Management of HIV/AIDS and Tenofovir alafenamide

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Difference between Management of HIV/AIDS and Tenofovir alafenamide

Management of HIV/AIDS vs. Tenofovir alafenamide

The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection. Tenofovir alafenamide (INN/USAN; trade name Vemlidy) is a nucleotide reverse transcriptase inhibitor and a prodrug of tenofovir. It was developed by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (TDF), TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead was awarded FDA approval in November 2016 for the drug Vemlidy. Gilead announced a phase 3 clinical trial evaluating a single-tablet regimen combining tenofovir alafenamide with cobicistat, emtricitabine and elvitegravir and developed a coformulation of the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48-week study comparing elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil (trade name Stribild) to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (trade name Genvoya), the results showed the newer drug to be noninferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. The FDA approved the TAF-based treatment regimen for treatment of HIV-1 in November 2015. Genvoya is the first TAF-based regimen to receive approval.

Similarities between Management of HIV/AIDS and Tenofovir alafenamide

Management of HIV/AIDS and Tenofovir alafenamide have 17 things in common (in Unionpedia): Cobicistat, Darunavir, Elvitegravir, Elvitegravir/cobicistat/emtricitabine/tenofovir, Emtricitabine, Emtricitabine/rilpivirine/tenofovir, Emtricitabine/tenofovir, Fixed-dose combination (antiretroviral), Gilead Sciences, Hepatitis B, HIV, International nonproprietary name, Nucleotide, Protease inhibitor (pharmacology), Reverse-transcriptase inhibitor, Rilpivirine, Tenofovir disoproxil.

Cobicistat

Cobicistat, with trade name Tybost (formerly GS-9350) is a licensed drug for use in the treatment of human immunodeficiency virus infection (HIV/AIDS).

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Darunavir

Darunavir (DRV), sold under the brand name Prezista among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.

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Elvitegravir

Elvitegravir (EVG) is an integrase inhibitor used to treat HIV infection.

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Elvitegravir/cobicistat/emtricitabine/tenofovir

Elvitegravir/cobicistat/emtricitabine/tenofovir (brand name Stribild), also known as the Quad pill, is a fixed dose combination drug for the treatment of HIV/AIDS.

Elvitegravir/cobicistat/emtricitabine/tenofovir and Management of HIV/AIDS · Elvitegravir/cobicistat/emtricitabine/tenofovir and Tenofovir alafenamide · See more »

Emtricitabine

Emtricitabine (commonly called FTC, systematic name 2',3'-dideoxy-5-fluoro-3'-thiacytidine), with trade name Emtriva (formerly Coviracil), is a nucleoside reverse transcriptase inhibitor (NRTI) for the prevention and treatment of HIV infection in adults and children.

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Emtricitabine/rilpivirine/tenofovir

Emtricitabine/rilpivirine/tenofovir (trade names Complera, Eviplera) is a fixed dose combination of antiretroviral drugs for the treatment of HIV.

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Emtricitabine/tenofovir

Emtricitabine/tenofovir, sold under the brand name Truvada among others, is a medication used to treat and prevent HIV/AIDS.

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Fixed-dose combination (antiretroviral)

Fixed-dose combinations of antiretrovirals are multiple antiretroviral drugs combined into a single pill, which helps reduce pill burden.

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Gilead Sciences

Gilead Sciences, Inc., commonly known as Gilead Sciences or Gilead (also styled GILEAD), is an American biopharmaceutical company that researches, develops and commercializes drugs.

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Hepatitis B

Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver.

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HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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Nucleotide

Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.

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Protease inhibitor (pharmacology)

Protease inhibitors (PIs) are a class of antiviral drugs that are widely used to treat HIV/AIDS and hepatitis C. Protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles.

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Reverse-transcriptase inhibitor

Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses.

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Rilpivirine

Rilpivirine (TMC278, trade name Edurant) is a pharmaceutical drug, developed by Tibotec, for the treatment of HIV infection.

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Tenofovir disoproxil

Tenofovir disoproxil, sold under the trade name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS.

Management of HIV/AIDS and Tenofovir disoproxil · Tenofovir alafenamide and Tenofovir disoproxil · See more »

The list above answers the following questions

What Management of HIV/AIDS and Tenofovir alafenamide have in common
What are the similarities between Management of HIV/AIDS and Tenofovir alafenamide

Management of HIV/AIDS and Tenofovir alafenamide Comparison

Management of HIV/AIDS has 164 relations, while Tenofovir alafenamide has 30. As they have in common 17, the Jaccard index is 8.76% = 17 / (164 + 30).

References

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