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Reading frame

Index Reading frame

In molecular biology, a reading frame is a way of dividing the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule into a set of consecutive, non-overlapping triplets. [1]

58 relations: A23 virus, Acidophiles in acid mine drainage, Alternative splicing, BLAST, Bunyamwera virus, Cat senses, Cathepsin D, CDKN2A, Copy-number variation, Crick, Brenner et al. experiment, DnaX ribosomal frameshifting element, Dopamine receptor D5, Drisapersen, Duchenne muscular dystrophy, Edward Trifonov, Eteplirsen, Evolutionary capacitance, Exon skipping, Frame, Frameshift mutation, Fusion protein, Gateway Technology, Genetic assimilation, Genetic code, Genome evolution, Glossary of genetics, Hepatitis C alternative reading frame stem-loop, HIV Rev response element, Index of biochemistry articles, Index of genetics articles, Index of molecular biology articles, Insertion (genetics), Inverted repeat, Koala retrovirus, List of MeSH codes (G14), Major urinary proteins, Melanoma, Minor capsid proteins VP2 and VP3, MT-ND4, MT-ND4L, Mutation, Open reading frame, Overlapping gene, P14arf, Phage display, RNA silencing suppressor p19, RNA splicing, Schmallenberg virus, Sequence analysis, Short interspersed nuclear element, ..., Silent mutation, Subtypes of HIV, Suppressor mutation, Tay–Sachs disease, Tetratricopeptide repeat protein 39B, Translation (biology), Translational frameshift, Trinucleotide repeat disorder. Expand index (8 more) »

A23 virus

The A23 virus is a viral serotype classified as a part of Enterovirus B species of in the genus Enterovirus.

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Acidophiles in acid mine drainage

The outflow of acidic liquids and other pollutants from mines is often catalysed by acid-loving microorganisms; these are the acidophiles in acid mine drainage.

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Alternative splicing

Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.

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BLAST

In bioinformatics, BLAST for Basic Local Alignment Search Tool is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA sequences.

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Bunyamwera virus

The Bunyamwera virus (BUNV) is a negative-sense, single-stranded enveloped RNA virus.

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Cat senses

Cat senses are adaptations that allow cats to be highly efficient predators.

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Cathepsin D

Cathepsin D is a protein that in humans is encoded by the CTSD gene.

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CDKN2A

CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3.

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Copy-number variation

Copy number variation (CNV) is a phenomenon in which sections of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.

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Crick, Brenner et al. experiment

The Crick, Brenner et al.

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DnaX ribosomal frameshifting element

The DnaX ribosomal frameshifting element is a RNA element found in the mRNA of the dnaX gene in E. coli.

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Dopamine receptor D5

Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene.

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Drisapersen

Drisapersen (also known as Kyndrisa, PRO051 and GSK2402968) is an experimental drug that was under development by BioMarin, after acquisition of Prosensa, for the treatment of Duchenne muscular dystrophy.

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Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy.

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Edward Trifonov

Edward Nikolayevich Trifonov (אדוארד טריפונוב, Эдуapд Тpифoнoв; b. March 31, 1937) is a Russian-born Israeli molecular biophysicist and a founder of Israeli bioinformatics.

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Eteplirsen

Eteplirsen (Exondys 51, Sarepta Therapeutics Inc.), also called AVI-4658, is a drug designed for treatment, but not a cure, of some mutations that cause Duchenne muscular dystrophy (DMD), a genetic degenerative muscle disease. Eteplirsen only targets mutations in a region implicated in 13% of DMD cases. After a controversial debate surrounding the efficacy of the drug, eteplirsen received accelerated approval from the US Food and Drug administration in late 2016. A year's worth of treatment with Eteplirsen is expected to cost approximately $300,000. A comprehensive review of the molecule and its clinical trials was published in early 2017.

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Evolutionary capacitance

Evolutionary capacitance is the storage and release of variation, just as electric capacitors store and release charge.

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Exon skipping

In molecular biology, exon skipping is a form of RNA splicing used to cause cells to “skip” over faulty or misaligned sections of genetic code, leading to a truncated but still functional protein despite the genetic mutation.

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Frame

A frame is often a structural system that supports other components of a physical construction and/or steel frame that limits the construction's extent.

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Frameshift mutation

A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three.

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Fusion protein

Fusion proteins or chimeric (\kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins.

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Gateway Technology

The Gateway cloning System, invented and commercialized by Invitrogen since the late 1990s, is a molecular biology method that enables researchers to efficiently transfer DNA-fragments between plasmids using a proprietary set of recombination sequences, the "Gateway att" sites, and two proprietary enzyme mixes, called "LR Clonase", and "BP Clonase".

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Genetic assimilation

Genetic assimilation is a process by which a phenotype originally produced in response to an environmental condition, such as exposure to a teratogen, later becomes genetically encoded via artificial selection or natural selection.

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Genetic code

The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or mRNA sequences) into proteins.

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Genome evolution

Genome evolution is the process by which a genome changes in structure (sequence) or size over time.

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Glossary of genetics

This is a glossary of terms and concepts commonly used in the study of genetics and related disciplines in biology.

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Hepatitis C alternative reading frame stem-loop

Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome.

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HIV Rev response element

The HIV-1 Rev response element (RRE) is a highly structured, ~350 nucleotide RNA segment present in the Env coding region of unspliced and partially spliced viral mRNAs.

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Index of biochemistry articles

Biochemistry is the study of the chemical processes in living organisms.

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Index of genetics articles

Genetics (from Ancient Greek γενετικός genetikos, “genite” and that from γένεσις genesis, “origin”), a discipline of biology, is the science of heredity and variation in living organisms.

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Index of molecular biology articles

This is a list of topics in molecular biology.

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Insertion (genetics)

In genetics, an insertion (also called an insertion mutation) is the addition of one or more nucleotide base pairs into a DNA sequence.

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Inverted repeat

An inverted repeat (or IR) is a single stranded sequence of nucleotides followed downstream by its reverse complement.

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Koala retrovirus

Koala retrovirus (KoRV) is a retrovirus that is present in many populations of koalas.

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List of MeSH codes (G14)

The following is a list of the "G" codes for MeSH.

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Major urinary proteins

Major urinary proteins (Mups), also known as α2u-globulins, are a subfamily of proteins found in abundance in the urine and other secretions of many animals.

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Melanoma

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Minor capsid proteins VP2 and VP3

Minor capsid protein VP2 and minor capsid protein VP3 are viral proteins that are components of the polyomavirus capsid.

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MT-ND4

NADH-ubiquinone oxidoreductase chain 4 is a protein that in humans is encoded by the mitochondrial gene MT-ND4.

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MT-ND4L

NADH-ubiquinone oxidoreductase chain 4L is a protein that in humans is encoded by the mitochondrial gene MT-ND4L.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Open reading frame

In molecular genetics, an open reading frame (ORF) is the part of a reading frame that has the ability to be translated.

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Overlapping gene

An overlapping gene is a gene whose expressible nucleotide sequence partially overlaps with the expressible nucleotide sequence of another gene.

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P14arf

p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus).

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Phage display

Phage display is a laboratory technique for the study of protein–protein, protein–peptide, and protein–DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them.

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RNA silencing suppressor p19

RNA silencing suppressor p19 (also known as Tombusvirus P19 core protein and 19 kDa symptom severity modulator) is a protein expressed from the ORF4 gene in the genome of tombusviruses.

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RNA splicing

In molecular biology, splicing is the editing of the nascent precursor messenger RNA (pre-mRNA) transcript into a mature messenger RNA (mRNA).

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Schmallenberg virus

Schmallenberg virus is the informal name given to a recently isolated orthobunyavirus, which has not been given a formal name, initially reported in October 2011 to cause congenital malformations and stillbirths in cattle, sheep, goats, and possibly alpaca.

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Sequence analysis

In bioinformatics, sequence analysis is the process of subjecting a DNA, RNA or peptide sequence to any of a wide range of analytical methods to understand its features, function, structure, or evolution.

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Short interspersed nuclear element

Short Interspersed Nuclear Elements (SINEs) are non-autonomous, non-coding transposable elements (TEs) that are 50-500 base pairs long.

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Silent mutation

Silent mutations are mutations in DNA that do not have an observable effect on the organism's phenotype.

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Subtypes of HIV

One of the obstacles to treatment of the human immunodeficiency virus is its high genetic variability.

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Suppressor mutation

A suppressor mutation is a second mutation that alleviates or reverts the phenotypic effects of an already existing mutation in a process defined synthetic rescue.

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Tay–Sachs disease

Tay–Sachs disease is a genetic disorder that results in the destruction of nerve cells in the brain and spinal cord.

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Tetratricopeptide repeat protein 39B

Tetratricopeptide repeat protein 39B is a protein that in humans is encoded by the TTC39B gene.

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Translation (biology)

In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.

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Translational frameshift

Translational frameshifting or ribosomal frameshifting refers to an alternative process of protein translation.

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Trinucleotide repeat disorder

Trinucleotide repeat disorders (also known as trinucleotide repeat expansion disorders, triplet repeat expansion disorders or codon reiteration disorders) are a set of genetic disorders caused by trinucleotide repeat expansion, a kind of mutation where trinucleotide repeats in certain genes or intronsDavid W. Sanders & Clifford P. Brangwynne (2017), Nature, 546, 215–216 (08 June 2017) exceed the normal, stable threshold, which differs per gene.

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Reading frames.

References

[1] https://en.wikipedia.org/wiki/Reading_frame

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