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30 relations: Agonist, Antidepressant, Anxiolytic, Binding selectivity, Enantiomer, Endogeny (biology), ERB-196, Erteberel, Estradiol, Estrogen receptor alpha, Estrogen receptor beta, GPER, IC50, Intrinsic activity, Ligand (biochemistry), Liquiritigenin, Menerba, Nonsteroidal, Nyasol, Organic compound, Oxytocin, Phytoestrogens, Prinaberel, Racemic mixture, Receptor (biochemistry), Scientific method, WAY-166818, WAY-200070, WAY-214156, 8β-VE2.
Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Antidepressant
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
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Anxiolytic
An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety.
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Binding selectivity
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
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Enantiomer
In chemistry, an enantiomer, also known as an optical isomer (and archaically termed antipode or optical antipode), is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).
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Endogeny (biology)
Endogenous substances and processes are those that originate from within an organism, tissue, or cell.
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ERB-196
ERB-196, also known as WAY-202196, is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ.
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Erteberel
Erteberel (former developmental code name LY-500307), also known as selective estrogen receptor beta agonist-1 (SERBA-1), is a synthetic, nonsteroidal estrogen which acts as a selective ERβ agonist and is under development by Eli Lilly for the treatment of schizophrenia.
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Estradiol
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
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Estrogen receptor alpha
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.
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Estrogen receptor beta
Estrogen receptor beta (ER-β), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is one of two main types of estrogen receptor, a nuclear receptor which is activated by the sex hormone estrogen.
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GPER
G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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Intrinsic activity
Intrinsic activity (IA) or efficacy refers to the relative ability of a drug-receptor complex to produce a maximum functional response.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Liquiritigenin
Liquiritigenin is a flavanone that was isolated from Glycyrrhiza uralensis, and is found in a variety of plants, including Glycyrrhiza glabra (licorice).
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Menerba
Menerba, also known as Menopause Formula 101 (MF-101), is a botanical drug candidate that acts as a selective estrogen receptor modulator (SERM) which is being studied for its potential to relieve hot flashes associated with menopause.
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Nonsteroidal
Nonsteroidal is a term which is used to describe a compound that is not a steroid.
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Nyasol
Nyasol, also known as cis-hinokiresinol or as (Z)-hinokiresinol, is a lignan that is found in Anemarrhena asphodeloides.
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Organic compound
In chemistry, an organic compound is generally any chemical compound that contains carbon.
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Oxytocin
Oxytocin (Oxt) is a peptide hormone and neuropeptide.
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Phytoestrogens
Phytoestrogens are plant-derived xenoestrogens (see estrogen) not generated within the endocrine system, but consumed by eating phytoestrogenic plants.
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Prinaberel
Prinaberel (INN, USAN) (developmental code names ERB-041, WAY-202041) is a synthetic, nonsteroidal, and highly selective agonist of the ERβ subtype of the estrogen receptor.
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Racemic mixture
In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Scientific method
Scientific method is an empirical method of knowledge acquisition, which has characterized the development of natural science since at least the 17th century, involving careful observation, which includes rigorous skepticism about what one observes, given that cognitive assumptions about how the world works influence how one interprets a percept; formulating hypotheses, via induction, based on such observations; experimental testing and measurement of deductions drawn from the hypotheses; and refinement (or elimination) of the hypotheses based on the experimental findings.
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WAY-166818
WAY-166818 is a synthetic, nonsteroidal estrogen related to WAY-200070 which is used in scientific research.
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WAY-200070
WAY-200070 is a synthetic, nonsteroidal, highly selective agonist of ERβ.
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WAY-214156
WAY-214156 is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ.
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8β-VE2
8β-VE2, or 8β-vinylestradiol, also known as 8β-vinylestra-1,3,5(10)-triene-3β,17β-diol, is a synthetic estrogen featuring an estradiol core.
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References
[1] https://en.wikipedia.org/wiki/Diarylpropionitrile
