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79 relations: A-349,821, ABT-239, Acetylcholine, Agonist, Alzheimer's disease, Amine, Antihistamine, Anxiety, Aromaticity, Attention deficit hyperactivity disorder, Autoreceptor, Basal ganglia, Betahistine, Bioavailability, Biochemical Pharmacology (journal), Calcium, Cataplexy, Central nervous system, Cerebral cortex, Cerebrospinal fluid, Ciproxifan, Circadian rhythm, Clinical trial, Clobenpropit, Cognition, Conessine, CYP3A4, Cytochrome P450, Dopamine, Drug development, First pass effect, G protein–coupled receptor, GABAergic, Gamma-Aminobutyric acid, Gene isoform, Glutamic acid, Headache, Hepatotoxicity, HERG, Heteroreceptor, Hippocampus, Histamine, Histamine H3 receptor, Histamine H4 receptor, Hypnagogia, Imidazole, In vivo, Insomnia, Inverse agonist, Isozyme, ..., Journal of Pharmacology and Experimental Therapeutics, Ligand, Lipophilicity, Long QT syndrome, Medication, Metabolic pathway, Narcolepsy, Neurodegeneration, Neuropsychiatry, Neurotransmitter, Nootropic, Norepinephrine, Orphan drug, P-glycoprotein, Parkinson's disease, Pathophysiology, Peripheral nervous system, Pharmacology, Phospholipidosis, Pitolisant, Potassium channel, Receptor antagonist, Schizophrenia, Sedation, Serotonin, Side effect, Stimulant, Thalamocortical radiations, Thioperamide. Expand index (29 more) »
A-349,821
A-349,821 is a potent and selective histamine H3 receptor antagonist (or possibly an inverse agonist).
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ABT-239
ABT-239 is an H3-receptor inverse agonist developed by Abbott.
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Acetylcholine
Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals, including humans, as a neurotransmitter—a chemical message released by nerve cells to send signals to other cells.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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Amine
In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.
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Antihistamine
Antihistamines are drugs which treat allergic rhinitis and other allergies.
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Anxiety
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.
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Aromaticity
In organic chemistry, the term aromaticity is used to describe a cyclic (ring-shaped), planar (flat) molecule with a ring of resonance bonds that exhibits more stability than other geometric or connective arrangements with the same set of atoms.
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Attention deficit hyperactivity disorder
Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.
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Autoreceptor
An autoreceptor is a type of receptor located in the membranes of presynaptic nerve cells.
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Basal ganglia
The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.
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Betahistine
Betahistine, sold under the brand name Serc among others, is an anti-vertigo medication.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Biochemical Pharmacology (journal)
Biochemical Pharmacology is a peer-reviewed medical journal published by Elsevier.
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Calcium
Calcium is a chemical element with symbol Ca and atomic number 20.
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Cataplexy
Cataplexy is a sudden and transient episode of muscle weakness accompanied by full conscious awareness, typically triggered by emotions such as laughing, crying, or terror.
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Cerebral cortex
The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.
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Cerebrospinal fluid
Cerebrospinal fluid (CSF) is a clear, colorless body fluid found in the brain and spinal cord.
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Ciproxifan
Ciproxifan is an extremely potent histamine H3 inverse agonist/antagonist.
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Circadian rhythm
A circadian rhythm is any biological process that displays an endogenous, entrainable oscillation of about 24 hours.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Clobenpropit
Clobenpropit is a histamine H3 receptor antagonist.
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Cognition
Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".
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Conessine
Conessine is a steroid alkaloid found in a number of plant species from the Apocynaceae family, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
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Drug development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.
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First pass effect
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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GABAergic
GABAergic means "pertaining to or affecting the neurotransmitter GABA".
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Gamma-Aminobutyric acid
gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.
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Gene isoform
Gene isoforms are mRNAs that are produced from the same locus but are different in their transcription start sites (TSSs), protein coding DNA sequences (CDSs) and/or untranslated regions (UTRs), potentially altering gene function.
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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Headache
Headache is the symptom of pain anywhere in the region of the head or neck.
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Hepatotoxicity
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
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HERG
hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel.
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Heteroreceptor
A heteroreceptor is a receptor regulating the synthesis and/or the release of mediators other than its own ligand.
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Hippocampus
The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.
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Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
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Histamine H3 receptor
Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release.
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Histamine H4 receptor
The histamine H4 receptor is, like the other three histamine receptors, a member of the G protein-coupled receptor superfamily.
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Hypnagogia
Hypnagogia, also referred to as "hypnagogic hallucinations", is the experience of the transitional state from wakefulness to sleep: the hypnagogic state of consciousness, during the onset of sleep.
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Imidazole
Imidazole is an organic compound with the formula C3N2H4.
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In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
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Inverse agonist
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.
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Isozyme
Isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.
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Journal of Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and Experimental Therapeutics (a.k.a. JPET) is a peer-reviewed scientific journal covering pharmacology.
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Ligand
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
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Lipophilicity
Lipophilicity (from Greek λίπος "fat" and φίλος "friendly"), refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.
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Long QT syndrome
Long QT syndrome (LQTS) is a condition which affects repolarization of the heart after a heartbeat.
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Medication
A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
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Metabolic pathway
In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell.
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Narcolepsy
Narcolepsy is a long-term neurological disorder that involves a decreased ability to regulate sleep-wake cycles.
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Neurodegeneration
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.
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Neuropsychiatry
Neuropsychiatry is a branch of medicine that deals with mental disorders attributable to diseases of the nervous system.
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Neurotransmitter
Neurotransmitters are endogenous chemicals that enable neurotransmission.
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Nootropic
Nootropics, also known as smart drugs and cognitive enhancers, are drugs, supplements, and other substances that purport to improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals.
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Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
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Orphan drug
An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.
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P-glycoprotein
P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Pathophysiology
Pathophysiology or physiopathology is a convergence of pathology with physiology.
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Peripheral nervous system
The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).
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Pharmacology
Pharmacology is the branch of biology concerned with the study of drug action, where a drug can be broadly defined as any man-made, natural, or endogenous (from within body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word pharmacon is used as a term to encompass these endogenous and exogenous bioactive species).
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Phospholipidosis
Phospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues.
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Pitolisant
Pitolisant, also known as tiprolisant, and sold under the brand name Wakix, is a potent and selective inverse agonist of the histamine H3 receptor (Ki.
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Potassium channel
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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Sedation
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
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Stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.
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Thalamocortical radiations
Thalamocortical radiations are the fibers between the thalamus and the cerebral cortex.
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Thioperamide
Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier.
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References
[1] https://en.wikipedia.org/wiki/H3_receptor_antagonist
