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191 relations: ABT-418, Acamprosate, Aceglutamide, Adatanserin, Adult neurogenesis, Allopregnanolone, Alzheimer's Drug Discovery Foundation, Aptiganel, Argiotoxin, Aromatase, Arylcyclohexylamine, Axotomy, BAY 38-7271, Benzofuranylpropylaminopentane, Bifemelane, BNN-20, BNN-27, BRL-52537, Butylphthalide, C16 (drug), Canadian Spinal Research Organization, Cannabidiol, Caroverine, CGP-37849, Child psychopathology, CI-966, Ciclosporin, Clinical uses of mesenchymal stem cells, Clobenpropit, Clostridium sporogenes, Conantokin, Crocetin, DCG-IV, Delucemine, Deoxygedunin, Derrick Morgan (American football), Dexanabinol, Discodermolide, Ditolylguanidine, Effects of cannabis, Eliprodil, Emoxypine, Endophyte, Erythropoietin in neuroprotection, Estradiol, Estrogen and neurodegenerative diseases, Estrogen receptor alpha, Eugene Monroe, Fabomotizole, GABA analogue, ..., Galanin, Gene therapy for epilepsy, Gerald Muench, Ginsenoside, Giovanna Mallucci, Gliosis, GTS-21, GYKI-52,466, HA-966, Harry Demopoulos, Honokiol, HU-210, Hyperkinesia, Hypothermia cap, Ibudilast, Ibuprofen, Igmesine, Indantadol, Indeloxazine, Inferior olivary nucleus, Insulin-like growth factor, Ischemic cascade, Ispronicline, Κ-opioid receptor, James C. Tsai, Kaitocephalin, Ketogenic diet, Ladostigil, Lamotrigine, Late life depression, Leteprinim, Levomethamphetamine, Licostinel, LINGO1, List of neurosteroids, Lithium (medication), LM22A-4, Lubeluzole, LY-235959, LY-379,268, LY-503430, Management of Parkinson's disease, Mark B. Barron, Mechanism of anoxic depolarization in the brain, Medical Marijuana, Inc., Membrane progesterone receptor, Merrilactone A, Mervyn Maze, Microglia, Minocycline, Moclobemide, Motor pool (neuroscience), MTEP, Multiple sclerosis, Neonatal stroke, Neramexane, Neural stem cell, Neuroangiogenesis, Neuromelanin, Neuroprotectin, Neuroregeneration, Neurosteroid, Neurotensin, Nitric oxide synthase, Nizofenone, NMDA receptor, Olesoxime, Omigapil, Opioid receptor, P3 peptide, P7C3, Parkin (ligase), Parkinson's disease, Parkinson's disease clinical research, Pentylenetetrazol, Periventricular leukomalacia, Perzinfotel, Peter Calabresi, PF-4800567, PI3K/AKT/mTOR pathway, Piclozotan, Plumbagin, Pozanicline, Pregnenolone, Progesterone, Propentofylline, Protein C, Quinolinic acid, Quinpirole, Quisqualamine, RANBP2, Rapastinel, Recreational drug use, Remacemide, Repinotan, Ro5-4864, S-18986, Sabeluzole, SCH-58261, Selegiline, Selfotel, Semax, SER-601, Serotonin releasing agent, SIB-1893, Simon Mitchell, Sleeping disorders following traumatic brain injury, Solanezumab, Sophora flavescens, Spinal cord injury, Spinal cord injury research, Spinal muscular atrophy, SSR-180,575, Stem-cell therapy, STIM2, Stroke, Taltirelin, Targeted temperature management, TC-1698, Teniloxazine, Tezampanel, The Swedish Parkinson Academy, Timeline of stroke, Tolibut, Traumatic brain injury, Traxoprodil, U-89843A, Vision rehabilitation, Vitamin D and neurology, WAY-317538, Xenon, Zonampanel, (+)-Naloxone, 10β,17β-Dihydroxyestra-1,4-dien-3-one, 2-Methyl-6-(phenylethynyl)pyridine, 3-Hydroxymorphinan, 3-Indolepropionic acid, 4'-Dimethylamino-7,8-dihydroxyflavone, 6-Hydroxymelatonin, 7,8,3'-Trihydroxyflavone, 7β-Hydroxyepiandrosterone. Expand index (141 more) »
ABT-418
ABT-418 is a drug developed by Abbott, that has nootropic, neuroprotective and anxiolytic effects, and has been researched for treatment of both Alzheimer's disease and ADHD.
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Acamprosate
Acamprosate, sold under the brand name Campral, is a medication used along with counselling to treat alcohol dependence.
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Aceglutamide
Aceglutamide (brand name Neuramina), or aceglutamide aluminum (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan.
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Adatanserin
Adatanserin (WY-50,324, SEB-324) is a mixed 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2C receptor antagonist.
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Adult neurogenesis
Neurogenesis is the process by which neurons are generated from neural stem cells.
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Allopregnanolone
Allopregnanolone, also known as 5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), as well as brexanolone, is an endogenous inhibitory pregnane neurosteroid.
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Alzheimer's Drug Discovery Foundation
The Alzheimer's Drug Discovery Foundation (ADDF) is a nonprofit organization founded in 1998 by co-chairmen Leonard A. Lauder and Ronald S. Lauder of the Estée Lauder Companies cosmetics family and led by Dr.
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Aptiganel
Aptiganel (Cerestat; CNS-1102) is an unsuccessful drug candidate which acts as a noncompetitive NMDA antagonist, and that was under development by Cambridge Neuroscience, Inc as a treatment for stroke.
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Argiotoxin
Argiotoxins represent a class of polyamine toxins isolated from the orb-weaver spider (Araneus gemma and Argiope lobata).
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Aromatase
Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens.
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Arylcyclohexylamine
Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical, designer, and experimental drugs.
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Axotomy
An axotomy is the cutting or otherwise severing of an axon.
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BAY 38-7271
Originally synthesized by chemist Wayne E. Kenney, BAY 38-7271 (KN 38-7271) is a drug which is a cannabinoid receptor agonist developed by Bayer AG.
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Benzofuranylpropylaminopentane
(-)-1-(Benzofuran-2-yl)-2-propylaminopentane ((-)-BPAP), BFPAPn, or BFPAP is a drug with an unusual effects profile.
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Bifemelane
Bifemelane (INN) (Alnert, Celeport), or bifemelane hydrochloride (JAN), also known as 4-(O-benzylphenoxy)-N-methylbutylamine, is an antidepressant and cerebral activator that is widely used in the treatment of cerebral infarction patients with depressive symptoms in Japan, and in the treatment of senile dementia as well.
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BNN-20
BNN-20, also known as 17β-spiro-(androst-5-en-17,2'-oxiran)-3β-ol, is a synthetic neurosteroid, "microneurotrophin", and analogue of the endogenous neurosteroid dehydroepiandrosterone (DHEA).
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BNN-27
BNN-27, also known as 17α,20R-epoxypregn-5-ene-3β,21-diol, is a synthetic neurosteroid and "microneurotrophin" and analogue of the endogenous neurosteroid dehydroepiandrosterone (DHEA).
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BRL-52537
BRL-52537 is a drug which acts as a potent and highly selective κ-opioid agonist.
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Butylphthalide
Butylphthalide (3-n-butylphthalide or NBP) is one of the chemical constituents in celery oil, along with sedanolide, which is primarily responsible for the aroma and taste of celery.
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C16 (drug)
C16 or PKRi is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR).
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Canadian Spinal Research Organization
The Canadian Spinal Research Organization is a nationally registered charity whose mission is improve the physical quality of life for persons with spinal cord injuries (SCI) and related neurological deficits, as well as reduce the number of spinal cord injuries through awareness and prevention programs.
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Cannabidiol
Cannabidiol (CBD) is a naturally occurring cannabinoid constituent of cannabis.
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Caroverine
Caroverine (Spasmium, Spadon, Tinnex) is a drug used in tinnitus treatment improves mechanosensitivity and mechanotransduction phenomenon and otoneuroprotective (inner ear protective) agent in some countries.
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CGP-37849
CGP-37849 is a competitive antagonist at the NMDA receptor.
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Child psychopathology
Child psychopathology refers to the scientific study of mental disorders in children and adolescents.
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CI-966
CI-966 (developmental code name) is a central nervous system depressant acting as a GABA reuptake inhibitor, specifically a highly potent and selective blocker of the GABA transporter 1 (GAT-1) (IC50.
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Ciclosporin
Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product.
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Clinical uses of mesenchymal stem cells
Adult mesenchymal stem cells (MSCs) are being used by researchers in the fields of regenerative medicine and tissue engineering, to artificially reconstruct human tissue which has been previously damaged.
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Clobenpropit
Clobenpropit is a histamine H3 receptor antagonist.
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Clostridium sporogenes
Clostridium sporogenes is a species of Gram-positive bacteria that belongs to the genus Clostridium.
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Conantokin
Conantokins are a small family of helical peptides that are derived from the venom of predatory marine snails of the genus Conus.
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Crocetin
Crocetin is a natural apocarotenoid dicarboxylic acid that is found in the crocus flower and Gardenia jasminoides (fruits).
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DCG-IV
DCG-IV is a research drug which acts as a group-selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).
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Delucemine
Delucemine (NPS-1506) is a drug which acts as an NMDA antagonist and a serotonin reuptake inhibitor, and has neuroprotective effects.
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Deoxygedunin
Deoxygedunin, or 14,15-deoxygedunin, is a naturally occurring tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), a plant that has been used in India since ancient times as a remedy for various ailments.
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Derrick Morgan (American football)
Derrick Lee Morgan (born January 6, 1989) is an American football linebacker for the Tennessee Titans of the National Football League (NFL).
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Dexanabinol
Dexanabinol (HU-211 or ETS2101) is a synthetic cannabinoid derivative in development by e-Therapeutics plc.
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Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule.
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Ditolylguanidine
Ditolylguanidine is a sigma receptor agonist.
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Effects of cannabis
The effects of cannabis are caused by the chemical compounds in the plant, including cannabinoids, such as tetrahydrocannabinol (THC), which is only one of more than 100 different cannabinoids present in the plant.
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Eliprodil
Eliprodil (codenamed SL-82.0715) is a NMDA antagonist drug candidate that failed a Phase III clinical trial for the treatment of acute ischemic stroke in 1996, sponsored by Synthélabo Recherche.
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Emoxypine
Emoxypine (2-ethyl-6-methyl-3-hydroxypyridine), also known as Mexidol or Mexifin when used as the succinate salt, is an antioxidant manufactured in Russia by Pharmasoft Pharmaceuticals.
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Endophyte
An endophyte is an endosymbiont, often a bacterium or fungus, that lives within a plant for at least part of its life cycle without causing apparent disease.
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Erythropoietin in neuroprotection
Erythropoietin in neuroprotection is the use of the glycoprotein erythropoietin (Epo) for neuroprotection.
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Estradiol
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
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Estrogen and neurodegenerative diseases
Neurodegenerative diseases can disrupt the normal human homeostasis and result in abnormal estrogen levels.
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Estrogen receptor alpha
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.
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Eugene Monroe
Eugene Christopher Monroe (born April 18, 1987) is a former American football offensive tackle who played seven seasons in the National Football League (NFL).
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Fabomotizole
Fabomotizole (INN) (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s.
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GABA analogue
A GABA analogue is a compound which is an analogue or derivative of the neurotransmitter gamma-Aminobutyric acid (GABA) (the IUPAC of which is 4-aminobutanoic acid).
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Galanin
Galanin is a neuropeptide encoded by the GAL gene, that is widely expressed in the brain, spinal cord, and gut of humans as well as other mammals.
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Gene therapy for epilepsy
Gene therapy is being studied for some forms of epilepsy.
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Gerald Muench
Gerald Muench is a senior faculty in the discipline of Pharmacology and has been working as Founder Chair, Pharmacology Department, UWS School of Medicine, University of Western Sydney.
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Ginsenoside
Ginsenosides or panaxosides are a class of natural product steroid glycosides and triterpene saponins.
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Giovanna Mallucci
Giovanna Mallucci is a professor in the Department of Clinical Neurosciences at the University of Cambridge.
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Gliosis
Gliosis is a nonspecific reactive change of glial cells in response to damage to the central nervous system (CNS).
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GTS-21
GTS-21 (DMBX-A) is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors.
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GYKI-52,466
GYKI-52466 is a 2,3-benzodiazepine that acts as an ionotropic glutamate receptor antagonist, which is a non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA-, kainate- and NMDA-induced responses respectively), orally-active anticonvulsant, and skeletal muscle relaxant.
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HA-966
HA-966 or (±) 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist / low efficacy partial agonist.
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Harry Demopoulos
Harry B. Demopoulos is a researcher in the medical aspects of free radicals, especially in the areas of ischaemic injury, the toxicity of anticancer drugs, and in spinal cord injury.
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Honokiol
Honokiol is a lignan isolated from the bark, seed cones, and leaves of trees belonging to the genus Magnolia.
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HU-210
HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol by a group led by Professor Raphael Mechoulam at the Hebrew University.
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Hyperkinesia
Hyperkinesia, also known as hyperkinesis, refers to an increase in muscular activity that can result in excessive abnormal movements, excessive normal movements, or a combination of both.
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Hypothermia cap
A hypothermia cap (also referred to as cold cap or cooling cap) is a therapeutic device used to cool the human scalp.
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Ibudilast
Ibudilast (development codes: AV-411 or MN-166) is an anti-inflammatory drug used mainly in Japan, which acts as a phosphodiesterase inhibitor, inhibiting the PDE4 subtype to the greatest extent, but also showing significant inhibition of other PDE subtypes.
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Ibuprofen
Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation.
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Igmesine
Igmesine (JO-1,784) is a sigma receptor agonist (IC50.
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Indantadol
Indantadol (CHF-3381, V-3381) is a drug which was formerly being investigated as an anticonvulsant and neuroprotective and is now under development for the treatment of neuropathic pain and chronic cough in Europe by Vernalis and Chiesi.
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Indeloxazine
Indeloxazine (INN) (Elen, Noin) is an antidepressant and cerebral activator that was marketed in Japan and South Korea by Yamanouchi Pharmaceutical Co., Ltd for the treatment of psychiatric symptoms associated with cerebrovascular diseases, namely depression resulting from stroke, emotional disturbance, and avolition.
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Inferior olivary nucleus
The inferior olivary nucleus (ION), is an evolutionarily conserved structure found in the medulla oblongata underneath the superior olivary nucleus.
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Insulin-like growth factor
The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin.
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Ischemic cascade
The ischemic (ischaemic) cascade is a series of biochemical reactions that are initiated in the brain and other aerobic tissues after seconds to minutes of ischemia (inadequate blood supply).
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Ispronicline
Ispronicline (TC-1734, AZD-3480) is an experimental drug which acts as a partial agonist at neural nicotinic acetylcholine receptors.
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Κ-opioid receptor
The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.
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James C. Tsai
James C. Tsai is President, New York Eye and Ear Infirmary of Mount Sinai, the nation’s first and longest operating specialty hospital, founded in 1820.
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Kaitocephalin
Kaitocephalin is a non-selective ionotropic glutamate receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate.
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Ketogenic diet
The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children.
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Ladostigil
Ladostigil (TV-3,326) is a novel neuroprotective agent being investigated for the treatment of neurodegenerative disorders like Alzheimer's disease, Lewy body disease, and Parkinson's disease.
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Lamotrigine
Lamotrigine, sold as the brand name Lamictal among others, is an anticonvulsant medication used to treat epilepsy and bipolar disorder.
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Late life depression
Late life depression refers to a major depressive episode occurring for the first time in an older person (usually over 50 or 60 years of age).
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Leteprinim
Leteprinim (Neotrofin, AIT-082) is a hypoxanthine derivative drug with neuroprotective and nootropic effects.
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Levomethamphetamine
LevomethamphetamineOther names include l-methamphetamine, levodesoxyephedrine, l-desoxyephedrine, levmetamfetamine (INN and USAN).
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Licostinel
Licostinel (INN) (code name ACEA-1021) is a competitive, silent antagonist of the glycine site of the NMDA receptor (Kb.
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LINGO1
Leucine rich repeat and Immunoglobin-like domain-containing protein 1 also known as LINGO-1 is a protein which is encoded by the LINGO1 gene in humans.
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List of neurosteroids
This is a list of neurosteroids, or natural and synthetic steroids that are active on the mammalian nervous system through receptors other than steroid hormone receptors.
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Lithium (medication)
Lithium compounds, also known as lithium salts, are primarily used as a psychiatric medication.
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LM22A-4
LM22A-4 is a synthetic, selective small-molecule partial agonist of TrkB (EC50 for TrkB activation.
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Lubeluzole
Lubeluzole (Prosynap) is a drug which acts as an indirect NMDA antagonist.
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LY-235959
LY-235959 is a competitive antagonist at the NMDA receptor.
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LY-379,268
LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).
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LY-503430
LY-503430 is an AMPA receptor positive allosteric modulator developed by Eli Lilly.
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Management of Parkinson's disease
Management of Parkinson's disease (PD), due to its chronic nature, requires a broad-based program including patient and family education, support group services, general wellness maintenance, exercise, and nutrition.
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Mark B. Barron
Mark B. Barron (born Mark Bowen) is an American entrepreneur and inventor.
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Mechanism of anoxic depolarization in the brain
Anoxic depolarization is a progressive and uncontrollable depolarization of neurons during stroke or brain ischemia in which there is an inadequate supply of blood to the brain.
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Medical Marijuana, Inc.
Medical Marijuana, Inc. (traded over the counter as MJNA), is a holding company with subsidiaries that make and sell a range of hemp-based products.
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Membrane progesterone receptor
Membrane progesterone receptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR) family which bind the endogenous progestogen and neurosteroid progesterone, as well as the neurosteroid allopregnanolone.
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Merrilactone A
Merrilactone A is one of the four sesquiterpenes that were newly discovered from the fruit of Illicium merrillianum in 2000.
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Mervyn Maze
Mervyn Maze, MD, MB ChB has been a Professor in the Departments of Anesthesia and Pain Medicine, Intensive Care at the since 1988.
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Microglia
Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord.
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Minocycline
Minocycline is a broad-spectrum tetracycline antibiotic, and has a broader spectrum than the other members of the group.
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Moclobemide
Moclobemide (sold as Amira, Aurorix, Clobemix, Depnil and Manerix) is a reversible inhibitor of monoamine oxidase A (RIMA) drug primarily used to treat depression and social anxiety. It is not approved for use in the United States, but is approved in other Western countries such as the UK and Australia (TGA approved in December 2000). It is produced by affiliates of the Hoffmann–La Roche pharmaceutical company. Initially, Aurorix was also marketed by Roche in South Africa, but was withdrawn after its patent rights expired and Cipla Medpro's Depnil and Pharma Dynamic's Clorix became available at half the cost. No significant rise in blood pressure occurs when moclobemide is combined with amines such as tyramine-containing foods or pressor amine drugs, unlike with the older nonselective and irreversible monoamine oxidase inhibitors (MAOIs), which cause a severe rise in blood pressure with such combination. Due to the lack of anticholinergic, cardiovascular, cognitive and psychomotor impairments moclobemide is advantageous in the elderly as well as those with cardiovascular disease.
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Motor pool (neuroscience)
A motor pool consists of all individual motor neurons that innervate a single muscle.
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MTEP
3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5.
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Multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.
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Neonatal stroke
Neonatal Stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood supply of the developing brain in the first 28 days of life.
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Neramexane
Neramexane is a drug related to memantine, which acts as an NMDA antagonist and has neuroprotective effects.
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Neural stem cell
Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the neurons and glia of the nervous system of all animals during embryonic development.
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Neuroangiogenesis
Neuroangiogenesis is a term used to describe the coordinated growth of nerves and blood vessels.
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Neuromelanin
Neuromelanin (NM) is a dark pigment found in the brain which is structurally related to melanin.
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Neuroprotectin
Neuroprotectin D1 (NPD1) (10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA.
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Neuroregeneration
Neuroregeneration refers to the regrowth or repair of nervous tissues, cells or cell products.
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Neurosteroid
Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.
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Neurotensin
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.
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Nitric oxide synthase
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.
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Nizofenone
Nizofenone (Ekonal, Midafenone) is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain).
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NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
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Olesoxime
Olesoxime (TRO19622) is an experimental neuroprotective drug.
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Omigapil
Omigapil (TCH346 or CGP3466) is a drug that was developed by Novartis and tested in clinical trials for its ability to help treat Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).
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Opioid receptor
Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.
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P3 peptide
p3 peptide also known as amyloid β- peptide (Aβ)17–40/42 is the peptide resulting from the α- and γ-secretase cleavage from the amyloid precursor protein (APP).
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P7C3
P7C3 (pool 7, compound 3) is a drug related to latrepirdine (dimebon) which has neuroprotective and proneurogenic effects and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.
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Parkin (ligase)
Parkin is a 465-residue E3 ubiquitin ligase that plays a critical role in ubiquitination- the process whereby molecules are covalently labelled with ubiquitin (Ub) and directed towards degradation in proteasomes or lysosomes.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Parkinson's disease clinical research
Parkinson's disease clinical research (also known as clinical trials, medical research, research studies, or clinical studies) is any study intended to help answer questions about etiology, diagnostic approaches or new treatments by studying their effects on human subjects.
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Pentylenetetrazol
Pentylenetetrazol, also known as pentylenetetrazole, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, Cardiazol, deumacard or PTZ, is a drug formerly used as a circulatory and respiratory stimulant.
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Periventricular leukomalacia
Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles.
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Perzinfotel
Perzinfotel (EAA-090) is a drug which acts as a potent NMDA antagonist.
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Peter Calabresi
Peter Calabresi is an American neurology researcher, director of the Johns Hopkins Multiple Sclerosis (MS) Center and an Associate Professor of Neurology.
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PF-4800567
PF-4800567 is a drug developed by Pfizer which acts as a selective inhibitor of the enzyme Casein kinase 1 epsilon (CK1-ε), and has mainly been used in the study of the casein kinase 1 enzymes in the regulation of circadian rhythm, as well as showing potential neuroprotective effects.
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PI3K/AKT/mTOR pathway
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.
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Piclozotan
Piclozotan (SUN-N4057) is a selective 5-HT1A receptor partial agonist, which has neuroprotective effects in animal studies.
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Plumbagin
Plumbagin or 5-hydroxy-2-methyl-1,4-naphthoquinone is an organic compound with the chemical formula.
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Pozanicline
Pozanicline (INN, codenamed ABT-089) is a drug developed by Abbott, that has nootropic and neuroprotective effects.
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Pregnenolone
Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids.
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Progesterone
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
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Propentofylline
Propentofylline (HWA 285) is a xanthine derivative with purported neuroprotective effects.
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Protein C
Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals.
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Quinolinic acid
Quinolinic acid (abbreviated QUIN or QA), also known as pyridine-2,3-dicarboxylic acid, is a dicarboxylic acid with a pyridine backbone.
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Quinpirole
Quinpirole is a psychoactive drug and research chemical which acts as a selective D2 and D3 receptor agonist.
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Quisqualamine
Quisqualamine is the α-decarboxylated analogue of quisqualic acid, as well as a relative of the neurotransmitters glutamate and γ-aminobutyric acid (GABA).
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RANBP2
RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene.
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Rapastinel
Rapastinel (former developmental code names GLYX-13, BV-102) is a novel antidepressant that is under development by Allergan (previously Naurex) as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder.
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Recreational drug use
Recreational drug use is the use of a psychoactive drug to induce an altered state of consciousness for pleasure, by modifying the perceptions, feelings, and emotions of the user.
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Remacemide
Remacemide is a drug which acts as a low-affinity NMDA antagonist with sodium channel blocking properties.
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Repinotan
Repinotan (BAYx3702), an aminomethylchroman derivative, is a selective 5-HT1A receptor full agonist with high potency and efficacy.
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Ro5-4864
Ro5-4864 (4'-chlorodiazepam) is a drug which is a benzodiazepine derivative of diazepam.
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S-18986
S-18986 is a positive allosteric modulator of the AMPA receptor related to cyclothiazide.
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Sabeluzole
Sabeluzole (R-58,735) is a nootropic and neuroprotective drug which was originally developed for the treatment of Alzheimer's disease, and has subsequently been researched for other applications such as sleep apnoea.
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SCH-58261
SCH-58261 is a drug which acts as a potent and selective antagonist for the adenosine receptor A2A, with more than 50x selectivity for A2A over other adenosine receptors.
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Selegiline
Selegiline, also known as L-deprenyl, is a substituted phenethylamine.
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Selfotel
Selfotel (CGS-19755) is a drug which acts as a competitive NMDA antagonist, directly competing with glutamate for binding to the receptor.
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Semax
Semax is a drug which is used mostly in Russia and Ukraine for a broad range of conditions but predominantly for its purported nootropic, neuroprotective, and neurogenic/neurorestorative properties.
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SER-601
SER-601 (COR-167) is a drug which acts as a potent and selective cannabinoid CB2 receptor agonist, based on a quinolone-3-carboxylic acid core structure, with 190x selectivity for CB2 over the related CB1 receptor.
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Serotonin releasing agent
A serotonin releasing agent (SRA) is a type of drug that induces the release of serotonin into the neuronal synaptic cleft.
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SIB-1893
SIB-1893 is a drug used in scientific research which was one of the first compounds developed that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5.
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Simon Mitchell
Simon Mitchell (born 1958) is a New Zealand physician specialising in occupational medicine, hyperbaric medicine and anesthesiology.
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Sleeping disorders following traumatic brain injury
Sleep disorder is a common repercussion of traumatic brain injury (TBI).
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Solanezumab
Solanezumab (proposed INN, LY2062430) is a monoclonal antibody being investigated by Eli Lilly as a neuroprotector for patients with Alzheimer's disease.
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Sophora flavescens
Sophora flavescens, the shrubby sophora, is a species of plant in the genus Sophora a genus of the Fabaceae family, that contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands.About fifteen species in this genus have a long history of use in traditional Chinese medicines.
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Spinal cord injury
A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function.
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Spinal cord injury research
Spinal cord injury research seeks new ways to cure or treat spinal cord injury in order to lessen the debilitating effects of the injury in the short or long term.
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Spinal muscular atrophy
Spinal muscular atrophy (SMA) is a rare neuromuscular disorder characterised by loss of motor neurons and progressive muscle wasting, often leading to early death.
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SSR-180,575
SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO.
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Stem-cell therapy
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.
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STIM2
Stromal interaction molecule 2 (STIM2) is a protein that in humans is encoded by the STIM2 gene.
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Stroke
A stroke is a medical condition in which poor blood flow to the brain results in cell death.
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Taltirelin
Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects, and little development of tolerance following prolonged dosing.
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Targeted temperature management
Targeted temperature management (TTM) previously known as therapeutic hypothermia or protective hypothermia is an active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes during recovery after a period of stopped blood flow to the brain.
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TC-1698
TC-1698 is a drug developed by Targacept which acts as a partial agonist for the α7 subtype of neural nicotinic acetylcholine receptors.
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Teniloxazine
Teniloxazine (Lucelan, Metatone), also known as sufoxazine and sulfoxazine, is a drug which is marketed in Japan.
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Tezampanel
Tezampanel (INN, USAN) (code names LY-293,558, NGX-424) is a drug originally developed by Eli Lilly which acts as a competitive antagonist of the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainate receptor.
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The Swedish Parkinson Academy
The Swedish Parkinson Academy (Svenska Parkinsonakademien; SPA) was founded in 2007 and is based at Lund University in Sweden.
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Timeline of stroke
This is a timeline of stroke, describing especially major discoveries, developments and organizations concerning the disease.
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Tolibut
Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia.
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Traumatic brain injury
Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force injures the brain.
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Traxoprodil
Traxoprodil (developmental code name CP-101606) is a drug developed by Pfizer which acts as an NMDA antagonist, selective for the NR2B subunit.
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U-89843A
U-89843A (PNU-89843) is a sedative drug which acts as an agonist at GABAA receptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes.
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Vision rehabilitation
Vision rehabilitation (often called vision rehab) is a term for a medical rehabilitation to improve vision or low vision.
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Vitamin D and neurology
Vitamin D is a steroid hormone that plays a vital role in calcium and phosphate absorption.
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WAY-317538
WAY-317538 (SEN-12333) is a drug that acts as a potent and selective full agonist for the α7 subtype of neural nicotinic acetylcholine receptors.
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Xenon
Xenon is a chemical element with symbol Xe and atomic number 54.
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Zonampanel
Zonampanel (INN, code name YM872) is a quinoxalinedione derivative drug and competitive antagonist of the AMPA receptor which was being investigated by Yamanouchi/Astellas Pharma as a neuroprotective drug for the treatment of ischemic stroke but never completed clinical trials.
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(+)-Naloxone
(+)-Naloxone (dextro-naloxone) is a drug which is the "unnatural" enantiomer of the opioid antagonist drug (−)-naloxone.
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10β,17β-Dihydroxyestra-1,4-dien-3-one
10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED) is an orally active, centrally selective estrogen and a biosynthetic prodrug of estradiol which was discovered by Laszlo Prokai and colleagues.
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2-Methyl-6-(phenylethynyl)pyridine
2-Methyl-6-(phenylethynyl)pyridine (MPEP) is a research drug which was one of the first compounds found to act as a selective antagonist for the metabotropic glutamate receptor subtype mGluR5.
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3-Hydroxymorphinan
3-Hydroxymorphinan (3-HM), or morphinan-3-ol, is a psychoactive drug of the morphinan family.
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3-Indolepropionic acid
3-Indolepropionic acid (IPA), or indole-3-propionic acid, is a potent neuroprotective antioxidant, plant auxin, and natural product in humans that is being studied for therapeutic use in Alzheimer's disease.
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4'-Dimethylamino-7,8-dihydroxyflavone
4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF) is a synthetic flavone and selective small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), which was derived from structural modification of 7,8-dihydroxyflavone (7,8-DHF).
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6-Hydroxymelatonin
6-Hydroxymelatonin (6-OHM) is a naturally occurring, endogenous, major active metabolite of melatonin.
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7,8,3'-Trihydroxyflavone
7,8,3′-Trihydroxyflavone (7,8,3'-THF) is a flavone and small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from 7,8-dihydroxyflavone (7,8-DHF).
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7β-Hydroxyepiandrosterone
7β-Hydroxyepiandrosterone (7β-OH-EPIA), also known as 5α-androstan-3β,7β-diol-17-one, is an endogenous androgen, estrogen, and neurosteroid that is produced from dehydroepiandrosterone and epiandrosterone.
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Neuroprotectant, Neuroprotective, Neuroprotective agent, Neuroprotective drug.
References
[1] https://en.wikipedia.org/wiki/Neuroprotection
