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122 relations: Acyltransferase, Adrenocorticotropic hormone, Aldosterone, Allergy, ALOX12, ALOX15, Arachidonate 5-lipoxygenase, Arachidonic acid, Arachidonic acid 5-hydroperoxide, Aspirin, Atherosclerosis, Autocrine signalling, B cell, Basophil, Bengt I. Samuelsson, Birth, Bone remodeling, Bronchoalveolar lavage, Bronchoconstriction, CC chemokine receptors, CCL2, CCL5, Cell surface receptor, Cerebral cortex, Chemotaxis, Chirality (chemistry), Cis–trans isomerism, Cyclic adenosine monophosphate, CYP1A2, CYP1B1, CYP2S1, CYP4F3, Cytochrome P450, Cytochrome P450, family 1, member A1, Dendritic cell, Double bond, Eicosanoid, Eosinophil, Eotaxin, Epoxide, Ester, Foam cell, G beta-gamma complex, G protein, G protein–coupled receptor, Gi alpha subunit, GPR81, Gram-negative bacteria, Granulocyte colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor, ..., H295R, Heme, Homology (biology), Hormone, Hydroxy group, In vitro, In vivo, Inflammation, Innate immune system, International Union of Pure and Applied Chemistry, Ketone, Leukotriene A4, Leukotriene B4, Leukotriene B4 receptor, Leukotriene C4, Leukotriene C4 synthase, Leukotriene D4, Leukotriene E4, Leukotriene-A4 hydrolase, Leydig cell, Lipopolysaccharide, Lipoxin, Luteinizing hormone, Lymphocyte, Macrophage, Malignant transformation, MAPK/ERK pathway, Mast cell, Monocyte, Na+/K+-ATPase, Neutrophil, Neutrophil extracellular traps, Niacin, Niacin receptor 1, Niacin receptor 2, Nicotinamide adenine dinucleotide phosphate, Organic peroxide, Oxidative stress, Oxoeicosanoid receptor 1, P38 mitogen-activated protein kinases, Paracrine signalling, Pathology, Peroxidase, Peroxisome proliferator-activated receptor gamma, Phosphatidylethanolamine, Phosphoinositide 3-kinase, Phospholipase A2, Phospholipid, Physiology, PLA2G4A, Platelet-activating factor, Polyunsaturated fatty acid, Progesterone, Prostaglandin, Prostaglandin E2, Prostaglandin-endoperoxide synthase 2, Protein kinase B, Protein kinase C, Reactive oxygen species, Stereoisomerism, Steroid, Steroidogenic acute regulatory protein, Superoxide, Synaptosome, Testosterone, Tubuloglomerular feedback, Unified atomic mass unit, Zebrafish, 12-Hydroxyeicosatetraenoic acid, 15-Hydroxyeicosatetraenoic acid, 5-Hydroxyeicosanoid dehydrogenase, 5-oxo-eicosatetraenoic acid. Expand index (72 more) »
Acyltransferase
Acyltransferase is a type of transferase enzyme that acts upon acyl groups.
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Adrenocorticotropic hormone
Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.
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Aldosterone
Aldosterone, the main mineralocorticoid hormone, is a steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland.
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Allergy
Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment.
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ALOX12
ALOX12, also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p13.3.
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ALOX15
ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products.
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Arachidonate 5-lipoxygenase
Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene.
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Arachidonic acid
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).
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Arachidonic acid 5-hydroperoxide
Arachidonic acid 5-hydroperoxide (5-hydroperoxyeicosatetraenoic acid, 5-HPETE) is an intermediate in the metabolism of arachidonic acid by the ALOX5 enzyme in humans or Alox5 enzyme in other mammals.
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Aspirin
Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Autocrine signalling
Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell.
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B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
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Basophil
Basophils are a type of white blood cells.
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Bengt I. Samuelsson
Bengt Ingemar Samuelsson (born 21 May 1934) is a Swedish biochemist.
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Birth
Birth is the act or process of bearing or bringing forth offspring.
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Bone remodeling
Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
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Bronchoalveolar lavage
Bronchoalveolar lavage (BAL; informally, "bronchoalveolar washing") is a medical procedure in which a bronchoscope is passed through the mouth or nose into the lungs and fluid is squirted into a small part of the lung and then collected for examination.
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Bronchoconstriction
Bronchoconstriction is the constriction of the airways in the lungs due to the tightening of surrounding smooth muscle, with consequent coughing, wheezing, and shortness of breath.
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CC chemokine receptors
CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family.
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CCL2
For the ICAO airport code see Candle Lake Airpark, for the diradical compound see Dichlorocarbene. The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2.
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CCL5
Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene.
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Cell surface receptor
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.
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Cerebral cortex
The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.
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Chemotaxis
Chemotaxis (from chemo- + taxis) is the movement of an organism in response to a chemical stimulus.
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Chirality (chemistry)
Chirality is a geometric property of some molecules and ions.
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Cis–trans isomerism
Cis–trans isomerism, also known as geometric isomerism or configurational isomerism, is a term used in organic chemistry.
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Cyclic adenosine monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.
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CYP1A2
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
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CYP1B1
Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene.
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CYP2S1
Cytochrome P450 2S1 is a protein that in humans is encoded by the CYP2S1 gene.
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CYP4F3
Leukotriene-B(4) omega-hydroxylase 2 is an enzyme that in humans is encoded by the CYP4F3 gene.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Cytochrome P450, family 1, member A1
Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene.
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Dendritic cell
Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.
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Double bond
A double bond in chemistry is a chemical bond between two chemical elements involving four bonding electrons instead of the usual two.
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Eicosanoid
Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, 20 carbon units in length.
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Eosinophil
Eosinophils sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply. These cells are eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes: Normally transparent, it is this affinity that causes them to appear brick-red after staining with eosin, a red dye, using the Romanowsky method. The staining is concentrated in small granules within the cellular cytoplasm, which contain many chemical mediators, such as eosinophil peroxidase, ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic protein. These mediators are released by a process called degranulation following activation of the eosinophil, and are toxic to both parasite and host tissues. In normal individuals, eosinophils make up about 1–3% of white blood cells, and are about 12–17 micrometres in size with bilobed nuclei. While they are released into the bloodstream as neutrophils are, eosinophils reside in tissue They are found in the medulla and the junction between the cortex and medulla of the thymus, and, in the lower gastrointestinal tract, ovary, uterus, spleen, and lymph nodes, but not in the lung, skin, esophagus, or some other internal organs under normal conditions. The presence of eosinophils in these latter organs is associated with disease. For instance, patients with eosinophilic asthma have high levels of eosinophils that lead to inflammation and tissue damage, making it more difficult for patients to breathe. Eosinophils persist in the circulation for 8–12 hours, and can survive in tissue for an additional 8–12 days in the absence of stimulation. Pioneering work in the 1980s elucidated that eosinophils were unique granulocytes, having the capacity to survive for extended periods of time after their maturation as demonstrated by ex-vivo culture experiments.
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Eotaxin
The eotaxins are a CC chemokine subfamily of eosinophil chemotactic proteins.
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Epoxide
An epoxide is a cyclic ether with a three-atom ring.
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Ester
In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.
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Foam cell
Foam cells are the fat-laden M2 macrophages that serve as the hallmark of early stage atherosclerotic lesion formation.
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G beta-gamma complex
The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a component of heterotrimeric G proteins.
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G protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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Gi alpha subunit
Gi alpha subunit (Gαi, or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.
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GPR81
G protein-coupled receptor 81, also known as GPR81, is a protein that in humans is encoded by the GPR81 gene.
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Gram-negative bacteria
Gram-negative bacteria are bacteria that do not retain the crystal violet stain used in the gram-staining method of bacterial differentiation.
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Granulocyte colony-stimulating factor
Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.
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Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine.
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H295R
H295R (also referred to as NCI-H295R) is an angiotensin-II-responsive steroid-producing adrenocortical cell line.
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Heme
Heme or haem is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands.
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Homology (biology)
In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.
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Hormone
A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.
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Hydroxy group
A hydroxy or hydroxyl group is the entity with the formula OH.
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In vitro
In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
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In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Innate immune system
The innate immune system, also known as the non-specific immune system or in-born immunity system, is an important subsystem of the overall immune system that comprises the cells and mechanisms involved in the defense of the host from infection by other organisms.
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International Union of Pure and Applied Chemistry
The International Union of Pure and Applied Chemistry (IUPAC) is an international federation of National Adhering Organizations that represents chemists in individual countries.
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Ketone
In chemistry, a ketone (alkanone) is an organic compound with the structure RC(.
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Leukotriene A4
Leukotriene A4 is a leukotriene.
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Leukotriene B4
Leukotriene B4 (LTB4) is a leukotriene involved in inflammation.
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Leukotriene B4 receptor
The leukotriene B4 receptors (BLTRs) include the following two receptors.
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Leukotriene C4
Leukotriene C4 (LTC4) is a leukotriene.
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Leukotriene C4 synthase
Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.
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Leukotriene D4
Leukotriene D4 (LTD4) is one of the leukotrienes.
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Leukotriene E4
Leukotriene E4 (LTE4) is a cysteinyl leukotriene involved in inflammation.
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Leukotriene-A4 hydrolase
Leukotriene A4 hydrolase, also known as LTA4H is a human gene.
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Leydig cell
Leydig cells, also known as interstitial cells of Leydig, are found adjacent to the seminiferous tubules in the testicle.
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Lipopolysaccharide
Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.
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Lipoxin
Lipoxins (LXs or Lxs), an acronym for lipoxygenase interaction products, are bioactive autacoid metabolites of arachidonic acid made by various cell types.
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Luteinizing hormone
Luteinizing hormone (LH, also known as lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland.
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Lymphocyte
A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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Malignant transformation
Malignant transformation is the process by which cells acquire the properties of cancer.
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MAPK/ERK pathway
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
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Mast cell
A mast cell (also known as a mastocyte or a labrocyte) is a type of white blood cell.
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Monocyte
Monocytes are a type of leukocyte, or white blood cell.
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Na+/K+-ATPase
-ATPase (sodium-potassium adenosine triphosphatase, also known as the pump or sodium–potassium pump) is an enzyme (an electrogenic transmembrane ATPase) found in the plasma membrane of all animal cells.
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Neutrophil
Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.
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Neutrophil extracellular traps
Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens.
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Niacin
Niacin, also known as nicotinic acid, is an organic compound and a form of vitamin B3, an essential human nutrient.
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Niacin receptor 1
Hydroxycarboxylic acid receptor 2 (HCA2), also known as niacin receptor 1 (NIACR1) and GPR109A, is a protein which in humans is encoded by the HCAR2 gene.
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Niacin receptor 2
Hydroxycarboxylic acid receptor 3 (HCA3), also known as niacin receptor 2 (NIACR2) and GPR109B, is a protein which in humans is encoded by the HCAR3 gene.
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Nicotinamide adenine dinucleotide phosphate
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
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Organic peroxide
Organic peroxides are organic compounds containing the peroxide functional group (ROOR′).
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Oxidative stress
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.
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Oxoeicosanoid receptor 1
Oxoeicosanoid receptor 1 (OXER1) also known as G-protein coupled receptor 170 (GPR170) is a protein that in humans is encoded by the OXER1 gene located on human chromosome 2p21; it is the principle receptor for the 5-Hydroxyicosatetraenoic acid family of carboxy fatty acid metabolites derived from arachidonic acid.
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P38 mitogen-activated protein kinases
P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.
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Paracrine signalling
Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells.
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Pathology
Pathology (from the Ancient Greek roots of pathos (πάθος), meaning "experience" or "suffering" and -logia (-λογία), "study of") is a significant field in modern medical diagnosis and medical research, concerned mainly with the causal study of disease, whether caused by pathogens or non-infectious physiological disorder.
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Peroxidase
Peroxidases (EC number) are a large family of enzymes that typically catalyze a reaction of the form: For many of these enzymes the optimal substrate is hydrogen peroxide, but others are more active with organic hydroperoxides such as lipid peroxides.
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Peroxisome proliferator-activated receptor gamma
Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor that in humans is encoded by the PPARG gene.
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Phosphatidylethanolamine
Phosphatidylethanolamines are a class of phospholipids found in biological membranes.
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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Phospholipase A2
Phospholipases A2 (PLA2s) are enzymes that release fatty acids from the second carbon group of glycerol.
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Phospholipid
Phospholipids are a class of lipids that are a major component of all cell membranes.
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Physiology
Physiology is the scientific study of normal mechanisms, and their interactions, which work within a living system.
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PLA2G4A
Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene.
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Platelet-activating factor
Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, platelet aggregation and degranulation, inflammation, and anaphylaxis.
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Polyunsaturated fatty acid
Polyunsaturated fatty acids (PUFAs) are fatty acids that contain more than one double bond in their backbone.
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Progesterone
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
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Prostaglandin
The prostaglandins (PG) are a group of physiologically active lipid compounds having diverse hormone-like effects in animals.
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Prostaglandin E2
Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin which is used as a medication.
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Prostaglandin-endoperoxide synthase 2
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (The HUGO official symbol is PTGS2; HGNC ID, HGNC:9605), also known as cyclooxygenase-2 or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.
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Protein kinase B
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
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Protein kinase C
Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
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Reactive oxygen species
Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.
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Stereoisomerism
In stereochemistry, stereoisomers are isomeric molecules that have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space.
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Steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
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Steroidogenic acute regulatory protein
The steroidogenic acute regulatory protein, commonly referred to as StAR (STARD1), is a transport protein that regulates cholesterol transfer within the mitochondria, which is the rate-limiting step in the production of steroid hormones.
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Superoxide
A superoxide is a compound that contains the superoxide anion, which has the chemical formula.
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Synaptosome
A synaptosome is an isolated synaptic terminal from a neuron.
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Testosterone
Testosterone is the primary male sex hormone and an anabolic steroid.
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Tubuloglomerular feedback
In the physiology of the kidney, tubuloglomerular feedback (TGF) is a feedback system inside the kidneys.
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Unified atomic mass unit
The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).
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Zebrafish
The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.
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12-Hydroxyeicosatetraenoic acid
12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a Hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z Cis–trans isomerism configuration (Z.
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15-Hydroxyeicosatetraenoic acid
15-Hydroxyeicosatetraenoic acid (also termed 15-HETE, 15(S)-HETE, and 15S-HETE) is an eicosanoid, i.e. a metabolite of arachidonic acid.
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5-Hydroxyeicosanoid dehydrogenase
5-Hydroxyeicosanoid dehydrogenase (5-HEDH) or more formally, nicotinamide adenine dinucleotide phosphate (NADP+)-dependent dehydrogenase, is an enzyme that metabolizes an eicosanoid product of arachidonate 5-lipoxygenase (5-LOX), 5(S)-hydroxy-6S,8Z,11Z,14Z-eicosatetraenoic acid (i.e. 5-(S)-HETE; see 5-HETE) to its 5-keto analog, 5-oxo-eicosatetraenoic acid (i.e. 5-oxo-6S,8Z,11Z,14Z-eicosatetraenoic acid or 5-oxo-ETE).
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5-oxo-eicosatetraenoic acid
5-Oxo-eicosatetraenoic acid (i.e. 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; also termed 5-oxo-ETE and 5-oxoETE) is a Nonclassic eicosanoid metabolite of arachidonic acid and the most potent naturally occurring member of the 5-HETE family of cell signaling agents.
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Redirects here:
5-HETE, 5-Hydroxyeicosatetraenoic acid and 5-oxo-eicosatetraenoic acid, 5-Hydroxyeicosatetraenoic acid and 5-oxo-eicosatetreaenoic acid, 5-Hydroxyicosatetraenoic acid, 5-Hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid, 5-hydroxyeicosatetraenoic acid, Hydroxyicosatetraenoate.
References
[1] https://en.wikipedia.org/wiki/5-Hydroxyeicosatetraenoic_acid
