Transactivation domain and Transcription factor

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Difference between Transactivation domain and Transcription factor

Transactivation domain vs. Transcription factor

The transactivation domain or trans-activating domain (TAD) is a transcription factor scaffold domain which contains binding sites for other proteins such as transcription coregulators. In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

C-jun

c-Jun is a protein that in humans is encoded by the JUN gene.

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CEBPB

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.

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DNA-binding protein

DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA.

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Gal4 transcription factor

The Gal4 transcription factor is a positive regulator of gene expression of galactose-induced genes.

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GAL4/UAS system

The GAL4-UAS system is a biochemical method used to study gene expression and function in organisms such as the fruit fly.

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Gcn4

Gcn4 is a transcription factor and a “master regulator” for gene expression which regulates close to one tenth of the yeast genome.

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Herpes simplex virus protein vmw65

Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor) is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.

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HSF1

Heat shock factor 1 (HSF1) is a protein that in humans is encoded by the HSF1 gene.

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KMT2A

Histone-lysine N-methyltransferase 2A also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia 1 (MLL1), or zinc finger protein HRX (HRX) is an enzyme that in humans is encoded by the KMT2A gene.

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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.

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NFAT

Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response.

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NFATC2

Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.

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P53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

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Pho4

Pho4 is a basic helix-loop-helix (bHLH) transcription factor found in S. cerevisiae and other yeasts.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Sp1 transcription factor

Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene.

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TCF3

Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene.

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Transcription coregulator

In molecular biology and genetics, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes.

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