GABAB receptor and Ligand-gated ion channel

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Difference between GABAB receptor and Ligand-gated ion channel

GABAB receptor vs. Ligand-gated ion channel

GABAB receptors (GABABR) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels. Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.

Action potential

In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise.

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Adenylyl cyclase

Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.

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Baclofen

Baclofen, sold under the brand name Lioresal among others, is a medication used to treat spasticity.

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Cell surface receptor

Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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CGP-7930

CGP-7930 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.

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Ethanol

Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.

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Fendiline

Fendiline is a calcium channel blocker.

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GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

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Gamma-Aminobutyric acid

gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.

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Gamma-Hydroxybutyric acid

γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a psychoactive drug.

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Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Peripheral nervous system

The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).

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Phenibut

Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic and sedative effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications.

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Potassium

Potassium is a chemical element with symbol K (from Neo-Latin kalium) and atomic number 19.

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Saclofen

Saclofen is a competitive antagonist for the GABAB receptor.

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SCH-50911

SCH-50911 is a selective GABAB antagonist.

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