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214 relations: A. K. Mukherjee, AB5 toxin, Abdominal aortic aneurysm, Acetylcholinesterase, Acrosin, Active site, Activity-based proteomics, Adaptive immune system, AEBSF, Alpha-2-Macroglobulin, Alpha-lytic endopeptidase, Ancrod, Angiostatin, Antagonistic Coevolution, Aphanoascus fulvescens, Aprotinin, Asparagine peptide lyase, Aspartic protease, Aspergillus fumigatus, AUP1, Aureolysin, Azurophilic granule, B13R (virus protein), Bacillus licheniformis, Batroxobin, Bürgi–Dunitz angle, Brian S. Hartley, Buserelin, C3-convertase, C5-convertase, CA1 (gene), Camostat, Cantharidin, Cathepsin, Cathepsin C, Cathepsin G, CCDC113, CELA3A, CELA3B, Cerastocytin, Chaperone (protein), Chemerin, Chymase, Clp protease family, Coagulation, Complement component 4, Complement factor I, Cordeauxia, Crohn's disease, Cysteine protease, ..., Cytotoxic T cell, Dabigatran, Degranulation, Discovery and development of direct thrombin inhibitors, Drotrecogin alfa, Ecotin, EGF-like domain, Elastase, Endopeptidase inhibitor, Endothelial protein C receptor, Enteropeptidase, Enzyme catalysis, Enzyme kinetics, Extracellular matrix, Factor D, Factor IX, Factor VII, Factor X, Factor XI, Factor XII, Fc receptor, Fibroblast activation protein, alpha, Flippin–Lodge angle, Gastric lipase, Gelatinase biosynthesis-activating pheromone, Glecaprevir/pibrentasvir, Glutamic protease, Glutamyl endopeptidase GluV8, Glutamyl endopeptidase I, Granulocyte, Granzyme, Granzyme B, Grazoprevir, GZMB, HABP2, HGFAC, Hirudin, Homology modeling, Howel–Evans syndrome, HtrA serine peptidase 2, Hydrogen-bond catalysis, Hypoprothrombinemia, IgA-specific metalloendopeptidase, Implantation (human embryo), In-gel digestion, Inhibitor of apoptosis, Intramembrane protease, Β-Lactamase inhibitor, Kalicludine, Kallikrein, Kazal domain, Keratinase, Kinin–kallikrein system, KLK4, KLK5, KLK7, KLK9, Knoll Pharmaceuticals, LCCL domain, LCHN, LEKTI, LEKTI-2, Leupeptin, List of biophysically important macromolecular crystal structures, List of EC numbers (EC 3), List of enzymes, List of examples of convergent evolution, List of MeSH codes (D08), List of MeSH codes (D16), Lon protease family, Magnetotactic bacteria, Mannose-binding protein-associated serine protease, Maslinic acid, MASP1 (protein), Mast cell, Methoxy arachidonyl fluorophosphonate, Milwaukee shoulder syndrome, Monofluorophosphate, Myeloid and erythroid nuclear termination stage-specific protein, Narlaprevir, Nattokinase, Nest (protein structural motif), Netherton syndrome, Neutrophil, NS3 (HCV), Outer membrane porin D, Ovalbumin, Ovomucoid, PA clan, Pacifastin, Pancreatic elastase, Papain, Paritaprevir, Pathophysiology of hypertension, Penicillium chrysogenum, Peptidase 1 (mite), Peptidase Do, Peptidylprolyl isomerase A, Philodryas olfersii, Plasmin, Plasminogen activator, Plasminogen activator inhibitor-1, Plasminogen activator inhibitor-2, PMSF, Polysulfated glycosaminoglycan, Prekallikrein, Proprotein convertase 2, Prostate-specific antigen, Protease, Protease-activated receptor, Proteases (medical and related uses), Protein C, Protein catabolism, Protein domain, Protein superfamily, Protein Z, Proteinase 3, Proteinase K, Proteolysis, PRSS2, PRSS3, PRSS8, Puromycin, Purpureocillium, Randy Read, Reelin, RHBDF1, RHBDF2, Rhomboid protease, Rhomboid, veinlet-like 2 (drosophila), Serine, Serine hydrolase, Serpin, SERPINA2, Signal peptidase, Skin whitening, Sp/KLF family, SPINT2, Sporothrix schenckii, Statistical coupling analysis, Streptococcus pyogenes, Subtilase, Subtilisin, Tej P. Singh, TEV protease, Threonine protease, Thrombin, Thrombin receptor, Tissue factor, Tissue plasminogen activator, TMPRSS3, Toxin, Trichoderma longibrachiatum, Tripeptidyl peptidase I, Trypsin, Trypsin 1, Trypsin inhibitor, Tryptase, TSG-6, Ulinastatin, Urokinase, Venoms in medicine, Wheat allergy, (S)-hydroxynitrile lyase. Expand index (164 more) »
A. K. Mukherjee
Ashis K. Mukherjee is an Indian molecular biologist, bio-technologist and the Head of the Department of Molecular Biology and Biotechnology of the Tezpur University.
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AB5 toxin
The AB5 toxins are six-component protein complexes secreted by certain pathogenic bacteria known to cause human diseases such as cholera, dysentery, and hemolytic-uremic syndrome.
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Abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA or triple A) is a localized enlargement of the abdominal aorta such that the diameter is greater than 3 cm or more than 50% larger than normal diameter.
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Acetylcholinesterase
Acetylcholinesterase, encoded by HGNC gene ACHE; EC 3.1.1.7) is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
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Acrosin
Acrosin is a digestive enzyme that acts as a protease.
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Active site
In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.
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Activity-based proteomics
Activity-based proteomics, or activity-based protein profiling (ABPP) is a functional proteomic technology that uses chemical probes that react with mechanistically related classes of enzymes.
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Adaptive immune system
The adaptive immune system, also known as the acquired immune system or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate pathogens or prevent their growth.
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AEBSF
AEBSF or 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride is a water-soluble, irreversible serine protease inhibitor with a molecular weight of 239.5 Da. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
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Alpha-2-Macroglobulin
alpha-2-Macroglobulin (α2M) is a large (720 KDa) plasma protein found in the blood.
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Alpha-lytic endopeptidase
Alpha-lytic endopeptidase or Alpha-lytic protease (myxobacter alpha-lytic proteinase, alpha-lytic proteinase, alpha-lytic protease, Mycobacterium sorangium alpha-lytic proteinase, Myxobacter 495 alpha-lytic proteinase) is an enzyme isolated from the myxobacterium Lysobacter enzymogenes.
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Ancrod
Ancrod (current brand name: Viprinex) is a defibrinogenating agent derived from the venom of the Malayan pit viper.
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Angiostatin
Angiostatin is a naturally occurring protein found in several animal species, including humans.
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Antagonistic Coevolution
Sexual antagonistic co-evolution is the relationship between males and females where sexual morphology changes over time to counteract the opposite's sex traits to achieve the maximum reproductive success.
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Aphanoascus fulvescens
Aphanoascus fulvescens is a mould fungus that behaves as a keratinophilic saprotroph and belongs to the Ascomycota.
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Aprotinin
The drug aprotinin (Trasylol, previously Bayer and now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes.
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Asparagine peptide lyase
Asparagine peptide lyase are one of the seven groups in which proteases, also termed proteolytic enzymes, peptidases, or proteinases, are classified according to their catalytic residue.
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Aspartic protease
Aspartic proteases are a catalytic type of protease enzymes that use an activated water molecule bound to one or more aspartate residues for catalysis of their peptide substrates.
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Aspergillus fumigatus
Aspergillus fumigatus is a fungus of the genus Aspergillus, and is one of the most common Aspergillus species to cause disease in individuals with an immunodeficiency.
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AUP1
Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.
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Aureolysin
Aureolysin (protease III, staphylococcal metalloprotease, Staphylococcus aureus neutral proteinase) is an extracellular metalloprotease expressed by Staphylococcus aureus.
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Azurophilic granule
An azurophilic granule is a cellular object readily stainable with a Romanowsky stain.
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B13R (virus protein)
B13R (sometimes called SPI-2) is a protein expressed by vaccinia virus.
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Bacillus licheniformis
Bacillus licheniformis is a bacterium commonly found in the soil.
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Batroxobin
Batroxobin, also known as reptilase, is a snake venom produced by Bothrops atrox and Bothrops moojeni, venomous species of pit viper found east of the Andes in South America.
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Bürgi–Dunitz angle
The Bürgi–Dunitz angle (BD angle) is one of two angles that fully define the geometry of "attack" (approach via collision) of a nucleophile on a trigonal unsaturated center in a molecule, originally the carbonyl center in an organic ketone, but now extending to aldehyde, ester, and amide carbonyls, and to alkenes (olefins) as well.
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Brian S. Hartley
Brian Selby Hartley (born 1926) FRS is a British biochemist.
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Buserelin
Buserelin, sold under the brand name Suprefact among others, is a medication which is used primarily in the treatment of prostate cancer and endometriosis.
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C3-convertase
C3 convertase (C2, C4bC2b, (formerly C4bC2a)C3bBb, complement C.hivin.4.hivin2, complement C3 convertase) belongs to family of serine proteases and is necessary in innate immunity as a part of the complement system which eventuate in opsonisation of particles, release of inflammatory peptides, C5 convertase formation and cell lysis.
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C5-convertase
C5 convertase is an enzyme belonging to a family of serine proteases that play key role in the innate immunity.
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CA1 (gene)
Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene.
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Camostat
Camostat (INN) or FOY-305 is a serine protease inhibitor.
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Cantharidin
Cantharidin is an odorless, colorless fatty substance of the terpenoid class, which is secreted by many species of blister beetles.
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Cathepsin
Cathepsins (Ancient Greek kata- "down" and hepsein "boil"; abbreviated CTS) are proteases (enzymes that degrade proteins) found in all animals as well as other organisms.
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Cathepsin C
Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I) is a lysosomal exo-cysteine protease belonging to the peptidase C1 family.
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Cathepsin G
Cathepsin G is a protein that in humans is encoded by the CTSG gene.
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CCDC113
Coiled-coil domain-containing protein 113 also known as HSPC065, GC16Pof6842 and GC16P044152, is a protein that in humans is encoded by the CCDC113 gene.
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CELA3A
Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene.
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CELA3B
Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in humans is encoded by the CELA3B gene.
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Cerastocytin
Cerastocytin is a thrombin-like serine protease in snake venom.
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Chaperone (protein)
In molecular biology, molecular chaperones are proteins that assist the covalent folding or unfolding and the assembly or disassembly of other macromolecular structures.
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Chemerin
Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), tazarotene-induced gene 2 protein (TIG2), or RAR-responsive protein TIG2 is a protein that in humans is encoded by the RARRES2 gene.
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Chymase
Chymases (mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8).
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Clp protease family
In molecular biology, the CLP protease family is a family of serine peptidases belong to the MEROPS peptidase family S14 (ClpP endopeptidase family, clan SK).
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Coagulation
Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.
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Complement component 4
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system.
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Complement factor I
Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene.
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Cordeauxia
Cordeauxia edulis is a plant in the Fabaceae family and the sole species in the genus Cordeauxia.
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Crohn's disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus.
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Cysteine protease
Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins.
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Cytotoxic T cell
A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.
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Dabigatran
Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant medication which can be taken by mouth.
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Degranulation
Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells.
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Discovery and development of direct thrombin inhibitors
Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various diseases.
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Drotrecogin alfa
Drotrecogin alfa (activated) (Xigris, marketed by Eli Lilly and Company) is a recombinant form of human activated protein C that has anti-thrombotic, anti-inflammatory, and profibrinolytic properties.
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Ecotin
In molecular biology, ecotin is a protease inhibitor which belongs to MEROPS inhibitor family I11, clan IN.
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EGF-like domain
The EGF-like domain is an evolutionary conserved protein domain, which derives its name from the epidermal growth factor where it was first described.
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Elastase
In molecular biology, elastase is an enzyme from the class of proteases (peptidases) that break down proteins.
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Endopeptidase inhibitor
An endopeptidase inhibitor is a drug that inhibits one or more endopeptidase enzymes.
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Endothelial protein C receptor
Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene.
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Enteropeptidase
Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and is involved in digestion in humans and other animals.
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Enzyme catalysis
Enzyme catalysis is the increase in the rate of a chemical reaction by the active site of a protein.
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Enzyme kinetics
Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes.
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Extracellular matrix
In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by support cells that provides structural and biochemical support to the surrounding cells.
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Factor D
Factor D (C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) a protein which in humans is encoded by the CFD gene.
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Factor IX
Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1.
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Factor VII
Factor VII (blood-coagulation factor VIIa, activated blood coagulation factor VII, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade.
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Factor X
Factor X, also known by the eponym Stuart–Prower factor, is an enzyme of the coagulation cascade.
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Factor XI
Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade.
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Factor XII
Coagulation factor XII, also known as Hageman factor, is a plasma protein.
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Fc receptor
An Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells – that contribute to the protective functions of the immune system.
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Fibroblast activation protein, alpha
Fibroblast activation protein alpha is a 170 kDa melanoma membrane-bound gelatinase, protein that in humans is encoded by the FAP gene.
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Flippin–Lodge angle
The Flippin–Lodge angle is one of two angles used by organic and biological chemists studying the relationship between a molecule's chemical structure and ways that it reacts, for reactions involving "attack" of an electron-rich reacting species, the nucleophile, on an electron-poor reacting species, the electrophile.
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Gastric lipase
Gastric lipase, also known as LIPF, is an enzymatic protein that, in humans, is encoded by the LIPF gene.
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Gelatinase biosynthesis-activating pheromone
Gelatinase biosynthesis-activating pheromone abbreviated as GBAP is a cyclic peptide produced by pathogenic bacteria such as Enterococcus faecalis.
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Glecaprevir/pibrentasvir
Glecaprevir/pibrentasvir (trade name Mavyret in the US and Maviret in Europe) is a combination drug containing glecaprevir (100 mg) and pibrentasvir (40 mg).
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Glutamic protease
Glutamic proteases are a group of proteolytic enzymes containing a glutamic acid residue within the active site.
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Glutamyl endopeptidase GluV8
Glutamyl endopeptidase (SspA, V8 protease, GluV8, endoproteinase Glu-C, staphylococcal serine proteinase) is an extracellular bacterial serine protease of the glutamyl endopeptidase I family that was initially isolated from the Staphylococcus aureus strain V8.
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Glutamyl endopeptidase I
Glutamyl endopeptidase I is a family of extracellular bacterial serine proteases.
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Granulocyte
Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm.
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Granzyme
Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells.
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Granzyme B
Granzyme B is a serine protease most commonly found in the granules of cytotoxic lymphocytes (CTLs), natural killer cells (NK cells) and cytotoxic T cells.
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Grazoprevir
Grazoprevir is a drug approved for the treatment of hepatitis C. It was developed by Merck and completed Phase III trials, used in combination with the NS5A replication complex inhibitor elbasvir under the trade name Zepatier, either with or without ribavirin.
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GZMB
Granzyme B is a serine protease that in humans is encoded by the GZMB gene.
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HABP2
Hyaluronan-binding protein 2 is a protein that in humans is encoded by the HABP2 gene.
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HGFAC
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.
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Hirudin
Hirudin is a naturally occurring peptide in the salivary glands of blood-sucking leeches (such as Hirudo medicinalis) that has a blood anticoagulant property.
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Homology modeling
Homology modeling, also known as comparative modeling of protein, refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template").
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Howel–Evans syndrome
Howel–Evans syndrome is an extremely rare condition involving thickening of the skin in the palms of the hands and the soles of the feet (hyperkeratosis).
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HtrA serine peptidase 2
Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene.
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Hydrogen-bond catalysis
Hydrogen-bond catalysis is a type of organocatalysis that relies on use of hydrogen bonding interactions to accelerate and control organic reactions.
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Hypoprothrombinemia
Hypoprothrombinemia is a rare blood disorder in which a deficiency in immunoreactive prothrombin (Factor II), produced in the liver, results in an impaired blood clotting reaction, leading to an increased physiological risk for spontaneous bleeding.
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IgA-specific metalloendopeptidase
IgA-specific metalloendopeptidase (immunoglobulin A1 proteinase, IgA protease, IgA1-specific proteinase, IgA1 protease, IgA1 proteinase) is an enzyme.
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Implantation (human embryo)
In humans, implantation is the stage of pregnancy at which the already fertilized egg adheres to the wall of the uterus.
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In-gel digestion
The in-gel digestion is part of the sample preparation for the mass spectrometric identification of proteins in course of proteomic analysis.
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Inhibitor of apoptosis
Apoptosis, or programmed cell death, is a highly regulated process used by many multicellular organisms.
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Intramembrane protease
Intramembrane proteases (IMPs), also known as intramembrane-cleaving proteases (I-CLiPs), are enzymes that have the property of cleaving transmembrane domains of integral membrane proteins.
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Β-Lactamase inhibitor
Beta-lactamases are a family of enzymes involved in bacterial resistance to beta-lactam antibiotics.
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Kalicludine
Kalicludine (AsKC) is a blocker of the voltage-dependent potassium channel Kv1.2 found in the snakeslocks anemone Anemonia viridis (Anemonia sulcata), which it uses to paralyse prey.
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Kallikrein
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins.
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Kazal domain
The Kazal domain is an evolutionary conserved protein domain usually indicative of serine protease inhibitors.
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Keratinase
Keratinases are proteolytic enzymes that digest keratin.
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Kinin–kallikrein system
The kinin–kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research.
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KLK4
Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.
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KLK5
Kallikrein-related peptidase 5 (KLK5), formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis.
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KLK7
Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene.
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KLK9
Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.
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Knoll Pharmaceuticals
Knoll Pharmaceuticals was a drug development company founded by Albert Knoll and Hans Knoll in Germany in 1886.
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LCCL domain
In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Coch-5b2 (Cochlin) and Lgl1.
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LCHN
LCHN is a protein that in humans is encoded by the KIAA1147 gene (NCBI Gene ID 57189) located on chromosome 7.
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LEKTI
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene.
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LEKTI-2
Lympho-epithelial Kazal-type related inhibitor 2 (LEKTI-2) is a protein encoded by the SPINK9 gene in humans.
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Leupeptin
Leupeptin, also known as N-acetyl-L-leucyl-L-leucyl-L-argininal, is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. It is often used during in vitro experiments when a specific enzymatic reaction is being studied. When cells are lysed for these studies, proteases, many of which are contained within lysosomes, are released. These proteases, if freely present in the lysate, would destroy any products from the reaction being studied, and make the experiment uninterpretable. For example, leupeptin could be used in a calpain extraction to keep calpain from being hydrolyzed by specific proteases. The suggested concentration is 1-10 µM (0.5-5 µg/ml). Leupeptin is an organic compound produced by actinomycetes, which inhibits serine, cysteine and threonine proteases. Leupeptin inhibits serine proteinases (trypsin (Ki.
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List of biophysically important macromolecular crystal structures
Crystal structures of protein and nucleic acid molecules and their complexes are central to the practice of most parts of biophysics, and have shaped much of what we understand scientifically at the atomic-detail level of biology.
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List of EC numbers (EC 3)
This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.
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List of enzymes
This page lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission numbering system.
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List of examples of convergent evolution
Convergent evolution — the repeated evolution of similar traits in multiple lineages which all ancestrally lack the trait — is rife in nature, as illustrated by the examples below.
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List of MeSH codes (D08)
This is the fourth part of the list of the "D" codes for MeSH.
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List of MeSH codes (D16)
This is the fourth part of the list of the "D" codes for MeSH.
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Lon protease family
In molecular biology, the Lon protease family is a family of proteases.
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Magnetotactic bacteria
Magnetotactic bacteria (or MTB) are a polyphyletic group of bacteria discovered by Richard P. Blakemore in 1975, that orient along the magnetic field lines of Earth's magnetic field.
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Mannose-binding protein-associated serine protease
Mannose-binding protein-associated serine protease are serine proteases involved in the complement system.
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Maslinic acid
Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct of olive oil extraction.
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MASP1 (protein)
Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene.
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Mast cell
A mast cell (also known as a mastocyte or a labrocyte) is a type of white blood cell.
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Methoxy arachidonyl fluorophosphonate
Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases.
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Milwaukee shoulder syndrome
Milwaukee shoulder syndrome (apatite-associated destructive arthritis) is a rheumatological condition similar to calcium pyrophosphate dihydrate deposition disease (CPPD).
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Monofluorophosphate
Monofluorophosphate is an anion with the formula PO3F2−, which is a phosphate group with one oxygen atom substituted with a fluoride atom.
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Myeloid and erythroid nuclear termination stage-specific protein
Myeloid and erythroid nuclear termination stage-specific protein (MENT) is a member of the serpin family of protease inhibitors, and participates in DNA and chromatin condensation.
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Narlaprevir
Narlaprevir (trade name Arlansa, codenamed SCH 900518), is an inhibitor of NS3/4A serine protease, intended for the treatment of chronic hepatitis C caused by genotype 1 virus) in combination with other antiviral drugs. Narlaprevir is the first Russian tableted medication for the treatment of chronic hepatitis C.
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Nattokinase
Nattokinase (pronounced nat-oh-KAI-nase) is an enzyme extracted and purified from a Japanese food called nattō.
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Nest (protein structural motif)
The Nest is a type of protein structural motif.
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Netherton syndrome
Netherton syndrome is a severe, autosomal recessive form of ichthyosis associated with mutations in the SPINK5 gene.
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Neutrophil
Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.
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NS3 (HCV)
Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is 70 kDa cleavage product of the hepatitis C virus polyprotein.
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Outer membrane porin D
Outer membrane porin D is a protein family containing bacterial outer membrane porins which are involved in transport of cationic amino acids, peptides, antibiotics and other compounds.
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Ovalbumin
Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up approximately 55% of the total protein.
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Ovomucoid
Ovomucoid is a protein found in egg whites.
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PA clan
The PA clan ('''P'''roteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology.
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Pacifastin
Pacifastin is a family of serine proteinase inhibitors found in arthropods.
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Pancreatic elastase
Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin.
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Papain
Papain, also known as papaya proteinase I, is a cysteine protease enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis).
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Paritaprevir
Paritaprevir (previously known as ABT-450) is an acylsulfonamide inhibitor of the NS3-4A serine protease manufactured by Abbott Laboratories that shows promising results as a treatment of hepatitis C. When given in combination with ritonavir and ribavirin for 12 weeks, the rate of sustained virologic response at 24 weeks after treatment has been estimated to be 95% for those with hepatitis C virus genotype 1.
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Pathophysiology of hypertension
Pathophysiology is a branch of medicine which explains the function of the body as it relates to diseases and conditions.
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Penicillium chrysogenum
Penicillium chrysogenum or P. notatum (formerly) is a species of fungus in the family Trichocomaceae.
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Peptidase 1 (mite)
Peptidase 1 (mite), also known as endopeptidase 1 (mite), is an enzyme found in various species of mites.
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Peptidase Do
Peptidase Do (DegP, DegP protease, HtrA, high temperature requirement protease A, HrtA heat shock protein, protease Do, Do protease) is an enzyme.
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Peptidylprolyl isomerase A
Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the PPIA gene on chromosome 7.
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Philodryas olfersii
Philodryas olfersii is a species of colubrid snake, endemic to South America, known by the common names Lichtenstein's green racer, The Reptile Database.
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Plasmin
Plasmin is an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots.
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Plasminogen activator
Plasminogen activators are serine proteases that catalyze the activation of plasmin via proteolytic cleavage of its zymogen form plasminogen.
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Plasminogen activator inhibitor-1
Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene.
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Plasminogen activator inhibitor-2
Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that inactivates tPA and urokinase.
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PMSF
In biochemistry, phenylmethane sulfonyl fluoride or phenylmethylsulfonyl fluoride (PMSF) is a serine protease inhibitor commonly used in the preparation of cell lysates.
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Polysulfated glycosaminoglycan
) --> Polysulfated glycosaminoglycan (PSGAG), sold under the brand name Adequan, is an injectable drug for dogs and horses that is used to alleviate the lameness, pain, and lowered range of motion caused by arthritis. It is made of repeat disaccharide units (comprising hexosamine and hexuronic acid), and is similar to glycosaminoglycans already present in the cartilage; PSAG thus easily integrates itself there. In vitro studies have shown it to inhibit the enzymes that degrade cartilage and bone, as well as suppress inflammation and stimulate the synthesis of replacement cartilage. While it can cause an increased risk of bleeding, its relatively safe and has a high LD50. PSAG and is one of the most widely prescribed joint supplements for horses. While it is widely used, some studies still show conflicting results in terms of efficacy, causing some to claim that PSGAG is not solely responsible for the significant mitigation of arthritis seen in success cases.
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Prekallikrein
Prekallikrein (PK), also known as Fletcher factor, is an 85,000 Mr serine protease that complexes with high-molecular-weight kininogen.
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Proprotein convertase 2
Proprotein convertase 2 (PC2) also known as prohormone convertase 2 or neuroendocrine convertase 2 (NEC2) is a serine protease and proprotein convertase PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates.
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Prostate-specific antigen
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus. PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia.
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Protease
A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.
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Protease-activated receptor
Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain.
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Proteases (medical and related uses)
Proteases (also sometimes referred to as proteolytic enzymes or peptidases) are in use, or have been proposed or tried, for a number of purposes related to medicine or surgery.
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Protein C
Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals.
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Protein catabolism
Protein catabolism is the breakdown of proteins into amino acids and simple derivative compounds, for transport into the cell through the plasma membrane and ultimately for the polymerization into new proteins via the use of ribonucleic acids (RNA) and ribosomes.
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Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.
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Protein superfamily
A protein superfamily is the largest grouping (clade) of proteins for which common ancestry can be inferred (see homology).
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Protein Z
Protein Z (PZ or PROZ) is a protein which in humans is encoded by the PROZ gene.
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Proteinase 3
Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene.
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Proteinase K
In molecular biology Proteinase K (protease K, endopeptidase K, Tritirachium alkaline proteinase, Tritirachium album serine proteinase, Tritirachium album proteinase K) is a broad-spectrum serine protease.
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Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
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PRSS2
Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.
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PRSS3
Protease, serine, 3 is a protein that in humans is encoded by the PRSS3 gene.
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PRSS8
Prostasin is a protein that in humans is encoded by the PRSS8 gene.
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Puromycin
Puromycin is an antibiotic protein synthesis inhibitor which causes premature chain termination during translation.
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Purpureocillium
Purpureocillium is a fungal genus in the Ophiocordycipitaceae family.
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Randy Read
Randy John Read (born 9 June 1957) is a Wellcome Trust Principal Research Fellow and Professor of Protein Crystallography at the University of Cambridge.
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Reelin
Reelin (RELN) is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell-cell interactions.
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RHBDF1
Inactive rhomboid protein 1 (iRhom1) also known as rhomboid 5 homolog 1 or rhomboid family member 1 (RHBDF1) is a protein that in humans is encoded by the RHBDF1 gene.
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RHBDF2
Rhomboid family member 2 is a protein that in humans is encoded by the RHBDF2 gene.
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Rhomboid protease
The rhomboid proteases are a family of enzymes that exist in almost all species.
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Rhomboid, veinlet-like 2 (drosophila)
Rhomboid, veinlet-like 2 (Drosophila) is a protein that in humans is encoded by the RHBDL2 gene.
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Serine
Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.
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Serine hydrolase
Serine hydrolases are one of the largest known enzyme classes comprising approximately ~200 enzymes or 1% of the genes in the human proteome.
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Serpin
Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life.
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SERPINA2
Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 is a protein that in humans is encoded by the SERPINA2 gene.
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Signal peptidase
Signal peptidases are enzymes that convert secretory and some membrane proteins to their mature forms by cleaving their signal peptides from their N-terminals.
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Skin whitening
Skin whitening is the practice of using substances, mixtures, or physical treatments to lighten skin color.
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Sp/KLF family
The Sp/KLF family (specificity protein/Krüppel-like factor) is a family of transcription factors, including the Kruppel-like factors as well as Sp1, Sp2, Sp3, Sp4, Sp8, Sp9; and possibly Sp5 and Sp7.
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SPINT2
Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene.
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Sporothrix schenckii
Sporothrix schenckii is a fungus that can be found worldwide in the environment.
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Statistical coupling analysis
Statistical coupling analysis or SCA is a technique used in bioinformatics to measure covariation between pairs of amino acids in a protein multiple sequence alignment (MSA).
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Streptococcus pyogenes
Streptococcus pyogenes is a species of Gram-positive bacteria.
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Subtilase
Subtilases are a family of subtilisin-like serine proteases.
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Subtilisin
Subtilisin is a non-specific protease (a protein-digesting enzyme) initially obtained from Bacillus subtilis.
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Tej P. Singh
Tej P. Singh (born 1944) is an Indian biophysicist known for his work in the fields of Rational Structure-based drug design, Protein Structure biology and X-ray crystallography. He has played an active role in the development of drug design in the fields of Antibacterial therapeutics, Tuberculosis, Inflammation, Cancer and Gastropathy. He is a fellow of six academies, namely, the Third World Academy of Sciences, Indian National Science Academy, National Academy of Sciences Indian Academy of Sciences, Alexander von Humboldt Foundation and Biotech Research Society of India.
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TEV protease
TEV protease (Tobacco Etch Virus nuclear-inclusion-a endopeptidase) is a highly sequence-specific cysteine protease from Tobacco Etch Virus (TEV).
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Threonine protease
Threonine proteases are a family of proteolytic enzymes harbouring a threonine (Thr) residue within the active site.
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Thrombin
Thrombin (fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
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Thrombin receptor
There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor).
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Tissue factor
Tissue factor, also called platelet tissue factor, factor III, or CD142 is a protein encoded by the F3 gene, present in subendothelial tissue and leukocytes.
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Tissue plasminogen activator
Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots.
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TMPRSS3
Transmembrane protease, serine 3 is an enzyme that in humans is encoded by the TMPRSS3 gene.
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Toxin
A toxin (from toxikon) is a poisonous substance produced within living cells or organisms; synthetic toxicants created by artificial processes are thus excluded.
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Trichoderma longibrachiatum
Trichoderma longibrachiatum is a fungus in the genus Trichoderma.
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Tripeptidyl peptidase I
Tripeptidyl-peptidase 1, also known as Lysosomal pepstatin-insensitive protease, is an enzyme that in humans is encoded by the TPP1 gene.
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Trypsin
Trypsin is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyzes proteins.
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Trypsin 1
Trypsin-1, also known as cationic trypsinogen, is a protein that in humans is encoded by the PRSS1 gene.
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Trypsin inhibitor
A trypsin inhibitor is a type of serine protease inhibitor that reduces the biological activity of trypsin.
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Tryptase
Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
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TSG-6
Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans is encoded by the TNFAIP6 (tumor necrosis factor, alpha-induced protein 6) gene.
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Ulinastatin
Ulinastatin, as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine or synthetically produced and has molecular weight of 25 - 25kDa.
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Urokinase
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals.
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Venoms in medicine
Venom in medicine is the medicinal use of venoms for therapeutic benefit in treating diseases.
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Wheat allergy
Wheat allergy is an allergy to wheat which typically presents itself as a food allergy, but can also be a contact allergy resulting from occupational exposure.
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(S)-hydroxynitrile lyase
(S)-hydroxynitrile lyase ((S)-cyanohydrin producing hydroxynitrile lyase, (S)-oxynitrilase, (S)-HbHNL, (S)-MeHNL, hydroxynitrile lyase, oxynitrilase, HbHNL, MeHNL, (S)-selective hydroxynitrile lyase, (S)-cyanohydrin carbonyl-lyase (cyanide forming), hydroxynitrilase) is an enzyme with systematic name (S)-cyanohydrin lyase (cyanide forming).
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Redirects here:
Chymotrypsin-like endopeptidase, EC 3.4.21.-, Ser protease, Serine endopeptidase, Serine endopeptidases, Serine proteases, Serine proteinase, Serine proteinase inhibitors, Serine type carboxypeptidase.
References
[1] https://en.wikipedia.org/wiki/Serine_protease
