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SOX2

Index SOX2

SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. [1]

59 relations: Adult neurogenesis, Ageing, Anophthalmia, Bone morphogenetic protein 4, Brachyury, Brpf1, CAF-1, Cell potency, Cellular differentiation, Cerebral organoid, Chromosome 3, CUL4B, Dental pulp stem cells, Development of the digestive system, ENOX2, Eomesodermin, Fbx15, Foregut, Germ line development, GLIS1, Homeobox protein NANOG, Hypopituitarism, Induced pluripotent stem cell, Induced stem cells, Jun dimerization protein, Lens placode, List of OMIM disorder codes, Master regulator, Microphthalmia, Musashi rna binding protein 2, Muse cell, Myc, Neuronal lineage marker, Oct-4, Olfactory epithelium, Organ of Corti, PDX1, Reprogramming, Rex1, SALL4, Serrate RNA effector molecule homolog, Shinya Yamanaka, SIX3, SOX gene family, SOX1, SOX10, SOX21, SOX2OT, State switching, Stem cell, ..., Stem cell genomics, Stem cell marker, Stem-cell niche, Subgranular zone, Super-enhancer, Telomerase reverse transcriptase, Toll-like receptor, Transdifferentiation, XIST. Expand index (9 more) »

Adult neurogenesis

Neurogenesis is the process by which neurons are generated from neural stem cells.

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Ageing

Ageing or aging (see spelling differences) is the process of becoming older.

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Anophthalmia

Anophthalmia, (Greek: ανόφθαλμος, "without eye"), is the medical term for the absence of one or both eyes.

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Bone morphogenetic protein 4

Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene.

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Brachyury

Brachyury is a protein that in humans is encoded by the T gene.

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Brpf1

Peregrin also known as bromodomain and PHD finger-containing protein 1 is a protein that in humans is encoded by the BRPF1 gene located on 3p26-p25.

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CAF-1

CAF-1 (chromatin assembly factor-1) is a complex, including Chaf1a (p150), Chaf1b (p60) and p50 subunits that assembles histone tetramers onto replicating DNA in vitro This complex is histone chaperone involved in creating cellular memory of somatic cell identity – cellular differentiation.

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Cell potency

Cell potency is a cell's ability to differentiate into other cell types The more cell types a cell can differentiate into, the greater its potency.

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Cerebral organoid

A cerebral organoid describes artificially grown, in vitro, miniature organs resembling the brain.

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Chromosome 3

Chromosome 3 is one of the 23 pairs of chromosomes in humans.

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CUL4B

Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome.

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Dental pulp stem cells

Dental pulp stem cells (DPSCs) are stem cells present in the dental pulp, the soft living tissue within teeth.

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Development of the digestive system

The development of the digestive system concerns the epithelium of the digestive system and the parenchyma of its derivatives, which originate from the endoderm.

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ENOX2

ENOX2 is a gene located on the long arm of the X chromosome in humans.

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Eomesodermin

Eomesodermin also known as T-box brain protein 2 (Tbr2) is a protein that in humans is encoded by the EOMES gene.

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Fbx15

Fbx15, otherwise known as Fbxo15, is a protein expressed in undifferentiated embryonic stem cells.

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Foregut

The foregut is the anterior part of the alimentary canal, from the mouth to the duodenum at the entrance of the bile duct, and is attached to the abdominal walls by mesentery.

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Germ line development

The cells that give rise to the gametes are often set aside during embryonic cleavage.

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GLIS1

Glis1 (Glis Family Zinc Finger 1) is gene encoding a Krüppel-like protein of the same name whose locus is found on Chromosome 1p32.3.

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Homeobox protein NANOG

NANOG (pron. nanOg) is a transcription factor critically involved with self-renewal of undifferentiated embryonic stem cells.

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Hypopituitarism

Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain.

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Induced pluripotent stem cell

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from adult cells.

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Induced stem cells

Induced stem cells (iSC) are stem cells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming.

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Jun dimerization protein

Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene.

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Lens placode

The Lens placode is a thickened portion of ectoderm which serves as the precursor to the lens.

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List of OMIM disorder codes

This is a list of disorder codes in the Online Mendelian Inheritance in Man (OMIM) database.

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Master regulator

In genetics, a master regulator is a gene at the top of a gene regulation hierarchy, particularly in regulatory pathways related to cell fate and differentiation.

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Microphthalmia

Microphthalmia (Greek: μικρός micros.

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Musashi rna binding protein 2

Musashi RNA binding protein 2 is a protein that in humans is encoded by the MSI2 gene.

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Muse cell

A muse cell (multi-lineage differentiating stress enduring cell) is a endogenous non-tumorigenic pluripotent stem cell.

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Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors.

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Neuronal lineage marker

A Neuronal lineage marker is an endogenous tag that is expressed in different cells along neurogenesis and differentiated cells such as neurons.

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Oct-4

Oct-4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a protein that in humans is encoded by the POU5F1 gene.

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Olfactory epithelium

The olfactory epithelium is a specialized epithelial tissue inside the nasal cavity that is involved in smell.

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Organ of Corti

The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea.

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PDX1

PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor necessary for pancreatic development, including β-cell maturation, and duodenal differentiation.

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Reprogramming

In biology, reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development or in cell culture.

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Rex1

Rex1 (Zfp-42) is a known marker of pluripotency, and is usually found in undifferentiated embryonic stem cells.

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SALL4

Sal-like protein 4 (SALL4) is a transcription factor encoded by a member of the Spalt-like (SALL) gene family, SALL4.

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Serrate RNA effector molecule homolog

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.

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Shinya Yamanaka

is a Japanese Nobel Prize-winning stem cell researcher.

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SIX3

Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene.

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SOX gene family

SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group).

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SOX1

SOX1 is a gene, which encodes a transcription factor in the HMG (high mobility group) DNA binding domain, and functions primarily in neurogenesis.

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SOX10

Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.

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SOX21

Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene.

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SOX2OT

SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons.

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State switching

State switching (a.k.a. phenotypic switching) is a fundamental physiological process in which a cell/organism undergoes spontaneous, and potentially reversible, transitions between different phenotypes.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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Stem cell genomics

Stem cell genomics analyzes the genomes of stem cells.

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Stem cell marker

Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells.

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Stem-cell niche

Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate.

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Subgranular zone

The subgranular zone (SGZ) is a brain region in the hippocampus where adult neurogenesis occurs.

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Super-enhancer

In genetics, a super-enhancer is a region of the mammalian genome comprising multiple enhancers that is collectively bound by an array of transcription factor proteins to drive transcription of genes involved in cell identity.

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Telomerase reverse transcriptase

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

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Toll-like receptor

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system.

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Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, is a process in which one mature somatic cell transforms into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type.

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XIST

Xist (X-inactive specific transcript) is an RNA gene on the X chromosome of the placental mammals that acts as a major effector of the X inactivation process.

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Redirects here:

SOX2 (gene), Sox2.

References

[1] https://en.wikipedia.org/wiki/SOX2

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