Rebeccamycin

Rebeccamycin (NSC 655649) is a weak topoisomerase I inhibitor isolated from Nocardia sp. It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases. ^[1]

5 relations: NCI-60, Nocardia, Protein kinase, Staurosporine, Topoisomerase.

NCI-60

The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity.

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Nocardia

Nocardia is a genus of weakly staining Gram-positive, catalase-positive, rod-shaped bacteria.

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Protein kinase

A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).

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Staurosporine

Staurosporine (antibiotic AM-2282 or STS) is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus.

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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA.

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References

[1] https://en.wikipedia.org/wiki/Rebeccamycin

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