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65 relations: Abbott Laboratories, Adalimumab, Antibody, Bacteria, Bacterial display, Bacteriophage, Biopanning, Buffering agent, Cambridge Antibody Technology, Capsid, Code, Coding region, Complementary DNA, Directed evolution, DNA, DNA ligase, DNA sequencing, DNA-binding protein, Drug discovery, Elution, Enterobacteria phage T4, Escherichia coli, Filamentous bacteriophage, Fragment antigen-binding, Gene duplication, Genotype, German Cancer Research Center, Greg Winter, Helper virus, In vitro, John McCafferty, Laboratory of Molecular Biology, Lambda phage, Ligand, M13 bacteriophage, Microtiter plate, Mimotope, MRNA display, Multiple cloning site, Natural selection, Nucleic acid hybridization, Nucleic acid sequence, PelB leader sequence, Peptide, Phagemid, Phenotype, Protein, Protein engineering, Protein fragment library, Protein–protein interaction, ..., Reading frame, Ribosome display, Scripps Research Institute, T7 phage, Tetanospasmin, Therapy, Transduction (genetics), Translation (biology), Tumor antigen, Tumor necrosis factor alpha, Two-hybrid screening, Ultrasound, Vector (molecular biology), Virus, Yeast display. Expand index (15 more) »
Abbott Laboratories
Abbott Laboratories is an American health care company with headquarters in Lake Bluff, Illinois, United States.
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Adalimumab
Adalimumab, sold under the trade name Humira among others, is a medication used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, chronic psoriasis, hidradenitis suppurativa, and juvenile idiopathic arthritis.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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Bacteria
Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.
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Bacterial display
Bacterial display (or bacteria display or bacterial surface display) is a protein engineering technique used for in vitro protein evolution.
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Bacteriophage
A bacteriophage, also known informally as a phage, is a virus that infects and replicates within Bacteria and Archaea.
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Biopanning
Biopanning is an affinity selection technique which selects for peptides that bind to a given target.
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Buffering agent
A buffering agent is a weak acid or base used to maintain the acidity (pH) of a solution near a chosen value after the addition of another acid or base.
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Cambridge Antibody Technology
Cambridge Antibody Technology (officially Cambridge Antibody Technology Group Plc, informally CAT) was a biotechnology company headquartered in Cambridge, England, United Kingdom.
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Capsid
A capsid is the protein shell of a virus.
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Code
In communications and information processing, code is a system of rules to convert information—such as a letter, word, sound, image, or gesture—into another form or representation, sometimes shortened or secret, for communication through a communication channel or storage in a storage medium.
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Coding region
The coding region of a gene, also known as the CDS (from CoDing Sequence), is that portion of a gene's DNA or RNA that codes for protein.
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Complementary DNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.
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Directed evolution
Directed evolution (DE, "gelenkte Evolution") is a method used in protein engineering that mimics the process of natural selection to evolve proteins or nucleic acids toward a user-defined goal.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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DNA ligase
DNA ligase is a specific type of enzyme, a ligase, that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond.
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DNA sequencing
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule.
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DNA-binding protein
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA.
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Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
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Elution
In analytical and organic chemistry, elution is the process of extracting one material from another by washing with a solvent; as in washing of loaded ion-exchange resins to remove captured ions.
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Enterobacteria phage T4
Enterobacteria phage T4 is a bacteriophage that infects Escherichia coli bacteria.
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Escherichia coli
Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).
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Filamentous bacteriophage
A filamentous bacteriophage is a type of bacteriophage, or virus of bacteria, defined by its filament-like or rod-like shape.
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Fragment antigen-binding
The antigen-binding (Fab) fragment is a region on an antibody that binds to antigens.
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Gene duplication
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.
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Genotype
The genotype is the part of the genetic makeup of a cell, and therefore of an organism or individual, which determines one of its characteristics (phenotype).
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German Cancer Research Center
The German Cancer Research Center (known as the Deutsches Krebsforschungszentrum or simply DKFZ in German and also known as the German Cancer Consortium), is a national cancer research center based in Heidelberg, Germany.
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Greg Winter
Sir Gregory Paul Winter (born 14 April 1951) is a British biochemist, a pioneer of therapeutic monoclonal antibodies.
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Helper virus
A helper virus is a virus used when producing copies of a helper dependent viral vector which does not have the ability to replicate on its own.
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In vitro
In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
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John McCafferty
John McCafferty is a British scientist, one of the founders of Cambridge Antibody Technology, well known as one of the inventors of scFv antibody fragment phage display, a technology that revolutionised the monoclonal antibody drug discovery.
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Laboratory of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s, since then it remains a major medical research laboratory with a much broader focus.
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Lambda phage
Enterobacteria phage λ (lambda phage, coliphage λ) is a bacterial virus, or bacteriophage, that infects the bacterial species Escherichia coli (E. coli).
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Ligand
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
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M13 bacteriophage
M13 is a virus that infects the bacterium Escherichia coli.
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Microtiter plate
A microtiter plate (spelled Microtiter is a registered trade name in the United States) or microplate or microwell plate or multiwell, is a flat plate with multiple "wells" used as small test tubes.
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Mimotope
A mimotope is a macromolecule, often a peptide, which mimics the structure of an epitope.
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MRNA display
mRNA display is a display technique used for in vitro protein, and/or peptide evolution to create molecules that can bind to a desired target.
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Multiple cloning site
A multiple cloning site (MCS), also called a polylinker, is a short segment of DNA which contains many (up to ~20) restriction sites - a standard feature of engineered plasmids.
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Natural selection
Natural selection is the differential survival and reproduction of individuals due to differences in phenotype.
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Nucleic acid hybridization
In molecular biology, hybridization (or hybridisation) is a phenomenon in which single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules anneal to complementary DNA or RNA.
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Nucleic acid sequence
A nucleic acid sequence is a succession of letters that indicate the order of nucleotides forming alleles within a DNA (using GACT) or RNA (GACU) molecule.
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PelB leader sequence
The pelB leader sequence is a sequence of amino acids which when attached to a protein, directs the protein to the bacterial periplasm, where the sequence is removed by a signal peptidase.
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Phagemid
A phagemid or phasmid is a DNA-based cloning vector, which has both bacteriophage and plasmid properties.
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Phenotype
A phenotype is the composite of an organism's observable characteristics or traits, such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest).
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein engineering
Protein engineering is the process of developing useful or valuable proteins.
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Protein fragment library
Protein backbone fragment libraries have been used successfully in a variety of structural biology applications, including homology modeling,Kolodny, R., Guibas, L., Levitt, M., and Koehl, P. (2005, March).
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Reading frame
In molecular biology, a reading frame is a way of dividing the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule into a set of consecutive, non-overlapping triplets.
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Ribosome display
Ribosome display is a technique used to perform in vitro protein evolution to create proteins that can bind to a desired ligand.
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Scripps Research Institute
The Scripps Research Institute (TSRI) is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences.
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T7 phage
Bacteriophage T7 (or the T7 phage) is a bacteriophage, a virus that infects susceptible bacterial cells, that is composed of DNA and infects most strains of Escherichia coli.
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Tetanospasmin
Tetanus toxin is an extremely potent neurotoxin produced by the vegetative cell of Clostridium tetani in anaerobic conditions, causing tetanus.
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Therapy
Therapy (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a diagnosis.
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Transduction (genetics)
Transduction is the process by which foreign DNA is introduced into a cell by a virus or viral vector.
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Translation (biology)
In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.
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Tumor antigen
Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host.
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Tumor necrosis factor alpha
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.
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Two-hybrid screening
Two-hybrid screening (originally known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively.
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Ultrasound
Ultrasound is sound waves with frequencies higher than the upper audible limit of human hearing.
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Vector (molecular biology)
In molecular cloning, a vector is a DNA molecule used as a vehicle to artificially carry foreign genetic material into another cell, where it can be replicated and/or expressed (e.g.- plasmid, cosmid, Lambda phages).
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Virus
A virus is a small infectious agent that replicates only inside the living cells of other organisms.
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Yeast display
Yeast display (or yeast surface display) is a protein engineering technique that uses the expression of recombinant proteins incorporated into the cell wall of yeast for isolating and engineering antibodies.
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References
[1] https://en.wikipedia.org/wiki/Phage_display
