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48 relations: Aqueous solution, Assay, Automation, Biology, Caenorhabditis elegans, Cell (biology), Chemical compound, Chemistry, Colony picker, Compound management, Dimethyl sulfoxide, DNA-encoded chemical library, Drug discovery, Dual-flashlight plot, EC50, Embryo, Experiment, Fluorescence microscope, Genomics, High throughput biology, High-content screening, Hill equation (biochemistry), Hit to lead, IC50, Lab on a Chip (journal), Laboratory automation, Litre, Microscopy, Microtiter plate, National Institutes of Health, Open access (infrastructure), Pipette, Protein, Robot, Robotics, Rockefeller University, Royal Society of Chemistry, Scientific control, Small interfering RNA, Small molecule, Strictly standardized mean difference, Synthetic genetic array, T-statistic, Two-hybrid screening, University of California, Los Angeles, Virtual screening, Z-factor, Zebrafish.
Aqueous solution
An aqueous solution is a solution in which the solvent is water.
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Assay
An assay is an investigative (analytic) procedure in laboratory medicine, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a target entity (the analyte).
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Automation
Automation is the technology by which a process or procedure is performed without human assistance.
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Biology
Biology is the natural science that studies life and living organisms, including their physical structure, chemical composition, function, development and evolution.
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Caenorhabditis elegans
Caenorhabditis elegans is a free-living (not parasitic), transparent nematode (roundworm), about 1 mm in length, that lives in temperate soil environments.
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Cell (biology)
The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.
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Chemical compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) composed of atoms from more than one element held together by chemical bonds.
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Chemistry
Chemistry is the scientific discipline involved with compounds composed of atoms, i.e. elements, and molecules, i.e. combinations of atoms: their composition, structure, properties, behavior and the changes they undergo during a reaction with other compounds.
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Colony picker
A colony picker is an instrument used to automatically identify microbial colonies growing on a solid media, pick them and duplicate them either onto solid or liquid media.
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Compound management
Drug discovery depends on methods by which many different chemicals are assayed for their activity.
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Dimethyl sulfoxide
Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO.
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DNA-encoded chemical library
DNA-encoded chemical libraries (DEL) is a technology for the synthesis and screening on unprecedented scale of collections of small molecule compounds.
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Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
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Dual-flashlight plot
In statistics, a dual-flashlight plot is a type of scatter-plot in which the standardized mean (SMCV) is plotted against the mean of a contrast variable representing a comparison of interest.
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EC50
Half maximal effective concentration (EC50) refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.
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Embryo
An embryo is an early stage of development of a multicellular diploid eukaryotic organism.
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Experiment
An experiment is a procedure carried out to support, refute, or validate a hypothesis.
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Fluorescence microscope
A fluorescence microscope is an optical microscope that uses fluorescence and phosphorescence instead of, or in addition to, reflection and absorption to study properties of organic or inorganic substances.
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Genomics
Genomics is an interdisciplinary field of science focusing on the structure, function, evolution, mapping, and editing of genomes.
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High throughput biology
High throughput cell biology is the use of automation equipment with classical cell biology techniques to address biological questions that are otherwise unattainable using conventional methods.
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High-content screening
High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner.
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Hill equation (biochemistry)
No description.
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Hit to lead
Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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Lab on a Chip (journal)
Lab on a Chip is a peer-reviewed scientific journal which publishes original (primary) research and review articles on any aspect of miniaturisation at the micro and nano scale.
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Laboratory automation
Laboratory automation is a multi-disciplinary strategy to research, develop, optimize and capitalize on technologies in the laboratory that enable new and improved processes.
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Litre
The litre (SI spelling) or liter (American spelling) (symbols L or l, sometimes abbreviated ltr) is an SI accepted metric system unit of volume equal to 1 cubic decimetre (dm3), 1,000 cubic centimetres (cm3) or 1/1,000 cubic metre. A cubic decimetre (or litre) occupies a volume of 10 cm×10 cm×10 cm (see figure) and is thus equal to one-thousandth of a cubic metre. The original French metric system used the litre as a base unit. The word litre is derived from an older French unit, the litron, whose name came from Greek — where it was a unit of weight, not volume — via Latin, and which equalled approximately 0.831 litres. The litre was also used in several subsequent versions of the metric system and is accepted for use with the SI,, p. 124. ("Days" and "hours" are examples of other non-SI units that SI accepts.) although not an SI unit — the SI unit of volume is the cubic metre (m3). The spelling used by the International Bureau of Weights and Measures is "litre", a spelling which is shared by almost all English-speaking countries. The spelling "liter" is predominantly used in American English. One litre of liquid water has a mass of almost exactly one kilogram, because the kilogram was originally defined in 1795 as the mass of one cubic decimetre of water at the temperature of melting ice. Subsequent redefinitions of the metre and kilogram mean that this relationship is no longer exact.
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Microscopy
Microscopy is the technical field of using microscopes to view objects and areas of objects that cannot be seen with the naked eye (objects that are not within the resolution range of the normal eye).
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Microtiter plate
A microtiter plate (spelled Microtiter is a registered trade name in the United States) or microplate or microwell plate or multiwell, is a flat plate with multiple "wells" used as small test tubes.
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National Institutes of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research, founded in the late 1870s.
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Open access (infrastructure)
In the context of infrastructure, open access involves physical infrastructure such as railways and physical telecommunications network plant being made available to clients other than the owners, for a fee.
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Pipette
A pipette (sometimes spelled pipet) is a laboratory tool commonly used in chemistry, biology and medicine to transport a measured volume of liquid, often as a media dispenser.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Robot
A robot is a machine—especially one programmable by a computer— capable of carrying out a complex series of actions automatically.
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Robotics
Robotics is an interdisciplinary branch of engineering and science that includes mechanical engineering, electronics engineering, computer science, and others.
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Rockefeller University
The Rockefeller University is a center for scientific research, primarily in the biological and medical sciences, that provides doctoral and postdoctoral education.
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Royal Society of Chemistry
The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemical sciences".
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Scientific control
A scientific control is an experiment or observation designed to minimize the effects of variables other than the independent variable.
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Small interfering RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway.
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Small molecule
Within the fields of molecular biology and pharmacology, a small molecule is a low molecular weight (< 900 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm.
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Strictly standardized mean difference
In statistics, the strictly standardized mean difference (SSMD) is a measure of effect size.
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Synthetic genetic array
Synthetic genetic array analysis (SGA) is a high-throughput technique for exploring synthetic lethal and synthetic sick genetic interactions (SSL).
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T-statistic
In statistics, the t-statistic is the ratio of the departure of the estimated value of a parameter from its hypothesized value to its standard error.
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Two-hybrid screening
Two-hybrid screening (originally known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively.
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University of California, Los Angeles
The University of California, Los Angeles (UCLA) is a public research university in the Westwood district of Los Angeles, United States.
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Virtual screening
Virtual screening (VS) is a computational technique used in drug discovery to search libraries of small molecules in order to identify those structures which are most likely to bind to a drug target, typically a protein receptor or enzyme.
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Z-factor
The Z-factor is a measure of statistical effect size.
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Zebrafish
The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.
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High throughput drug screening, High throughput screening, High throughput screening (HTS), High-throughput experimentation, High-throughput screening (HTS).
References
[1] https://en.wikipedia.org/wiki/High-throughput_screening
