VCaP

VCaP cells are a cell line of human prostate cancer commonly used in the field of oncology. ^[1]

7 relations: Androgen receptor, ERG (gene), Immortalised cell line, Oncology, Prostate cancer, Prostate-specific antigen, TMPRSS2.

Androgen receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.

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ERG (gene)

ERG (ETS-related gene) is an oncogene.

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Immortalised cell line

An immortalized cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.

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Oncology

Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer.

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Prostate cancer

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.

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Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus. PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia.

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TMPRSS2

Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene.

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References

[1] https://en.wikipedia.org/wiki/VCaP

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