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13 relations: Active metabolite, Bone marrow suppression, Camptothecin, Carboxylesterase, Chemotherapy, Diarrhea, Glucuronidation, Irinotecan, NK012, Sacituzumab govitecan, TOP1, Toxicity, UDP glucuronosyltransferase 1 family, polypeptide A1.
Active metabolite
An active metabolite is an active form of a drug after it has been processed by the body.
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Bone marrow suppression
Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes).
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Camptothecin
Camptothecin (CPT) is a topoisomerase inhibitor.
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Carboxylesterase
In enzymology, a carboxylesterase or carboxylic-ester hydrolase is an enzyme that catalyzes a chemical reaction of the form Thus, the two substrates of this enzyme are carboxylic ester and H2O, whereas its two products are alcohol and carboxylate.
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Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.
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Diarrhea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose or liquid bowel movements each day.
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Glucuronidation
Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.
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Irinotecan
Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer.
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NK012
NK012 is a 'nanodevice' formulation of SN-38 (an irinotecan metabolite).
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Sacituzumab govitecan
Sacituzumab govitecan (IMMU-132 or hRS7-SN-38) is an investigational antibody-drug conjugate.
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TOP1
DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.
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Toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism.
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UDP glucuronosyltransferase 1 family, polypeptide A1
UDP-glucuronosyltransferase 1-1 also known as UGT-1A is an enzyme that in humans is encoded by the UGT1A1 gene.
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7-ethyl-10-hydroxy-camptothecin.
