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52 relations: Alpha-synuclein, Alternative splicing, Alzheimer's disease, Astrocyte, Axon, C-terminus, Central nervous system, Chromosome 17, Chronic traumatic encephalopathy, Corticobasal degeneration, Dementia, Dendrite, Exon, Exosome complex, Frontotemporal dementia, Frontotemporal dementia and parkinsonism linked to chromosome 17, FYN, Gene, Haplogroup, Hyperphosphorylation, Intrinsically disordered proteins, Kinase, MAP6, Microtubule, Microtubule-associated protein, Microtubule-associated protein 2, N-terminus, Nervous system, Neurodegeneration, Neurofibrillary tangle, Neuron, Oligodendrocyte, Parkinson's disease, Pathogenesis, Phosphorylation, Pick's disease, Primary age-related tauopathy, Prion, Progressive supranuclear palsy, Protein domain, Protein folding, Protein isoform, Protein–protein interaction, Proteopathy, S100B, Self-assembly, Tau, Tauopathy, Transcription (biology), Traumatic brain injury, ..., Tubulin, YWHAZ. Expand index (2 more) »
Alpha-synuclein
Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene.
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Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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Astrocyte
Astrocytes (Astro from Greek astron.
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Axon
An axon (from Greek ἄξων áxōn, axis) or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that typically conducts electrical impulses known as action potentials, away from the nerve cell body.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Chromosome 17
Chromosome 17 is one of the 23 pairs of chromosomes in humans.
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Chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease found in people who have had multiple head injuries.
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Corticobasal degeneration
Corticobasal degeneration (CBD) or corticobasal ganglionic degeneration (CBGD) is a rare, progressive neurodegenerative disease involving the cerebral cortex and the basal ganglia.
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Dementia
Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.
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Dendrite
Dendrites (from Greek δένδρον déndron, "tree"), also dendrons, are branched protoplasmic extensions of a nerve cell that propagate the electrochemical stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites project.
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Exon
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
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Exosome complex
The exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of degrading various types of RNA (ribonucleic acid) molecules.
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Frontotemporal dementia
The frontotemporal dementias (FTD) encompass six types of dementia involving the frontal or temporal lobes.
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Frontotemporal dementia and parkinsonism linked to chromosome 17
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant neurodegenerative disorder and Parkinson plus syndrome, which has three cardinal features: behavioral and personality changes, cognitive impairment, and motor symptoms.
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FYN
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Haplogroup
A haplotype is a group of genes in an organism that are inherited together from a single parent, and a haplogroup (haploid from the ἁπλούς, haploûs, "onefold, simple" and group) is a group of similar haplotypes that share a common ancestor with a single-nucleotide polymorphism mutation.
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Hyperphosphorylation
Hyperphosphorylation occurs when a biochemical with multiple phosphorylation sites is fully saturated.
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Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure.
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Kinase
In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.
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MAP6
Microtubule-associated protein 6 (MAP6) or stable tubule-only polypeptide (STOP or STOP protein) is a protein that in humans is encoded by the MAP6 gene.
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Microtubule
Microtubules are tubular polymers of tubulin that form part of the cytoskeleton that provides the cytoplasm of eukaryotic cells and some bacteria with structure and shape.
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Microtubule-associated protein
In cell biology, microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton.
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Microtubule-associated protein 2
Microtubule-associated protein 2 is a protein that in humans is encoded by the MAP2 gene.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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Nervous system
The nervous system is the part of an animal that coordinates its actions by transmitting signals to and from different parts of its body.
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Neurodegeneration
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.
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Neurofibrillary tangle
Neurofibrillary tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary marker of Alzheimer's disease.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Oligodendrocyte
Oligodendrocytes, or oligodendroglia,.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Pathogenesis
The pathogenesis of a disease is the biological mechanism (or mechanisms) that leads to the diseased state.
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Phosphorylation
In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.
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Pick's disease
Pick's disease is a term that can be used in two different ways.
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Primary age-related tauopathy
Primary age-related tauopathy (PART) is a recently described neuropathological designation used to describe the neurofibrillary tangles (NFT) that are commonly observed in the brains of normally aged individuals that can occur independently of the amyloid plaques of Alzheimer's disease (AD).
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Prion
Prions are misfolded proteins that are associated with several fatal neurodegenerative diseases in animals and humans.
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Progressive supranuclear palsy
Progressive supranuclear palsy (PSP; or the Steele–Richardson–Olszewski syndrome, after the doctors who described it in 1963) is a degenerative disease involving the gradual deterioration and death of specific volumes of the brain.
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Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.
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Protein folding
Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Proteopathy
In medicine, proteopathy (Proteo-; -pathy; proteopathies pl.; proteopathic adj.) refers to a class of diseases in which certain proteins become structurally abnormal, and thereby disrupt the function of cells, tissues and organs of the body.
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S100B
S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.
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Self-assembly
Self-assembly is a process in which a disordered system of pre-existing components forms an organized structure or pattern as a consequence of specific, local interactions among the components themselves, without external direction.
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Tau
Tau (uppercase Τ, lowercase τ; ταυ) is the 19th letter of the Greek alphabet.
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Tauopathy
Tauopathy belongs to a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in neurofibrillary or gliofibrillary tangles in the human brain.
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Transcription (biology)
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
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Traumatic brain injury
Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force injures the brain.
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Tubulin
Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily.
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YWHAZ
14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8.
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Redirects here:
MAPT, MAPT (gene), MAPT gene, Microtubule-associated protein tau, PTau, Tau (protein), Tau deposition, Tau proteins.
References
[1] https://en.wikipedia.org/wiki/Tau_protein
