23 relations: Antiprogestogen, Asoprisnil, Asoprisnil ecamate, CYP3A4, Danazol, Emergency contraception, Gestrinone, List of investigational hormonal agents, Menometrorrhagia, Metapristone, Nuclear receptor, Progesterone receptor, Selective androgen receptor modulator, Selective glucocorticoid receptor modulator, Selective receptor modulator, Sex-hormonal agent, SPRM, Telapristone, Ulipristal acetate, Uterine fibroid, Vilaprisan, 5α-Dihydrolevonorgestrel, 5α-Dihydronorethisterone.
Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body.
Asoprisnil (INN; developmental code name J-867) is a synthetic, steroidal selective progesterone receptor modulator that was under development by Schering and TAP Pharmaceutical Products for the treatment of uterine fibroids.
Asoprisnil ecamate (INN) (developmental code name J-956) is a synthetic, steroidal selective progesterone receptor modulator (SPRM) which was under development for the treatment of endometriosis, uterine fibroids, and menopausal symptoms but was discontinued.
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
Danazol, sold under the brand name Danocrine among others, is a medication which is used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema, and other conditions.
Emergency contraception (EC), or emergency postcoital contraception, are birth control measures that may be used after sexual intercourse to prevent pregnancy.
Gestrinone, sold under the brand names Dimetrose and Nemestran among others, is a medication which is used in the treatment of endometriosis.
This is a list of investigational hormonal agents, or hormonal agents that are currently under development for clinical use but are not yet approved.
Menometrorrhagia is a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal.
Metapristone (developmental code name RU-42633; also known as desmethylmifepristone) is the major metabolite of mifepristone (RU-486, RU-38486) and a selective progesterone receptor modulator (SPRM) which itself was never marketed.
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.
Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands.
Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as dissociated glucocorticoid receptor agonists (DIGRAs) are a class of experimental drugs designed to share many of the desirable anti-inflammatory, immunosuppressive, or anticancer properties of classical glucocorticoid drugs but with fewer side effects such as skin atrophy.
In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues.
A sex-hormonal agent, also known as a sex-hormone receptor modulator, is a type of hormonal agent which specifically modulates the effects of sex hormones and of their biological targets, the sex hormone receptors.
SPRM may refer to.
Telapristone, as telapristone acetate (proposed brand names Proellex, Progenta; former code name CDB-4124), is a synthetic, steroidal selective progesterone receptor modulator (SPRM) related to mifepristone which is under development by Repros Therapeutics for the treatment of breast cancer, endometriosis, and uterine fibroids.
Ulipristal acetate, sold under the brand name Ella among others, is a medication used for emergency birth control and uterine fibroids.
Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus.
Vilaprisan (INN, USAN) (developmental code name BAY-1002670) is a synthetic, steroidal selective progesterone receptor modulator (SPRM) which is under development by Bayer HealthCare Pharmaceuticals for the treatment of endometriosis and uterine fibroids.
5α-Dihydrolevonorgestrel (5α-DHLNG) is an active metabolite of the progestin levonorgestrel which is formed by 5α-reductase.
5α-Dihydronorethisterone (5α-DHNET, dihydronorethisterone, 17α-ethynyl-5α-dihydro-19-nortestosterone, or 17α-ethynyl-5α-estran-17β-ol-3-one) is a major active metabolite of norethisterone (norethindrone).
Discovery and Development of Selective progesterone receptor modulators, Discovery and development of selective progesterone receptor modulators, Selective Progesterone Receptor Modulators, Selective progesterone receptor modulators.