorphin), is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides Metenkephalin, and to a lesser extent, Leuenkephalin.

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Proprotein convertase 1

Proprotein convertase 1, also known as prohormone convertase, prohormone convertase 3, or neuroendocrine convertase 1 and often abbreviated as PC1/3 is an enzyme that in humans is encoded by the PCSK1 gene.

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Protein precursor

A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule.

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Proteolysis

Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.

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Red hair

Red hair (or ginger hair) occurs naturally in 1–2% of the human population.

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Teleost leptins

Teleost leptins are a family of peptide hormones found in fish (teleostei) that are orthologs of the mammalian hormone leptin.

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Redirects here:

POMC, POMC (gene), Pre-proopiomelanocortin, Preopiomelanocortin, Preproopiomelanocortin, Pro-opimelanocortin, Pro-opiomelanocortin.

References

[1] https://en.wikipedia.org/wiki/Proopiomelanocortin

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