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50 relations: Anaphylaxis, Anti-diabetic medication, Astellas Pharma, Beta cell, Bioavailability, Biological half-life, Blood pressure, Blood sugar level, Body mass index, Boehringer Ingelheim, Canagliflozin, Clearance (pharmacology), Dapagliflozin, Diabetes management, Diabetes mellitus type 2, Diabetes.co.uk, Dose–response relationship, Drug development, Empagliflozin, Endothelium, Epithelium, Ertugliflozin, Food and Drug Administration, Glimepiride, Heart, Human body weight, Hypoglycemia, Insulin, Ipragliflozin, Ketoacidosis, Mechanism of action, Metabolic pathway, Metformin, Pharmacokinetics, Phlorizin, Pioglitazone, Plasma protein binding, Proximal tubule, Reabsorption, Remogliflozin etabonate, Renal function, Renal glucose reabsorption, Sanofi, Sergliflozin etabonate, SGLT2, Sitagliptin, SLC5A1, Tofogliflozin, Urinary tract infection, Vaginal yeast infection.
Anaphylaxis
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
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Anti-diabetic medication
Drugs used in diabetes treat diabetes mellitus by lowering glucose levels in the blood.
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Astellas Pharma
is a Japanese pharmaceutical company, formed on 1 April 2005 from the merger of and.
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Beta cell
Beta cells (β cells) are a type of cell found in the pancreatic islets of the pancreas.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Biological half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
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Blood pressure
Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.
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Blood sugar level
The blood sugar level, blood sugar concentration, or blood glucose level is the amount of glucose present in the blood of humans and other animals.
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Body mass index
The body mass index (BMI) or Quetelet index is a value derived from the mass (weight) and height of an individual.
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Boehringer Ingelheim
C.H. Boehringer Sohn AG & Ko.
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Canagliflozin
No description.
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Clearance (pharmacology)
In pharmacology, the clearance is a pharmacokinetic measurement of the volume of plasma from which a substance is completely removed per unit time; the usual units are mL/min.
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Dapagliflozin
Dapagliflozin (INN, USAN, trade name Farxiga in the U.S. and Forxiga in the EU and Russia) is a drug of the gliflozin class, used to treat type 2 diabetes.
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Diabetes management
The term diabetes includes several different metabolic disorders that all, if left untreated, result in abnormally high concentration of a sugar called glucose in the blood.
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Diabetes mellitus type 2
Diabetes mellitus type 2 (also known as type 2 diabetes) is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
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Diabetes.co.uk
Diabetes.co.uk is a British-based brand and digital communication channel with over 650,000 members, providing digital therapeutics, news and information on diabetes, evidence-based education programmes, newsletters, cookbooks and a patient network that improves the health of people with diabetes, the Diabetes Forum.
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Dose–response relationship
The dose–response relationship, or exposure–response relationship, describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a chemical) after a certain exposure time, or to a food.
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Drug development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.
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Empagliflozin
Empagliflozin (trade name Jardiance) is a drug of the gliflozin class, approved for the treatment of type 2 diabetes in adults in 2014.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Epithelium
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
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Ertugliflozin
Ertugliflozin (INN; trade name Steglatro) is a drug for the treatment of type 2 diabetes.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Glimepiride
Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug.
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Heart
The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.
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Human body weight
Human body weight refers to a person's mass or weight.
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Hypoglycemia
Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels.
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Insulin
Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.
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Ipragliflozin
Ipragliflozin (INN, trade names Suglat) is a pharmaceutical drug for treatment of type 2 diabetes.
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Ketoacidosis
Ketoacidosis is a metabolic state associated with high concentrations of ketone bodies, formed by the breakdown of fatty acids and the deamination of amino acids.
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Mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.
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Metabolic pathway
In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell.
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Metformin
Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight.
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Pharmacokinetics
Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered to a living organism.
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Phlorizin
Phlorizin (also referred to as phloridzin; chemical name phloretin-2'-β-D-glucopyranoside) is a glucoside of phloretin, a dihydrochalcone, a family of bicyclic flavonoids, which in turn is a subgroup in the diverse phenylpropanoid synthesis pathway in plants.
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Pioglitazone
Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione (TZD) class with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes.
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Plasma protein binding
Plasma protein binding refers to the degree to which medications attach to proteins within the blood.
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Proximal tubule
The proximal tubule is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle.
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Reabsorption
In renal physiology, reabsorption or tubular reabsorption is the process by which the nephron removes water and solutes from the tubular fluid (pre-urine) and returns them to the circulating blood.
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Remogliflozin etabonate
Remogliflozin etabonate (INN/USAN) is a proposed drug of the gliflozin class for the treatment of non-alcoholic steatohepatitis ("NASH") and type 2 diabetes.
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Renal function
Renal function, in nephrology, is an indication of the kidney's condition and its role in renal physiology.
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Renal glucose reabsorption
Renal glucose reabsorption is the part of kidney (renal) physiology that deals with the retrieval of filtered glucose, preventing it from disappearing from the body through the urine.
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Sanofi
Sanofi S.A. is a French multinational pharmaceutical company headquartered in Gentilly, France, as of 2013 the world's fifth-largest by prescription sales.
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Sergliflozin etabonate
Sergliflozin etabonate (INN/USAN, codenamed GW869682X) is an investigational anti-diabetic drug being developed by GlaxoSmithKline.
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SGLT2
The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter)) gene.
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Sitagliptin
Sitagliptin (INN;, previously identified as MK-0431 and marketed as the phosphate salt under the trade name Januvia) is an oral antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
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SLC5A1
Sodium/glucose cotransporter 1 also known as solute carrier family 5 member 1 is a protein that in humans is encoded by the SLC5A1 gene.
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Tofogliflozin
Tofogliflozin (INN, USAN, codenamed CSG452) is an experimental drug for the treatment of diabetes mellitus and is being developed by Chugai Pharma in collaboration with Kowa and Sanofi.
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Urinary tract infection
A urinary tract infection (UTI) is an infection that affects part of the urinary tract.
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Vaginal yeast infection
Vaginal yeast infection, also known as candidal vulvovaginitis and vaginal thrush, is excessive growth of yeast in the vagina that results in irritation.
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Gliflozins, SGLT-2 inhibitor, SGLT2 inhibitor, SGLT2 inhibitors, Sodium glucose transporter (SGLT2) inhibitors.
References
[1] https://en.wikipedia.org/wiki/Gliflozin
