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192 relations: Abbott Laboratories, Abbott Medical Optics, Abiraterone, Acclarent, Actelion, Acuvue, Adalimumab, Adverse effect, Alex Gorsky, American Red Cross, Animas Corporation, Ankylosing spondylitis, Ann Jordan, Antipsychotic, Antiseptic, Arkansas, Asia-Pacific, Atrial fibrillation, B cell, Baby powder, Band-Aid, Bedaquiline, Belgian Congo, Benadryl, Bernhard Joos, Bipolar disorder, Birmingham, Alabama, Born Rich (film), Bortezomib, Boston Scientific, California, CD19, CD3 (immunology), Cetirizine, Chairman, Chicago metropolitan area, Chief executive officer, Chief financial officer, Cilag, Class action, Clean & Clear, Constant Janssen, Contact lens, Coronary stent, Cosmetics, Credo, Crohn's disease, Crucell, Cyanide, Darunavir, ..., David Satcher, Delaware and Raritan Canal, Dementia, DePuy, Direct marketing, Dow Jones Industrial Average, Dressing (medical), Drug discovery, Edward Mead Johnson, Ethicon Inc., Etravirine, Farnesyltransferase, Federal Court of Australia, First aid, Food and Drug Administration, Foreign Corrupt Practices Act, Fort Washington, Pennsylvania, Fortive, Fortune 500, Frederick Barnett Kilmer, Gastrointestinal tract, Gedeon Richter plc, Geneva Conventions, George F. Merson, Ghostwriter, Golimumab, GPR84, Guam, Henry N. Cobb, Ibuprofen, Incorporation (business), Infliximab, Interleukin 12, Interleukin 23, International, International Committee of the Red Cross, International Red Cross and Red Crescent Movement, Ionis Pharmaceuticals, Iraq, James E. Burke, James Wood Johnson, Jamie Johnson (filmmaker), Janssen Biotech, Janssen Pharmaceutica, Janssen-Cilag, Johnson & Johnson, Johnson & Johnson Pharmaceutical Research and Development, Johnson's Baby, Joseph Biederman, Joseph Lister, Lawsuit, LifeScan, List of largest pharmaceutical settlements, List of tallest buildings in New Brunswick, New Jersey, Los Angeles Times, Louisiana, Mary Lea Johnson Richards, Mary Sue Coleman, McNeil Consumer Healthcare, Mead Johnson, Medical equipment, Meibomian gland, Mentor (company), Methylphenidate, Missouri, Multinational corporation, Neutrogena, New Brunswick, New Jersey, New Jersey, New Jersey Route 18, New York University, Newsweek, Northeast Corridor, Omnicare, Opioid epidemic, Ortho Pharmaceutical, Ortho-McNeil Pharmaceutical, Ovacome, Ovarian cancer, Over-the-counter drug, Paliperidone, Paracetamol, Paul Stoffels, Pei Cobb Freed & Partners, Pfizer, Pharmaceutical industry, Philadelphia, Philip B. Hofmann, Platinum Equity, Polycarbonate, Prescription drug, Product recall, Psoriasis, Psychiatrist, Public company, Public relations, Puerto Rico, Ralph S. Larsen, Reservation (law), Reuters, Rheumatoid arthritis, Richard B. Sellars, Risperidone, Robert L. McNeil Jr., Robert Wood Johnson I, Robert Wood Johnson II, Robert Wood Johnson University Hospital, S&P 100, S&P 500 Index, Sandi Peterson, Sanitation, Sanofi, Schaffhausen, Sense (molecular biology), Shareholder, Skillman, New Jersey, South Carolina, Spring House, Pennsylvania, St. Louis, Susan Lindquist, Synthes, Takeda, TearScience, Telaprevir, Texas, The New York Times, The Wall Street Journal, Tuberculosis, Tumor necrosis factor superfamily, Turnhout, Tylenol (brand), U.S. Securities and Exchange Commission, Ulcerative colitis, United States, United States Department of Justice, Ustekinumab, Washington (state), Whistleblower, William C. Weldon, William Perez, Zodiac (schooner), 2,4,6-Tribromophenol. Expand index (142 more) »
Abbott Laboratories
Abbott Laboratories is an American health care company with headquarters in Lake Bluff, Illinois, United States.
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Abbott Medical Optics
Abbott Medical Optics Inc. earlier known as Advanced Medical Optics, Inc. (also known as AMO) is a global medical supply company.
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Abiraterone
Abiraterone, developmental code name CB-7598, also known as 17-(3-pyridyl)androsta-5,16-dien-3β-ol, is a synthetic, steroidal CYP17A1 inhibitor.
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Acclarent
Acclarent, Inc. began as a privately held, venture-backed company, and is now a subsidiary of Johnson & Johnson.
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Actelion
Actelion is a pharmaceuticals and bio-technology company established in December 1997, headquartered in Allschwil near Basel in Switzerland.
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Acuvue
Acuvue (from "Accurate view") is a brand of disposable contact lenses made by Jacksonville and Limerick-based Vistakon, a subsidiary of Johnson & Johnson (J&J).
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Adalimumab
Adalimumab, sold under the trade name Humira among others, is a medication used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, chronic psoriasis, hidradenitis suppurativa, and juvenile idiopathic arthritis.
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Adverse effect
In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery.
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Alex Gorsky
Alex Gorsky is Chairman of the Board and Chief Executive Officer of Johnson & Johnson and Chairman of the Executive Committee, the Company’s senior leadership team.
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American Red Cross
The American Red Cross (ARC), also known as the American National Red Cross, is a humanitarian organization that provides emergency assistance, disaster relief, and disaster preparedness education in the United States.
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Animas Corporation
Animas Corporation is an American company that specializes in making insulin pumps, used by people with diabetes.
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Ankylosing spondylitis
Ankylosing spondylitis (AS) is a type of arthritis in which there is long term inflammation of the joints of the spine.
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Ann Jordan
Ann Dibble Jordan (born 1935) previously known as Ann Cook, is a company director and formal social worker.
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Antipsychotic
Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.
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Antiseptic
Antiseptics (from Greek ἀντί anti, "against" and σηπτικός sēptikos, "putrefactive") are antimicrobial substances that are applied to living tissue/skin to reduce the possibility of infection, sepsis, or putrefaction.
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Arkansas
Arkansas is a state in the southeastern region of the United States, home to over 3 million people as of 2017.
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Asia-Pacific
Asia-Pacific or Asia Pacific (abbreviated as APAC, Asia-Pac, AsPac, APJ, JAPA or JAPAC) is the part of the world in or near the Western Pacific Ocean.
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Atrial fibrillation
Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm characterized by rapid and irregular beating of the atria.
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B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
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Baby powder
Baby powder is an astringent powder used for preventing diaper rash, as a deodorant, and for other cosmetic uses.
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Band-Aid
Band-Aid is a brand name of American pharmaceutical and medical devices giant Johnson & Johnson's line of adhesive bandages.
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Bedaquiline
Bedaquiline, sold under the brand name Sirturo, is a medication used to treat active tuberculosis.
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Belgian Congo
The Belgian Congo (Congo Belge,; Belgisch-Congo) was a Belgian colony in Central Africa between 1908 and 1960 in what is now the Democratic Republic of the Congo (DRC).
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Benadryl
Benadryl is a brand name for a number of different antihistamine medications used to treat allergies.
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Bernhard Joos
Bernhard Joos (18 December 1899 Schaffhausen, Switzerland - 8 June 1990 Paradiso, Switzerland), was the son of Dr.
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Bipolar disorder
Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.
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Birmingham, Alabama
Birmingham is the most populous city in the U.S. state of Alabama and the seat of Jefferson County.
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Born Rich (film)
Born Rich is a 2003 documentary film (filmed primarily between 1999-2001) about the experience of growing up in wealthy families.
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Bortezomib
Bortezomib (BAN, INN and USAN; marketed as Velcade by Takeda Oncology; Chemobort by Cytogen and Bortecad by Cadila Healthcare) is an anti-cancer drug and the first therapeutic proteasome inhibitor to be used in humans.
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Boston Scientific
Boston Scientific Corporation (Boston Scientific) is a manufacturer of medical devices used in interventional medical specialties, including interventional radiology, interventional cardiology, peripheral interventions, neuromodulation, neurovascular intervention, electrophysiology, cardiac surgery, vascular surgery, endoscopy, oncology, urology and gynecology.
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California
California is a state in the Pacific Region of the United States.
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CD19
B-lymphocyte antigen CD19, also known as CD19 molecule ('''C'''luster of '''D'''ifferentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19.
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CD3 (immunology)
In immunology, the CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8+ naive T cells) and also T helper cells (CD4+ naive T cells).
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Cetirizine
Cetirizine, prominently marketed under the brand name Zyrtec among others, is a potent second-generation antihistamine used in the treatment of hay fever, allergies, angioedema, and urticaria.
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Chairman
The chairman (also chairperson, chairwoman or chair) is the highest officer of an organized group such as a board, a committee, or a deliberative assembly.
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Chicago metropolitan area
The Chicago metropolitan area, or Chicagoland, is the metropolitan area that includes the city of Chicago, Illinois, and its suburbs.
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Chief executive officer
Chief executive officer (CEO) is the position of the most senior corporate officer, executive, administrator, or other leader in charge of managing an organization especially an independent legal entity such as a company or nonprofit institution.
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Chief financial officer
The chief financial officer (CFO) is the officer of a company that has primary responsibility for managing the company's finances, including financial planning, management of financial risks, record-keeping, and financial reporting.
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Cilag
Cilag AG is a Swiss pharmaceutical company.
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Class action
A class action, class suit, or representative action is a type of lawsuit where one of the parties is a group of people who are represented collectively by a member of that group.
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Clean & Clear
Clean & Clear is a line of dermatology products owned by Johnson & Johnson.
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Constant Janssen
Dr.
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Contact lens
A contact lens, or simply contact, is a thin lens placed directly on the surface of the eye.
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Coronary stent
A coronary stent is a tube-shaped device placed in the coronary arteries that supply blood to the heart, to keep the arteries open in the treatment of coronary heart disease.
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Cosmetics
Cosmetics are substances or products used to enhance or alter the appearance of the face or fragrance and texture of the body.
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Credo
A credo (pronounced, Latin for "I believe") is a statement of religious belief, such as the Apostles' Creed.
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Crohn's disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus.
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Crucell
Crucell is a biotechnology company specializing in vaccines and biopharmaceutical technologies.
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Cyanide
A cyanide is a chemical compound that contains the group C≡N.
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Darunavir
Darunavir (DRV), sold under the brand name Prezista among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.
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David Satcher
David Satcher, (born March 2, 1941) is an American physician, and public health administrator.
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Delaware and Raritan Canal
The Delaware and Raritan Canal (D&R Canal) is a canal in central New Jersey, United States, built in the 1830s, that served to connect the Delaware River to the Raritan River.
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Dementia
Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.
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DePuy
DePuy Synthes is a franchise of orthopaedic and neurosurgery companies.
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Direct marketing
Direct marketing is a form of advertising where organizations communicate directly to customers through a variety of media including cell phone text messaging, email, websites, online adverts, database marketing, fliers, catalog distribution, promotional letters, and targeted television, newspaper, and magazine advertisements, as well as outdoor advertising.
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Dow Jones Industrial Average
The Dow Jones Industrial Average (DJIA), or simply the Dow, is a stock market index that shows how 30 large, publicly owned companies based in the United States have traded during a standard trading session in the stock market.
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Dressing (medical)
A dressing is a sterile pad or compress applied to a wound to promote healing and protect the wound from further harm.
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Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
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Edward Mead Johnson
Edward Mead Johnson (April 23, 1852 – March 20, 1934) was an American businessman and one of the co-founders of Johnson & Johnson.
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Ethicon Inc.
Ethicon, Inc. is a subsidiary of Johnson & Johnson.
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Etravirine
Etravirine (ETR, brand name Intelence, formerly known as TMC125) is a drug used for the treatment of HIV.
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Farnesyltransferase
Farnesyltransferase is one of the three enzymes in the prenyltransferase group.
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Federal Court of Australia
The Federal Court of Australia is an Australian superior court of record which has jurisdiction to deal with most civil disputes governed by federal law (with the exception of family law matters), along with some summary (less serious) criminal matters.
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First aid
First aid is the assistance given to any person suffering a sudden illness or injury, with care provided to preserve life, prevent the condition from worsening, or to promote recovery.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Foreign Corrupt Practices Act
The Foreign Corrupt Practices Act of 1977 (FCPA) (et seq.) is a United States federal law known primarily for two of its main provisions, one that addresses accounting transparency requirements under the Securities Exchange Act of 1934 and another concerning bribery of foreign officials.
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Fort Washington, Pennsylvania
Fort Washington is a census-designated place and suburb of Philadelphia in Montgomery County, Pennsylvania, United States.
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Fortive
Fortive is a diversified industrial conglomerate company headquartered in Everett, Washington, United States.
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Fortune 500
The Fortune 500 is an annual list compiled and published by Fortune magazine that ranks 500 of the largest United States corporations by total revenue for their respective fiscal years.
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Frederick Barnett Kilmer
Frederick Barnett Kilmer (15 December 1851 – 28 December 1934) was an American pharmacist, author, public health activist and the director of Scientific Laboratories for the Johnson & Johnson company from 1889 to 1934.
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Gastrointestinal tract
The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.
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Gedeon Richter plc
Richter Gedeon Nyrt. is a Hungarian multinational pharmaceutical and biotechnology company headquartered in Budapest, Hungary.
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Geneva Conventions
Original document as PDF in single pages, 1864 The Geneva Conventions comprise four treaties, and three additional protocols, that establish the standards of international law for humanitarian treatment in war.
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George F. Merson
George Fowlie Merson FRSE FPS FCS (1866-1959) was a Scottish pharmacist who produced an artificial surgical catgut called Mersuture.
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Ghostwriter
A ghostwriter is hired to write literary or journalistic works, speeches, or other texts that are officially credited to another person as the author.
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Golimumab
Golimumab (CNTO 148) is a human monoclonal antibody which is used as an immunosuppressive drug and marketed under the brand name Simponi.
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GPR84
Probable G-protein coupled receptor 84 is a protein that in humans is encoded by the GPR84 gene.
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Guam
Guam (Chamorro: Guåhån) is an unincorporated and organized territory of the United States in Micronesia in the western Pacific Ocean.
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Henry N. Cobb
Henry N. Cobb (born April 8, 1926, in Boston, Massachusetts) is an American architect and founding partner with I.M. Pei of Pei Cobb Freed & Partners, an international architectural firm based in New York City.
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Ibuprofen
Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation.
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Incorporation (business)
Incorporation is the formation of a new corporation (a corporation being a legal entity that is effectively recognized as a person under the law).
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Infliximab
Infliximab (trade names Remicade among others) is a chimeric monoclonal antibody biologic drug that works against tumor necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases.
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Interleukin 12
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.
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Interleukin 23
Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an IL12B (IL-12p40) subunit (that is shared with IL12) and the (IL-23p19) subunit.
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International
International mostly means something (a company, language, or organization) involving more than a single country.
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International Committee of the Red Cross
The International Committee of the Red Cross (ICRC) is a humanitarian institution based in Geneva, Switzerland, and a three-time Nobel Prize Laureate.
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International Red Cross and Red Crescent Movement
The International Red Cross and Red Crescent Movement is an international humanitarian movement with approximately 17 million volunteers, members and staff worldwide which was founded to protect human life and health, to ensure respect for all human beings, and to prevent and alleviate human suffering.
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Ionis Pharmaceuticals
Ionis Pharmaceuticals (known as Isis Pharmaceuticals until December 2015) is a publicly traded pharmaceutical company based in Carlsbad, California, United States.
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Iraq
Iraq (or; العراق; عێراق), officially known as the Republic of Iraq (جُمُهورية العِراق; کۆماری عێراق), is a country in Western Asia, bordered by Turkey to the north, Iran to the east, Kuwait to the southeast, Saudi Arabia to the south, Jordan to the southwest and Syria to the west.
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James E. Burke
James E. Burke (February 28, 1925 – September 28, 2012) was the chief executive officer (CEO) of Johnson & Johnson from 1976 to 1989, a company for which he worked forty years.
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James Wood Johnson
James Wood Johnson (1856–1932) was an American businessman and one of the co-founders of Johnson & Johnson.
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Jamie Johnson (filmmaker)
James Wittenborn Johnson (born 1979) is an American heir apparent, filmmaker, and socialite.
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Janssen Biotech
Janssen Biotech, Inc., formerly Centocor Biotech, Inc., is a biotechnology company that was founded in Philadelphia in 1979 with an initial goal of developing new diagnostic assays using monoclonal antibody technology.
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Janssen Pharmaceutica
Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium.
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Janssen-Cilag
Janssen-Cilag is a subsidiary of the Johnson & Johnson pharmaceutical company.
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Johnson & Johnson
Johnson & Johnson is an American multinational medical devices, pharmaceutical and consumer packaged goods manufacturing company founded in 1886.
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Johnson & Johnson Pharmaceutical Research and Development
Johnson & Johnson Pharmaceutical Research and Development (J&JPRD) is a subsidiary of Johnson & Johnson that is responsible for discovering and developing pharmaceutical drugs.
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Johnson's Baby
Johnson's Baby is an American brand of baby cosmetics and skin care products owned by Johnson & Johnson.
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Joseph Biederman
Joseph Biederman is Chief of the Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD at the Massachusetts General Hospital, professor of psychiatry at Harvard Medical School.
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Joseph Lister
Joseph Lister, 1st Baron Lister, (5 April 182710 February 1912), known between 1883 and 1897 as Sir Joseph Lister, Bt., was a British surgeon and a pioneer of antiseptic surgery.
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Lawsuit
A lawsuit (or suit in law) is "a vernacular term for a suit, action, or cause instituted or depending between two private persons in the courts of law." A lawsuit is any proceeding by a party or parties against another in a court of law.
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LifeScan
LifeScan, Inc. is a Scottish diagnostic systems manufacturer which products focus on the diabetes market, specifically blood glucose monitoring systems.
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List of largest pharmaceutical settlements
The following is a list of the 20 largest settlements reached between the United States Department of Justice and pharmaceutical companies from 1991 to 2012, ordered by the size of the total settlement.
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List of tallest buildings in New Brunswick, New Jersey
New Brunswick, New Jersey, located in the central part of the state, is home to the main campus of Rutgers University and Johnson and Johnson, which built a new headquarters in 1983.
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Los Angeles Times
The Los Angeles Times is a daily newspaper which has been published in Los Angeles, California since 1881.
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Louisiana
Louisiana is a state in the southeastern region of the United States.
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Mary Lea Johnson Richards
Mary Lea Johnson Richards (August 20, 1926 – May 3, 1990) was an American heiress, entrepreneur, and Broadway producer.
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Mary Sue Coleman
Mary Sue Coleman (born October 2, 1943) is the current President of the Association of American Universities (AAU).
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McNeil Consumer Healthcare
McNeil Consumer Healthcare is an American medicals products company belonging to the Johnson & Johnson healthcare products group.
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Mead Johnson
Mead Johnson Nutrition is a leading manufacturer of infant formula both domestically and globally with its flagship product Enfamil.
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Medical equipment
Medical equipment (also known as armamentarium) is designed to aid in the diagnosis, monitoring or treatment of medical conditions.
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Meibomian gland
The Meibomian glands (often written with a small m, and also called tarsal glands) are a holocrine type of exocrine glands, at the rim of the eyelids inside the tarsal plate, responsible for the supply of meibum, an oily substance that prevents evaporation of the eye's tear film.
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Mentor (company)
Mentor Worldwide LLC is an American company that supplies surgical aesthetics products to plastic surgeons.
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Methylphenidate
Methylphenidate, sold under various trade names, Ritalin being one of the most commonly known, is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
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Missouri
Missouri is a state in the Midwestern United States.
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Multinational corporation
A multinational corporation (MNC) or worldwide enterprise is a corporate organization that owns or controls production of goods or services in at least one country other than its home country.
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Neutrogena
Neutrogena is an American brand of skin care, hair care and cosmetics, that is headquartered in Los Angeles, California.
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New Brunswick, New Jersey
New Brunswick is a city in Middlesex County, New Jersey, United States, in the New York City metropolitan area.
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New Jersey
New Jersey is a state in the Mid-Atlantic region of the Northeastern United States.
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New Jersey Route 18
Route 18 is a state highway in the US state of New Jersey.
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New York University
New York University (NYU) is a private nonprofit research university based in New York City.
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Newsweek
Newsweek is an American weekly magazine founded in 1933.
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Northeast Corridor
The Northeast Corridor (NEC) is an electrified railroad line in the Northeast megalopolis of the United States.
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Omnicare
Omnicare was an American company working in the health care industry, established in April 1981 as a spinoff of healthcare businesses from Chemed and W. R. Grace and Company.
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Opioid epidemic
The opioid epidemic or opioid crisis is the rapid increase in the use of prescription and non-prescription opioid drugs in the United States and Canada beginning in the late 1990s and continuing throughout the next two decades.
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Ortho Pharmaceutical
Ortho Pharmaceutical was initially formed in the United States in 1931 as a subsidiary of Johnson & Johnson to market the first prescription spermicidal contraceptive jelly, Ortho-Gynol.
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Ortho-McNeil Pharmaceutical
The company was formed from the merger of Ortho Pharmaceutical and McNeil Pharmaceutical in 1993.
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Ovacome
Ovacome is a charitable incorporated organisation based in London which supports women affected by ovarian cancer.
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Ovarian cancer
Ovarian cancer is a cancer that forms in or on an ovary.
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Over-the-counter drug
Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a prescription from a healthcare professional, as opposed to prescription drugs, which may be sold only to consumers possessing a valid prescription.
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Paliperidone
Paliperidone, sold under the trade name Invega among others, is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications.
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Paracetamol
--> Acetanilide was the first aniline derivative serendipitously found to possess analgesic as well as antipyretic properties, and was quickly introduced into medical practice under the name of Antifebrin by A. Cahn and P. Hepp in 1886. But its unacceptable toxic effects, the most alarming being cyanosis due to methemoglobinemia, prompted the search for less toxic aniline derivatives. Harmon Northrop Morse had already synthesised paracetamol at Johns Hopkins University via the reduction of ''p''-nitrophenol with tin in glacial acetic acid in 1877, but it was not until 1887 that clinical pharmacologist Joseph von Mering tried paracetamol on humans. In 1893, von Mering published a paper reporting on the clinical results of paracetamol with phenacetin, another aniline derivative. Von Mering claimed that, unlike phenacetin, paracetamol had a slight tendency to produce methemoglobinemia. Paracetamol was then quickly discarded in favor of phenacetin. The sales of phenacetin established Bayer as a leading pharmaceutical company. Overshadowed in part by aspirin, introduced into medicine by Heinrich Dreser in 1899, phenacetin was popular for many decades, particularly in widely advertised over-the-counter "headache mixtures", usually containing phenacetin, an aminopyrine derivative of aspirin, caffeine, and sometimes a barbiturate. Paracetamol is the active metabolite of phenacetin and acetanilide, both once popular as analgesics and antipyretics in their own right. However, unlike phenacetin, acetanilide and their combinations, paracetamol is not considered carcinogenic at therapeutic doses. Von Mering's claims remained essentially unchallenged for half a century, until two teams of researchers from the United States analyzed the metabolism of acetanilide and paracetamol. In 1947 David Lester and Leon Greenberg found strong evidence that paracetamol was a major metabolite of acetanilide in human blood, and in a subsequent study they reported that large doses of paracetamol given to albino rats did not cause methemoglobinemia. In three papers published in the September 1948 issue of the Journal of Pharmacology and Experimental Therapeutics, Bernard Brodie, Julius Axelrod and Frederick Flinn confirmed using more specific methods that paracetamol was the major metabolite of acetanilide in human blood, and established that it was just as efficacious an analgesic as its precursor. They also suggested that methemoglobinemia is produced in humans mainly by another metabolite, phenylhydroxylamine. A follow-up paper by Brodie and Axelrod in 1949 established that phenacetin was also metabolised to paracetamol. This led to a "rediscovery" of paracetamol. It has been suggested that contamination of paracetamol with 4-aminophenol, the substance von Mering synthesised it from, may be the cause for his spurious findings. Paracetamol was first marketed in the United States in 1950 under the name Triagesic, a combination of paracetamol, aspirin, and caffeine. Reports in 1951 of three users stricken with the blood disease agranulocytosis led to its removal from the marketplace, and it took several years until it became clear that the disease was unconnected. Paracetamol was marketed in 1953 by Sterling-Winthrop Co. as Panadol, available only by prescription, and promoted as preferable to aspirin since it was safe for children and people with ulcers. In 1955, paracetamol was marketed as Children's Tylenol Elixir by McNeil Laboratories. In 1956, 500 mg tablets of paracetamol went on sale in the United Kingdom under the trade name Panadol, produced by Frederick Stearns & Co, a subsidiary of Sterling Drug Inc. In 1963, paracetamol was added to the British Pharmacopoeia, and has gained popularity since then as an analgesic agent with few side-effects and little interaction with other pharmaceutical agents. Concerns about paracetamol's safety delayed its widespread acceptance until the 1970s, but in the 1980s paracetamol sales exceeded those of aspirin in many countries, including the United Kingdom. This was accompanied by the commercial demise of phenacetin, blamed as the cause of analgesic nephropathy and hematological toxicity. In 1988 Sterling Winthrop was acquired by Eastman Kodak which sold the over the counter drug rights to SmithKline Beecham in 1994. Available without a prescription since 1959, it has since become a common household drug. Patents on paracetamol have long expired, and generic versions of the drug are widely available.
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Paul Stoffels
Paul Stoffels (born 8 March 1962 in Turnhout, Belgium) is a Belgian MD, who studied medicine at the University of Hasselt and the University of Antwerp (UA).
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Pei Cobb Freed & Partners
Pei Cobb Freed & Partners is an American architectural firm based in New York City, with major projects in more than a hundred cities around the world. Pei Cobb Freed & Partners. Retrieved 2012-09-07. Its work is noted for excellence in design. The American Institute of Architects. Retrieved 2012-09-06. Brandeis University. Retrieved 2012-09-05. Pei Cobb Freed & Partners. Retrieved 2012-09-05. The firm provides a full range of architectural services, as well as planning and urban design. Projects designed by Pei Cobb Freed & Partners have received more than 200 awards for design excellence, including 24 AIA National Honor Awards. In addition, the firm has been recognized numerous times for design excellence in the totality of its practice. The firm has changed names twice.
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Pfizer
Pfizer Inc. is an American pharmaceutical conglomerate headquartered in New York City, with its research headquarters in Groton, Connecticut.
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Pharmaceutical industry
The pharmaceutical industry (or medicine industry) is the commercial industry that discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as different types of medicine and medications.
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Philadelphia
Philadelphia is the largest city in the U.S. state and Commonwealth of Pennsylvania, and the sixth-most populous U.S. city, with a 2017 census-estimated population of 1,580,863.
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Philip B. Hofmann
Philip B. Hofmann (May 25, 1909 – December 29, 1986) was an American businessman.
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Platinum Equity
Platinum Equity, LLC is an American private equity investment firm founded by Tom Gores in 1995.
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Polycarbonate
Polycarbonates (PC) are a group of thermoplastic polymers containing carbonate groups in their chemical structures.
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Prescription drug
A prescription drug (also prescription medication or prescription medicine) is a pharmaceutical drug that legally requires a medical prescription to be dispensed.
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Product recall
A product recall is a request to return a product after the discovery of safety issues or product defects that might endanger the consumer or put the maker/seller at risk of legal action.
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Psoriasis
Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin.
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Psychiatrist
A psychiatrist is a physician who specializes in psychiatry, the branch of medicine devoted to the diagnosis, prevention, study, and treatment of mental disorders.
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Public company
A public company, publicly traded company, publicly held company, publicly listed company, or public corporation is a corporation whose ownership is dispersed among the general public in many shares of stock which are freely traded on a stock exchange or in over the counter markets.
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Public relations
Public relations (PR) is the practice of managing the spread of information between an individual or an organization (such as a business, government agency, or a nonprofit organization) and the public.
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Puerto Rico
Puerto Rico (Spanish for "Rich Port"), officially the Commonwealth of Puerto Rico (Estado Libre Asociado de Puerto Rico, "Free Associated State of Puerto Rico") and briefly called Porto Rico, is an unincorporated territory of the United States located in the northeast Caribbean Sea.
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Ralph S. Larsen
Ralph S. Larsen (November 18, 1938 – March 9, 2016) was an American businessman.
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Reservation (law)
A reservation in international law is a caveat to a state's acceptance of a treaty.
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Reuters
Reuters is an international news agency headquartered in London, United Kingdom.
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Rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints.
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Richard B. Sellars
Richard Beverland Sellars (September 9, 1915 – June 25, 2010) was an American business executive who served as chairman and CEO of Johnson & Johnson as part of 40 years with the healthcare product firm.
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Risperidone
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
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Robert L. McNeil Jr.
Robert Lincoln McNeil Jr. (July 13, 1915 – May 20, 2010) was an American chemist and pharmaceutical industry executive.
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Robert Wood Johnson I
Robert Wood Johnson I (February 20, 1845 – February 7, 1910) was an American industrialist.
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Robert Wood Johnson II
Robert Wood "General" Johnson II (April 4, 1893 – January 30, 1968) was an American businessman.
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Robert Wood Johnson University Hospital
The Robert Wood Johnson University Hospital (RWJUH) is an American 965-bed hospital with campuses in New Brunswick (Robert Wood Johnson University Hospital New Brunswick), and Somerville, New Jersey (Somerset Medical Center), and serves as a flagship hospital of RWJBarnabas Health.
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S&P 100
The S&P 100 Index is a stock market index of United States stocks maintained by Standard & Poor's.
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S&P 500 Index
The Standard & Poor's 500, often abbreviated as the S&P 500, or just the S&P, is an American stock market index based on the market capitalizations of 500 large companies having common stock listed on the NYSE or NASDAQ.
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Sandi Peterson
Sandi Peterson (born 1959) is an American businesswoman and has been group worldwide chairman at Johnson & Johnson since 2012.
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Sanitation
Sanitation refers to public health conditions related to clean drinking water and adequate treatment and disposal of human excreta and sewage.
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Sanofi
Sanofi S.A. is a French multinational pharmaceutical company headquartered in Gentilly, France, as of 2013 the world's fifth-largest by prescription sales.
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Schaffhausen
Schaffhausen (Schafuuse; Schaffhouse; Sciaffusa; Schaffusa; Shaffhouse) is a town with historic roots, a municipality in northern Switzerland, and the capital of the canton of the same name; it has an estimated population of 36,000.
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Sense (molecular biology)
In molecular biology and genetics, the sense of nucleic acid molecules (often DNA or RNA) is the nature of their roles and their complementary molecules' nucleic acid units' roles in specifying amino acids.
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Shareholder
A shareholder or stockholder is an individual or institution (including a corporation) that legally owns one or more shares of stock in a public or private corporation.
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Skillman, New Jersey
Skillman is an unincorporated community and census-designated place (CDP) located within Montgomery Township, in Somerset County, New Jersey, United States.
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South Carolina
South Carolina is a U.S. state in the southeastern region of the United States.
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Spring House, Pennsylvania
Spring House is a census-designated place (CDP) in Montgomery County, Pennsylvania, United States.
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St. Louis
St.
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Susan Lindquist
Susan Lee Lindquist, ForMemRS (June 5, 1949 – October 27, 2016) was an American professor of biology at MIT specializing in molecular biology, particularly the protein folding problem within a family of molecules known as heat-shock proteins, and prions.
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Synthes
Synthes Holding AG (formerly Synthes-Stratec) is a multinational medical device manufacturer based in Solothurn, Switzerland and West Chester, Pennsylvania, United States.
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Takeda
is a Japanese family name.
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TearScience
TearScience is an American company founded in 2005 that develops, manufactures and markets ophthalmic medical devices aiding in the identification and treatment of Meibomian gland Dysfunction, also known as Dry eye disease, which is a condition that affect as many as 25 million Americans.
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Telaprevir
Telaprevir (VX-950), marketed under the brand names Incivek and Incivo, is a pharmaceutical drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson.
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Texas
Texas (Texas or Tejas) is the second largest state in the United States by both area and population.
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The New York Times
The New York Times (sometimes abbreviated as The NYT or The Times) is an American newspaper based in New York City with worldwide influence and readership.
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The Wall Street Journal
The Wall Street Journal is a U.S. business-focused, English-language international daily newspaper based in New York City.
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Tuberculosis
Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB).
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Tumor necrosis factor superfamily
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers.
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Turnhout
Turnhout is a Belgian municipality located in the Flemish province of Antwerp.
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Tylenol (brand)
Tylenol is a brand of drugs advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough headache, and influenza.
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U.S. Securities and Exchange Commission
The U.S. Securities and Exchange Commission (SEC) is an independent agency of the United States federal government.
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Ulcerative colitis
Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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United States Department of Justice
The United States Department of Justice (DOJ), also known as the Justice Department, is a federal executive department of the U.S. government, responsible for the enforcement of the law and administration of justice in the United States, equivalent to the justice or interior ministries of other countries. The department was formed in 1870 during the Ulysses S. Grant administration. The Department of Justice administers several federal law enforcement agencies including the Federal Bureau of Investigation (FBI), and the Drug Enforcement Administration (DEA). The department is responsible for investigating instances of financial fraud, representing the United States government in legal matters (such as in cases before the Supreme Court), and running the federal prison system. The department is also responsible for reviewing the conduct of local law enforcement as directed by the Violent Crime Control and Law Enforcement Act of 1994. The department is headed by the United States Attorney General, who is nominated by the President and confirmed by the Senate and is a member of the Cabinet. The current Attorney General is Jeff Sessions.
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Ustekinumab
Ustekinumab, sold under the brand name Stelara, is a human monoclonal antibody used to treat psoriasis.
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Washington (state)
Washington, officially the State of Washington, is a state in the Pacific Northwest region of the United States.
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Whistleblower
A whistleblower (also written as whistle-blower or whistle blower) is a person who exposes any kind of information or activity that is deemed illegal, unethical, or not correct within an organization that is either private or public.
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William C. Weldon
William C. Weldon (born November 26, 1948) is a former chairman of Johnson & Johnson, He was the eighth chairman in Johnson & Johnson's history of more than one hundred years.
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William Perez
William David "Bill" Perez (born September 10, 1947) is an American businessman who was the chief executive officer of Wm. Wrigley Jr. Company.
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Zodiac (schooner)
Zodiac is a two-masted schooner designed by William H. Hand, Jr. for Robert Wood Johnson and J. Seward Johnson, heirs to the Johnson & Johnson pharmaceuticals fortune.
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2,4,6-Tribromophenol
2,4,6-Tribromophenol (TBP) is a brominated derivative of phenol.
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References
[1] https://en.wikipedia.org/wiki/Johnson_%26_Johnson
